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Cma1 Gene Detail
Summary
  • Symbol
    Cma1
  • Name
    chymase 1, mast cell
  • Synonyms
    Mcp5, Mcp-5, Mcpt5, MMCP-5
  • Feature Type
    protein coding gene
  • IDs
    MGI:96941
    NCBI Gene: 17228
  • Gene Overview
    MyGene.info: CMA1
Location & Maps
more
  • Sequence Map
    Chr14:55941453-55944661 bp, - strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      3209 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 14, 28.19 cM
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    CMA1, chymase 1
  • Vertebrate Orthologs
    8
  • Human Ortholog
    CMA1, chymase 1
    Orthology source: HomoloGene
  • Synonyms
    chymase, CYH, MCT1
  • Links
    NCBI Gene ID: 1215
    neXtProt AC: NX_P23946

  • Chr Location
    14q11.2; chr14:24505346-24508690 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    4
  • Chemically induced (other)
    1
  • Targeted
    3
  • Genomic Mutations
    1 involving Cma1
  • Incidental Mutations
    APF
Mice homozygous for a knock-out allele display a reduction in mast cell-mediated ischemia reperfusion injury of skeletal muscle.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000022225 Ensembl Gene Model | MGI Sequence Detail 3209 C57BL/6J ±  kb
transcript ENSMUST00000022834 Ensembl | MGI Sequence Detail 1074 Not Applicable  
polypeptide ENSMUSP00000022834 Ensembl | MGI Sequence Detail 260 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    162 from dbSNP Build 142
Protein
Information
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  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000005619 chymase
  • EC
  • InterPro Domains
    IPR001314 Peptidase S1A, chymotrypsin family
    IPR009003 Peptidase S1, PA clan
    IPR001254 Serine proteases, trypsin domain
    IPR018114 Serine proteases, trypsin family, histidine active site
    IPR033116 Serine proteases, trypsin family, serine active site
Molecular
Reagents
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  • All nucleic 52
    Genomic 11
    cDNA 38
    Primer pair 3

    Microarray probesets 5
Other
Accession IDs
less
MGD-MRK-12147, MGD-MRK-12155, MGD-MRK-2025
References
more
  • Summaries
    All 47
    Developmental Gene Expression 7
    Gene Ontology 5
    Phenotypes 8
  • Earliest
    J:11290 Huang RY, et al., Cloning and structural analysis of MMCP-1, MMCP-4 and MMCP-5, three mouse mast cell-specific serine proteases. Eur J Immunol. 1991 Jul;21(7):1611-21
  • Latest
    J:209921 Bankova LG, et al., Mouse mast cell proteases 4 and 5 mediate epidermal injury through disruption of tight junctions. J Immunol. 2014 Mar 15;192(6):2812-20

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/17/2016
MGI 6.05
The Jackson Laboratory