Rab8a
Gene Detail

Symbol Name ID

Rab8a RAB8A, member RAS oncogene family MGI:96960

Synonyms

Mel

Feature Type

protein coding gene

Genetic Map

Chromosome 8

34.84 cM
Detailed Genetic Map ± 1 cM


Mapping data(6)

Sequence Map

Chr8:72161200-72183904 bp, + strand From VEGA annotation of GRCm38   22705 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:128222  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: Ras-related protein Rab
Gene Tree: Rab8a

Human homologs

Human Homolog		RAB8A, RAB8A, member RAS oncogene family
NCBI Gene ID		4218
neXtProt AC		NX_P61006
Human Synonyms		MEL, RAB8
Human Chr (Location)		19p13.1; chr19:16222490-16244445 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(9) : Targeted(5) Gene trapped(4)
 

Mice homozygous for a null allele die 3 to 4 weeks after birth and exhibit cachexia, diarrhea, intestinal swelling, shortened microvilli with inclusion bodies, and a failure to absorb nutrients.

 

Gene Ontology (GO) classifications

All GO classifications: (33 annotations)

Process	axonogenesis, cilium assembly, ...
Component	cell projection, cytoplasm, ...
Function	GDP binding, GTPase activity, ...

External Resources: FuncBase

Expression

Literature Summary: (2 records)
cDNA source data(14)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(16) Genomic(2) cDNA(14)
Microarray probesets(5)

Other database links

VEGA Gene Model	OTTMUSG00000022245 (Evidence)
Ensembl Gene Model	ENSMUSG00000003037 (Evidence)
Entrez Gene	17274 (Evidence)
DFCI	TC1572097, TC1626327, TC1728670
DoTS	DT.101156527, DT.101399880, DT.110882882, DT.110883134, DT.110883483, DT.494705, DT.97382377, DT.99862287
NIA Mouse Gene Index	U009483
PDB	2FU5
Consensus CDS Project	CCDS22409.1
International Mouse Knockout Project Status	Rab8a

Sequences

Length	Strain/Species
genomic	OTTMUSG00000022245	VEGA Gene Model | MGI Sequence Detail	22705	C57BL/6J
transcript	OTTMUST00000052947	VEGA | MGI Sequence Detail	4550	Not Applicable
polypeptide	OTTMUSP00000025154	VEGA | MGI Sequence Detail	207	Not Applicable

All sequences(49) RefSeq(2) UniProt(3)

Polymorphisms

RFLP(1) : SNPs(129 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR001806	Small GTPase superfamily
InterPro	IPR003579	Small GTPase superfamily, Rab type
InterPro	IPR005225	Small GTP-binding protein domain
Protein Ontology	PR:000013642	ras-related protein Rab-8A

References

(Earliest) J:10993 Saunders AM, et al., A molecular genetic linkage map of mouse chromosome 7. Genomics. 1990 Nov;8(3):525-35
(Latest) J:192810 Esseltine JL, et al., Rab8 modulates metabotropic glutamate receptor subtype 1 intracellular trafficking and signaling in a protein kinase C-dependent manner. J Neurosci. 2012 Nov 21;32(47):16933-42a
All references(50)

Other accession IDs

MGD-MRK-12190, MGI:2142414