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Krt8
Gene Detail
Symbol

Name
ID
Krt8
keratin 8
MGI:96705
Synonyms
Card2, cytokeratin8, cytokeratin 8, cytokeratin-8, EndoA, K8, Krt-2.8, Krt2-8
Feature Type
protein coding gene
Genetic Map
Chromosome 15
57.20 cM
Detailed Genetic Map ± 1 cM


Mapping data(10)
Sequence Map
Chr15:101996711-102004342 bp, - strand
From NCBI annotation of GRCm38

  7632 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:55643  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog; 3 zebrafish

HCOP human homology predictions: KRT8
Gene Tree: Krt8

Human
homologs
KRT8, keratin 8, type II
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 3856
neXtProt AC: NX_P05787

Human Synonyms: CARD2, CK8, CK-8, CYK8, K2C8, K8, KO

Human Chr (Location): 12q13; chr12:52897187-52949866 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(9) : Radiation induced(1) Targeted(8)
Genomic Mutations involving Krt8 (2)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a null allele show partial background-sensitive embryonic lethality, placental defects, impaired female fertility, abnormal hematopoiesis, diarrhea, colorectal hyperplasia, anorectal prolapse, and high liver sensitivity to toxins, apoptotic stimuli and diet-induced steatosis.
 
Phenotype Images(2)
Interactions
Krt8 interacts with 29 markers (Mir1a-1, Mir1a-2, Mir28b, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (174 records)
Data Summary: Results (472)    Tissues (124)    Images (116)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 97
RNA in situ 358
Northern blot 5
Western blot 1
RT-PCR 11
cDNA source data(358)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: GEISHA KRT8 ; Xenbase krt8, krt8.2 ; ZFIN krt8    NEW 
Molecular
reagents
All nucleic(370) Genomic(6) cDNA(360) Primer pair(4)
Microarray probesets(3)
Other database
links
Ensembl Gene Model ENSMUSG00000049382 (Evidence)
Entrez Gene 16691 (Evidence)
UniGene 358618
DFCI TC1573848, TC1595408
DoTS DT.101229431, DT.101309721, DT.101309742, DT.101720151, DT.110836278, DT.91324866, DT.94173904, DT.94320828
NIA Mouse Gene Index U036682, U111517
Consensus CDS Project CCDS27868.1
International Mouse Phenotyping Consortium Status Krt8
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 16691 NCBI Gene Model | MGI Sequence Detail 7632 C57BL/6J ±  kb
transcript NM_031170 RefSeq | MGI Sequence Detail 1805 C57BL/6 
polypeptide P11679 UniProt | EBI | MGI Sequence Detail 490 Not Applicable 

For the selected sequences
All sequences(53) RefSeq(2) UniProt(1)
Polymorphisms
All PCR and RFLP(3) : PCR(1) RFLP(2) SNPs within 2kb(118 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001664 Intermediate filament protein
InterPro IPR018039 Intermediate filament protein, conserved site
InterPro IPR003054 Type II keratin
Protein Ontology PR:000009495 keratin, type II cytoskeletal 8
Graphical View of Protein Domain Structure
References
(Earliest) J:152889 Aufderheide E, et al., Epithelial-mesenchymal interactions in the developing kidney lead to expression of tenascin in the mesenchyme. J Cell Biol. 1987 Jul;105(1):599-608
(Latest) J:219800 Lungova V, et al., Ontogeny of the mouse vocal fold epithelium. Dev Biol. 2015 Mar 15;399(2):263-82
All references(248)
Other
accession IDs
MGD-MRK-11638, MGD-MRK-11660, MGI:2145935, MGI:2146105, MGI:2146133

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory