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Lif Gene Detail
Summary
  • Symbol
    Lif
  • Name
    leukemia inhibitory factor
  • Feature Type
    protein coding gene
  • IDs
    MGI:96787
    NCBI Gene: 16878
  • Gene Overview
    MyGene.info: LIF
  • Alliance
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:4257568-4272514 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 2.94 cM, cytoband A1-A2
  • Mapping Data
    18 experiments
  • Sequence Tags
Strain
Comparison
more
  • SNPs within 2kb
    62 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_96787
protein coding gene Chr11:4257557-4272514 (+)
129S1/SvImJ MGP_129S1SvImJ_G0017981
protein coding gene Chr11:1193323-1220046 (+)
A/J MGP_AJ_G0017954
protein coding gene Chr11:1202123-1217346 (+)
AKR/J MGP_AKRJ_G0017918
protein coding gene Chr11:1257095-1272357 (+)
BALB/cJ MGP_BALBcJ_G0017922
protein coding gene Chr11:1173462-1188937 (+)
C3H/HeJ MGP_C3HHeJ_G0017735
protein coding gene Chr11:1156755-1171733 (+)
C57BL/6NJ MGP_C57BL6NJ_G0018375
protein coding gene Chr11:1273900-1291663 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0016033
protein coding gene Chr11:1082086-1097774 (+)
CAST/EiJ MGP_CASTEiJ_G0017297
protein coding gene Chr11:1119976-1137762 (+)
CBA/J MGP_CBAJ_G0017710
protein coding gene Chr11:1519721-1535714 (+)
DBA/2J MGP_DBA2J_G0017821
protein coding gene Chr11:1107465-1122529 (+)
FVB/NJ MGP_FVBNJ_G0017812
protein coding gene Chr11:1139940-1154915 (+)
LP/J MGP_LPJ_G0017891
protein coding gene Chr11:1298668-1313553 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0017838
protein coding gene Chr11:1184020-1211104 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0018414
protein coding gene Chr11:1267918-1283208 (+)
PWK/PhJ MGP_PWKPhJ_G0017078
protein coding gene Chr11:1109892-1125406 (+)
SPRET/EiJ MGP_SPRETEiJ_G0016874
protein coding gene Chr11:1229582-1246654 (+)
WSB/EiJ MGP_WSBEiJ_G0017351
protein coding gene Chr11:1130825-1146101 (+)



Homology
more
  • Human Ortholog
    LIF, LIF interleukin 6 family cytokine
  • Vertebrate Orthologs
    8
  • Human Ortholog
    LIF, LIF interleukin 6 family cytokine
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CDF, DIA, HILDA, MLPLI
  • Links
    NCBI Gene ID: 3976
    neXtProt AC: NX_P15018
    UniProt: P15018

  • Chr Location
    22q12.2; chr22:30240447-30246851 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    67 phenotypes from 3 alleles in 9 genetic backgrounds
    38 phenotypes from multigenic genotypes
    63 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygotes for targeted null mutations have reduced numbers of stem cells in spleen and bone marrow, enhanced inflammatory responses, impaired sensory neuron regrowth, and uterine insufficiency. Heterozygotes show intermediate numbers of stem cells.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 16878 NCBI Gene Model | MGI Sequence Detail 14947 C57BL/6J ±  kb
    transcript NM_001039537 RefSeq | MGI Sequence Detail 4114 C57BL/6  
    polypeptide P09056 UniProt | EBI | MGI Sequence Detail 203 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 40
      Genomic 7
      cDNA 24
      Primer pair 6
      Other 3

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-11807
    References
    more
    • Summaries
      All 220
      Developmental Gene Expression 34
      Gene Ontology 19
      Phenotypes 63
    • Earliest
      J:9088 Gearing DP, et al., Molecular cloning and expression of cDNA encoding a murine myeloid leukaemia inhibitory factor (LIF). EMBO J. 1987 Dec 20;6(13):3995-4002
    • Latest
      J:262884 Pannicke T, et al., Electrophysiological characterization of Muller cells from the ischemic retina of mice deficient in the leukemia inhibitory factor. Neurosci Lett. 2018 Mar 23;670:69-74

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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    Funding Information
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    last database update
    10/08/2019
    MGI 6.14
    The Jackson Laboratory