Blnk
Gene Detail

Symbol Name ID

Blnk B cell linker MGI:96878

Synonyms

BASH, Bca, BCA, BLNK, Ly57, Ly-57, SLP-65

Feature Type

protein coding gene

Genetic Map

Chromosome 19

34.26 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr19:40928927-40994535 bp, - strand From VEGA annotation of GRCm38   65609 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:32038  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Blnk

Human homologs

Human Homolog		BLNK, B-cell linker
NCBI Gene ID		29760
neXtProt AC		NX_Q8WV28
Human Synonyms		AGM4, BASH, bca, BLNK-S, LY57, SLP65, SLP-65
Human Chr (Location)		10q23.2-q23.33; chr10:97951455-98031333 (-)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human BLNK

Alleles and phenotypes

All alleles(56) : Targeted(6) Gene trapped(49) Chemically induced(1)
 

Homozygotes for targeted null mutations exhibit a partial block in pre-B cell development, a lack of B1 B cells, reduced numbers of mature B cells, lower IgM and IgG3 serum levels, poor IgM immune responses, and a high incidence of pre-B cell lymphoma.

 
Alleles Annotated to Human Diseases(1)   

Gene Ontology (GO) classifications

All GO classifications: (7 annotations)

Process	B cell activation, intracellular signal transduction
Component	cytoplasm, membrane, ...
Function	protein binding, SH3/SH2 adaptor activity

External Resources: FuncBase

Expression

Literature Summary: (3 records)
Data Summary: Results (39)    Tissues (19)    Images (13)
Theiler Stages: 10, 18, 20, 23, 25, 28

Assay Type	Results
RNA in situ	24
Northern blot	12
RT-PCR	3

cDNA source data(16)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(18) cDNA(16) Primer pair(1) Other(1)
Microarray probesets(4)

Other database links

VEGA Gene Model	OTTMUSG00000031860 (Evidence)
Ensembl Gene Model	ENSMUSG00000061132 (Evidence)
Entrez Gene	17060 (Evidence)
UniGene	9749
DFCI	TC1585301
DoTS	DT.40169214, DT.87041294
NIA Mouse Gene Index	U039027
PDB	2EO6
Consensus CDS Project	CCDS37983.1
International Mouse Knockout Project Status	Blnk

Sequences

Length	Strain/Species
genomic	OTTMUSG00000031860	VEGA Gene Model | MGI Sequence Detail	65609	C57BL/6J
transcript	OTTMUST00000078999	VEGA | MGI Sequence Detail	2097	Not Applicable
polypeptide	OTTMUSP00000042094	VEGA | MGI Sequence Detail	457	Not Applicable

All sequences(31) RefSeq(2) UniProt(3)

Polymorphisms

RFLP(1) : SNPs(576 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR000980	SH2 domain
Protein Ontology	PR:000004761	B-cell linker protein

References

(Earliest) J:2171 Rochelle JM, et al., A linkage map of mouse chromosome 19: definition of comparative mapping relationships with human chromosomes 10 and 11 including the MEN1 locus. Genomics. 1992 Sep;14(1):26-31
(Latest) J:190706 Ta VB, et al., Highly restricted usage of Ig H chain VH14 family gene segments in Slp65-deficient pre-B cell leukemia in mice. J Immunol. 2012 Nov 15;189(10):4842-51
All references(89)

Other accession IDs

MGD-MRK-11999, MGD-MRK-12042, MGI:1278314