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Krt16 Gene Detail
Summary
  • Symbol
    Krt16
  • Name
    keratin 16
  • Synonyms
    K16, Krt1-16
  • Feature Type
    protein coding gene
  • IDs
    MGI:96690
    NCBI Gene: 16666
  • Gene Overview
    MyGene.info: KRT16
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:100246091-100248902 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 63.44 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    52 from dbSNP Build 142
  • Strain Annotations
    17
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_96690
protein coding gene Chr11:100246091-100248902 (-)
129S1/SvImJ MGP_129S1SvImJ_G0019146
protein coding gene Chr11:103001324-103006439 (-)
A/J MGP_AJ_G0019114
protein coding gene Chr11:98675760-98679451 (-)
AKR/J MGP_AKRJ_G0019083
protein coding gene Chr11:101720480-101726183 (-)
BALB/cJ MGP_BALBcJ_G0019088
protein coding gene Chr11:99168107-99172152 (-)
C3H/HeJ MGP_C3HHeJ_G0018897
protein coding gene Chr11:101911743-101918880 (-)
C57BL/6NJ MGP_C57BL6NJ_G0019537
protein coding gene Chr11:106148103-106155359 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0017164
protein coding gene Chr11:96107644-96112495 (-)
CAST/EiJ MGP_CASTEiJ_G0018451
protein coding gene Chr11:102866066-102881508 (-)
CBA/J MGP_CBAJ_G0018866
protein coding gene Chr11:110603763-110608881 (-)
DBA/2J no annotation
FVB/NJ MGP_FVBNJ_G0018968
protein coding gene Chr11:97744730-97747310 (-)
LP/J MGP_LPJ_G0019047
protein coding gene Chr11:103536294-103542033 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0018999
protein coding gene Chr11:110224138-110237684 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0019575
protein coding gene Chr11:102077434-102079653 (-)
PWK/PhJ MGP_PWKPhJ_G0018214
protein coding gene Chr11:99238283-99254047 (-)
SPRET/EiJ MGP_SPRETEiJ_G0018006
protein coding gene Chr11:101778647-101784916 (-)
WSB/EiJ MGP_WSBEiJ_G0018500
protein coding gene Chr11:102059928-102062667 (-)



Homology
more
  • Human Ortholog
    KRT16, keratin 16
  • Vertebrate Orthologs
    7
  • Human Ortholog
    KRT16, keratin 16
    Orthology source: HGNC, HomoloGene
  • Synonyms
    CK16, FNEPPK, K16, K1CP, KRT16A, NEPPK, PC1
  • Links
    NCBI Gene ID: 3868
    neXtProt AC: NX_P08779
    UniProt: P08779

  • Chr Location
    17q21.2; chr17:41609778-41612827 (-)  GRCh38.p7

Human Diseases
more
  • Diseases
    2 with Krt16 mouse models; 2 with human KRT16 associations

Human Disease Mouse Models
      
IDs
View 1 model
IDs
View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    14 phenotypes from 1 allele in 1 genetic background
    13 phenotypes from multigenic genotypes
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit partial neonatal and postnatal lethality, decreased body weight, abnormal tongue epithelium and hyperkertotic calluses in areas of physical pressure.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 16666 NCBI Gene Model | MGI Sequence Detail 2812 C57BL/6J ±  kb
    transcript NM_001313958 RefSeq | MGI Sequence Detail 1583 C57BL/6  
    polypeptide Q9Z2K1 UniProt | EBI | MGI Sequence Detail 469 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 24
      cDNA 22
      Primer pair 2

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-11645, MGI:2144125
    References
    more
    • Summaries
      All 53
      Developmental Gene Expression 11
      Diseases 1
      Gene Ontology 7
      Phenotypes 13
    • Earliest
      J:16017 Steinert PM, et al., Complete amino acid sequence of a mouse epidermal keratin subunit and implications for the structure of intermediate filaments. Nature. 1983 Apr 28;302(5911):794-800
    • Latest
      J:261187 Kerns ML, et al., Sexual Dimorphism in Response to an NRF2 Inducer in a Model for Pachyonychia Congenita. J Invest Dermatol. 2018 May;138(5):1094-1100

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    12/04/2018
    MGI 6.13
    The Jackson Laboratory