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Marcks Gene Detail
Summary
  • Symbol
    Marcks
  • Name
    myristoylated alanine rich protein kinase C substrate
  • Synonyms
    Macs
  • Feature Type
    protein coding gene
  • IDs
    MGI:96907
    NCBI Gene: 17118
Location & Maps
more
  • Sequence Map
    Chr10:37133375-37138920 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      5546 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 10, 19.49 cM
  • Mapping Data
    3 experiments
Homology
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Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    19 phenotypes from 1 allele in 1 genetic background
    3 images
    22 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    10
  • Chemically induced (other)
    1
  • Radiation induced
    1
  • Targeted
    8
  • Genomic Mutations
    2 involving Marcks
Homozygous null mutants exhibit perinatal lethality, absence of the corpus callosum and other forebrain commisures, neuronal ectopia, and defects of cortical and retinal lamination. About one-fourth of fetuses are exencephalic.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000042361 VEGA Gene Model | MGI Sequence Detail 5546 C57BL/6J ±  kb
transcript OTTMUST00000111641 VEGA | MGI Sequence Detail 4048 Not Applicable  
polypeptide OTTMUSP00000062544 VEGA | MGI Sequence Detail 309 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    10 from dbSNP Build 142
  • RFLP
Protein
Information
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  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000010184 myristoylated alanine-rich C-kinase substrate
  • PDB
  • InterPro Domains
    IPR002101 Myristoylated alanine-rich C-kinase substrate MARCKS
Molecular
Reagents
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  • All nucleic 23
    Genomic 3
    cDNA 19
    Other 1

    Microarray probesets 4
Other
Accession IDs
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MGD-MRK-12095, MGD-MRK-12116
References
more
  • Summaries
    All 59
    Developmental Gene Expression 15
    Gene Ontology 7
    Phenotypes 22
  • Earliest
    J:11069 Seykora JT, et al., Cloning and molecular characterization of the murine macrophage 68-kDa protein kinase C substrate and its regulation by bacterial lipopolysaccharide. Proc Natl Acad Sci U S A. 1991 Mar 15;88(6):2505-9
  • Latest
    J:229763 Lee SM, et al., Myristoylated alanine-rich C kinase substrate (MARCKS) regulates the expression of proinflammatory cytokines in macrophages through activation of p38/JNK MAPK and NF-kappaB. Cell Immunol. 2015 Aug;296(2):115-21

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory