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Lmnb2
Gene Detail
Symbol

Name
ID
Lmnb2
lamin B2
MGI:96796
Synonyms
lamin B3
Feature Type
protein coding gene
Genetic Map
Chromosome 10
39.72 cM, cytoband C
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr10:80901203-80918245 bp, - strand
From VEGA annotation of GRCm38

  17043 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:7818  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Lmnb2

Human
homologs
Human Homolog LMNB2, lamin B2
NCBI Gene ID 84823
neXtProt AC  NX_Q03252
Human Synonyms  LAMB2, LMN2
Human Chr (Location)  19p13.3; chr19:2428165-2456968 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human LMNB2
Mutations,
alleles, and
phenotypes
All mutations/alleles(9) : Gene trapped(3) Targeted(6)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele exhibit neonatal death with abnormal brain development.
 
Interactions
Lmnb2 interacts with 188 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (8 annotations)
Component intermediate filament, lamin filament, ...
Function structural molecule activity
External Resources: FuncBase
Expression
Literature Summary: (9 records)
Data Summary: Results (9)    Tissues (4)    Images (2)    Tissue x Stage Matrix (view)
Assay TypeResults
RT-PCR 9
cDNA source data(60)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(72) Genomic(8) cDNA(61) Primer pair(3)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000031736 (Evidence)
Ensembl Gene ModelENSMUSG00000062075 (Evidence)
Entrez Gene16907 (Evidence)
UniGene7362
DFCITC1576846, TC1595730, TC1595848, TC1771466
DoTSDT.495901, DT.60102810, DT.91444605
NIA Mouse Gene IndexU032025
Consensus CDS ProjectCCDS24037.1
International Mouse Knockout Project StatusLmnb2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000031736 VEGA Gene Model | MGI Sequence Detail 17043 C57BL/6J ±  kb
transcript OTTMUST00000078602 VEGA | MGI Sequence Detail 3531 Not Applicable 
polypeptide OTTMUSP00000041821 VEGA | MGI Sequence Detail 615 Not Applicable 

For the selected sequences
All sequences(43) RefSeq(4) UniProt(3)
Polymorphisms
SNPs within 2kb(95 from dbSNP Build 137)    SNPs within 2kb including multiple locations(97)
Protein-related
information
ResourceIDDescription
InterPro IPR001664 Intermediate filament protein
InterPro IPR018039 Intermediate filament protein, conserved site
InterPro IPR001322 Lamin Tail Domain
Protein Ontology PR:000009861 lamin-B2
References
(Earliest) J:16565 Riedel W, et al., Nucleotide sequence of the full-length mouse lamin C cDNA and its deduced amino-acid sequence. Biochim Biophys Acta. 1989 Jun 1;1008(1):119-22
(Latest) J:197315 Jung HJ, et al., Farnesylation of lamin B1 is important for retention of nuclear chromatin during neuronal migration. Proc Natl Acad Sci U S A. 2013 May 21;110(21):E1923-32
All references(49)
Other
accession IDs
MGD-MRK-11820

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/16/2014
MGI 5.20
The Jackson Laboratory