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Krt16
Gene Detail
Symbol

Name
ID
Krt16
keratin 16
MGI:96690
Synonyms
K16, Krt1-16
Feature Type
protein coding gene
Genetic Map
Chromosome 11
63.44 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr11:100246091-100248902 bp, - strand
From VEGA annotation of GRCm38

  2812 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:21145  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

Gene Tree: Krt16

Human
homologs
Human Homolog KRT16, keratin 16
NCBI Gene ID 3868
neXtProt AC  NX_P08779
Human Synonyms  CK16, FNEPPK, K16, K1CP, KRT16A, NEPPK, PC1
Human Chr (Location)  17q21.2; chr17:41609778-41612827 (-)  GRCh38
Disease Associations  (2) Diseases Associated with Human KRT16
Mutations,
alleles, and
phenotypes
All mutations/alleles(1) : Targeted(1)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele exhibit partial neonatal and postnatal lethality, decreased body weight, abnormal tongue epithelium and hyperkertotic calluses in areas of physical pressure.
 
Human Diseases Modeled Using Mouse Krt16 (2)    Alleles Annotated to Human Diseases(1)   
Interactions
Krt16 interacts with 30 markers (Mir18, Mir31, Mir153, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (11 annotations)
Process aging, hair cycle, ...
Component cytoskeleton, extracellular vesicular exosome, ...
Function protein binding, structural constituent of cytoskeleton, ...
External Resources: FuncBase
Expression
Literature Summary: (7 records)
Data Summary: Results (172)    Tissues (25)    Images (25)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 167
RT-PCR 5
cDNA source data(21)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(23) cDNA(21) Primer pair(2)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000002540 (Evidence)
Ensembl Gene ModelENSMUSG00000053797 (Evidence)
Entrez Gene16666 (Evidence)
UniGene422799
DFCITC1583688
DoTSDT.55199717, DT.87069641
NIA Mouse Gene IndexU033419
Consensus CDS ProjectCCDS25414.1
International Mouse Knockout Project StatusKrt16
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000002540 VEGA Gene Model | MGI Sequence Detail 2812 C57BL/6J ±  kb
transcript OTTMUST00000004966 VEGA | MGI Sequence Detail 1565 Not Applicable 
polypeptide OTTMUSP00000002391 VEGA | MGI Sequence Detail 469 Not Applicable 

For the selected sequences
All sequences(26) RefSeq(4) UniProt(3)
Polymorphisms
SNPs within 2kb(55 from dbSNP Build 137)    SNPs within 2kb including multiple locations(59)
Protein-related
information
ResourceIDDescription
InterPro IPR001664 Intermediate filament protein
InterPro IPR018039 Intermediate filament protein, conserved site
InterPro IPR002957 Keratin, type I
Protein Ontology PR:000009456 keratin, type I cytoskeletal 16
References
(Earliest) J:16017 Steinert PM, et al., Complete amino acid sequence of a mouse epidermal keratin subunit and implications for the structure of intermediate filaments. Nature. 1983 Apr 28;302(5911):794-800
(Latest) J:202957 Lessard JC, et al., Keratin 16 regulates innate immunity in response to epidermal barrier breach. Proc Natl Acad Sci U S A. 2013 Nov 26;110(48):19537-42
All references(43)
Disease annotation references (2)
Other
accession IDs
MGD-MRK-11645, MGI:2144125

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
10/08/2014
MGI 5.20
The Jackson Laboratory