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Mbl1 Gene Detail
Summary
  • Symbol
    Mbl1
  • Name
    mannose-binding lectin (protein A) 1
  • Synonyms
    MBL-A, MBP-A
  • Feature Type
    protein coding gene
  • IDs
    MGI:96923
    NCBI Gene: 17194
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:41151458-41159601 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 14, 22.36 cM
  • Mapping Data
    8 experiments
Strain
Comparison
more
  • SNPs within 2kb
    76 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_96923
protein coding gene Chr14:41151456-41163904 (+)
129S1/SvImJ MGP_129S1SvImJ_G0021198
protein coding gene Chr14:34783333-34790082 (+)
A/J MGP_AJ_G0021146
protein coding gene Chr14:33437666-33444515 (+)
AKR/J MGP_AKRJ_G0021123
protein coding gene Chr14:34805473-34812267 (+)
BALB/cJ MGP_BALBcJ_G0021150
protein coding gene Chr14:33653607-33661042 (+)
C3H/HeJ MGP_C3HHeJ_G0020933
protein coding gene Chr14:34765235-34772049 (+)
C57BL/6NJ MGP_C57BL6NJ_G0021582
protein coding gene Chr14:36182861-36191446 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0019144
protein coding gene Chr14:33057794-33063960 (+)
CAST/EiJ MGP_CASTEiJ_G0020458
protein coding gene Chr14:34534327-34542659 (+)
CBA/J MGP_CBAJ_G0020899
protein coding gene Chr14:37414042-37420914 (+)
DBA/2J MGP_DBA2J_G0021022
protein coding gene Chr14:33395470-33402845 (+)
FVB/NJ MGP_FVBNJ_G0021006
protein coding gene Chr14:33334325-33342030 (+)
LP/J MGP_LPJ_G0021091
protein coding gene Chr14:35020762-35028119 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0021032
protein coding gene Chr14:37033093-37044940 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0021615
protein coding gene Chr14:34589651-34598781 (+)
PWK/PhJ MGP_PWKPhJ_G0020206
protein coding gene Chr14:32865927-32873526 (+)
SPRET/EiJ MGP_SPRETEiJ_G0020030
protein coding gene Chr14:34211310-34221997 (+)
WSB/EiJ MGP_WSBEiJ_G0020513
protein coding gene Chr14:34705381-34712116 (+)



Homology
more
  • Human Ortholog
    MBL1P, mannose binding lectin 1, pseudogene
  • Vertebrate Orthologs
    6
  • Human Ortholog
    MBL1P, mannose binding lectin 1, pseudogene
    Orthology source: HGNC
  • Synonyms
    COLEC3P, MBL1P1
  • Links
    NCBI Gene ID: 8512

  • Chr Location
    10q22.3; chr10:79920178-79923119 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    10 phenotypes from 3 alleles in 3 genetic backgrounds
    13 phenotypes from multigenic genotypes
    53 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous inactivation does not result in overt abnormalities. However mutant mice have shown increased survival in a mouse model of acute septic peritonitis.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000037780 Ensembl Gene Model | MGI Sequence Detail 8144 C57BL/6J ±  kb
transcript ENSMUST00000225792 Ensembl | MGI Sequence Detail 1563 Not Applicable  
polypeptide ENSMUSP00000153147 Ensembl | MGI Sequence Detail 239 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 37
    Genomic 6
    cDNA 31

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-12124
References
more
  • Summaries
    All 94
    Gene Ontology 4
    Phenotypes 53
  • Earliest
    J:22454 Sastry K, et al., Molecular characterization of the mouse mannose-binding proteins. The mannose-binding protein A but not C is an acute phase reactant. J Immunol. 1991 Jul 15;147(2):692-7
  • Latest
    J:283349 Aykut B, et al., The fungal mycobiome promotes pancreatic oncogenesis via activation of MBL. Nature. 2019 Oct;574(7777):264-267

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
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last database update
02/18/2020
MGI 6.14
The Jackson Laboratory