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Lef1
Gene Detail
Symbol

Name
ID
Lef1
lymphoid enhancer binding factor 1
MGI:96770
Synonyms
Lef-1, lymphoid enhancer factor 1
Feature Type
protein coding gene
Genetic Map
Chromosome 3
60.78 cM
Detailed Genetic Map ± 1 cM


Mapping data(7)
Sequence Map
Chr3:131110471-131224356 bp, + strand
From VEGA annotation of GRCm38

  113886 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:7813  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: LEF1
Gene Tree: Lef1

Human
homologs
LEF1, lymphoid enhancer-binding factor 1
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 51176
neXtProt AC: NX_Q9UJU2

Human Synonyms: LEF-1, TCF10, TCF1ALPHA, TCF7L3

Human Chr (Location): 4q23-q25; chr4:108047545-108168956 (-)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human LEF1

Mutations,
alleles, and
phenotypes
All mutations/alleles(11) : Gene trapped(4) Targeted(7)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Homozygotes for targeted null mutations lack teeth, mammary glands, hair, dentate gyrus granule cells, and submucosal glands, and die postnatally. Mutants' pro-B cells exhibit defects in proliferation and survival.
 
Interactions
Lef1 interacts with 201 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (143 annotations)
Process alpha-beta T cell differentiation, anatomical structure regression, ...
Component cytoplasm, nucleus, ...
Function armadillo repeat domain binding, beta-catenin binding, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (277 records)
Data Summary: Results (829)    Tissues (596)    Images (151)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 41
RNA in situ 743
Northern blot 12
RT-PCR 33
cDNA source data(67)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: GEISHA LEF1 ; Xenbase lef1 ; ZFIN lef1    NEW 
Molecular
reagents
All nucleic(87) Genomic(1) cDNA(72) Primer pair(7) Other(7)
Microarray probesets(5)
Other database
links
VEGA Gene Model OTTMUSG00000020276 (Evidence)
Ensembl Gene Model ENSMUSG00000027985 (Evidence)
Entrez Gene 16842 (Evidence)
UniGene 255219
DFCI TC1578581, TC1586991, TC1587963, TC1599012, TC1631022, TC1704377, TC1762627
DoTS DT.101138159, DT.101307293, DT.101375180, DT.101721252, DT.533548, DT.533549, DT.94342537
PDB 2LEF, 3OUW, 3OUX
Consensus CDS Project CCDS17842.1, CCDS71319.1, CCDS71320.1
International Mouse Phenotyping Consortium Status Lef1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000020276 VEGA Gene Model | MGI Sequence Detail 113886 C57BL/6J ±  kb
transcript OTTMUST00000048123 VEGA | MGI Sequence Detail 3482 Not Applicable 
polypeptide OTTMUSP00000021970 VEGA | MGI Sequence Detail 397 Not Applicable 

For the selected sequences
All sequences(70) RefSeq(12) UniProt(6)
Polymorphisms
RFLP(1) : SNPs within 2kb(522 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR027397 Catenin binding domain
InterPro IPR013558 CTNNB1 binding, N-teminal
InterPro IPR009071 High mobility group (HMG) box domain
InterPro IPR024940 Transcription factor TCF/LEF
Protein Ontology PR:000009751 lymphoid enhancer-binding factor 1
References
(Earliest) J:10393 Mattei MG, et al., Chromosomal localization of the three members of the jun proto-oncogene family in mouse and man. Oncogene. 1990 Jan;5(1):151-6
(Latest) J:218613 Chen J, et al., The ciliopathy gene rpgrip1l is essential for hair follicle development. J Invest Dermatol. 2015 Mar;135(3):701-9
All references(371)
Other
accession IDs
MGD-MRK-11782, MGD-MRK-11783, MGI:2139722

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
05/20/2015
MGI 5.22
The Jackson Laboratory