About   Help   FAQ
Lef1 Gene Detail
Summary
  • Symbol
    Lef1
  • Name
    lymphoid enhancer binding factor 1
  • Synonyms
    Lef-1, lymphoid enhancer factor 1
  • Feature Type
    protein coding gene
  • IDs
    MGI:96770
    NCBI Gene: 16842
Location & Maps
more
  • Sequence Map
    Chr3:131110471-131224356 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      113886 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 3, 60.78 cM
  • Mapping Data
    7 experiments
Homology
more
  • Human Ortholog
    LEF1, lymphoid enhancer binding factor 1
  • Vertebrate Orthologs
    9
  • Human Ortholog
    LEF1, lymphoid enhancer binding factor 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    LEF-1, TCF10, TCF1ALPHA, TCF7L3
  • Links
    NCBI Gene ID: 51176
    neXtProt AC: NX_Q9UJU2

  • Chr Location
    4q25; chr4:108047545-108168956 (-)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 7813
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed
  • HCOP
    human homology predictions: LEF1
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with human LEF1 associations

Human Disease Mouse Models
       Lymphoid Enhancer-Binding Factor 1; LEF1   OMIM: 153245
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    46 phenotypes from 4 alleles in 5 genetic backgrounds
    19 phenotypes from multigenic genotypes
    58 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    17
  • Chemically induced (other)
    1
  • Gene trapped
    4
  • Radiation induced
    1
  • Targeted
    8
  • Transgenic
    3
  • Genomic Mutations
    2 involving Lef1
  • Incidental Mutations
Mice homozygous for a null allele are small and die postnatally showing lack of teeth, mammary and uterine glands, whiskers, body hair, dermal-associated fat, and a dentate gyrus, as well as defects in hippocampus morphology, hair follicle development, retinal vasculature, and vascular regression.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000020276 VEGA Gene Model | MGI Sequence Detail 113886 C57BL/6J ±  kb
transcript OTTMUST00000048123 VEGA | MGI Sequence Detail 3482 Not Applicable  
polypeptide OTTMUSP00000021970 VEGA | MGI Sequence Detail 397 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    522 from dbSNP Build 142
  • RFLP
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 91
    Genomic 1
    cDNA 74
    Primer pair 7
    Other 9

    Microarray probesets 5
Other
Accession IDs
less
MGD-MRK-11782, MGD-MRK-11783, MGI:2139722
References
more
  • Summaries
    All 409
    Developmental Gene Expression 315
    Gene Ontology 47
    Phenotypes 58
  • Earliest
    J:10393 Mattei MG, et al., Chromosomal localization of the three members of the jun proto-oncogene family in mouse and man. Oncogene. 1990 Jan;5(1):151-6
  • Latest
    J:236406 Takada Y, et al., Brg1 plays an essential role in development and homeostasis of the duodenum through regulation of Notch signaling. Development. 2016 Oct 1;143(19):3532-3539

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
11/22/2016
MGI 6.06
The Jackson Laboratory