Lpl
Gene Detail

Symbol Name ID

Lpl lipoprotein lipase MGI:96820

STS

D8Mit26

Synonyms

O 1-4-5

Feature Type

protein coding gene

Genetic Map

Chromosome 8

33.88 cM
Detailed Genetic Map ± 1 cM


Mapping data(32)

Sequence Map

Chr8:68880491-68907448 bp, + strand From VEGA annotation of GRCm38   26958 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:200  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: lipoprotein lipase, LIPH type
Gene Tree: Lpl

Human homologs

Human Homolog		LPL, lipoprotein lipase
NCBI Gene ID		4023
neXtProt AC		NX_P06858
Human Synonyms		HDLCQ11, LIPD
Human Chr (Location)		8p22; chr8:19796582-19824770 (+)  GRCh37.p10
Disease Associations		(3) Diseases Associated with Human LPL

Alleles and phenotypes

All alleles(4) : Targeted(4)
 

Homozygotes for targeted null mutations become cyanotic and die within 2 days of birth due to chylomicron engorgement of capillaries. Mutants show hypertriglyceridemia and reduced fat stores. Heterozygotes show 1.5-2-fold elevated triglyceride levels.

 
Human Diseases Modeled Using Mouse Lpl (1)    Alleles Annotated to Human Diseases(2)    Phenotype Images(6)

Gene Ontology (GO) classifications

All GO classifications: (34 annotations)

Process	fatty acid biosynthetic process, lipid catabolic process, ...
Component	anchored to membrane, cell surface, ...
Function	apolipoprotein binding, catalytic activity, ...

External Resources: FuncBase

Expression

Literature Summary: (16 records)
Data Summary: Results (402)    Tissues (131)    Images (49)
Theiler Stages: 22, 23, 25, 26, 28

Assay Type	Results
RNA in situ	346
Northern blot	56

cDNA source data(369)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress

Molecular reagents

All nucleic(382) Genomic(6) cDNA(375) Other(1)
Microarray probesets(5)

Other database links

VEGA Gene Model	OTTMUSG00000036084 (Evidence)
Ensembl Gene Model	ENSMUSG00000015568 (Evidence)
Entrez Gene	16956 (Evidence)
UniGene	1514
DFCI	TC1573803, TC1655563
DoTS	DT.101262120, DT.55107370, DT.87055594, DT.91286492, DT.91340815, DT.94387885, DT.94405090, DT.99846664, DT.99866938
NIA Mouse Gene Index	U009398
EC	3.1.1.34
Consensus CDS Project	CCDS40357.1
International Mouse Knockout Project Status	Lpl

Sequences

Length	Strain/Species
genomic	OTTMUSG00000036084	VEGA Gene Model | MGI Sequence Detail	26958	C57BL/6J
transcript	OTTMUST00000092709	VEGA | MGI Sequence Detail	4115	Not Applicable
polypeptide	OTTMUSP00000051299	VEGA | MGI Sequence Detail	474	Not Applicable

All sequences(145) RefSeq(2) UniProt(19)

Polymorphisms

RFLP(10) : SNPs(181 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR000734	Lipase
InterPro	IPR008976	Lipase/lipooxygenase, PLAT/LH2
InterPro	IPR013818	Lipase, N-terminal
InterPro	IPR002330	Lipoprotein lipase
InterPro	IPR016272	Lipoprotein lipase, LIPH
InterPro	IPR001024	Lipoxygenase, LH2
Protein Ontology	PR:000009897	lipoprotein lipase

References

(Earliest) J:8759 Kirchgessner TG, et al., The sequence of cDNA encoding lipoprotein lipase. A member of a lipase gene family. J Biol Chem. 1987 Jun 25;262(18):8463-6
(Latest) J:192805 Nyren R, et al., Localization of lipoprotein lipase and GPIHBP1 in mouse pancreas: effects of diet and leptin deficiency. BMC Physiol. 2012;12:14
All references(147)

Other accession IDs

MGD-MRK-11871