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Mc2r
Gene Detail
 Symbol
Name
ID
Mc2r
melanocortin 2 receptor
MGI:96928
Synonyms Acthr, adrenocorticotropic hormone receptor
Feature Type protein coding gene
Genetic Map
Chromosome 18
41.89 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr18:68406907-68429251 bp, - strand
From Ensembl annotation of GRCm38

  22345 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:444  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: melanocortin receptor
Gene Tree: Mc2r

Human
homologs
Human Homolog MC2R, melanocortin 2 receptor (adrenocorticotropic hormone)
NCBI Gene ID 4158
neXtProt AC  NX_Q01718
Human Synonyms  ACTHR
Human Chr (Location)  18p11.2; chr18:13882044-13915536 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human MC2R
Mutations,
alleles, and
phenotypes
All mutations/alleles(2) : Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a null allele exhibit postnatal lethality due to impaired gluconeogenesis.
 
Human Diseases Modeled Using Mouse Mc2r (1)    Alleles Annotated to Human Diseases(1)    Phenotype Images(2)
Interactions
Mc2r interacts with 120 markers (Mir1b, Mir7-1, Mir23a, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (14 annotations)
Process G-protein coupled receptor signaling pathway, positive regulation of cAMP biosynthetic process, ...
Component cytoplasm, integral component of membrane, ...
Function corticotropin receptor activity, G-protein coupled receptor activity, ...
External Resources: FuncBase
Expression
Literature Summary: (7 records)
Data Summary: Results (77)    Tissues (32)    Images (28)
Theiler Stages: 15, 18, 19, 20, 21, 22, 23, 25, 28
Assay TypeResults
RNA in situ 26
RT-PCR 51
cDNA source data(15)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(22) Genomic(4) cDNA(15) Primer pair(2) Other(1)
Microarray probesets(4)
Other database
links
Ensembl Gene ModelENSMUSG00000045569 (Evidence)
Entrez Gene17200 (Evidence)
UniGene426053
DFCITC1587117
DoTSDT.55130004, DT.94280508, DT.99844126
NIA Mouse Gene IndexU038532
Consensus CDS ProjectCCDS29328.1
International Mouse Knockout Project StatusMc2r
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000045569 Ensembl Gene Model | MGI Sequence Detail 22345 C57BL/6J ±  kb
transcript ENSMUST00000052347 Ensembl | MGI Sequence Detail 1562 Not Applicable 
polypeptide ENSMUSP00000058691 Ensembl | MGI Sequence Detail 296 Not Applicable 

For the selected sequences
All sequences(31) RefSeq(8) UniProt(2)
Polymorphisms RFLP(1) : SNPs within 2kb(179 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001168 Adrenocorticotrophin (ACTH) receptor
InterPro IPR017452 GPCR, rhodopsin-like, 7TM
InterPro IPR000276 G protein-coupled receptor, rhodopsin-like
InterPro IPR001671 Melanocortin/ACTH receptor
Protein Ontology PR:000001182 adrenocorticotropic hormone receptor
References (Earliest) J:20041 Magenis RE, et al., Mapping of the ACTH, MSH, and neural (MC3 and MC4) melanocortin receptors in the mouse and human. Mamm Genome. 1994 Aug;5(8):503-8
(Latest) J:183740 Moller CL, et al., Characterization of murine melanocortin receptors mediating adipocyte lipolysis and examination of signalling pathways involved. Mol Cell Endocrinol. 2011 Jul 20;341(1-2):9-17
All references(56)
Disease annotation references (1)
Other
accession IDs
MGD-MRK-12130

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/23/2014
MGI 5.19
The Jackson Laboratory