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Krt17 Gene Detail
Summary
  • Symbol
    Krt17
  • Name
    keratin 17
  • Synonyms
    K17, Krt1-17
  • Feature Type
    protein coding gene
  • IDs
    MGI:96691
    NCBI Gene: 16667
  • Gene Overview
    MyGene.info: KRT17
Location & Maps
more
  • Sequence Map
    Chr11:100256217-100261029 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      4813 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 63.44 cM
  • Mapping Data
    4 experiments
Homology
more
  • Human Ortholog
    KRT17, keratin 17
  • Vertebrate Orthologs
    18
  • Human Ortholog
    KRT17, keratin 17
    Orthology source: HomoloGene
  • Synonyms
    39.1, CK-17, K17, PC, PC2, PCHC1
  • Links
    NCBI Gene ID: 3872
    neXtProt AC: NX_Q04695

  • Chr Location
    17q21.2; chr17:41619440-41624630 (-)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 363
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 western clawed frog;10 zebrafish
  • HCOP
    human homology predictions: KRT17
  • Gene Tree
Human Diseases
more
  • Diseases
    2 with human KRT17 associations

Human Disease Mouse Models
       Pachyonychia Congenita 2; PC2   OMIM: 167210 View 1 model
Steatocystoma Multiplex   OMIM: 184500
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    12 phenotypes from 1 allele in 3 genetic backgrounds
    4 phenotypes from multigenic genotypes
    21 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    16
  • Gene trapped
    7
  • Targeted
    9
  • Genomic Mutations
    1 involving Krt17
  • Incidental Mutations
Mice homozygous for a knock-out allele display age- and strain-dependent alopecia associated with frequent absence of vibrissae, increased hair fragility, abnormal hair cycling, altered hair follicle morphology, and apoptosis in matrix cells.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000002546 VEGA Gene Model | MGI Sequence Detail 4813 C57BL/6J ±  kb
transcript OTTMUST00000004974 VEGA | MGI Sequence Detail 1551 Not Applicable  
polypeptide OTTMUSP00000002397 VEGA | MGI Sequence Detail 433 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    67 from dbSNP Build 142
  • PCR
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 95
    Genomic 5
    cDNA 87
    Primer pair 3

    Microarray probesets 4
Other
Accession IDs
less
MGD-MRK-11646
References
more
  • Summaries
    All 88
    Developmental Gene Expression 47
    Diseases 2
    Gene Ontology 9
    Phenotypes 21
  • Earliest
    J:16017 Steinert PM, et al., Complete amino acid sequence of a mouse epidermal keratin subunit and implications for the structure of intermediate filaments. Nature. 1983 Apr 28;302(5911):794-800
  • Latest
    J:231070 Liu Y, et al., Gorab Is Required for Dermal Condensate Cells to Respond to Hedgehog Signals during Hair Follicle Morphogenesis. J Invest Dermatol. 2016 Feb;136(2):378-86

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory