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Ldhb
Gene Detail
Symbol

Name
ID
Ldhb
lactate dehydrogenase B
MGI:96763
Synonyms
H-Ldh, lactate dehydrogenase-B, Ldh-2
Feature Type
protein coding gene
Genetic Map
Chromosome 6
74.17 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr6:142490249-142507957 bp, - strand
From VEGA annotation of GRCm38

  17709 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:55647  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 2 zebrafish

HCOP human homology predictions: LDHB
Protein SuperFamily: L-lactate/malate dehydrogenase
Gene Tree: Ldhb

Human
homologs
LDHB, lactate dehydrogenase B
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 3945
neXtProt AC: NX_P07195

Human Synonyms: HEL-S-281, LDH-B, LDHBD, LDH-H, TRG-5

Human Chr (Location): 12p12.2-p12.1; chr12:21635341-21657971 (-)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human LDHB

Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Gene trapped(3) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Electrophoretic variants of LDHB are determined by: the a allele with fast anodal mobility in all inbred strains tested; and the b allele with slower mobility in Peru-Coppock stock. Three additional variants are known in wild M. spretus from southern France and Spain. Alleles are codominant.
 
Interactions
Ldhb interacts with 59 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (22 annotations)
Process carbohydrate metabolic process, carboxylic acid metabolic process, ...
Component cytoplasm, extracellular exosome, ...
Function catalytic activity, identical protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (9 records)
Data Summary: Results (323)    Tissues (104)    Images (42)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 323
cDNA source data(17)
Other mouse links: GEO   Expression Atlas
Other vertebrate links: Xenbase ldhb ; ZFIN ldhba, ldhbb    NEW 
Molecular
reagents
All nucleic(18) cDNA(17) Primer pair(1)
Microarray probesets(6)
Other database
links
VEGA Gene Model OTTMUSG00000016379 (Evidence)
Ensembl Gene Model ENSMUSG00000030246 (Evidence)
Entrez Gene 16832 (Evidence)
DFCI TC1573939, TC1593533, TC1620265, TC1738980
DoTS DT.101293205, DT.40168399, DT.496769, DT.94360799
NIA Mouse Gene Index U028005, U046716, U056762
EC 1.1.1.27
Consensus CDS Project CCDS20684.1
International Mouse Phenotyping Consortium Status Ldhb
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000016379 VEGA Gene Model | MGI Sequence Detail 17709 C57BL/6J ±  kb
transcript OTTMUST00000039419 VEGA | MGI Sequence Detail 1304 Not Applicable 
polypeptide OTTMUSP00000017612 VEGA | MGI Sequence Detail 334 Not Applicable 

For the selected sequences
All sequences(44) RefSeq(4) UniProt(3)
Polymorphisms
SNPs within 2kb(289 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR015955 Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal
InterPro IPR022383 Lactate/malate dehydrogenase, C-terminal
InterPro IPR001236 Lactate/malate dehydrogenase, N-terminal
InterPro IPR011304 L-lactate dehydrogenase
InterPro IPR018177 L-lactate dehydrogenase, active site
InterPro IPR001557 L-lactate/malate dehydrogenase
InterPro IPR016040 NAD(P)-binding domain
Protein Ontology PR:000009742 L-lactate dehydrogenase B chain
References
(Earliest) J:5101 Epstein CJ, Mammalian oocytes: X chromosome activity. Science. 1969 Mar 7;163(871):1078-9
(Latest) J:208341 Seth A, et al., Prox1 ablation in hepatic progenitors causes defective hepatocyte specification and increases biliary cell commitment. Development. 2014 Feb;141(3):538-47
All references(56)
Other
accession IDs
MGD-MRK-11766, MGD-MRK-11772, MGI:2141472

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
07/28/2015
MGI 5.22
The Jackson Laboratory