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Cma1
Gene Detail
 Symbol
Name
ID
Cma1
chymase 1, mast cell
MGI:96941
Synonyms Mcp5, Mcp-5, Mcpt5, MMCP-5
Feature Type protein coding gene
Genetic Map
Chromosome 14
28.19 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr14:55941453-55944661 bp, - strand
From Ensembl annotation of GRCm38

  3209 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:55606  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 2 cattle; 1 dog

Protein SuperFamily: trypsin
Gene Tree: Cma1

Human
homologs
Human Homolog CMA1, chymase 1, mast cell
NCBI Gene ID 1215
neXtProt AC  NX_P23946
Human Synonyms  chymase, CYH, MCT1
Human Chr (Location)  14q11.2; chr14:24505506-24508265 (-)  GRCh38
Alleles
and
phenotypes
All alleles(3) : Targeted(3)
Incidental mutations (data from APF )
 
Mice homozygous for a knock-out allele display a reduction in mast cell-mediated ischemia reperfusion injury of skeletal muscle.
 
Gene Ontology
(GO)
classifications
All GO classifications: (13 annotations)
Process interleukin-1 beta biosynthetic process, positive regulation of angiogenesis, ...
Component extracellular matrix, extracellular region, ...
Function catalytic activity, hydrolase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (7 records)
Data Summary: Results (43)    Tissues (33)   
Theiler Stages: 6, 7, 9, 11, 13, 15, 17, 19, 20, 21, 22, 23, 24, 25, 26
Assay TypeResults
RNA in situ 23
Northern blot 15
RT-PCR 5
cDNA source data(38)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(52) Genomic(11) cDNA(38) Primer pair(3)
Microarray probesets(5)
Other database
links
Ensembl Gene ModelENSMUSG00000022225 (Evidence)
Entrez Gene17228 (Evidence)
UniGene1252
DFCITC1580529
DoTSDT.40186813, DT.533470
NIA Mouse Gene IndexU035595
EC3.4.21.39
Consensus CDS ProjectCCDS27135.1
International Mouse Knockout Project StatusCma1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000022225 Ensembl Gene Model | MGI Sequence Detail 3209 C57BL/6J ±  kb
transcript ENSMUST00000022834 Ensembl | MGI Sequence Detail 1074 Not Applicable 
polypeptide ENSMUSP00000022834 Ensembl | MGI Sequence Detail 260 Not Applicable 

For the selected sequences
All sequences(21) RefSeq(2) UniProt(2)
Polymorphisms SNPs within 2kb(171 from dbSNP Build 137)    SNPs within 2kb including multiple locations(175)
Protein-related
information
ResourceIDDescription
InterPro IPR001254 Peptidase S1
InterPro IPR001314 Peptidase S1A, chymotrypsin-type
InterPro IPR018114 Peptidase S1, trypsin family, active site
InterPro IPR009003 Trypsin-like cysteine/serine peptidase domain
Protein Ontology PR:000005619 chymase
References (Earliest) J:11290 Huang RY, et al., Cloning and structural analysis of MMCP-1, MMCP-4 and MMCP-5, three mouse mast cell-specific serine proteases. Eur J Immunol. 1991 Jul;21(7):1611-21
(Latest) J:209921 Bankova LG, et al., Mouse mast cell proteases 4 and 5 mediate epidermal injury through disruption of tight junctions. J Immunol. 2014 Mar 15;192(6):2812-20
All references(54)
Other
accession IDs
MGD-MRK-12147, MGD-MRK-12155, MGD-MRK-2025

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory