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Rab8a
Gene Detail
Symbol

Name
ID
Rab8a
RAB8A, member RAS oncogene family
MGI:96960
Synonyms
Mel
Feature Type
protein coding gene
Genetic Map
Chromosome 8
34.84 cM
Detailed Genetic Map ± 1 cM


Mapping data(6)
Sequence Map
Chr8:72161200-72183904 bp, + strand
From VEGA annotation of GRCm38

  22705 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:100934  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: Ras-related protein Rab
Gene Tree: Rab8a

Human
homologs
Human Homolog RAB8A, RAB8A, member RAS oncogene family
NCBI Gene ID 4218
neXtProt AC  NX_P61006
Human Synonyms  MEL, RAB8
Human Chr (Location)  19p13.1; chr19:16111680-16133635 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(9) : Gene trapped(4) Targeted(5)
Incidental mutations (data from APF )
 
Mice homozygous for a null allele die 3 to 4 weeks after birth and exhibit cachexia, diarrhea, intestinal swelling, shortened microvilli with inclusion bodies, and a failure to absorb nutrients.
 
Interactions
Rab8a interacts with 317 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (70 annotations)
Process axonogenesis, cell projection organization, ...
Component cell projection, centrosome, ...
Function GDP binding, GTPase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (2 records)
cDNA source data(14)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(16) Genomic(2) cDNA(14)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000022245 (Evidence)
Ensembl Gene ModelENSMUSG00000003037 (Evidence)
Entrez Gene17274 (Evidence)
DFCITC1572097, TC1626327, TC1728670
DoTSDT.101156527, DT.101399880, DT.110882882, DT.110883134, DT.110883483, DT.494705, DT.97382377, DT.99862287
NIA Mouse Gene IndexU009483
PDB2FU5
Consensus CDS ProjectCCDS22409.1
International Mouse Knockout Project StatusRab8a
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000022245 VEGA Gene Model | MGI Sequence Detail 22705 C57BL/6J ±  kb
transcript OTTMUST00000052947 VEGA | MGI Sequence Detail 4550 Not Applicable 
polypeptide OTTMUSP00000025154 VEGA | MGI Sequence Detail 207 Not Applicable 

For the selected sequences
All sequences(53) RefSeq(4) UniProt(5)
Polymorphisms
RFLP(1) : SNPs within 2kb(252 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
InterPro IPR001806 Small GTPase superfamily
InterPro IPR003579 Small GTPase superfamily, Rab type
InterPro IPR005225 Small GTP-binding protein domain
Protein Ontology PR:000013642 ras-related protein Rab-8A
References
(Earliest) J:10993 Saunders AM, et al., A molecular genetic linkage map of mouse chromosome 7. Genomics. 1990 Nov;8(3):525-35
(Latest) J:211898 Sato T, et al., Rab8a and Rab8b are essential for several apical transport pathways but insufficient for ciliogenesis. J Cell Sci. 2014 Jan 15;127(Pt 2):422-31
All references(58)
Other
accession IDs
MGD-MRK-12190, MGI:2142414

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/09/2014
MGI 5.20
The Jackson Laboratory