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Mbl1
Gene Detail
 Symbol
Name
ID
Mbl1
mannose-binding lectin (protein A) 1
MGI:96923
Synonyms MBL-A, MBP-A
Feature Type protein coding gene
Genetic Map
Chromosome 14
22.36 cM
Detailed Genetic Map ± 1 cM


Mapping data(8)
Sequence Map
Chr14:41151456-41158959 bp, + strand
From NCBI annotation of GRCm38

  7504 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:55449  Vertebrate Homology Class
1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

Gene Tree: Mbl1

Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous inactivation does not result in overt abnormalities. However mutant mice have shown increased survival in a mouse model of acute septic peritonitis.
 
Interactions
Mbl1 interacts with 19 markers (Mir7-2, Mir7b, Mir9-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (24 annotations)
Process complement activation, classical pathway, complement activation, lectin pathway, ...
Component collagen trimer, extracellular region, ...
Function calcium-dependent protein binding, calcium ion binding, ...
External Resources: FuncBase
Expression
cDNA source data(29)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(36) Genomic(6) cDNA(30)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000037780 (Evidence)
Entrez Gene17194 (Evidence)
UniGene281805
DFCITC1583712, TC1644317
DoTSDT.491469
NIA Mouse Gene IndexU015518
Consensus CDS ProjectCCDS26961.1
International Mouse Knockout Project StatusMbl1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 17194 NCBI Gene Model | MGI Sequence Detail 7504 C57BL/6J ±  kb
transcript NM_010775 RefSeq | MGI Sequence Detail 923 C57BL/6 
polypeptide P39039 UniProt | EBI | MGI Sequence Detail 239 Not Applicable 

For the selected sequences
All sequences(25) RefSeq(6) UniProt(1)
Polymorphisms RFLP(1) : SNPs within 2kb(67 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR008160 Collagen triple helix repeat
InterPro IPR001304 C-type lectin
InterPro IPR018378 C-type lectin, conserved site
InterPro IPR016187 C-type lectin fold
InterPro IPR016186 C-type lectin-like
Protein Ontology PR:000010900 mannose-binding protein A
Graphical View of Protein Domain Structure
References (Earliest) J:22454 Sastry K, et al., Molecular characterization of the mouse mannose-binding proteins. The mannose-binding protein A but not C is an acute phase reactant. J Immunol. 1991 Jul 15;147(2):692-7
(Latest) J:204937 Takahashi K, et al., Intradermal immunization with wall teichoic acid (WTA) elicits and augments an anti-WTA IgG response that protects mice from methicillin-resistant Staphylococcus aureus infection independent of mannose-binding lectin status. PLoS One. 2013;8(8):e69739
All references(81)
Other
accession IDs
MGD-MRK-12124

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/12/2014
MGI 5.19
The Jackson Laboratory