Lif
Gene Detail

Symbol Name ID

Lif leukemia inhibitory factor MGI:96787

STS

D11Mit106, D11Mit16

Feature Type

protein coding gene

Genetic Map

Chromosome 11

2.94 cM, cytoband A1-A2
Detailed Genetic Map ± 1 cM


Mapping data(18)

Sequence Map

Chr11:4257557-4272514 bp, + strand From VEGA annotation of GRCm38   14958 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:1734  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken

Protein SuperFamily: leukemia inhibitory factor
Gene Tree: Lif

Human homologs

Human Homolog		LIF, leukemia inhibitory factor
NCBI Gene ID		3976
neXtProt AC		NX_P15018
Human Synonyms		CDF, DIA, HILDA, MLPLI
Human Chr (Location)		22q12.2; chr22:30636436-30642840 (-)  GRCh37.p10

Alleles and phenotypes

All alleles(10) : Targeted(4) Gene trapped(6)
 

Homozygotes for targeted null mutations have reduced numbers of stem cells in spleen and bone marrow, enhanced inflammatory responses, impaired sensory neuron regrowth, and uterine insufficiency. Heterozygotes show intermediate numbers of stem cells.

 

Gene Ontology (GO) classifications

All GO classifications: (60 annotations)

Process	astrocyte differentiation, blood vessel remodeling, ...
Component	cytoplasm, extracellular region, ...
Function	cytokine activity, growth factor activity, ...

External Resources: FuncBase

Expression

Literature Summary: (26 records)
Data Summary: Results (199)    Tissues (106)    Images (6)
Theiler Stages: 2, 3, 12, 13, 15, 16, 17, 18, 20, 21, 22, 23, 24, 25, 26, 28

Assay Type	Results
RNA in situ	30
RT-PCR	81
RNase protection	82
Nuclease S1	6

cDNA source data(21)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(37) Genomic(7) cDNA(24) Primer pair(4) Other(2)
Microarray probesets(5)

Other database links

VEGA Gene Model	OTTMUSG00000005061 (Evidence)
Ensembl Gene Model	ENSMUSG00000034394 (Evidence)
Entrez Gene	16878 (Evidence)
UniGene	4964
DFCI	TC1586281, TC1691634
DoTS	DT.87049633
NIA Mouse Gene Index	U012272
PDB	1A7M, 1LKI
Consensus CDS Project	CCDS24383.1, CCDS24384.1
International Mouse Knockout Project Status	Lif

Sequences

Length	Strain/Species
genomic	OTTMUSG00000005061	VEGA Gene Model | MGI Sequence Detail	14958	C57BL/6J
transcript	OTTMUST00000011278	VEGA | MGI Sequence Detail	4026	Not Applicable
polypeptide	OTTMUSP00000005253	VEGA | MGI Sequence Detail	203	Not Applicable

All sequences(39) RefSeq(4) UniProt(4)

Polymorphisms

All PCR and RFLP(4) : PCR(1) RFLP(3) SNPs(37 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR012351	Four-helical cytokine, core
InterPro	IPR009079	Four-helical cytokine-like, core
InterPro	IPR003624	Leukemia inhibitory factor
InterPro	IPR001581	Leukemia inhibitory factor /oncostatin
InterPro	IPR019827	Leukemia inhibitory factor /oncostatin, conserved site
Protein Ontology	PR:000009799	leukemia inhibitory factor

References

(Earliest) J:9088 Gearing DP, et al., Molecular cloning and expression of cDNA encoding a murine myeloid leukaemia inhibitory factor (LIF). EMBO J. 1987 Dec 20;6(13):3995-4002
(Latest) J:190157 Wang C, et al., UTX regulates mesoderm differentiation of embryonic stem cells independent of H3K27 demethylase activity. Proc Natl Acad Sci U S A. 2012 Sep 18;109(38):15324-9
All references(184)

Other accession IDs

MGD-MRK-11807