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Lcat
Gene Detail
Symbol

Name
ID
Lcat
lecithin cholesterol acyltransferase
MGI:96755
Synonyms
D8Wsu61e
Feature Type
protein coding gene
Genetic Map
Chromosome 8
53.06 cM
Detailed Genetic Map ± 1 cM


Mapping data(18)
Sequence Map
Chr8:105939551-105943382 bp, - strand
From VEGA annotation of GRCm38

  3832 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:68042  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: LCAT
Protein SuperFamily: phosphatidylcholine-sterol acyltransferase
Gene Tree: Lcat

Human
homologs
LCAT, lecithin-cholesterol acyltransferase
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 3931
neXtProt AC: NX_P04180

Human Chr (Location): 16q22.1; chr16:67939884-67944112 (-)  GRCh38.p2

Disease Associations: (2) Diseases Associated with Human LCAT

Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Targeted(5) Transgenic(1)
 
Homozygotes display severe hypoalphalipoproteinemia, variable hypertriglyceridemia, and accumulation of heterogeneous pre-beta HDL, as well as an attenuated increase in apoB-containing lipoproteins in response to dietary cholesterol.
 
Human Diseases Modeled in Mice Using Lcat (2)    Mutations Annotated to Human Diseases (1)    Phenotype Images(3)
Interactions
Lcat interacts with 3 markers (Mir146, Mir421, Mir1188)
Gene Ontology
(GO)
classifications
All GO classifications: (32 annotations)
Process cholesterol esterification, cholesterol homeostasis, ...
Component extracellular exosome, extracellular region, ...
Function apolipoprotein A-I binding, O-acyltransferase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (6 records)
Data Summary: Results (150)    Tissues (109)    Images (34)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 126
RT-PCR 24
cDNA source data(87)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase lcat    NEW 
Molecular
reagents
All nucleic(96) Genomic(3) cDNA(88) Primer pair(4) Other(1)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000031021 (Evidence)
Ensembl Gene Model ENSMUSG00000035237 (Evidence)
Entrez Gene 16816 (Evidence)
UniGene 1593
DFCI TC1577650
DoTS DT.493405, DT.55193528, DT.94219799, DT.94219802
NIA Mouse Gene Index U030190
EC 2.3.1.43
Consensus CDS Project CCDS22622.1
International Mouse Phenotyping Consortium Status Lcat
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000031021 VEGA Gene Model | MGI Sequence Detail 3832 C57BL/6J ±  kb
transcript OTTMUST00000076850 VEGA | MGI Sequence Detail 1342 Not Applicable 
polypeptide OTTMUSP00000040518 VEGA | MGI Sequence Detail 438 Not Applicable 

For the selected sequences
All sequences(25) RefSeq(2) UniProt(2)
Polymorphisms
RFLP(5) : SNPs within 2kb(51 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR003386 Lecithin:cholesterol/phospholipid:diacylglycerol acyltransferase
Protein Ontology PR:000009698 phosphatidylcholine-sterol acyltransferase
References
(Earliest) J:10041 Scherer G, et al., Gene mapping on mouse chromosome 8 by interspecific crosses: new data on a linkage group conserved on human chromosome 16q. Genomics. 1989 Aug;5(2):275-82
(Latest) J:210054 Dixon JL, et al., Loss of beta-carotene 15,15'-oxygenase in developing mouse tissues alters esterification of retinol, cholesterol and diacylglycerols. Biochim Biophys Acta. 2014 Jan;1841(1):34-43
All references(83)
Disease annotation references (1)
Other
accession IDs
MGD-MRK-11757, MGD-MRK-34112, MGI:106418, MGI:2142459

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory