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Krt5 Gene Detail
Summary
  • Symbol
    Krt5
  • Name
    keratin 5
  • Synonyms
    3300001P10Rik, K5, Krt2-5, Tfip8
  • Feature Type
    protein coding gene
  • IDs
    MGI:96702
    NCBI Gene: 110308
  • Gene Overview
    MyGene.info: KRT5
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr15:101707070-101712891 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      5822 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 15, 56.98 cM
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    KRT5, keratin 5
  • Vertebrate Orthologs
    8
  • Human Ortholog
    KRT5, keratin 5
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CK5, DDD, DDD1, EBS2, K5, KRT5A
  • Links
    NCBI Gene ID: 3852
    neXtProt AC: NX_P13647
    UniProt: P13647

  • Chr Location
    12q13.13; chr12:52514575-52520459 (-)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with Krt5 mouse models; 3 with human KRT5 associations

Human Disease Mouse Models
      
IDs
View 1 model
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    10 phenotypes from 2 alleles in 2 genetic backgrounds
    46 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions in this gene die within the first hour after birth. They have a loose, fragile epidermal layer and abnormal epithelium in parts of the digestive tract.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
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    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000028033 VEGA Gene Model | MGI Sequence Detail 5822 C57BL/6J ±  kb
    transcript OTTMUST00000069431 VEGA | MGI Sequence Detail 2190 Not Applicable  
    polypeptide OTTMUSP00000035258 VEGA | MGI Sequence Detail 580 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      34 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 107
      Genomic 5
      cDNA 101
      Primer pair 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-11657, MGI:1890361, MGI:1916515, MGI:2146203
    References
    more
    • Summaries
      All 307
      Developmental Gene Expression 219
      Diseases 2
      Gene Ontology 9
      Phenotypes 46
    • Earliest
      J:7688 Lane PW, et al., Association of megacolon with a new dominant spotting gene (Dom) in the mouse. J Hered. 1984 Nov-Dec;75(6):435-9
    • Latest
      J:263185 Huang M, et al., Multiple roles of epithelial heparan sulfate in stomach morphogenesis. J Cell Sci. 2018 May 29;131(10)

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    07/31/2018
    MGI 6.12
    The Jackson Laboratory