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Lif Gene Detail
Summary
  • Symbol
    Lif
  • Name
    leukemia inhibitory factor
  • Feature Type
    protein coding gene
  • IDs
    MGI:96787
    NCBI Gene: 16878
  • Gene Overview
    MyGene.info: LIF
Location & Maps
more
  • Sequence Map
    Chr11:4257557-4272514 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      14958 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 2.94 cM, cytoband A1-A2
  • Mapping Data
    18 experiments
  • Sequence Tags
Homology
more
  • Human Ortholog
    LIF, leukemia inhibitory factor
  • Vertebrate Orthologs
    8
  • Human Ortholog
    LIF, leukemia inhibitory factor
    Orthology source: HGNC, HomoloGene
  • Synonyms
    CDF, DIA, HILDA, MLPLI
  • Links
    NCBI Gene ID: 3976
    neXtProt AC: NX_P15018

  • Chr Location
    22q12.2; chr22:30240447-30257923 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    67 phenotypes from 3 alleles in 9 genetic backgrounds
    38 phenotypes from multigenic genotypes
    61 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    10
  • Gene trapped
    6
  • Targeted
    4
  • Incidental Mutations
Homozygotes for targeted null mutations have reduced numbers of stem cells in spleen and bone marrow, enhanced inflammatory responses, impaired sensory neuron regrowth, and uterine insufficiency. Heterozygotes show intermediate numbers of stem cells.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000005061 VEGA Gene Model | MGI Sequence Detail 14958 C57BL/6J ±  kb
transcript OTTMUST00000011278 VEGA | MGI Sequence Detail 4026 Not Applicable  
polypeptide OTTMUSP00000005253 VEGA | MGI Sequence Detail 203 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    62 from dbSNP Build 142
  • PCR
  • RFLP
Protein
Information
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  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000009799 leukemia inhibitory factor
  • PDB
  • InterPro Domains
    IPR012351 Four-helical cytokine, core
    IPR009079 Four-helical cytokine-like, core
    IPR003624 Leukemia inhibitory factor
    IPR001581 Leukemia inhibitory factor /oncostatin
    IPR019827 Leukemia inhibitory factor /oncostatin, conserved site
Molecular
Reagents
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  • All nucleic 38
    Genomic 7
    cDNA 23
    Primer pair 5
    Other 3

    Microarray probesets 5
Other
Accession IDs
less
MGD-MRK-11807
References
more
  • Summaries
    All 185
    Developmental Gene Expression 29
    Gene Ontology 17
    Phenotypes 61
  • Earliest
    J:9088 Gearing DP, et al., Molecular cloning and expression of cDNA encoding a murine myeloid leukaemia inhibitory factor (LIF). EMBO J. 1987 Dec 20;6(13):3995-4002
  • Latest
    J:227622 Bellessort B, et al., Dlx5 and Dlx6 control uterine adenogenesis during post-natal maturation: possible consequences for endometriosis. Hum Mol Genet. 2016 Jan 1;25(1):97-108

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/12/2016
MGI 6.04
The Jackson Laboratory