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Lipe Gene Detail
Summary
  • Symbol
    Lipe
  • Name
    lipase, hormone sensitive
  • Synonyms
    4933403G17Rik, HSL
  • Feature Type
    protein coding gene
  • IDs
    MGI:96790
    NCBI Gene: 16890
  • Gene Overview
    MyGene.info: LIPE
  • Alliance
  • Transcription Start Sites
    12 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:25379527-25398486 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 13.78 cM, cytoband A3
  • Mapping Data
    15 experiments
Strain
Comparison
more
  • SNPs within 2kb
    149 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_96790
protein coding gene Chr7:25379527-25398710 (-)
129S1/SvImJ MGP_129S1SvImJ_G0031865
protein coding gene Chr7:23846833-23865894 (-)
A/J MGP_AJ_G0031844
protein coding gene Chr7:23227249-23246941 (-)
AKR/J MGP_AKRJ_G0031773
protein coding gene Chr7:23775275-23794259 (-)
BALB/cJ MGP_BALBcJ_G0031851
protein coding gene Chr7:23440961-23460396 (-)
C3H/HeJ MGP_C3HHeJ_G0031570
protein coding gene Chr7:24206901-24227581 (-)
C57BL/6NJ MGP_C57BL6NJ_G0032313
protein coding gene Chr7:24645372-24666020 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0029368
protein coding gene Chr7:24649615-24668724 (-)
CAST/EiJ MGP_CASTEiJ_G0030910
protein coding gene Chr7:17696277-17717684 (-)
CBA/J MGP_CBAJ_G0031535
protein coding gene Chr7:25558817-25577869 (-)
DBA/2J MGP_DBA2J_G0031689
protein coding gene Chr7:23129462-23149052 (-)
FVB/NJ MGP_FVBNJ_G0031642
protein coding gene Chr7:23131737-23150888 (-)
LP/J MGP_LPJ_G0031768
protein coding gene Chr7:24145209-24164378 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0031679
protein coding gene Chr7:25259938-25279034 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0032345
protein coding gene Chr7:23480982-23500011 (-)
PWK/PhJ MGP_PWKPhJ_G0030634
protein coding gene Chr7:18077114-18096763 (-)
SPRET/EiJ MGP_SPRETEiJ_G0030465
protein coding gene Chr7:14800716-14821476 (-)
WSB/EiJ MGP_WSBEiJ_G0031013
protein coding gene Chr7:23665337-23686354 (-)



Homology
more
  • Human Ortholog
    LIPE, lipase E, hormone sensitive type
  • Vertebrate Orthologs
    8
  • Human Ortholog
    LIPE, lipase E, hormone sensitive type
    Orthology source: HomoloGene, HGNC
  • Synonyms
    AOMS4, FPLD6, HSL, LHS
  • Links
    NCBI Gene ID: 3991
    neXtProt AC: NX_Q05469
    UniProt: Q05469

  • Chr Location
    19q13.2; chr19:42401507-42427426 (-)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with human LIPE associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    73 phenotypes from 6 alleles in 10 genetic backgrounds
    6 phenotypes from multigenic genotypes
    6 images
    71 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mutations of this locus result in abnormal lipid homeostasis and, in some lines, defects in spermatogenesis.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 16890 NCBI Gene Model | MGI Sequence Detail 18960 C57BL/6J ±  kb
transcript NM_010719 RefSeq | MGI Sequence Detail 3221 C57BL/6  
polypeptide P54310 UniProt | EBI | MGI Sequence Detail 759 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 14
    Genomic 3
    cDNA 10
    Other 1

    Microarray probesets 4
Other
Accession IDs
less
MGD-MRK-11812, MGI:1918310
References
more
  • Summaries
    All 142
    Developmental Gene Expression 6
    Gene Ontology 14
    Phenotypes 71
  • Earliest
    J:13548 Clamp PA, et al., Linkage relationships between ALPL, ENO1, GPI, PGD, and TGFB1 on porcine chromosome 6. Genomics. 1993 Aug;17(2):324-9
  • Latest
    J:269323 Vazquez P, et al., Increased FGF21 in brown adipose tissue of tyrosine hydroxylase heterozygous mice: implications for cold adaptation. J Lipid Res. 2018 Dec;59(12):2308-2320

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
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last database update
12/03/2019
MGI 6.14
The Jackson Laboratory