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Lcat Gene Detail
Summary
  • Symbol
    Lcat
  • Name
    lecithin cholesterol acyltransferase
  • Synonyms
    D8Wsu61e
  • Feature Type
    protein coding gene
  • IDs
    MGI:96755
    NCBI Gene: 16816
Location & Maps
more
  • Sequence Map
    Chr8:105939551-105943382 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      3832 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 8, 53.06 cM
  • Mapping Data
    18 experiments
Homology
more
  • Human Ortholog
    LCAT, lecithin-cholesterol acyltransferase
  • Vertebrate Orthologs
    9
  • Human Ortholog
    LCAT, lecithin-cholesterol acyltransferase
    Orthology source: HGNC, HomoloGene
  • Links
    NCBI Gene ID: 3931
    neXtProt AC: NX_P04180

  • Chr Location
    16q22.1; chr16:67939884-67944112 (-)  GRCh38.p2

Human Diseases
more
  • Diseases
    2 with Lcat mouse models; 2 with human LCAT associations

Human Disease Mouse Models
       Fish-Eye Disease; FED   OMIM: 136120 View 1 model
Lecithin:cholesterol Acyltransferase Deficiency   OMIM: 245900 View 2 models
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    28 phenotypes from 3 alleles in 6 genetic backgrounds
    31 phenotypes from multigenic genotypes
    3 images
    33 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    9
  • Targeted
    5
  • Transgenic
    4
Homozygotes display severe hypoalphalipoproteinemia, variable hypertriglyceridemia, and accumulation of heterogeneous pre-beta HDL, as well as an attenuated increase in apoB-containing lipoproteins in response to dietary cholesterol.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000031021 VEGA Gene Model | MGI Sequence Detail 3832 C57BL/6J ±  kb
transcript OTTMUST00000076850 VEGA | MGI Sequence Detail 1342 Not Applicable  
polypeptide OTTMUSP00000040518 VEGA | MGI Sequence Detail 438 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    48 from dbSNP Build 142
  • RFLP
Protein
Information
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  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000009698 phosphatidylcholine-sterol acyltransferase
  • EC
  • InterPro Domains
    IPR029058 Alpha/Beta hydrolase fold
    IPR003386 Lecithin:cholesterol/phospholipid:diacylglycerol acyltransferase
Molecular
Reagents
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  • All nucleic 97
    Genomic 3
    cDNA 88
    Primer pair 5
    Other 1

    Microarray probesets 4
Other
Accession IDs
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MGD-MRK-11757, MGD-MRK-34112, MGI:106418, MGI:2142459
References
more
  • Summaries
    All 83
    Developmental Gene Expression 7
    Diseases 1
    Gene Ontology 9
    Phenotypes 33
  • Earliest
    J:10041 Scherer G, et al., Gene mapping on mouse chromosome 8 by interspecific crosses: new data on a linkage group conserved on human chromosome 16q. Genomics. 1989 Aug;5(2):275-82
  • Latest
    J:231194 Petropoulou PI, et al., Lack of LCAT reduces the LPS-neutralizing capacity of HDL and enhances LPS-induced inflammation in mice. Biochim Biophys Acta. 2015 Oct;1852(10 Pt A):2106-15

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
07/12/2016
MGI 6.04
The Jackson Laboratory