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Krt5
Gene Detail
 Symbol
Name
ID
Krt5
keratin 5
MGI:96702
Synonyms 3300001P10Rik, K5, Krt2-5, Tfip8
Feature Type protein coding gene
Genetic Map
Chromosome 15
56.98 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr15:101707070-101712891 bp, - strand
From VEGA annotation of GRCm38

  5822 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:55461  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 dog; 1 chicken; 1 western clawed frog

Gene Tree: Krt5

Human
homologs
Human Homolog KRT5, keratin 5
NCBI Gene ID 3852
neXtProt AC  NX_P13647
Human Synonyms  CK5, DDD, DDD1, EBS2, K5, KRT5A
Human Chr (Location)  12q13.13; chr12:52514575-52520459 (-)  GRCh38
Disease Associations  (7) Diseases Associated with Human KRT5
Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Radiation induced(1) Targeted(5)
Genomic Mutations involving Krt5 (2)
Incidental mutations (data from APF )
 
Mice homozygous for disruptions in this gene die within the first hour after birth. They have a loose, fragile epidermal layer and abnormal epithelium in parts of the digestive tract.
 
Human Diseases Modeled Using Mouse Krt5 (1)    Alleles Annotated to Human Diseases(1)   
Interactions
Krt5 interacts with 62 markers (Mir92-1, Mir92-2, Mir103-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (14 annotations)
Component cytoplasm, extracellular vesicular exosome, ...
Function protein binding, scaffold protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (133 records)
Data Summary: Results (227)    Tissues (71)    Images (76)
Theiler Stages: 15, 17, 19, 20, 21, 22, 23, 25, 26, 28
Assay TypeResults
Immunohistochemistry 38
RNA in situ 186
RT-PCR 3
cDNA source data(99)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(106) Genomic(5) cDNA(100) Primer pair(1)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000028033 (Evidence)
Ensembl Gene ModelENSMUSG00000061527 (Evidence)
Entrez Gene110308 (Evidence)
UniGene451847
DFCITC1575544
DoTSDT.101129488, DT.496865, DT.94367440
NIA Mouse Gene IndexU202176
Consensus CDS ProjectCCDS27861.1
International Mouse Knockout Project StatusKrt5
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000028033 VEGA Gene Model | MGI Sequence Detail 5822 C57BL/6J ±  kb
transcript OTTMUST00000069431 VEGA | MGI Sequence Detail 2190 Not Applicable 
polypeptide OTTMUSP00000035258 VEGA | MGI Sequence Detail 580 Not Applicable 

For the selected sequences
All sequences(23) RefSeq(2) UniProt(3)
Polymorphisms SNPs within 2kb(34 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001664 Intermediate filament protein
InterPro IPR018039 Intermediate filament protein, conserved site
InterPro IPR003054 Type II keratin
Protein Ontology PR:000009481 keratin, type II cytoskeletal 5
References (Earliest) J:42282 Stoler A, et al., Use of monospecific antisera and cRNA probes to localize the major changes in keratin expression during normal and abnormal epidermal differentiation. J Cell Biol. 1988 Aug;107(2):427-46
(Latest) J:210599 Xu C, et al., Loss of Lkb1 and Pten leads to lung squamous cell carcinoma with elevated PD-L1 expression. Cancer Cell. 2014 May 12;25(5):590-604
All references(179)
Disease annotation references (1)
Other
accession IDs
MGD-MRK-11657, MGI:1890361, MGI:1916515, MGI:2146203

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory