Krt8
Gene Detail

Symbol Name ID

Krt8 keratin 8 MGI:96705

Synonyms

Card2, cytokeratin8, cytokeratin 8, cytokeratin-8, EndoA, K8, Krt-2.8, Krt2-8

Feature Type

protein coding gene

Genetic Map

Chromosome 15

57.20 cM
Detailed Genetic Map ± 1 cM


Mapping data(10)

Sequence Map

Chr15:101996711-102004342 bp, - strand From NCBI annotation of GRCm38   7632 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:55643  Vertebrate Homology Class
1 human; 1 mouse; 2 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog

Gene Tree: Krt8

Human homologs

Human Homolog		KRT8, keratin 8
NCBI Gene ID		3856
neXtProt AC		NX_P05787
Human Synonyms		CARD2, CK8, CK-8, CYK8, K2C8, K8, KO
Human Chr (Location)		12q13; chr12:53290971-53343650 (-)  GRCh37.p10

Alleles and phenotypes

All alleles(6) : Targeted(6)
 

Mice homozygous for a null allele show partial background-sensitive embryonic lethality, placental defects, impaired female fertility, abnormal hematopoiesis, diarrhea, colorectal hyperplasia, anorectal prolapse, and high liver sensitivity to toxins, apoptotic stimuli and diet-induced steatosis.

 

Gene Ontology (GO) classifications

All GO classifications: (25 annotations)

Process	cell differentiation involved in embryonic placenta development, cell morphogenesis involved in differentiation, ...
Component	cell periphery, costamere, ...
Function	protein binding, protein complex binding, ...

External Resources: FuncBase

Expression

Literature Summary: (141 records)
Data Summary: Results (395)    Tissues (73)    Images (67)
Theiler Stages: 2, 3, 4, 5, 8, 9, 11, 13, 15, 20, 21, 22, 23, 24, 25, 26, 28

Assay Type	Results
Immunohistochemistry	56
RNA in situ	312
Northern blot	5
Western blot	1
RT-PCR	21

cDNA source data(354)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(366) Genomic(6) cDNA(356) Primer pair(4)
Microarray probesets(3)

Other database links

Ensembl Gene Model	ENSMUSG00000049382 (Evidence)
Entrez Gene	16691 (Evidence)
UniGene	358618
DFCI	TC1573848, TC1595408
DoTS	DT.101229431, DT.101309721, DT.101309742, DT.101720151, DT.110836278, DT.91324866, DT.94173904, DT.94320828
NIA Mouse Gene Index	U036682, U111517
Consensus CDS Project	CCDS27868.1
International Mouse Knockout Project Status	Krt8

Sequences

Length	Strain/Species
genomic	16691	NCBI Gene Model | MGI Sequence Detail	7632	C57BL/6J
transcript	NM_031170	RefSeq | MGI Sequence Detail	1805	C57BL/6
polypeptide	P11679	UniProt | EBI | MGI Sequence Detail	490	Not Applicable

All sequences(53) RefSeq(2) UniProt(1)

Polymorphisms

All PCR and RFLP(3) : PCR(1) RFLP(2) SNPs(107 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR016044	Filament
InterPro	IPR001664	Intermediate filament protein
InterPro	IPR018039	Intermediate filament protein, conserved site
InterPro	IPR009053	Prefoldin
InterPro	IPR003054	Type II keratin
Protein Ontology	PR:000009495	keratin, type II cytoskeletal 8

Graphical View of Protein Domain Structure

References

(Earliest) J:152889 Aufderheide E, et al., Epithelial-mesenchymal interactions in the developing kidney lead to expression of tenascin in the mesenchyme. J Cell Biol. 1987 Jul;105(1):599-608
(Latest) J:194339 Li Y, et al., Mesothelial cells give rise to hepatic stellate cells and myofibroblasts via mesothelial-mesenchymal transition in liver injury. Proc Natl Acad Sci U S A. 2013 Feb 5;110(6):2324-9
All references(214)

Other accession IDs

MGD-MRK-11638, MGD-MRK-11660, MGI:2145935, MGI:2146105, MGI:2146133