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Blnk Gene Detail
Summary
  • Symbol
    Blnk
  • Name
    B cell linker
  • Synonyms
    BASH, Bca, BCA, BLNK, Ly57, Ly-57, SLP-65
  • Feature Type
    protein coding gene
  • IDs
    MGI:96878
    NCBI Gene: 17060
  • Gene Overview
    MyGene.info: BLNK
  • Alliance
    gene page
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr19:40928927-40994535 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 19, 34.26 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    813 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_96878
 protein coding gene Chr19:40928927-40994535 (-)
129S1/SvImJ MGP_129S1SvImJ_G0025117
 protein coding gene Chr19:40178964-40246742 (-)
A/J MGP_AJ_G0025094
 protein coding gene Chr19:38234385-38298007 (-)
AKR/J MGP_AKRJ_G0025062
 protein coding gene Chr19:39512776-39581735 (-)
BALB/cJ MGP_BALBcJ_G0025088
 protein coding gene Chr19:38298772-38367334 (-)
C3H/HeJ MGP_C3HHeJ_G0024848
 protein coding gene Chr19:39655231-39720910 (-)
C57BL/6NJ MGP_C57BL6NJ_G0025532
 protein coding gene Chr19:41259580-41330028 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0022945
 protein coding gene Chr19:37614908-37680209 (-)
CAST/EiJ MGP_CASTEiJ_G0024313
 protein coding gene Chr19:39288935-39357176 (-)
CBA/J MGP_CBAJ_G0024828
 protein coding gene Chr19:43262266-43336726 (-)
DBA/2J MGP_DBA2J_G0024960
 protein coding gene Chr19:38112669-38178419 (-)
FVB/NJ MGP_FVBNJ_G0024921
 protein coding gene Chr19:37865577-37930297 (-)
LP/J MGP_LPJ_G0025046
 protein coding gene Chr19:40197828-40268259 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0024952
 protein coding gene Chr19:42933061-43002061 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0025589
 protein coding gene Chr19:39539958-39605329 (-)
PWK/PhJ MGP_PWKPhJ_G0024063
 protein coding gene Chr19:37961020-38026296 (-)
SPRET/EiJ MGP_SPRETEiJ_G0023866
 protein coding gene Chr19:38279955-38350913 (-)
WSB/EiJ MGP_WSBEiJ_G0024383
 protein coding gene Chr19:39703177-39773158 (-)



Homology
more
  • Human Ortholog
    BLNK, B cell linker
  • Vertebrate Orthologs
    10
  • Human Ortholog
    BLNK, B cell linker
    Orthology source: HGNC, HomoloGene
  • Synonyms
    AGM4, BASH, bca, BLNK-S, LY57, SLP65, SLP-65
  • Links
    NCBI Gene ID: 29760
    neXtProt AC: NX_Q8WV28
    UniProt: Q8WV28

  • Chr Location
    10q24.1; chr10:96189171-96271576 (-)  GRCh38.p7
  • HomoloGene
    Vertebrate Homology Class 32038
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: BLNK
  • Gene Tree
    Blnk
Human Diseases
more
  • Diseases
    1 with human BLNK associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    37 phenotypes from 5 alleles in 7 genetic backgrounds
    38 phenotypes from multigenic genotypes
    50 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygotes for targeted null mutations exhibit a partial block in pre-B cell development, a lack of B1 B cells, reduced numbers of mature B cells, lower IgM and IgG3 serum levels, poor IgM immune responses, and a high incidence of pre-B cell lymphoma.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    18
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    39
  • Tissues
    19
  • cDNA Data
    17
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 17060 NCBI Gene Model | MGI Sequence Detail 65609 C57BL/6J ±  kb
    transcript NM_008528 RefSeq | MGI Sequence Detail 1783 C57BL/6  
    polypeptide Q9QUN3 UniProt | EBI | MGI Sequence Detail 457 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 19
      cDNA 17
      Primer pair 1
      Other 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-11999, MGD-MRK-12042, MGI:1278314
    References
    more
    • Summaries
      All 98
      Developmental Gene Expression 3
      Diseases 1
      Gene Ontology 7
      Phenotypes 50
    • Earliest
      J:2171 Rochelle JM, et al., A linkage map of mouse chromosome 19: definition of comparative mapping relationships with human chromosomes 10 and 11 including the MEN1 locus. Genomics. 1992 Sep;14(1):26-31
    • Latest
      J:258702 Haniuda K, et al., Autonomous membrane IgE signaling prevents IgE-memory formation. Nat Immunol. 2016 Sep;17(9):1109-17
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/04/2018
    MGI 6.13     		The Jackson Laboratory