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Krt17
Gene Detail
 Symbol
Name
ID
Krt17
keratin 17
MGI:96691
Synonyms K17, Krt1-17
Feature Type protein coding gene
Genetic Map
Chromosome 11
63.44 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr11:100256217-100261029 bp, - strand
From VEGA annotation of GRCm38

  4813 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:363  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 10 zebrafish

Gene Tree: Krt17

Human
homologs
Human Homolog KRT17, keratin 17
NCBI Gene ID 3872
neXtProt AC  NX_Q04695
Human Synonyms  K17, PC, PC2, PCHC1
Human Chr (Location)  17q21.2; chr17:41619440-41624630 (-)  GRCh38
Disease Associations  (2) Diseases Associated with Human KRT17
Mutations,
alleles, and
phenotypes
All mutations/alleles(14) : Gene trapped(7) Targeted(7)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele display age- and strain-dependent alopecia associated with frequent absence of vibrissae, increased hair fragility, abnormal hair cycling, altered hair follicle morphology, and apoptosis in matrix cells.
 
Alleles Annotated to Human Diseases(1)   
Interactions
Krt17 interacts with 40 markers (Mir22, Mir30a, Mir30d, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (18 annotations)
Process intermediate filament organization, keratinization, ...
Component cell periphery, cytoplasm, ...
Function MHC class II protein binding, MHC class II receptor activity, ...
External Resources: FuncBase
Expression
Literature Summary: (39 records)
Data Summary: Results (8)    Tissues (4)    Images (4)
Theiler Stages: 20, 25, 28
Assay TypeResults
Immunohistochemistry 2
RNA in situ 1
RT-PCR 5
cDNA source data(86)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(94) Genomic(5) cDNA(86) Primer pair(3)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000002546 (Evidence)
Ensembl Gene ModelENSMUSG00000035557 (Evidence)
Entrez Gene16667 (Evidence)
UniGene14046
DFCITC1579293
DoTSDT.60141887
NIA Mouse Gene IndexU116795
Consensus CDS ProjectCCDS25415.1
International Mouse Knockout Project StatusKrt17
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000002546 VEGA Gene Model | MGI Sequence Detail 4813 C57BL/6J ±  kb
transcript OTTMUST00000004974 VEGA | MGI Sequence Detail 1551 Not Applicable 
polypeptide OTTMUSP00000002397 VEGA | MGI Sequence Detail 433 Not Applicable 

For the selected sequences
All sequences(19) RefSeq(2) UniProt(1)
Polymorphisms PCR(1) : SNPs within 2kb(68 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001664 Intermediate filament protein
InterPro IPR018039 Intermediate filament protein, conserved site
InterPro IPR002957 Keratin, type I
InterPro IPR009053 Prefoldin
Protein Ontology PR:000009457 keratin, type I cytoskeletal 17
References (Earliest) J:16017 Steinert PM, et al., Complete amino acid sequence of a mouse epidermal keratin subunit and implications for the structure of intermediate filaments. Nature. 1983 Apr 28;302(5911):794-800
(Latest) J:206321 Veniaminova NA, et al., Keratin 79 identifies a novel population of migratory epithelial cells that initiates hair canal morphogenesis and regeneration. Development. 2013 Dec;140(24):4870-80
All references(82)
Disease annotation references (1)
Other
accession IDs
MGD-MRK-11646

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/12/2014
MGI 5.19
The Jackson Laboratory