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Mc2r
Gene Detail
Symbol

Name
ID
Mc2r
melanocortin 2 receptor
MGI:96928
Synonyms
Acthr, adrenocorticotropic hormone receptor
Feature Type
protein coding gene
Genetic Map
Chromosome 18
41.89 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr18:68406907-68429251 bp, - strand
From Ensembl annotation of GRCm38

  22345 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:444  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: MC2R
Protein SuperFamily: melanocortin receptor
Gene Tree: Mc2r

Human
homologs
MC2R, melanocortin 2 receptor (adrenocorticotropic hormone)
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 4158
neXtProt AC: NX_Q01718

Human Synonyms: ACTHR

Human Chr (Location): 18p11.2; chr18:13882044-13915707 (-)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human MC2R

Mutations,
alleles, and
phenotypes
All mutations/alleles(2) : Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a null allele exhibit postnatal lethality due to impaired gluconeogenesis.
 
Human Diseases Modeled in Mice Using Mc2r (1)    Mutations Annotated to Human Diseases (1)    Phenotype Images(2)
Interactions
Mc2r interacts with 120 markers (Mir1b, Mir7-1, Mir23a, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (8 records)
Data Summary: Results (77)    Tissues (38)    Images (28)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 26
RT-PCR 51
cDNA source data(15)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: ZFIN mc2r    NEW 
Molecular
reagents
All nucleic(22) Genomic(4) cDNA(15) Primer pair(2) Other(1)
Microarray probesets(4)
Other database
links
Ensembl Gene Model ENSMUSG00000045569 (Evidence)
Entrez Gene 17200 (Evidence)
UniGene 426053
DFCI TC1587117
DoTS DT.55130004, DT.94280508, DT.99844126
NIA Mouse Gene Index U038532
Consensus CDS Project CCDS29328.1
International Mouse Phenotyping Consortium Status Mc2r
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000045569 Ensembl Gene Model | MGI Sequence Detail 22345 C57BL/6J ±  kb
transcript ENSMUST00000052347 Ensembl | MGI Sequence Detail 1562 Not Applicable 
polypeptide ENSMUSP00000058691 Ensembl | MGI Sequence Detail 296 Not Applicable 

For the selected sequences
All sequences(32) RefSeq(8) UniProt(2)
Polymorphisms
RFLP(1) : SNPs within 2kb(179 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001168 Adrenocorticotrophin (ACTH) receptor
InterPro IPR017452 GPCR, rhodopsin-like, 7TM
InterPro IPR000276 G protein-coupled receptor, rhodopsin-like
InterPro IPR001671 Melanocortin/ACTH receptor
Protein Ontology PR:000001182 adrenocorticotropic hormone receptor
References
(Earliest) J:20041 Magenis RE, et al., Mapping of the ACTH, MSH, and neural (MC3 and MC4) melanocortin receptors in the mouse and human. Mamm Genome. 1994 Aug;5(8):503-8
(Latest) J:222045 Padua MB, et al., Combined loss of the GATA4 and GATA6 transcription factors in male mice disrupts testicular development and confers adrenal-like function in the testes. Endocrinology. 2015 May;156(5):1873-86
All references(54)
Disease annotation references (1)
Other
accession IDs
MGD-MRK-12130

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/18/2015
MGI 6.0
The Jackson Laboratory