Ldhb
Gene Detail

Symbol Name ID

Ldhb lactate dehydrogenase B MGI:96763

Synonyms

H-Ldh, lactate dehydrogenase-B, Ldh-2

Feature Type

protein coding gene

Genetic Map

Chromosome 6

74.17 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)

Sequence Map

Chr6:142490249-142507957 bp, - strand From VEGA annotation of GRCm38   17709 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:55647  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

Protein SuperFamily: L-lactate/malate dehydrogenase
Gene Tree: Ldhb

Human homologs

Human Homolog		LDHB, lactate dehydrogenase B
NCBI Gene ID		3945
neXtProt AC		NX_P07195
Human Synonyms		LDH-B, LDHBD, LDH-H, TRG-5
Human Chr (Location)		12p12.2-p12.1; chr12:21788275-21810789 (-)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human LDHB

Alleles and phenotypes

All alleles(5) : Targeted(2) Gene trapped(3)
 

Electrophoretic variants of LDHB are determined by: the a allele with fast anodal mobility in all inbred strains tested; and the b allele with slower mobility in Peru-Coppock stock. Three additional variants are known in wild M. spretus from southern France and Spain. Alleles are codominant.

 

Gene Ontology (GO) classifications

All GO classifications: (21 annotations)

Process	carbohydrate metabolic process, cellular carbohydrate metabolic process, ...
Component	cytoplasm, mitochondrion
Function	catalytic activity, identical protein binding, ...

External Resources: FuncBase

Expression

Literature Summary: (8 records)
Data Summary: Results (323)    Tissues (104)    Images (42)
Theiler Stages: 22, 23

Assay Type	Results
RNA in situ	323

cDNA source data(16)
External Resources: GEO   ArrayExpress

Molecular reagents

All nucleic(17) cDNA(16) Primer pair(1)
Microarray probesets(6)

Other database links

VEGA Gene Model	OTTMUSG00000016379 (Evidence)
Ensembl Gene Model	ENSMUSG00000030246 (Evidence)
Entrez Gene	16832 (Evidence)
DFCI	TC1573939, TC1593533, TC1738980
DoTS	DT.101293205, DT.496769, DT.94360799
EC	1.1.1.27
Consensus CDS Project	CCDS20684.1
International Mouse Knockout Project Status	Ldhb

Sequences

Length	Strain/Species
genomic	OTTMUSG00000016379	VEGA Gene Model | MGI Sequence Detail	17709	C57BL/6J
transcript	OTTMUST00000039419	VEGA | MGI Sequence Detail	1304	Not Applicable
polypeptide	OTTMUSP00000017612	VEGA | MGI Sequence Detail	334	Not Applicable

All sequences(35) RefSeq(2) UniProt(3)

Polymorphisms

SNPs within 2kb(289 from dbSNP Build 137)

Protein-related information

Resource	ID	Description
InterPro	IPR015955	Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal
InterPro	IPR022383	Lactate/malate dehydrogenase, C-terminal
InterPro	IPR001236	Lactate/malate dehydrogenase, N-terminal
InterPro	IPR011304	L-lactate dehydrogenase
InterPro	IPR018177	L-lactate dehydrogenase, active site
InterPro	IPR001557	L-lactate/malate dehydrogenase
InterPro	IPR016040	NAD(P)-binding domain
Protein Ontology	PR:000009742	L-lactate dehydrogenase B chain

References

(Earliest) J:5101 Epstein CJ, Mammalian oocytes: X chromosome activity. Science. 1969 Mar 7;163(871):1078-9
(Latest) J:193996 Chauvin T, et al., A systematic analysis of a deep mouse epididymal sperm proteome. Biol Reprod. 2012;87(6):141
All references(54)

Other accession IDs

MGD-MRK-11766, MGD-MRK-11772, MGI:2141472