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Krt16 Gene Detail
Summary
  • Symbol
    Krt16
  • Name
    keratin 16
  • Synonyms
    K16, Krt1-16
  • Feature Type
    protein coding gene
  • IDs
    MGI:96690
    NCBI Gene: 16666
  • Gene Overview
    MyGene.info: KRT16
Location & Maps
more
  • Sequence Map
    Chr11:100246091-100248902 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      2812 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 63.44 cM
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    KRT16, keratin 16
  • Vertebrate Orthologs
    7
  • Human Ortholog
    KRT16, keratin 16
    Orthology source: HGNC, HomoloGene
  • Synonyms
    CK16, FNEPPK, K16, K1CP, KRT16A, NEPPK, PC1
  • Links
    NCBI Gene ID: 3868
    neXtProt AC: NX_P08779

  • Chr Location
    17q21.2; chr17:41609778-41612827 (-)  GRCh38.p2

Human Diseases
more
  • Diseases
    2 with Krt16 mouse models; 2 with human KRT16 associations

Human Disease Mouse Models
       Pachyonychia Congenita 1; PC1   OMIM: 167200 View 1 model
Palmoplantar Keratoderma, Nonepidermolytic, Focal 1; FNEPPK1   OMIM: 613000 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    14 phenotypes from 1 allele in 1 genetic background
    13 phenotypes from multigenic genotypes
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    5
  • Targeted
    2
  • Transgenic
    3
  • Genomic Mutations
    1 involving Krt16
  • Incidental Mutations
Mice homozygous for a knock-out allele exhibit partial neonatal and postnatal lethality, decreased body weight, abnormal tongue epithelium and hyperkertotic calluses in areas of physical pressure.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000002540 VEGA Gene Model | MGI Sequence Detail 2812 C57BL/6J ±  kb
transcript OTTMUST00000004966 VEGA | MGI Sequence Detail 1565 Not Applicable  
polypeptide OTTMUSP00000002391 VEGA | MGI Sequence Detail 469 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    52 from dbSNP Build 142
Protein
Information
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  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000009456 keratin, type I cytoskeletal 16
  • InterPro Domains
    IPR001664 Intermediate filament protein
    IPR018039 Intermediate filament protein, conserved site
    IPR002957 Keratin, type I
Molecular
Reagents
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  • All nucleic 23
    cDNA 21
    Primer pair 2

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-11645, MGI:2144125
References
more
  • Summaries
    All 41
    Developmental Gene Expression 7
    Diseases 2
    Gene Ontology 7
    Phenotypes 11
  • Earliest
    J:16017 Steinert PM, et al., Complete amino acid sequence of a mouse epidermal keratin subunit and implications for the structure of intermediate filaments. Nature. 1983 Apr 28;302(5911):794-800
  • Latest
    J:202957 Lessard JC, et al., Keratin 16 regulates innate immunity in response to epidermal barrier breach. Proc Natl Acad Sci U S A. 2013 Nov 26;110(48):19537-42

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
08/23/2016
MGI 6.05
The Jackson Laboratory