Krt17
Gene Detail

Symbol Name ID

Krt17 keratin 17 MGI:96691

Synonyms

K17, Krt1-17

Feature Type

protein coding gene

Genetic Map

Chromosome 11

63.44 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)

Sequence Map

Chr11:100256217-100261029 bp, - strand From VEGA annotation of GRCm38   4813 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:363  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 10 zebrafish

Gene Tree: Krt17

Human homologs

Human Homolog		KRT17, keratin 17
NCBI Gene ID		3872
neXtProt AC		NX_Q04695
Human Synonyms		K17, PC, PC2, PCHC1
Human Chr (Location)		17q21.2; chr17:39775692-39780882 (-)  GRCh37.p10
Disease Associations		(2) Diseases Associated with Human KRT17

Alleles and phenotypes

All alleles(13) : Targeted(6) Gene trapped(7)
 

Mice homozygous for a knock-out allele display age- and strain-dependent alopecia associated with frequent absence of vibrissae, increased hair fragility, abnormal hair cycling, altered hair follicle morphology, and apoptosis in matrix cells.

 
Alleles Annotated to Human Diseases(1)   

Gene Ontology (GO) classifications

All GO classifications: (16 annotations)

Process	intermediate filament organization, keratinization, ...
Component	cell periphery, cytoplasm, ...
Function	MHC class II protein binding, MHC class II receptor activity, ...

External Resources: FuncBase

Expression

Literature Summary: (36 records)
Data Summary: Results (6)    Tissues (3)    Images (2)
Theiler Stages: 20, 28

Assay Type	Results
RNA in situ	1
RT-PCR	5

cDNA source data(86)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(94) Genomic(5) cDNA(86) Primer pair(3)
Microarray probesets(4)

Other database links

VEGA Gene Model	OTTMUSG00000002546 (Evidence)
Ensembl Gene Model	ENSMUSG00000035557 (Evidence)
Entrez Gene	16667 (Evidence)
UniGene	14046
DFCI	TC1579293
DoTS	DT.60141887
NIA Mouse Gene Index	U116795
Consensus CDS Project	CCDS25415.1
International Mouse Knockout Project Status	Krt17

Sequences

Length	Strain/Species
genomic	OTTMUSG00000002546	VEGA Gene Model | MGI Sequence Detail	4813	C57BL/6J
transcript	OTTMUST00000004974	VEGA | MGI Sequence Detail	1551	Not Applicable
polypeptide	OTTMUSP00000002397	VEGA | MGI Sequence Detail	433	Not Applicable

All sequences(19) RefSeq(2) UniProt(1)

Polymorphisms

PCR(1) : SNPs(44 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR016044	Filament
InterPro	IPR001664	Intermediate filament protein
InterPro	IPR018039	Intermediate filament protein, conserved site
InterPro	IPR002957	Keratin, type I
InterPro	IPR009053	Prefoldin
Protein Ontology	PR:000009457	keratin, type I cytoskeletal 17

References

(Earliest) J:16017 Steinert PM, et al., Complete amino acid sequence of a mouse epidermal keratin subunit and implications for the structure of intermediate filaments. Nature. 1983 Apr 28;302(5911):794-800
(Latest) J:193107 Jin C, et al., Deciphering gene expression program of MAP3K1 in mouse eyelid morphogenesis. Dev Biol. 2013 Feb 1;374(1):96-107
All references(76)

Other accession IDs

MGD-MRK-11646