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Marcks Gene Detail
Summary
  • Symbol
    Marcks
  • Name
    myristoylated alanine rich protein kinase C substrate
  • Synonyms
    Macs
  • Feature Type
    protein coding gene
  • IDs
    MGI:96907
    NCBI Gene: 17118
  • Gene Overview
    MyGene.info: MARCKS
  • Alliance
  • Transcription Start Sites
    13 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:37133375-37138920 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 10, 19.49 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    10 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_96907
protein coding gene Chr10:37133243-37138926 (-)
129S1/SvImJ MGP_129S1SvImJ_G0017145
protein coding gene Chr10:35565126-35570662 (-)
A/J MGP_AJ_G0017122
protein coding gene Chr10:34632960-34638500 (-)
AKR/J MGP_AKRJ_G0017082
protein coding gene Chr10:35078420-35083962 (-)
BALB/cJ MGP_BALBcJ_G0017085
protein coding gene Chr10:34590971-34596509 (-)
C3H/HeJ MGP_C3HHeJ_G0016905
protein coding gene Chr10:35401069-35406628 (-)
C57BL/6NJ MGP_C57BL6NJ_G0017543
protein coding gene Chr10:36637374-36642920 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0015240
protein coding gene Chr10:32718023-32723594 (-)
CAST/EiJ MGP_CASTEiJ_G0016484
protein coding gene Chr10:35574143-35579642 (-)
CBA/J MGP_CBAJ_G0016879
protein coding gene Chr10:38361125-38366650 (-)
DBA/2J MGP_DBA2J_G0016984
protein coding gene Chr10:34196777-34202313 (-)
FVB/NJ MGP_FVBNJ_G0016979
protein coding gene Chr10:33684081-33689619 (-)
LP/J MGP_LPJ_G0017061
protein coding gene Chr10:35536222-35543610 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0017009
protein coding gene Chr10:39114479-39122466 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0017579
protein coding gene Chr10:35041780-35047319 (-)
PWK/PhJ MGP_PWKPhJ_G0016265
protein coding gene Chr10:33985297-33990860 (-)
SPRET/EiJ MGP_SPRETEiJ_G0016049
protein coding gene Chr10:34882566-34888102 (-)
WSB/EiJ MGP_WSBEiJ_G0016547
protein coding gene Chr10:35338103-35346432 (-)



Homology
more
  • Human Ortholog
    MARCKS, myristoylated alanine rich protein kinase C substrate
  • Human Ortholog
    MARCKS, myristoylated alanine rich protein kinase C substrate
    Orthology source: HGNC
  • Synonyms
    80K-L, MACS, PKCSL, PRKCSL
  • Links
    NCBI Gene ID: 4082
    neXtProt AC: NX_P29966
    UniProt: P29966

  • Chr Location
    6q21; chr6:113857335-113863475 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    20 phenotypes from 1 allele in 1 genetic background
    3 images
    25 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous null mutants exhibit perinatal lethality, absence of the corpus callosum and other forebrain commisures, neuronal ectopia, and defects of cortical and retinal lamination. About one-fourth of fetuses are exencephalic.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000069662 Ensembl Gene Model | MGI Sequence Detail 5546 C57BL/6J ±  kb
    transcript ENSMUST00000092584 Ensembl | MGI Sequence Detail 4048 Not Applicable  
    polypeptide ENSMUSP00000090245 Ensembl | MGI Sequence Detail 309 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 24
      Genomic 4
      cDNA 19
      Other 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-12095, MGD-MRK-12116
    References
    more
    • Summaries
      All 77
      Developmental Gene Expression 16
      Gene Ontology 5
      Phenotypes 25
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:270211 Yang P, et al., Tip60- and sirtuin 2-regulated MARCKS acetylation and phosphorylation are required for diabetic embryopathy. Nat Commun. 2019 Jan 17;10(1):282

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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    Funding Information
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    last database update
    06/18/2019
    MGI 6.14
    The Jackson Laboratory