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Lipe
Gene Detail
Symbol

Name
ID
Lipe
lipase, hormone sensitive
MGI:96790
Synonyms
4933403G17Rik, HSL
Feature Type
protein coding gene
Genetic Map
Chromosome 7
13.78 cM, cytoband A3
Detailed Genetic Map ± 1 cM


Mapping data(15)
Sequence Map
Chr7:25379527-25398710 bp, - strand
From VEGA annotation of GRCm38

  19184 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3912  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: LIPE
Gene Tree: Lipe

Human
homologs
LIPE, lipase, hormone-sensitive
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 3991
neXtProt AC: NX_Q05469

Human Synonyms: AOMS4, FPLD6, HSL, LHS

Human Chr (Location): 19q13.2; chr19:42401507-42427426 (-)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human LIPE

Mutations,
alleles, and
phenotypes
All mutations/alleles(9) : Gene trapped(2) Targeted(7)
Incidental mutations (data from Mutagenetix , APF )
 
Mutations of this locus result in abnormal lipid homeostasis and, in some lines, defects in spermatogenesis.
 
Phenotype Images(6)
Interactions
Lipe interacts with 94 markers (Mir15a, Mir15b, Mir16-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (34 annotations)
Process cholesterol metabolic process, diacylglycerol catabolic process, ...
Component caveola, cytoplasm, ...
Function acylglycerol lipase activity, hormone-sensitive lipase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (2 records)
cDNA source data(7)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase lipe    NEW 
Molecular
reagents
All nucleic(12) Genomic(3) cDNA(8) Other(1)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000034139 (Evidence)
Ensembl Gene Model ENSMUSG00000003123 (Evidence)
Entrez Gene 16890 (Evidence)
DFCI TC1578450, TC1591037, TC1595039
DoTS DT.101734631, DT.533658, DT.55234143, DT.94203128, DT.97352293, DT.99847697
NIA Mouse Gene Index U028274, U097468
EC 3.1.1.79
Consensus CDS Project CCDS20981.1, CCDS20982.1
International Mouse Phenotyping Consortium Status Lipe
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000034139 VEGA Gene Model | MGI Sequence Detail 19184 C57BL/6J ±  kb
transcript OTTMUST00000086443 VEGA | MGI Sequence Detail 3713 Not Applicable 
polypeptide OTTMUSP00000046817 VEGA | MGI Sequence Detail 1072 Not Applicable 

For the selected sequences
All sequences(52) RefSeq(10) UniProt(4)
Polymorphisms
RFLP(2) : SNPs within 2kb(149 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR013094 Alpha/beta hydrolase fold-3
InterPro IPR010468 Hormone-sensitive lipase, N-terminal
InterPro IPR002168 Lipase, GDXG, active site
Protein Ontology PR:000009834 hormone-sensitive lipase
References
(Earliest) J:13597 Warden CH, et al., Chromosomal localization of lipolytic enzymes in the mouse: pancreatic lipase, colipase, hormone-sensitive lipase, hepatic lipase, and carboxyl ester lipase. J Lipid Res. 1993 Aug;34(8):1451-5
(Latest) J:219819 Ertunc ME, et al., Secretion of fatty acid binding protein aP2 from adipocytes through a nonclassical pathway in response to adipocyte lipase activity. J Lipid Res. 2015 Feb;56(2):423-34
All references(118)
Other
accession IDs
MGD-MRK-11812, MGI:1918310

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory