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Blnk
Gene Detail
Symbol

Name
ID
Blnk
B cell linker
MGI:96878
Synonyms
BASH, Bca, BCA, BLNK, Ly57, Ly-57, SLP-65
Feature Type
protein coding gene
Genetic Map
Chromosome 19
34.26 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr19:40928927-40994535 bp, - strand
From VEGA annotation of GRCm38

  65609 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:32038  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: BLNK
Gene Tree: Blnk

Human
homologs
BLNK, B-cell linker
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 29760
neXtProt AC: NX_Q8WV28

Human Synonyms: AGM4, BASH, bca, BLNK-S, LY57, SLP65, SLP-65

Human Chr (Location): 10q23.2-q23.33; chr10:96191699-96271576 (-)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human BLNK

Mutations,
alleles, and
phenotypes
All mutations/alleles(56) : Chemically induced (ENU)(1) Gene trapped(49) Targeted(6)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for targeted null mutations exhibit a partial block in pre-B cell development, a lack of B1 B cells, reduced numbers of mature B cells, lower IgM and IgG3 serum levels, poor IgM immune responses, and a high incidence of pre-B cell lymphoma.
 
Mutations Annotated to Human Diseases (1)   
Interactions
Blnk interacts with 67 markers (Mir93, Mir99a, Mir99b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (16 annotations)
Process B cell activation, immune response, ...
Component cytoplasm, intracellular, ...
Function protein binding, SH3/SH2 adaptor activity, ...
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (39)    Tissues (19)    Images (13)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 24
Northern blot 12
RT-PCR 3
cDNA source data(16)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase blnk    NEW 
Molecular
reagents
All nucleic(18) cDNA(16) Primer pair(1) Other(1)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000031860 (Evidence)
Ensembl Gene Model ENSMUSG00000061132 (Evidence)
Entrez Gene 17060 (Evidence)
UniGene 9749
DFCI TC1585301
DoTS DT.40169214, DT.87041294
NIA Mouse Gene Index U039027
PDB 2EO6
Consensus CDS Project CCDS37983.1
International Mouse Phenotyping Consortium Status Blnk
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000031860 VEGA Gene Model | MGI Sequence Detail 65609 C57BL/6J ±  kb
transcript OTTMUST00000078999 VEGA | MGI Sequence Detail 2097 Not Applicable 
polypeptide OTTMUSP00000042094 VEGA | MGI Sequence Detail 457 Not Applicable 

For the selected sequences
All sequences(31) RefSeq(2) UniProt(3)
Polymorphisms
RFLP(1) : SNPs within 2kb(819 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000980 SH2 domain
Protein Ontology PR:000004761 B-cell linker protein
References
(Earliest) J:2171 Rochelle JM, et al., A linkage map of mouse chromosome 19: definition of comparative mapping relationships with human chromosomes 10 and 11 including the MEN1 locus. Genomics. 1992 Sep;14(1):26-31
(Latest) J:216387 Kobayashi T, et al., B Cells Promote Tumor Immunity against B16F10 Melanoma. Am J Pathol. 2014;184(11):3120-9
All references(91)
Other
accession IDs
MGD-MRK-11999, MGD-MRK-12042, MGI:1278314

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory