About   Help   FAQ
Lif
Gene Detail
 Symbol
Name
ID
Lif
leukemia inhibitory factor
MGI:96787
STS D11Mit106, D11Mit16
Feature Type protein coding gene
Genetic Map
Chromosome 11
2.94 cM, cytoband A1-A2
Detailed Genetic Map ± 1 cM


Mapping data(18)
Sequence Map
Chr11:4257557-4272514 bp, + strand
From VEGA annotation of GRCm38

  14958 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1734  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken

Protein SuperFamily: leukemia inhibitory factor
Gene Tree: Lif

Human
homologs
Human Homolog LIF, leukemia inhibitory factor
NCBI Gene ID 3976
neXtProt AC  NX_P15018
Human Synonyms  CDF, DIA, HILDA, MLPLI
Human Chr (Location)  22q12.2; chr22:30240447-30257381 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(10) : Gene trapped(6) Targeted(4)
Incidental mutations (data from Mutagenetix )
 
Homozygotes for targeted null mutations have reduced numbers of stem cells in spleen and bone marrow, enhanced inflammatory responses, impaired sensory neuron regrowth, and uterine insufficiency. Heterozygotes show intermediate numbers of stem cells.
 
Interactions
Lif interacts with 278 markers (Mir1b, Mir7-1, Mir7-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (61 annotations)
Process astrocyte differentiation, blood vessel remodeling, ...
Component cytoplasm, extracellular region, ...
Function cytokine activity, growth factor activity, ...
External Resources: FuncBase
Expression
Literature Summary: (26 records)
Data Summary: Results (199)    Tissues (115)    Images (6)
Theiler Stages: 2, 3, 12, 13, 15, 16, 17, 18, 20, 21, 22, 23, 24, 25, 26, 27, 28
Assay TypeResults
RNA in situ 30
RT-PCR 81
RNase protection 82
Nuclease S1 6
cDNA source data(20)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(36) Genomic(7) cDNA(23) Primer pair(4) Other(2)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000005061 (Evidence)
Ensembl Gene ModelENSMUSG00000034394 (Evidence)
Entrez Gene16878 (Evidence)
UniGene4964
DFCITC1586281, TC1690525, TC1691634
DoTSDT.87049633, DT.94261751
NIA Mouse Gene IndexU012272
PDB1A7M, 1LKI
Consensus CDS ProjectCCDS24383.1, CCDS24384.1
International Mouse Knockout Project StatusLif
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000005061 VEGA Gene Model | MGI Sequence Detail 14958 C57BL/6J ±  kb
transcript OTTMUST00000011278 VEGA | MGI Sequence Detail 4026 Not Applicable 
polypeptide OTTMUSP00000005253 VEGA | MGI Sequence Detail 203 Not Applicable 

For the selected sequences
All sequences(50) RefSeq(12) UniProt(3)
Polymorphisms All PCR and RFLP(4) : PCR(1) RFLP(3) SNPs within 2kb(62 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR012351 Four-helical cytokine, core
InterPro IPR009079 Four-helical cytokine-like, core
InterPro IPR003624 Leukemia inhibitory factor
InterPro IPR001581 Leukemia inhibitory factor /oncostatin
InterPro IPR019827 Leukemia inhibitory factor /oncostatin, conserved site
Protein Ontology PR:000009799 leukemia inhibitory factor
References (Earliest) J:9088 Gearing DP, et al., Molecular cloning and expression of cDNA encoding a murine myeloid leukaemia inhibitory factor (LIF). EMBO J. 1987 Dec 20;6(13):3995-4002
(Latest) J:202078 Filant J, et al., Endometrial glands are essential for blastocyst implantation and decidualization in the mouse uterus. Biol Reprod. 2013 Apr;88(4):93
All references(186)
Other
accession IDs
MGD-MRK-11807

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
09/09/2014
MGI 5.19
The Jackson Laboratory