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Rab8a Gene Detail
Summary
  • Symbol
    Rab8a
  • Name
    RAB8A, member RAS oncogene family
  • Synonyms
    Mel
  • Feature Type
    protein coding gene
  • IDs
    MGI:96960
    NCBI Gene: 17274
  • Gene Overview
    MyGene.info: RAB8A
Location & Maps
more
  • Sequence Map
    Chr8:72161200-72183904 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      22705 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 8, 34.84 cM
  • Mapping Data
    6 experiments
Homology
more
  • Human Ortholog
    RAB8A, RAB8A, member RAS oncogene family
  • Vertebrate Orthologs
    9
  • Human Ortholog
    RAB8A, RAB8A, member RAS oncogene family
    Orthology source: HomoloGene, HGNC
  • Synonyms
    MEL, RAB8
  • Links
    NCBI Gene ID: 4218
    neXtProt AC: NX_P61006

  • Chr Location
    19p13.11; chr19:16111680-16133635 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    7 phenotypes from 3 alleles in 2 genetic backgrounds
    10 phenotypes from multigenic genotypes
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    10
  • Chemically induced (other)
    1
  • Gene trapped
    4
  • Targeted
    5
  • Genomic Mutations
    1 involving Rab8a
  • Incidental Mutations
    APF
Mice homozygous for a null allele die 3 to 4 weeks after birth and exhibit cachexia, diarrhea, intestinal swelling, shortened microvilli with inclusion bodies, and a failure to absorb nutrients.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000022245 VEGA Gene Model | MGI Sequence Detail 22705 C57BL/6J ±  kb
transcript OTTMUST00000052947 VEGA | MGI Sequence Detail 4550 Not Applicable  
polypeptide OTTMUSP00000025154 VEGA | MGI Sequence Detail 207 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    249 from dbSNP Build 142
  • RFLP
Protein
Information
less
Molecular
Reagents
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  • All nucleic 16
    Genomic 2
    cDNA 14

    Microarray probesets 5
Other
Accession IDs
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MGD-MRK-12190, MGI:2142414
References
more
  • Summaries
    All 56
    Developmental Gene Expression 2
    Gene Ontology 17
    Phenotypes 13
  • Earliest
    J:10993 Saunders AM, et al., A molecular genetic linkage map of mouse chromosome 7. Genomics. 1990 Nov;8(3):525-35
  • Latest
    J:233777 Ray JP, et al., The Interleukin-2-mTORc1 Kinase Axis Defines the Signaling, Differentiation, and Metabolism of T Helper 1 and Follicular B Helper T Cells. Immunity. 2015 Oct 20;43(4):690-702

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/29/2016
MGI 6.06
The Jackson Laboratory