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Lpl
Gene Detail
Symbol

Name
ID
Lpl
lipoprotein lipase
MGI:96820
STS
Synonyms
O 1-4-5
Feature Type
protein coding gene
Genetic Map
Chromosome 8
33.88 cM
Detailed Genetic Map ± 1 cM


Mapping data(32)
Sequence Map
Chr8:68880491-68907448 bp, + strand
From VEGA annotation of GRCm38

  26958 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:200  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 2 zebrafish

HCOP human homology predictions: LPL
Protein SuperFamily: lipoprotein lipase, LIPH type
Gene Tree: Lpl

Human
homologs
LPL, lipoprotein lipase
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 4023
neXtProt AC: NX_P06858

Human Synonyms: HDLCQ11, LIPD

Human Chr (Location): 8p22; chr8:19939071-19967259 (+)  GRCh38.p2

Disease Associations: (3) Diseases Associated with Human LPL

Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for targeted null mutations become cyanotic and die within 2 days of birth due to chylomicron engorgement of capillaries. Mutants show hypertriglyceridemia and reduced fat stores. Heterozygotes show 1.5-2-fold elevated triglyceride levels.
 
Human Diseases Modeled in Mice Using Lpl (1)    Mutations Annotated to Human Diseases (2)    Phenotype Images(6)
Interactions
Lpl interacts with 272 markers (Mir1b, Mir7-1, Mir7-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (35 annotations)
Process fatty acid biosynthetic process, lipid catabolic process, ...
Component anchored component of membrane, cell surface, ...
Function apolipoprotein binding, carboxylic ester hydrolase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (18 records)
Data Summary: Results (402)    Tissues (131)    Images (49)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 346
Northern blot 56
cDNA source data(373)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: GEISHA LPL ; Xenbase lpl ; ZFIN lpl    NEW 
Molecular
reagents
All nucleic(386) Genomic(6) cDNA(379) Other(1)
Microarray probesets(5)
Other database
links
VEGA Gene Model OTTMUSG00000036084 (Evidence)
Ensembl Gene Model ENSMUSG00000015568 (Evidence)
Entrez Gene 16956 (Evidence)
UniGene 1514
DFCI TC1573803, TC1655563
DoTS DT.101262120, DT.55107370, DT.87055594, DT.91286492, DT.91340815, DT.94387885, DT.94405090, DT.99846664, DT.99866938
NIA Mouse Gene Index U009398
EC 3.1.1.34
Consensus CDS Project CCDS40357.1
International Mouse Phenotyping Consortium Status Lpl
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000036084 VEGA Gene Model | MGI Sequence Detail 26958 C57BL/6J ±  kb
transcript OTTMUST00000092709 VEGA | MGI Sequence Detail 4115 Not Applicable 
polypeptide OTTMUSP00000051299 VEGA | MGI Sequence Detail 474 Not Applicable 

For the selected sequences
All sequences(146) RefSeq(2) UniProt(19)
Polymorphisms
RFLP(10) : SNPs within 2kb(302 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000734 Lipase
InterPro IPR008976 Lipase/lipooxygenase, PLAT/LH2
InterPro IPR013818 Lipase, N-terminal
InterPro IPR002330 Lipoprotein lipase
InterPro IPR016272 Lipoprotein lipase, LIPH
InterPro IPR001024 Lipoxygenase, LH2
Protein Ontology PR:000009897 lipoprotein lipase
References
(Earliest) J:8759 Kirchgessner TG, et al., The sequence of cDNA encoding lipoprotein lipase. A member of a lipase gene family. J Biol Chem. 1987 Jun 25;262(18):8463-6
(Latest) J:221431 Yang H, et al., Lipoprotein lipase deficiency leads to alpha-synuclein aggregation and ubiquitin C-terminal hydrolase L1 reduction. Neuroscience. 2015 Apr 2;290:1-10
All references(156)
Disease annotation references (2)
Other
accession IDs
MGD-MRK-11871

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory