Lef1
Gene Detail

Symbol Name ID

Lef1 lymphoid enhancer binding factor 1 MGI:96770

Synonyms

Lef-1, lymphoid enhancer factor 1

Feature Type

protein coding gene

Genetic Map

Chromosome 3

60.78 cM
Detailed Genetic Map ± 1 cM


Mapping data(7)

Sequence Map

Chr3:131110471-131224356 bp, + strand From VEGA annotation of GRCm38   113886 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:7813  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Lef1

Human homologs

Human Homolog		LEF1, lymphoid enhancer-binding factor 1
NCBI Gene ID		51176
neXtProt AC		NX_Q9UJU2
Human Synonyms		LEF-1, TCF10, TCF1ALPHA, TCF7L3
Human Chr (Location)		4q23-q25; chr4:108968701-109090112 (-)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human LEF1

Alleles and phenotypes

All alleles(10) : Targeted(6) Gene trapped(4)
 

Homozygotes for targeted null mutations lack teeth, mammary glands, hair, dentate gyrus granule cells, and submucosal glands, and die postnatally. Mutants' pro-B cells exhibit defects in proliferation and survival.

 

Gene Ontology (GO) classifications

All GO classifications: (136 annotations)

Process	alpha-beta T cell differentiation, anatomical structure regression, ...
Component	cytoplasm, nucleus, ...
Function	armadillo repeat domain binding, beta-catenin binding, ...

This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase

Expression

Literature Summary: (231 records)
Data Summary: Results (584)    Tissues (428)    Images (138)
Theiler Stages: 1, 2, 3, 4, 5, 11, 12, 13, 15, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 28

Assay Type	Results
Immunohistochemistry	31
RNA in situ	497
Northern blot	12
RT-PCR	44

cDNA source data(69)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress

Molecular reagents

All nucleic(89) Genomic(1) cDNA(74) Primer pair(7) Other(7)
Microarray probesets(5)

Other database links

VEGA Gene Model	OTTMUSG00000020276 (Evidence)
Ensembl Gene Model	ENSMUSG00000027985 (Evidence)
Entrez Gene	16842 (Evidence)
UniGene	255219
DFCI	TC1578581, TC1586991, TC1587963, TC1599012, TC1631022, TC1704377, TC1762627
DoTS	DT.101138159, DT.101307293, DT.101375180, DT.101721252, DT.533548, DT.533549, DT.94342537
PDB	2LEF, 3OUW, 3OUX
Consensus CDS Project	CCDS17842.1
International Mouse Knockout Project Status	Lef1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000020276	VEGA Gene Model | MGI Sequence Detail	113886	C57BL/6J
transcript	OTTMUST00000048123	VEGA | MGI Sequence Detail	3482	Not Applicable
polypeptide	OTTMUSP00000021970	VEGA | MGI Sequence Detail	397	Not Applicable

All sequences(64) RefSeq(6) UniProt(6)

Polymorphisms

RFLP(1) : SNPs(405 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR027397	Catenin binding domain
InterPro	IPR013558	CTNNB1 binding, N-teminal
InterPro	IPR009071	High mobility group (HMG) box domain
InterPro	IPR024940	Transcription factor TCF/LEF
Protein Ontology	PR:000009751	lymphoid enhancer-binding factor 1

References

(Earliest) J:10393 Mattei MG, et al., Chromosomal localization of the three members of the jun proto-oncogene family in mouse and man. Oncogene. 1990 Jan;5(1):151-6
(Latest) J:196080 Elsen GE, et al., The protomap is propagated to cortical plate neurons through an Eomes-dependent intermediate map. Proc Natl Acad Sci U S A. 2013 Mar 5;110(10):4081-6
All references(315)

Other accession IDs

MGD-MRK-11782, MGD-MRK-11783, MGI:2139722