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Krt5 Gene Detail
Summary
  • Symbol
    Krt5
  • Name
    keratin 5
  • Synonyms
    3300001P10Rik, K5, Krt2-5, Tfip8
  • Feature Type
    protein coding gene
  • IDs
    MGI:96702
    NCBI Gene: 110308
  • Gene Overview
    MyGene.info: KRT5
  • Alliance
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr15:101707070-101712891 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 15, 56.98 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    34 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_96702
protein coding gene Chr15:101707070-101712898 (-)
129S1/SvImJ MGP_129S1SvImJ_G0022383
protein coding gene Chr15:103831135-103839234 (-)
A/J MGP_AJ_G0022346
protein coding gene Chr15:99734065-99739834 (-)
AKR/J MGP_AKRJ_G0022321
protein coding gene Chr15:102765962-102771764 (-)
BALB/cJ MGP_BALBcJ_G0022349
protein coding gene Chr15:99806374-99813902 (-)
C3H/HeJ MGP_C3HHeJ_G0022116
protein coding gene Chr15:102841620-102848539 (-)
C57BL/6NJ MGP_C57BL6NJ_G0022798
protein coding gene Chr15:107689343-107695197 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0020321
protein coding gene Chr15:95546769-95552358 (-)
CAST/EiJ MGP_CASTEiJ_G0021642
protein coding gene Chr15:103686037-103694077 (-)
CBA/J MGP_CBAJ_G0022085
protein coding gene Chr15:111446542-111452861 (-)
DBA/2J MGP_DBA2J_G0022216
protein coding gene Chr15:99047063-99053964 (-)
FVB/NJ MGP_FVBNJ_G0022192
protein coding gene Chr15:98099631-98107693 (-)
LP/J MGP_LPJ_G0022285
protein coding gene Chr15:103987106-103994007 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0022214
protein coding gene Chr15:115080921-115086649 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0022810
protein coding gene Chr15:102785230-102791072 (-)
PWK/PhJ MGP_PWKPhJ_G0021382
protein coding gene Chr15:99191159-99197216 (-)
SPRET/EiJ MGP_SPRETEiJ_G0021214
protein coding gene Chr15:102640075-102645875 (-)
WSB/EiJ MGP_WSBEiJ_G0021692
protein coding gene Chr15:103424264-103430860 (-)



Homology
more
  • Human Ortholog
    KRT5, keratin 5
  • Vertebrate Orthologs
    8
  • Human Ortholog
    KRT5, keratin 5
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CK5, DDD, DDD1, EBS2, K5, KRT5A
  • Links
    NCBI Gene ID: 3852
    neXtProt AC: NX_P13647
    UniProt: P13647

  • Chr Location
    12q13.13; chr12:52514575-52520459 (-)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with Krt5 mouse models; 3 with human KRT5 associations

Human Disease Mouse Models
      
IDs
View 1 model
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    10 phenotypes from 2 alleles in 2 genetic backgrounds
    46 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions in this gene die within the first hour after birth. They have a loose, fragile epidermal layer and abnormal epithelium in parts of the digestive tract.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 110308 NCBI Gene Model | MGI Sequence Detail 5822 C57BL/6J ±  kb
    transcript NM_027011 RefSeq | MGI Sequence Detail 2205 C57BL/6  
    polypeptide Q922U2 UniProt | EBI | MGI Sequence Detail 580 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 107
      Genomic 5
      cDNA 101
      Primer pair 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-11657, MGI:1890361, MGI:1916515, MGI:2146203
    References
    more
    • Summaries
      All 310
      Developmental Gene Expression 223
      Diseases 2
      Gene Ontology 9
      Phenotypes 46
    • Earliest
      J:7688 Lane PW, et al., Association of megacolon with a new dominant spotting gene (Dom) in the mouse. J Hered. 1984 Nov-Dec;75(6):435-9
    • Latest
      J:266265 Kishimoto K, et al., Synchronized mesenchymal cell polarization and differentiation shape the formation of the murine trachea and esophagus. Nat Commun. 2018 Jul 19;9(1):2816

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    11/13/2018
    MGI 6.13
    The Jackson Laboratory