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Mbl1
Gene Detail
Symbol

Name
ID
Mbl1
mannose-binding lectin (protein A) 1
MGI:96923
Synonyms
MBL-A, MBP-A
Feature Type
protein coding gene
Genetic Map
Chromosome 14
22.36 cM
Detailed Genetic Map ± 1 cM


Mapping data(8)
Sequence Map
Chr14:41151456-41158959 bp, + strand
From Ensembl annotation of GRCm38

  7504 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:55449  Vertebrate Homology Class
1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

HCOP human homology predictions: MBL1P
Gene Tree: Mbl1

Human
homologs
MBL1P, mannose-binding lectin (protein A) 1, pseudogene
Orthology source: HGNC

IDs:
NCBI Gene ID: 8512

Human Synonyms: COLEC3P, MBL1P1

Human Chr (Location): 10q22.3; chr10:79920178-79923119 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous inactivation does not result in overt abnormalities. However mutant mice have shown increased survival in a mouse model of acute septic peritonitis.
 
Interactions
Mbl1 interacts with 19 markers (Mir7-2, Mir7b, Mir9-1, ...)
Gene Ontology
(GO)
classifications
Expression
cDNA source data(29)
Other mouse links: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(36) Genomic(6) cDNA(30)
Microarray probesets(3)
Other database
links
Ensembl Gene Model ENSMUSG00000037780 (Evidence)
Entrez Gene 17194 (Evidence)
UniGene 281805
DFCI TC1583712, TC1644317
DoTS DT.491469
NIA Mouse Gene Index U015518
Consensus CDS Project CCDS26961.1
International Mouse Phenotyping Consortium Status Mbl1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000037780 Ensembl Gene Model | MGI Sequence Detail 7504 C57BL/6J ±  kb
transcript ENSMUST00000047095 Ensembl | MGI Sequence Detail 923 Not Applicable 
polypeptide ENSMUSP00000048765 Ensembl | MGI Sequence Detail 239 Not Applicable 

For the selected sequences
All sequences(23) RefSeq(4) UniProt(1)
Polymorphisms
RFLP(1) : SNPs within 2kb(67 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR008160 Collagen triple helix repeat
InterPro IPR001304 C-type lectin
InterPro IPR018378 C-type lectin, conserved site
InterPro IPR016187 C-type lectin fold
InterPro IPR016186 C-type lectin-like
Protein Ontology PR:000010900 mannose-binding protein A
References
(Earliest) J:22454 Sastry K, et al., Molecular characterization of the mouse mannose-binding proteins. The mannose-binding protein A but not C is an acute phase reactant. J Immunol. 1991 Jul 15;147(2):692-7
(Latest) J:217801 Pavlov VI, et al., Human mannose-binding lectin inhibitor prevents myocardial injury and arterial thrombogenesis in a novel animal model. Am J Pathol. 2015 Feb;185(2):347-55
All references(80)
Other
accession IDs
MGD-MRK-12124

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory