Mc2r
Gene Detail

Symbol Name ID

Mc2r melanocortin 2 receptor MGI:96928

Synonyms

Acthr, adrenocorticotropic hormone receptor

Feature Type

protein coding gene

Genetic Map

Chromosome 18

41.89 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)

Sequence Map

Chr18:68406907-68429251 bp, - strand From Ensembl annotation of GRCm38   22345 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:444  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: melanocortin receptor
Gene Tree: Mc2r

Human homologs

Human Homolog		MC2R, melanocortin 2 receptor (adrenocorticotropic hormone)
NCBI Gene ID		4158
neXtProt AC		NX_Q01718
Human Synonyms		ACTHR
Human Chr (Location)		18p11.2; chr18:13882043-13915535 (-)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human MC2R

Alleles and phenotypes

All alleles(2) : Targeted(2)
 

Mice homozygous for a null allele exhibit postnatal lethality due to impaired gluconeogenesis.

 
Human Diseases Modeled Using Mouse Mc2r (1)    Alleles Annotated to Human Diseases(1)    Phenotype Images(2)

Gene Ontology (GO) classifications

All GO classifications: (14 annotations)

Process	G-protein coupled receptor signaling pathway, positive regulation of cAMP biosynthetic process, ...
Component	cytoplasm, integral to membrane, ...
Function	corticotropin receptor activity, G-protein coupled receptor activity, ...

External Resources: FuncBase

Expression

Literature Summary: (7 records)
Data Summary: Results (77)    Tissues (32)    Images (28)
Theiler Stages: 15, 18, 19, 20, 21, 22, 23, 25, 28

Assay Type	Results
RNA in situ	26
RT-PCR	51

cDNA source data(15)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(22) Genomic(4) cDNA(15) Primer pair(2) Other(1)
Microarray probesets(4)

Other database links

Ensembl Gene Model	ENSMUSG00000045569 (Evidence)
Entrez Gene	17200 (Evidence)
UniGene	426053
DFCI	TC1587117
DoTS	DT.55130004, DT.99844126
NIA Mouse Gene Index	U038532
Consensus CDS Project	CCDS29328.1
International Mouse Knockout Project Status	Mc2r

Sequences

Length	Strain/Species
genomic	ENSMUSG00000045569	Ensembl Gene Model | MGI Sequence Detail	22345	C57BL/6J
transcript	ENSMUST00000052347	Ensembl | MGI Sequence Detail	1562	Not Applicable
polypeptide	ENSMUSP00000058691	Ensembl | MGI Sequence Detail	296	Not Applicable

All sequences(27) RefSeq(6) UniProt(2)

Polymorphisms

RFLP(1) : SNPs(110 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR001168	Adrenocorticotrophin (ACTH) receptor
InterPro	IPR000276	GPCR, rhodopsin-like
InterPro	IPR017452	GPCR, rhodopsin-like, 7TM
InterPro	IPR001671	Melanocortin/ACTH receptor
Protein Ontology	PR:000001182	adrenocorticotropic hormone receptor

References

(Earliest) J:20041 Magenis RE, et al., Mapping of the ACTH, MSH, and neural (MC3 and MC4) melanocortin receptors in the mouse and human. Mamm Genome. 1994 Aug;5(8):503-8
(Latest) J:183740 Moller CL, et al., Characterization of murine melanocortin receptors mediating adipocyte lipolysis and examination of signalling pathways involved. Mol Cell Endocrinol. 2011 Jul 20;341(1-2):9-17
All references(56)

Other accession IDs

MGD-MRK-12130