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Lcat
Gene Detail
Symbol

Name
ID
Lcat
lecithin cholesterol acyltransferase
MGI:96755
Synonyms
D8Wsu61e
Feature Type
protein coding gene
Genetic Map
Chromosome 8
53.06 cM
Detailed Genetic Map ± 1 cM


Mapping data(18)
Sequence Map
Chr8:105939551-105943382 bp, - strand
From VEGA annotation of GRCm38

  3832 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:68042  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: phosphatidylcholine-sterol acyltransferase
Gene Tree: Lcat

Human
homologs
Human Homolog LCAT, lecithin-cholesterol acyltransferase
NCBI Gene ID 3931
neXtProt AC  NX_P04180
Human Chr (Location)  16q22.1; chr16:67939884-67944112 (-)  GRCh38
Disease Associations  (2) Diseases Associated with Human LCAT
Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Targeted(5)
 
Homozygotes display severe hypoalphalipoproteinemia, variable hypertriglyceridemia, and accumulation of heterogeneous pre-beta HDL, as well as an attenuated increase in apoB-containing lipoproteins in response to dietary cholesterol.
 
Human Diseases Modeled Using Mouse Lcat (2)    Alleles Annotated to Human Diseases(1)    Phenotype Images(3)
Interactions
Lcat interacts with 3 markers (Mir146, Mir421, Mir1188)
Gene Ontology
(GO)
classifications
All GO classifications: (32 annotations)
Process cholesterol esterification, cholesterol homeostasis, ...
Component extracellular region, extracellular space, ...
Function apolipoprotein A-I binding, O-acyltransferase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (6 records)
Data Summary: Results (150)    Tissues (109)    Images (34)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 126
RT-PCR 24
cDNA source data(87)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(96) Genomic(3) cDNA(88) Primer pair(4) Other(1)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000031021 (Evidence)
Ensembl Gene ModelENSMUSG00000035237 (Evidence)
Entrez Gene16816 (Evidence)
UniGene1593
DFCITC1577650
DoTSDT.493405, DT.55193528, DT.94219799, DT.94219802
NIA Mouse Gene IndexU030190
EC2.3.1.43
Consensus CDS ProjectCCDS22622.1
International Mouse Knockout Project StatusLcat
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000031021 VEGA Gene Model | MGI Sequence Detail 3832 C57BL/6J ±  kb
transcript OTTMUST00000076850 VEGA | MGI Sequence Detail 1342 Not Applicable 
polypeptide OTTMUSP00000040518 VEGA | MGI Sequence Detail 438 Not Applicable 

For the selected sequences
All sequences(26) RefSeq(2) UniProt(3)
Polymorphisms
RFLP(5) : SNPs within 2kb(51 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR003386 Lecithin:cholesterol/phospholipid:diacylglycerol acyltransferase
Protein Ontology PR:000009698 phosphatidylcholine-sterol acyltransferase
References
(Earliest) J:10041 Scherer G, et al., Gene mapping on mouse chromosome 8 by interspecific crosses: new data on a linkage group conserved on human chromosome 16q. Genomics. 1989 Aug;5(2):275-82
(Latest) J:210054 Dixon JL, et al., Loss of beta-carotene 15,15'-oxygenase in developing mouse tissues alters esterification of retinol, cholesterol and diacylglycerols. Biochim Biophys Acta. 2014 Jan;1841(1):34-43
All references(84)
Disease annotation references (1)
Other
accession IDs
MGD-MRK-11757, MGD-MRK-34112, MGI:106418, MGI:2142459

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/18/2014
MGI 5.20
The Jackson Laboratory