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Lipe Gene Detail
Summary
  • Symbol
    Lipe
  • Name
    lipase, hormone sensitive
  • Synonyms
    4933403G17Rik, HSL
  • Feature Type
    protein coding gene
  • IDs
    MGI:96790
    NCBI Gene: 16890
  • Gene Overview
    MyGene.info: LIPE
Location & Maps
more
  • Sequence Map
    Chr7:25379527-25398710 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      19184 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 13.78 cM, cytoband A3
  • Mapping Data
    15 experiments
Homology
more
  • Human Ortholog
    LIPE, lipase E, hormone sensitive type
  • Vertebrate Orthologs
    8
  • Human Ortholog
    LIPE, lipase E, hormone sensitive type
    Orthology source: HomoloGene
  • Synonyms
    AOMS4, FPLD6, HSL, LHS
  • Links
    NCBI Gene ID: 3991
    neXtProt AC: NX_Q05469

  • Chr Location
    19q13.2; chr19:42401507-42427426 (-)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with human LIPE associations

Human Disease Mouse Models
       Lipodystrophy, Familial Partial, Type 6; FPLD6   OMIM: 615980
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    68 phenotypes from 5 alleles in 9 genetic backgrounds
    6 phenotypes from multigenic genotypes
    6 images
    62 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    10
  • Gene trapped
    2
  • Targeted
    8
  • Incidental Mutations
Mutations of this locus result in abnormal lipid homeostasis and, in some lines, defects in spermatogenesis.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000034139 VEGA Gene Model | MGI Sequence Detail 19184 C57BL/6J ±  kb
transcript OTTMUST00000086443 VEGA | MGI Sequence Detail 3713 Not Applicable  
polypeptide OTTMUSP00000046817 VEGA | MGI Sequence Detail 1072 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    149 from dbSNP Build 142
  • RFLP
Protein
Information
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  • UniProt
    6 Sequences
  • Protein Ontology
    PR:000009834 hormone-sensitive lipase
  • EC
  • InterPro Domains
    IPR029058 Alpha/Beta hydrolase fold
    IPR013094 Alpha/beta hydrolase fold-3
    IPR010468 Hormone-sensitive lipase, N-terminal
    IPR002168 Lipase, GDXG, putative histidine active site
    IPR033140 Lipase, GDXG, putative serine active site
Molecular
Reagents
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  • All nucleic 12
    Genomic 3
    cDNA 8
    Other 1

    Microarray probesets 4
Other
Accession IDs
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MGD-MRK-11812, MGI:1918310
References
more
  • Summaries
    All 119
    Developmental Gene Expression 3
    Gene Ontology 12
    Phenotypes 62
  • Earliest
    J:13597 Warden CH, et al., Chromosomal localization of lipolytic enzymes in the mouse: pancreatic lipase, colipase, hormone-sensitive lipase, hepatic lipase, and carboxyl ester lipase. J Lipid Res. 1993 Aug;34(8):1451-5
  • Latest
    J:231197 Goeritzer M, et al., Active autophagy but not lipophagy in macrophages with defective lipolysis. Biochim Biophys Acta. 2015 Oct;1851(10):1304-16

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
08/23/2016
MGI 6.05
The Jackson Laboratory