Automated description from the Alliance of Genome Resources (Release 7.0.0)
Predicted to enable scaffold protein binding activity. Predicted to be a structural constituent of skin epidermis. Involved in several processes, including intermediate filament polymerization; regulation of cell migration; and response to mechanical stimulus. Located in cytoplasm; keratin filament; and plasma membrane. Is active in cornified envelope. Is expressed in several structures, including alimentary system; epithelium; genitourinary system; integumental system; and sensory organ. Used to study epidermolysis bullosa simplex Dowling-Meara type. Human ortholog(s) of this gene implicated in Dowling-Degos disease; epidermolysis bullosa simplex; and epidermolysis bullosa simplex with mottled pigmentation. Orthologous to human KRT5 (keratin 5).