Lcat
Gene Detail

Symbol Name ID

Lcat lecithin cholesterol acyltransferase MGI:96755

Synonyms

D8Wsu61e

Feature Type

protein coding gene

Genetic Map

Chromosome 8

53.06 cM
Detailed Genetic Map ± 1 cM


Mapping data(18)

Sequence Map

Chr8:105939551-105943382 bp, - strand From VEGA annotation of GRCm38   3832 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:68042  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: phosphatidylcholine-sterol acyltransferase
Gene Tree: Lcat

Human homologs

Human Homolog		LCAT, lecithin-cholesterol acyltransferase
NCBI Gene ID		3931
neXtProt AC		NX_P04180
Human Chr (Location)		16q22.1; chr16:67973787-67978015 (-)  GRCh37.p10
Disease Associations		(2) Diseases Associated with Human LCAT

Alleles and phenotypes

All alleles(3) : Targeted(3)
 

Homozygotes display severe hypoalphalipoproteinemia, variable hypertriglyceridemia, and accumulation of heterogeneous pre-beta HDL, as well as an attenuated increase in apoB-containing lipoproteins in response to dietary cholesterol.

 
Human Diseases Modeled Using Mouse Lcat (2)    Alleles Annotated to Human Diseases(1)    Phenotype Images(3)

Gene Ontology (GO) classifications

All GO classifications: (31 annotations)

Process	cholesterol esterification, cholesterol homeostasis, ...
Component	extracellular region, extracellular space, ...
Function	apolipoprotein A-I binding, O-acyltransferase activity, ...

External Resources: FuncBase

Expression

Literature Summary: (5 records)
Data Summary: Results (150)    Tissues (108)    Images (34)
Theiler Stages: 11, 22, 23, 28

Assay Type	Results
RNA in situ	126
RT-PCR	24

cDNA source data(87)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(96) Genomic(3) cDNA(88) Primer pair(4) Other(1)
Microarray probesets(4)

Other database links

VEGA Gene Model	OTTMUSG00000031021 (Evidence)
Ensembl Gene Model	ENSMUSG00000035237 (Evidence)
Entrez Gene	16816 (Evidence)
UniGene	1593
DFCI	TC1577650
DoTS	DT.493405, DT.55193528, DT.94219799, DT.94219802
NIA Mouse Gene Index	U030190
EC	2.3.1.43
Consensus CDS Project	CCDS22622.1
International Mouse Knockout Project Status	Lcat

Sequences

Length	Strain/Species
genomic	OTTMUSG00000031021	VEGA Gene Model | MGI Sequence Detail	3832	C57BL/6J
transcript	OTTMUST00000076850	VEGA | MGI Sequence Detail	1342	Not Applicable
polypeptide	OTTMUSP00000040518	VEGA | MGI Sequence Detail	438	Not Applicable

All sequences(25) RefSeq(2) UniProt(2)

Polymorphisms

RFLP(5) : SNPs(29 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR003386	Lecithin:cholesterol/phospholipid:diacylglycerol acyltransferase
Protein Ontology	PR:000009698	phosphatidylcholine-sterol acyltransferase

References

(Earliest) J:10041 Scherer G, et al., Gene mapping on mouse chromosome 8 by interspecific crosses: new data on a linkage group conserved on human chromosome 16q. Genomics. 1989 Aug;5(2):275-82
(Latest) J:192808 Hoekstra M, et al., LCAT deficiency in mice is associated with a diminished adrenal glucocorticoid function. J Lipid Res. 2013 Feb;54(2):358-64
All references(82)

Other accession IDs

MGD-MRK-11757, MGD-MRK-34112, MGI:106418, MGI:2142459