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Krt5
Gene Detail
Symbol

Name
ID
Krt5
keratin 5
MGI:96702
Synonyms
3300001P10Rik, K5, Krt2-5, Tfip8
Feature Type
protein coding gene
Genetic Map
Chromosome 15
56.98 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr15:101707070-101712891 bp, - strand
From VEGA annotation of GRCm38

  5822 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:55461  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog

HCOP human homology predictions: KRT5
Gene Tree: Krt5

Human
homologs
KRT5, keratin 5, type II
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 3852
neXtProt AC: NX_P13647

Human Synonyms: CK5, DDD, DDD1, EBS2, K5, KRT5A

Human Chr (Location): 12q13.13; chr12:52514575-52520459 (-)  GRCh38.p2

Disease Associations: (7) Diseases Associated with Human KRT5

Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Radiation induced(1) Targeted(5)
Genomic Mutations involving Krt5 (2)
Incidental mutations (data from APF , CvDC )
 
Mice homozygous for disruptions in this gene die within the first hour after birth. They have a loose, fragile epidermal layer and abnormal epithelium in parts of the digestive tract.
 
Human Diseases Modeled in Mice Using Krt5 (1)    Mutations Annotated to Human Diseases (1)    Phenotype Images(2)
Interactions
Krt5 interacts with 62 markers (Mir92-1, Mir92-2, Mir103-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (14 annotations)
Component cytoplasm, extracellular exosome, ...
Function protein binding, scaffold protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (156 records)
Data Summary: Results (234)    Tissues (75)    Images (83)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 45
RNA in situ 186
RT-PCR 3
cDNA source data(99)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: GEISHA KRT5 ; Xenbase krt1, krt5.2, krt5.7, krt6, LOC100489468 ; ZFIN krt5    NEW 
Molecular
reagents
All nucleic(106) Genomic(5) cDNA(100) Primer pair(1)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000028033 (Evidence)
Ensembl Gene Model ENSMUSG00000061527 (Evidence)
Entrez Gene 110308 (Evidence)
UniGene 451847
DFCI TC1575544
DoTS DT.101129488, DT.496865, DT.94367440
NIA Mouse Gene Index U202176
Consensus CDS Project CCDS27861.1
International Mouse Phenotyping Consortium Status Krt5
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000028033 VEGA Gene Model | MGI Sequence Detail 5822 C57BL/6J ±  kb
transcript OTTMUST00000069431 VEGA | MGI Sequence Detail 2190 Not Applicable 
polypeptide OTTMUSP00000035258 VEGA | MGI Sequence Detail 580 Not Applicable 

For the selected sequences
All sequences(23) RefSeq(2) UniProt(3)
Polymorphisms
SNPs within 2kb(34 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001664 Intermediate filament protein
InterPro IPR018039 Intermediate filament protein, conserved site
InterPro IPR003054 Type II keratin
Protein Ontology PR:000009481 keratin, type II cytoskeletal 5
References
(Earliest) J:42282 Stoler A, et al., Use of monospecific antisera and cRNA probes to localize the major changes in keratin expression during normal and abnormal epidermal differentiation. J Cell Biol. 1988 Aug;107(2):427-46
(Latest) J:220467 Galvis LA, et al., Repression of Igf1 expression by Ezh2 prevents basal cell differentiation in the developing lung. Development. 2015 Apr 15;142(8):1458-69
All references(204)
Disease annotation references (1)
Other
accession IDs
MGD-MRK-11657, MGI:1890361, MGI:1916515, MGI:2146203

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/30/2015
MGI 5.22
The Jackson Laboratory