Krt5
Gene Detail

Symbol Name ID

Krt5 keratin 5 MGI:96702

Synonyms

3300001P10Rik, K5, Krt2-5, Tfip8

Feature Type

protein coding gene

Genetic Map

Chromosome 15

56.98 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr15:101707070-101712891 bp, - strand From VEGA annotation of GRCm38   5822 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:55461  Vertebrate Homology Class
1 human; 1 mouse; 1 rhesus macaque; 1 dog; 1 chicken

Gene Tree: Krt5

Human homologs

Human Homolog		KRT5, keratin 5
NCBI Gene ID		3852
neXtProt AC		NX_P13647
Human Synonyms		CK5, DDD, EBS2, K5, KRT5A
Human Chr (Location)		12q13.13; chr12:52908359-52914243 (-)  GRCh37.p10
Disease Associations		(6) Diseases Associated with Human KRT5

Alleles and phenotypes

All alleles(4) : Targeted(4)
 

Mice homozygous for disruptions in this gene die within the first hour after birth. They have a loose, fragile epidermal layer and abnormal epithelium in parts of the digestive tract.

 
Human Diseases Modeled Using Mouse Krt5 (1)    Alleles Annotated to Human Diseases(1)   

Gene Ontology (GO) classifications

All GO classifications: (10 annotations)

Component	cytoplasm, intermediate filament, ...
Function	protein binding, scaffold protein binding, ...

External Resources: FuncBase

Expression

Literature Summary: (111 records)
Data Summary: Results (213)    Tissues (59)    Images (71)
Theiler Stages: 15, 17, 19, 20, 21, 22, 23, 25, 26, 28

Assay Type	Results
Immunohistochemistry	38
RNA in situ	172
RT-PCR	3

cDNA source data(101)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(108) Genomic(5) cDNA(102) Primer pair(1)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000028033 (Evidence)
Ensembl Gene Model	ENSMUSG00000061527 (Evidence)
Entrez Gene	110308 (Evidence)
UniGene	451847
DFCI	TC1575544
DoTS	DT.101129488, DT.496865, DT.94367440
NIA Mouse Gene Index	U202176
Consensus CDS Project	CCDS27861.1
International Mouse Knockout Project Status	Krt5

Sequences

Length	Strain/Species
genomic	OTTMUSG00000028033	VEGA Gene Model | MGI Sequence Detail	5822	C57BL/6J
transcript	OTTMUST00000069431	VEGA | MGI Sequence Detail	2190	Not Applicable
polypeptide	OTTMUSP00000035258	VEGA | MGI Sequence Detail	580	Not Applicable

All sequences(23) RefSeq(2) UniProt(3)

Polymorphisms

SNPs(23 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR016044	Filament
InterPro	IPR001664	Intermediate filament protein
InterPro	IPR018039	Intermediate filament protein, conserved site
InterPro	IPR003054	Type II keratin
Protein Ontology	PR:000009481	keratin, type II cytoskeletal 5

References

(Earliest) J:42282 Stoler A, et al., Use of monospecific antisera and cRNA probes to localize the major changes in keratin expression during normal and abnormal epidermal differentiation. J Cell Biol. 1988 Aug;107(2):427-46
(Latest) J:194534 Chang CY, et al., NFIB is a governor of epithelial-melanocyte stem cell behaviour in a shared niche. Nature. 2013 Mar 7;495(7439):98-102
All references(153)

Other accession IDs

MGD-MRK-11657, MGI:1890361, MGI:1916515, MGI:2146203