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Lmnb2 Gene Detail
Summary
  • Symbol
    Lmnb2
  • Name
    lamin B2
  • Synonyms
    lamin B3
  • Feature Type
    protein coding gene
  • IDs
    MGI:96796
    NCBI Gene: 16907
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr10:80901203-80918245 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      17043 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 10, 39.72 cM, cytoband C
  • Mapping Data
    5 experiments
Homology
more
  • Human Ortholog
    LMNB2, lamin B2
  • Vertebrate Orthologs
    10
  • Human Ortholog
    LMNB2, lamin B2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    EPM9, LAMB2, LMN2
  • Links
    NCBI Gene ID: 84823
    neXtProt AC: NX_Q03252
    UniProt: Q03252

  • Chr Location
    19p13.3; chr19:2428165-2456968 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 7818
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: LMNB2
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with human LMNB2 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    20 phenotypes from 5 alleles in 4 genetic backgrounds
    18 phenotypes from multigenic genotypes
    18 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit neonatal death with abnormal brain development.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
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    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000031736 VEGA Gene Model | MGI Sequence Detail 17043 C57BL/6J ±  kb
    transcript OTTMUST00000078602 VEGA | MGI Sequence Detail 3531 Not Applicable  
    polypeptide OTTMUSP00000041821 VEGA | MGI Sequence Detail 615 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      94 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 73
      Genomic 8
      cDNA 62
      Primer pair 3

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-11820
    References
    more
    • Summaries
      All 62
      Developmental Gene Expression 13
      Gene Ontology 7
      Phenotypes 18
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:246890 Stroud MJ, et al., Nesprin 1alpha2 is essential for mouse postnatal viability and nuclear positioning in skeletal muscle. J Cell Biol. 2017 Jul 03;216(7):1915-1924

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
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    last database update
    10/16/2018
    MGI 6.12
    The Jackson Laboratory