About   Help   FAQ
Lpl
Gene Detail
 Symbol
Name
ID
Lpl
lipoprotein lipase
MGI:96820
STS D8Mit26
Synonyms O 1-4-5
Feature Type protein coding gene
Genetic Map
Chromosome 8
33.88 cM
Detailed Genetic Map ± 1 cM


Mapping data(32)
Sequence Map
Chr8:68880491-68907448 bp, + strand
From VEGA annotation of GRCm38

  26958 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:200  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 dog; 1 chicken; 2 zebrafish

Protein SuperFamily: lipoprotein lipase, LIPH type
Gene Tree: Lpl

Human
homologs
Human Homolog LPL, lipoprotein lipase
NCBI Gene ID 4023
neXtProt AC  NX_P06858
Human Synonyms  HDLCQ11, LIPD
Human Chr (Location)  8p22; chr8:19939071-19967259 (+)  GRCh38
Disease Associations  (3) Diseases Associated with Human LPL
Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for targeted null mutations become cyanotic and die within 2 days of birth due to chylomicron engorgement of capillaries. Mutants show hypertriglyceridemia and reduced fat stores. Heterozygotes show 1.5-2-fold elevated triglyceride levels.
 
Human Diseases Modeled Using Mouse Lpl (1)    Alleles Annotated to Human Diseases(2)    Phenotype Images(6)
Interactions
Lpl interacts with 272 markers (Mir1b, Mir7-1, Mir7-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (35 annotations)
Process fatty acid biosynthetic process, lipid catabolic process, ...
Component anchored component of membrane, cell surface, ...
Function apolipoprotein binding, catalytic activity, ...
External Resources: FuncBase
Expression
Literature Summary: (16 records)
Data Summary: Results (402)    Tissues (131)    Images (49)
Theiler Stages: 22, 23, 25, 26, 28
Assay TypeResults
RNA in situ 346
Northern blot 56
cDNA source data(373)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(386) Genomic(6) cDNA(379) Other(1)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000036084 (Evidence)
Ensembl Gene ModelENSMUSG00000015568 (Evidence)
Entrez Gene16956 (Evidence)
UniGene1514
DFCITC1573803, TC1655563
DoTSDT.101262120, DT.55107370, DT.87055594, DT.91286492, DT.91340815, DT.94387885, DT.94405090, DT.99846664, DT.99866938
NIA Mouse Gene IndexU009398
EC3.1.1.34
Consensus CDS ProjectCCDS40357.1
International Mouse Knockout Project StatusLpl
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000036084 VEGA Gene Model | MGI Sequence Detail 26958 C57BL/6J ±  kb
transcript OTTMUST00000092709 VEGA | MGI Sequence Detail 4115 Not Applicable 
polypeptide OTTMUSP00000051299 VEGA | MGI Sequence Detail 474 Not Applicable 

For the selected sequences
All sequences(147) RefSeq(4) UniProt(19)
Polymorphisms RFLP(10) : SNPs within 2kb(302 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000734 Lipase
InterPro IPR008976 Lipase/lipooxygenase, PLAT/LH2
InterPro IPR013818 Lipase, N-terminal
InterPro IPR002330 Lipoprotein lipase
InterPro IPR016272 Lipoprotein lipase, LIPH
InterPro IPR001024 Lipoxygenase, LH2
Protein Ontology PR:000009897 lipoprotein lipase
References (Earliest) J:8759 Kirchgessner TG, et al., The sequence of cDNA encoding lipoprotein lipase. A member of a lipase gene family. J Biol Chem. 1987 Jun 25;262(18):8463-6
(Latest) J:208890 Picard A, et al., Hippocampal lipoprotein lipase regulates energy balance in rodents. Mol Metab. 2014 Apr;3(2):167-76
All references(153)
Disease annotation references (2)
Other
accession IDs
MGD-MRK-11871

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
08/12/2014
MGI 5.19
The Jackson Laboratory