Maoa
Gene Detail

Symbol Name ID

Maoa monoamine oxidase A MGI:96915

Synonyms

1110061B18Rik, MAO-A, MGC:27811

Feature Type

protein coding gene

Genetic Map

Chromosome X

11.78 cM, cytoband A2
Detailed Genetic Map ± 1 cM


Mapping data(11)

Sequence Map

ChrX:16619698-16687818 bp, + strand From VEGA annotation of GRCm38   68121 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:203  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog

Gene Tree: Maoa

Human homologs

Human Homolog		MAOA, monoamine oxidase A
NCBI Gene ID		4128
neXtProt AC		NX_P21397
Human Synonyms		MAO-A
Human Chr (Location)		Xp11.3; chrX:43514155-43606071 (+)  GRCh37.p10
Disease Associations		(2) Diseases Associated with Human MAOA

Alleles and phenotypes

All alleles(5) : Targeted(3) Transgenic(1) Spontaneous(1)
 

Homozygotes for a null allele show reduced LV systolic pressure and resistance to induced cardiac stress. Males hemizygous for a spontaneous allele show intermale aggression and hypoactivity. Hemizygotes for a transgenic gene disruption show altered behavior and adrenocortical response to stress.

 
Human Diseases Modeled Using Mouse Maoa (2)    Alleles Annotated to Human Diseases(2)   

Gene Ontology (GO) classifications

All GO classifications: (16 annotations)

Process	catecholamine metabolic process, dopamine catabolic process, ...
Component	integral to membrane, membrane, ...
Function	flavin adenine dinucleotide binding, oxidoreductase activity, ...

External Resources: FuncBase

Expression

Literature Summary: (10 records)
Data Summary: Results (359)    Tissues (143)    Images (56)
Theiler Stages: 19, 22, 23, 28

Assay Type	Results
RNA in situ	359

cDNA source data(24)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(27) Genomic(1) cDNA(25) Primer pair(1)
Microarray probesets(7)

Other database links

VEGA Gene Model	OTTMUSG00000016928 (Evidence)
Ensembl Gene Model	ENSMUSG00000025037 (Evidence)
Entrez Gene	17161 (Evidence)
DFCI	TC1576279
DoTS	DT.490331, DT.55230094, DT.55248946
NIA Mouse Gene Index	U019731
EC	1.4.3.4
Consensus CDS Project	CCDS30033.1
International Mouse Knockout Project Status	Maoa

Sequences

Length	Strain/Species
genomic	OTTMUSG00000016928	VEGA Gene Model | MGI Sequence Detail	68121	C57BL/6J
transcript	OTTMUST00000041061	VEGA | MGI Sequence Detail	4167	Not Applicable
polypeptide	OTTMUSP00000018396	VEGA | MGI Sequence Detail	526	Not Applicable

All sequences(43) RefSeq(2) UniProt(4)

Polymorphisms

RFLP(1) : SNPs(200 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR002937	Amine oxidase
InterPro	IPR001613	Flavin amine oxidase
Protein Ontology	PR:000010114	amine oxidase [flavin-containing] A

References

(Earliest) J:10089 Derry JM, et al., Localization of monoamine oxidase A and B genes on the mouse X chromosome. Nucleic Acids Res. 1989 Oct 25;17(20):8403
(Latest) J:192761 Alzghoul L, et al., Altered cerebellar organization and function in monoamine oxidase A hypomorphic mice. Neuropharmacology. 2012 Dec;63(7):1208-17
All references(105)

Other accession IDs

MGD-MRK-12111, MGI:1916081, MGI:2147818