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Krt17 Gene Detail
Summary
  • Symbol
    Krt17
  • Name
    keratin 17
  • Synonyms
    K17, Krt1-17
  • Feature Type
    protein coding gene
  • IDs
    MGI:96691
    NCBI Gene: 16667
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:100147043-100151855 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 11, 63.44 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    67 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_96691
protein coding gene Chr11:100147041-100151855 (-)
129S1/SvImJ MGP_129S1SvImJ_G0019147
protein coding gene Chr11:103015233-103020045 (-)
A/J MGP_AJ_G0019115
protein coding gene Chr11:98691194-98696010 (-)
AKR/J MGP_AKRJ_G0019084
protein coding gene Chr11:101735268-101740080 (-)
BALB/cJ MGP_BALBcJ_G0019089
protein coding gene Chr11:99179475-99184287 (-)
C3H/HeJ MGP_C3HHeJ_G0018898
protein coding gene Chr11:101926187-101930999 (-)
C57BL/6NJ MGP_C57BL6NJ_G0019538
protein coding gene Chr11:106183868-106188680 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0017165
protein coding gene Chr11:96120076-96124888 (-)
CAST/EiJ MGP_CASTEiJ_G0018452
protein coding gene Chr11:102897712-102902526 (-)
CBA/J MGP_CBAJ_G0018867
protein coding gene Chr11:110620340-110625152 (-)
DBA/2J MGP_DBA2J_G0018979
protein coding gene Chr11:98240657-98245469 (-)
FVB/NJ MGP_FVBNJ_G0018969
protein coding gene Chr11:97760312-97765124 (-)
LP/J MGP_LPJ_G0019048
protein coding gene Chr11:103551904-103556716 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0019000
protein coding gene Chr11:110246406-110251218 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0019576
protein coding gene Chr11:102087010-102091822 (-)
PWK/PhJ MGP_PWKPhJ_G0018215
protein coding gene Chr11:99267825-99272640 (-)
SPRET/EiJ MGP_SPRETEiJ_G0018007
protein coding gene Chr11:101792363-101797161 (-)
WSB/EiJ MGP_WSBEiJ_G0018501
protein coding gene Chr11:102072938-102077750 (-)



Homology
more
  • Human Ortholog
    KRT17, keratin 17
  • Vertebrate Orthologs
    12
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    KRT17, keratin 17
  • Synonyms
    39.1, CK-17, K17, PC, PC2, PCHC1
  • Links
    NCBI Gene ID: 3872
    neXtProt AC: NX_Q04695
    UniProt: Q04695

  • Chr Location
    17q21.2; chr17:41619442-41624842 (-)  GRCh38

Human Diseases
more
  • Diseases
    3 with human KRT17 associations

Human Disease Mouse Models
      
IDs
IDs
View 1 model
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    20 phenotypes from 3 alleles in 5 genetic backgrounds
    4 phenotypes from multigenic genotypes
    33 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele display age- and strain-dependent alopecia associated with frequent absence of vibrissae, increased hair fragility, abnormal hair cycling, altered hair follicle morphology, and apoptosis in matrix cells. Homozygosity for an allele expressing peptides with a non-functional NLS leads to enlarged skin keratinocyte nuclei.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000035557 Ensembl Gene Model | MGI Sequence Detail 4813 C57BL/6J ±  kb
    transcript ENSMUST00000080893 Ensembl | MGI Sequence Detail 1551 Not Applicable  
    polypeptide ENSMUSP00000079699 Ensembl | MGI Sequence Detail 433 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 100
      Genomic 5
      cDNA 89
      Primer pair 5
      Other 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-11646
    References
    more
    • Summaries
      All 135
      Developmental Gene Expression 72
      Diseases 1
      Gene Ontology 11
      Phenotypes 33
    • Earliest
      J:16017 Steinert PM, et al., Complete amino acid sequence of a mouse epidermal keratin subunit and implications for the structure of intermediate filaments. Nature. 1983 Apr 28;302(5911):794-800
    • Latest
      J:338882 Luo Y, et al., Keratin 17 covalently binds to alpha-enolase and exacerbates proliferation of keratinocytes in psoriasis. Int J Biol Sci. 2023;19(11):3395-3411

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    last database update
    03/12/2024
    MGI 6.23
    The Jackson Laboratory