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Blnk
Gene Detail
Symbol

Name
ID
Blnk
B cell linker
MGI:96878
Synonyms
BASH, Bca, BCA, BLNK, Ly57, Ly-57, SLP-65
Feature Type
protein coding gene
Genetic Map
Chromosome 19
34.26 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr19:40928927-40994535 bp, - strand
From VEGA annotation of GRCm38

  65609 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:32038  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Blnk

Human
homologs
Human Homolog BLNK, B-cell linker
NCBI Gene ID 29760
neXtProt AC  NX_Q8WV28
Human Synonyms  AGM4, BASH, bca, BLNK-S, LY57, SLP65, SLP-65
Human Chr (Location)  10q23.2-q23.33; chr10:96191699-96271576 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human BLNK
Mutations,
alleles, and
phenotypes
All mutations/alleles(56) : Chemically induced (ENU)(1) Gene trapped(49) Targeted(6)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for targeted null mutations exhibit a partial block in pre-B cell development, a lack of B1 B cells, reduced numbers of mature B cells, lower IgM and IgG3 serum levels, poor IgM immune responses, and a high incidence of pre-B cell lymphoma.
 
Alleles Annotated to Human Diseases(1)   
Interactions
Blnk interacts with 67 markers (Mir93, Mir99a, Mir99b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (10 annotations)
Process B cell activation, intracellular signal transduction, ...
Component cytoplasm, intracellular, ...
Function protein binding, SH3/SH2 adaptor activity
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (39)    Tissues (19)    Images (13)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 24
Northern blot 12
RT-PCR 3
cDNA source data(16)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(18) cDNA(16) Primer pair(1) Other(1)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000031860 (Evidence)
Ensembl Gene ModelENSMUSG00000061132 (Evidence)
Entrez Gene17060 (Evidence)
UniGene9749
DFCITC1585301
DoTSDT.40169214, DT.87041294
NIA Mouse Gene IndexU039027
PDB2EO6
Consensus CDS ProjectCCDS37983.1
International Mouse Knockout Project StatusBlnk
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000031860 VEGA Gene Model | MGI Sequence Detail 65609 C57BL/6J ±  kb
transcript OTTMUST00000078999 VEGA | MGI Sequence Detail 2097 Not Applicable 
polypeptide OTTMUSP00000042094 VEGA | MGI Sequence Detail 457 Not Applicable 

For the selected sequences
All sequences(31) RefSeq(2) UniProt(3)
Polymorphisms
RFLP(1) : SNPs within 2kb(819 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000980 SH2 domain
Protein Ontology PR:000004761 B-cell linker protein
References
(Earliest) J:2171 Rochelle JM, et al., A linkage map of mouse chromosome 19: definition of comparative mapping relationships with human chromosomes 10 and 11 including the MEN1 locus. Genomics. 1992 Sep;14(1):26-31
(Latest) J:208412 Stadhouders R, et al., Pre-B cell receptor signaling induces immunoglobulin kappa locus accessibility by functional redistribution of enhancer-mediated chromatin interactions. PLoS Biol. 2014 Feb;12(2):e1001791
All references(91)
Other
accession IDs
MGD-MRK-11999, MGD-MRK-12042, MGI:1278314

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
10/08/2014
MGI 5.20
The Jackson Laboratory