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Lipe
Gene Detail
Symbol

Name
ID
Lipe
lipase, hormone sensitive
MGI:96790
Synonyms
4933403G17Rik, HSL
Feature Type
protein coding gene
Genetic Map
Chromosome 7
13.78 cM, cytoband A3
Detailed Genetic Map ± 1 cM


Mapping data(15)
Sequence Map
Chr7:25379527-25398710 bp, - strand
From VEGA annotation of GRCm38

  19184 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3912  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 western clawed frog; 1 zebrafish

Gene Tree: Lipe

Human
homologs
Human Homolog LIPE, lipase, hormone-sensitive
NCBI Gene ID 3991
neXtProt AC  NX_Q05469
Human Synonyms  AOMS4, HSL, LHS
Human Chr (Location)  19q13.2; chr19:42401507-42427426 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human LIPE
Mutations,
alleles, and
phenotypes
All mutations/alleles(9) : Gene trapped(2) Targeted(7)
Incidental mutations (data from Mutagenetix , APF )
 
Mutations of this locus result in abnormal lipid homeostasis and, in some lines, defects in spermatogenesis.
 
Phenotype Images(6)
Interactions
Lipe interacts with 94 markers (Mir15a, Mir15b, Mir16-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (34 annotations)
Process cholesterol metabolic process, diacylglycerol catabolic process, ...
Component caveola, cytoplasm, ...
Function acylglycerol lipase activity, hormone-sensitive lipase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (2 records)
cDNA source data(7)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(12) Genomic(3) cDNA(8) Other(1)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000034139 (Evidence)
Ensembl Gene ModelENSMUSG00000003123 (Evidence)
Entrez Gene16890 (Evidence)
DFCITC1578450, TC1591037, TC1595039
DoTSDT.101734631, DT.533658, DT.55234143, DT.94203128, DT.97352293, DT.99847697
NIA Mouse Gene IndexU028274, U097468
EC3.1.1.79
Consensus CDS ProjectCCDS20981.1, CCDS20982.1
International Mouse Knockout Project StatusLipe
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000034139 VEGA Gene Model | MGI Sequence Detail 19184 C57BL/6J ±  kb
transcript OTTMUST00000086443 VEGA | MGI Sequence Detail 3713 Not Applicable 
polypeptide OTTMUSP00000046817 VEGA | MGI Sequence Detail 1072 Not Applicable 

For the selected sequences
All sequences(55) RefSeq(10) UniProt(7)
Polymorphisms
RFLP(2) : SNPs within 2kb(149 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR013094 Alpha/beta hydrolase fold-3
InterPro IPR010468 Hormone-sensitive lipase, N-terminal
InterPro IPR002168 Lipase, GDXG, active site
Protein Ontology PR:000009834 hormone-sensitive lipase
References
(Earliest) J:13548 Clamp PA, et al., Linkage relationships between ALPL, ENO1, GPI, PGD, and TGFB1 on porcine chromosome 6. Genomics. 1993 Aug;17(2):324-9
(Latest) J:207678 Ohno H, et al., EHMT1 controls brown adipose cell fate and thermogenesis through the PRDM16 complex. Nature. 2013 Dec 5;504(7478):163-7
All references(115)
Other
accession IDs
MGD-MRK-11812, MGI:1918310

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/18/2014
MGI 5.20
The Jackson Laboratory