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Cma1 Gene Detail
Summary
  • Symbol
    Cma1
  • Name
    chymase 1, mast cell
  • Synonyms
    Mcp5, Mcp-5, Mcpt5, MMCP-5
  • Feature Type
    protein coding gene
  • IDs
    MGI:96941
    NCBI Gene: 17228
  • Gene Overview
    MyGene.info: CMA1
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:55941451-55944675 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 14, 28.19 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    162 from dbSNP Build 142
  • Strain Annotations
    17
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_96941
protein coding gene Chr14:55941451-55944675 (-)
129S1/SvImJ MGP_129S1SvImJ_G0021378
protein coding gene Chr14:50006673-50010075 (-)
A/J MGP_AJ_G0021337
protein coding gene Chr14:48991815-48994725 (-)
AKR/J MGP_AKRJ_G0021313
protein coding gene Chr14:50762042-50766492 (-)
BALB/cJ MGP_BALBcJ_G0021341
protein coding gene Chr14:48965090-48967998 (-)
C3H/HeJ MGP_C3HHeJ_G0021121
protein coding gene Chr14:50446212-50449899 (-)
C57BL/6NJ MGP_C57BL6NJ_G0021779
protein coding gene Chr14:52505787-52510135 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0019326
protein coding gene Chr14:47351224-47354412 (-)
CAST/EiJ MGP_CASTEiJ_G0020640
protein coding gene Chr14:46707942-46711831 (-)
CBA/J MGP_CBAJ_G0021088
protein coding gene Chr14:54067956-54071466 (-)
DBA/2J MGP_DBA2J_G0021209
protein coding gene Chr14:48718420-48722127 (-)
FVB/NJ MGP_FVBNJ_G0021191
protein coding gene Chr14:48159626-48163290 (-)
LP/J MGP_LPJ_G0021283
protein coding gene Chr14:51042296-51045820 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0021215
protein coding gene Chr14:53416208-53419138 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0021806
protein coding gene Chr14:49932793-49937595 (-)
PWK/PhJ no annotation
SPRET/EiJ MGP_SPRETEiJ_G0020215
protein coding gene Chr14:45929126-45932355 (-)
WSB/EiJ MGP_WSBEiJ_G0020693
protein coding gene Chr14:50214579-50217667 (-)



Homology
more
  • Human Ortholog
    CMA1, chymase 1
  • Vertebrate Orthologs
    8
  • Human Ortholog
    CMA1, chymase 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    chymase, CYH, MCT1
  • Links
    NCBI Gene ID: 1215
    neXtProt AC: NX_P23946
    UniProt: P23946

  • Chr Location
    14q12; chr14:24505355-24508265 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele display a reduction in mast cell-mediated ischemia reperfusion injury of skeletal muscle.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 17228 NCBI Gene Model | MGI Sequence Detail 3225 C57BL/6J ±  kb
transcript NM_010780 RefSeq | MGI Sequence Detail 1090 C57BL/6  
polypeptide P21844 UniProt | EBI | MGI Sequence Detail 247 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 53
    Genomic 11
    cDNA 39
    Primer pair 3

    Microarray probesets 5
Other
Accession IDs
less
MGD-MRK-12147, MGD-MRK-12155, MGD-MRK-2025
References
more
  • Summaries
    All 55
    Developmental Gene Expression 7
    Gene Ontology 6
    Phenotypes 9
  • Earliest
    J:17707 Reynolds DS, et al., Different mouse mast cell populations express various combinations of at least six distinct mast cell serine proteases. Proc Natl Acad Sci U S A. 1990 Apr;87(8):3230-4
  • Latest
    J:258811 Valero-Jimenez A, et al., Transmembrane protease, serine 4 (TMPRSS4) is upregulated in IPF lungs and increases the fibrotic response in bleomycin-induced lung injury. PLoS One. 2018;13(3):e0192963

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
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last database update
08/06/2019
MGI 6.14
The Jackson Laboratory