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Mbl1 Gene Detail
Summary
  • Symbol
    Mbl1
  • Name
    mannose-binding lectin (protein A) 1
  • Synonyms
    MBL-A, MBP-A
  • Feature Type
    protein coding gene
  • IDs
    MGI:96923
    NCBI Gene: 17194
Location & Maps
more
  • Sequence Map
    Chr14:41151456-41158959 bp, + strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      7504 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    MBL1P, mannose-binding lectin (protein A) 1, pseudogene
  • Vertebrate Orthologs
    6
  • Human Ortholog
    MBL1P, mannose-binding lectin (protein A) 1, pseudogene
    Orthology source: HGNC
  • Synonyms
    COLEC3P, MBL1P1
  • Links
    NCBI Gene ID: 8512

  • Chr Location
    10q22.3; chr10:79920178-79923119 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    10 phenotypes from 3 alleles in 3 genetic backgrounds
    13 phenotypes from multigenic genotypes
    44 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
Homozygous inactivation does not result in overt abnormalities. However mutant mice have shown increased survival in a mouse model of acute septic peritonitis.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • cDNA Data
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000037780 Ensembl Gene Model | MGI Sequence Detail 7504 C57BL/6J ±  kb
transcript ENSMUST00000047095 Ensembl | MGI Sequence Detail 923 Not Applicable  
polypeptide ENSMUSP00000048765 Ensembl | MGI Sequence Detail 239 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    67 from dbSNP Build 137
  • RFLP
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 36
    Genomic 6
    cDNA 30

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-12124
References
more
  • Summaries
    All 77
    Gene Ontology 4
    Phenotypes 44
  • Earliest
    J:22454 Sastry K, et al., Molecular characterization of the mouse mannose-binding proteins. The mannose-binding protein A but not C is an acute phase reactant. J Immunol. 1991 Jul 15;147(2):692-7
  • Latest
    J:217801 Pavlov VI, et al., Human mannose-binding lectin inhibitor prevents myocardial injury and arterial thrombogenesis in a novel animal model. Am J Pathol. 2015 Feb;185(2):347-55

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
01/26/2016
MGI 6.02
The Jackson Laboratory