Lpltm1Bres
Targeted Allele Detail
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Symbol: |
Lpltm1Bres |
Name: |
lipoprotein lipase; targeted mutation 1, Jan L Breslow |
MGI ID: |
MGI:2651805 |
Synonyms: |
L1, LPL- |
Gene: |
Lpl Location: Chr8:69333207-69359584 bp, + strand Genetic Position: Chr8, 33.88 cM
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Alliance: |
Lpltm1Bres page
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Gross pathology of Lpltm1Bres/Lpltm1Bres pups at 14-16 hours after birth
Show the 5 phenotype image(s) involving this allele.
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Germline Transmission: |
Earliest citation of germline transmission:
J:30062
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Parent Cell Line: |
J1 (ES Cell)
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Strain of Origin: |
129S4/SvJae
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Allele Type: |
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Targeted (Null/knockout) |
Mutations: |
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Insertion, Intragenic deletion
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Mutation details: Sequence encompassing a portion of exon 1, including the start codon and signal sequence, and all of exon 2 was replaced with a neomycin selection cassette inserted by homologous recombination. Lipoprotein lipase activity was shown to be almost completely ablated in homozygous mutant mice.
(J:30062)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Lpl Mutation: |
43 strains or lines available
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Original: |
J:30062 Weinstock PH, et al., Severe hypertriglyceridemia, reduced high density lipoprotein, and neonatal death in lipoprotein lipase knockout mice. Mild hypertriglyceridemia with impaired very low density lipoprotein clearance in heterozygotes. J Clin Invest. 1995 Dec;96(6):2555-68 |
All: |
26 reference(s) |
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