Sequence Detail

ID/Version

Q9Z2K1 (UniProt | EBI)

Last sequence update: 2007-01-23
Last annotation update: 2024-03-27

Sequence description from provider

RecName: Full=Keratin, type I cytoskeletal 16;AltName: Full=Cytokeratin-16; Short=CK-16;AltName: Full=Keratin-16; Short=K16;

Provider

SWISS-PROT

Sequence

Polypeptide 469 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Krt16	keratin 16	21	99	13	5

Sequence references in MGI

J:51225 Porter RM, et al., cDNA cloning, expression, and assembly characteristics of mouse keratin 16. J Biol Chem. 1998 Nov 27;273(48):32265-72
J:76311 Peters B, et al., Complete cytolysis and neonatal lethality in keratin 5 knockout mice reveal its fundamental role in skin integrity and in epidermolysis bullosa simplex. Mol Biol Cell. 2001 Jun;12(6):1775-89
J:80753 Bernot KM, et al., Keratin 16 expression defines a subset of epithelial cells during skin morphogenesis and the hair cycle. J Invest Dermatol. 2002 Nov;119(5):1137-49
J:108710 Tong X, et al., Keratin 17 modulates hair follicle cycling in a TNFalpha-dependent fashion. Genes Dev. 2006 May 15;20(10):1353-64
J:184621 Lessard JC, et al., Keratin 16-null mice develop palmoplantar keratoderma, a hallmark feature of pachyonychia congenita and related disorders. J Invest Dermatol. 2012 May;132(5):1384-91
J:202957 Lessard JC, et al., Keratin 16 regulates innate immunity in response to epidermal barrier breach. Proc Natl Acad Sci U S A. 2013 Nov 26;110(48):19537-42
J:217292 Wawersik M, et al., Forced expression of keratin 16 alters the adhesion, differentiation, and migration of mouse skin keratinocytes. Mol Biol Cell. 2000 Oct;11(10):3315-27
J:229462 Allen EH, et al., Keratin 12 missense mutation induces the unfolded protein response and apoptosis in Meesmann epithelial corneal dystrophy. Hum Mol Genet. 2016 Mar 15;25(6):1176-91
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89