Krt16
Gene Detail

Symbol Name ID

Krt16 keratin 16 MGI:96690

Synonyms

K16, Krt1-16

Feature Type

protein coding gene

Genetic Map

Chromosome 11

63.44 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)

Sequence Map

Chr11:100246091-100248902 bp, - strand From VEGA annotation of GRCm38   2812 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:21145  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog

Gene Tree: Krt16

Human homologs

Human Homolog		KRT16, keratin 16
NCBI Gene ID		3868
neXtProt AC		NX_P08779
Human Synonyms		CK16, FNEPPK, K16, K1CP, KRT16A, NEPPK
Human Chr (Location)		17q21.2; chr17:39766030-39769079 (-)  GRCh37.p10
Disease Associations		(4) Diseases Associated with Human KRT16

Alleles and phenotypes

All alleles(1) : Targeted(1)
 

Mice homozygous for a knock-out allele exhibit partial neonatal and postnatal lethality, decreased body weight, abnormal tongue epithelium and hyperkertotic calluses in areas of physical pressure.

 
Human Diseases Modeled Using Mouse Krt16 (1)    Alleles Annotated to Human Diseases(1)   

Gene Ontology (GO) classifications

All GO classifications: (5 annotations)

Process	intermediate filament cytoskeleton organization
Component	intermediate filament
Function	protein binding, structural constituent of cytoskeleton, ...

External Resources: FuncBase

Expression

Literature Summary: (6 records)
Data Summary: Results (172)    Tissues (25)    Images (25)
Theiler Stages: 20, 23, 28

Assay Type	Results
RNA in situ	167
RT-PCR	5

cDNA source data(21)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(23) cDNA(21) Primer pair(2)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000002540 (Evidence)
Ensembl Gene Model	ENSMUSG00000053797 (Evidence)
Entrez Gene	16666 (Evidence)
UniGene	422799
DFCI	TC1583688
DoTS	DT.55199717, DT.87069641
NIA Mouse Gene Index	U033419
Consensus CDS Project	CCDS25414.1
International Mouse Knockout Project Status	Krt16

Sequences

Length	Strain/Species
genomic	OTTMUSG00000002540	VEGA Gene Model | MGI Sequence Detail	2812	C57BL/6J
transcript	OTTMUST00000004966	VEGA | MGI Sequence Detail	1565	Not Applicable
polypeptide	OTTMUSP00000002391	VEGA | MGI Sequence Detail	469	Not Applicable

All sequences(24) RefSeq(2) UniProt(3)

Polymorphisms

SNPs(40 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR016044	Filament
InterPro	IPR001664	Intermediate filament protein
InterPro	IPR018039	Intermediate filament protein, conserved site
InterPro	IPR002957	Keratin, type I
Protein Ontology	PR:000009456	keratin, type I cytoskeletal 16

References

(Earliest) J:16017 Steinert PM, et al., Complete amino acid sequence of a mouse epidermal keratin subunit and implications for the structure of intermediate filaments. Nature. 1983 Apr 28;302(5911):794-800
(Latest) J:184621 Lessard JC, et al., Keratin 16-null mice develop palmoplantar keratoderma, a hallmark feature of pachyonychia congenita and related disorders. J Invest Dermatol. 2012 May;132(5):1384-91
All references(40)

Other accession IDs

MGD-MRK-11645, MGI:2144125