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Krt8
Gene Detail
Symbol

Name
ID
Krt8
keratin 8
MGI:96705
Synonyms
Card2, cytokeratin8, cytokeratin 8, cytokeratin-8, EndoA, K8, Krt-2.8, Krt2-8
Feature Type
protein coding gene
Genetic Map
Chromosome 15
57.20 cM
Detailed Genetic Map ± 1 cM


Mapping data(10)
Sequence Map
Chr15:101996711-102004342 bp, - strand
From NCBI annotation of GRCm38

  7632 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:55643  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog; 3 zebrafish

Gene Tree: Krt8

Human
homologs
Human Homolog KRT8, keratin 8
NCBI Gene ID 3856
neXtProt AC  NX_P05787
Human Synonyms  CARD2, CK8, CK-8, CYK8, K2C8, K8, KO
Human Chr (Location)  12q13; chr12:52897187-52949866 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(8) : Radiation induced(1) Targeted(7)
Genomic Mutations involving Krt8 (2)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a null allele show partial background-sensitive embryonic lethality, placental defects, impaired female fertility, abnormal hematopoiesis, diarrhea, colorectal hyperplasia, anorectal prolapse, and high liver sensitivity to toxins, apoptotic stimuli and diet-induced steatosis.
 
Interactions
Krt8 interacts with 30 markers (Mir1a-1, Mir1a-2, Mir28b, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (160 records)
Data Summary: Results (472)    Tissues (123)    Images (115)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 95
RNA in situ 360
Northern blot 5
Western blot 1
RT-PCR 11
cDNA source data(358)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(370) Genomic(6) cDNA(360) Primer pair(4)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000049382 (Evidence)
Entrez Gene16691 (Evidence)
UniGene358618
DFCITC1573848, TC1595408
DoTSDT.101229431, DT.101309721, DT.101309742, DT.101720151, DT.110836278, DT.91324866, DT.94173904, DT.94320828
NIA Mouse Gene IndexU036682, U111517
Consensus CDS ProjectCCDS27868.1
International Mouse Knockout Project StatusKrt8
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 16691 NCBI Gene Model | MGI Sequence Detail 7632 C57BL/6J ±  kb
transcript NM_031170 RefSeq | MGI Sequence Detail 1805 C57BL/6 
polypeptide P11679 UniProt | EBI | MGI Sequence Detail 490 Not Applicable 

For the selected sequences
All sequences(53) RefSeq(2) UniProt(1)
Polymorphisms
All PCR and RFLP(3) : PCR(1) RFLP(2) SNPs within 2kb(118 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001664 Intermediate filament protein
InterPro IPR018039 Intermediate filament protein, conserved site
InterPro IPR003054 Type II keratin
Protein Ontology PR:000009495 keratin, type II cytoskeletal 8
Graphical View of Protein Domain Structure
References
(Earliest) J:152889 Aufderheide E, et al., Epithelial-mesenchymal interactions in the developing kidney lead to expression of tenascin in the mesenchyme. J Cell Biol. 1987 Jul;105(1):599-608
(Latest) J:211179 Urbach A, et al., Lin28 sustains early renal progenitors and induces Wilms tumor. Genes Dev. 2014 May 1;28(9):971-82
All references(237)
Other
accession IDs
MGD-MRK-11638, MGD-MRK-11660, MGI:2145935, MGI:2146105, MGI:2146133

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/18/2014
MGI 5.20
The Jackson Laboratory