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Krt10
Gene Detail
Symbol

Name
ID
Krt10
keratin 10
MGI:96685
Synonyms
cytokeratin 10, D130054E02Rik, K10, K1C1, keratin 10, Krt-1.10, Krt1-10, suprabasal cytokeratin 10
Feature Type
protein coding gene
Genetic Map
Chromosome 11
62.92 cM
Detailed Genetic Map ± 1 cM


Mapping data(12)
Sequence Map
Chr11:99385254-99389364 bp, - strand
From VEGA annotation of GRCm38

  4111 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:137236  Vertebrate Homology Class
1 mouse; 1 western clawed frog

HCOP human homology predictions: KRT10
Gene Tree: Krt10

Human
homologs
KRT10, keratin 10, type I
Orthology source: HGNC

IDs:
NCBI Gene ID: 3858
neXtProt AC: NX_P13645

Human Synonyms: BCIE, BIE, CK10, EHK, K10, KPP

Human Chr (Location): 17q21; chr17:40818117-40822618 (-)  GRCh38.p2

Disease Associations: (3) Diseases Associated with Human KRT10

Mutations,
alleles, and
phenotypes
All mutations/alleles(21) : Chemically induced (ENU)(1) Gene trapped(14) Targeted(6)
Genomic Mutations involving Krt10 (1)
 
Mutations may result in hyperkeratosis and blistering of the skin.
 
Human Diseases Modeled in Mice Using Krt10 (1)    Mutations Annotated to Human Diseases (1)    Phenotype Images(4)
Interactions
Krt10 interacts with 86 markers (Mir19a, Mir19b-1, Mir19b-2, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (127 records)
Data Summary: Results (185)    Tissues (44)    Images (48)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 18
RNA in situ 159
RT-PCR 8
cDNA source data(132)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: GEISHA KRT9 ; Xenbase LOC100487422    NEW 
Molecular
reagents
All nucleic(142) Genomic(5) cDNA(135) Primer pair(2)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000004962 (Evidence)
Ensembl Gene Model ENSMUSG00000019761 (Evidence)
Entrez Gene 16661 (Evidence)
UniGene 22662
DFCI TC1572984, TC1596480, TC1672183
DoTS DT.40149249, DT.91312376
NIA Mouse Gene Index U033390
Consensus CDS Project CCDS25380.1
International Mouse Phenotyping Consortium Status Krt10
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000004962 VEGA Gene Model | MGI Sequence Detail 4111 C57BL/6J ±  kb
transcript OTTMUST00000011028 VEGA | MGI Sequence Detail 2094 Not Applicable 
polypeptide OTTMUSP00000005149 VEGA | MGI Sequence Detail 561 Not Applicable 

For the selected sequences
All sequences(31) RefSeq(4) UniProt(2)
Polymorphisms
SNPs within 2kb(52 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001664 Intermediate filament protein
InterPro IPR018039 Intermediate filament protein, conserved site
InterPro IPR002957 Keratin, type I
Protein Ontology PR:000009451 keratin, type I cytoskeletal 10
References
(Earliest) J:16017 Steinert PM, et al., Complete amino acid sequence of a mouse epidermal keratin subunit and implications for the structure of intermediate filaments. Nature. 1983 Apr 28;302(5911):794-800
(Latest) J:218061 Krishnaswami SR, et al., Fate and Plasticity of the Epidermis in Response to Congenital Activation of BRAF. J Invest Dermatol. 2015 Feb;135(2):481-9
All references(195)
Disease annotation references (1)
Other
accession IDs
MGD-MRK-11630, MGD-MRK-11640, MGI:2441944

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/28/2015
MGI 5.22
The Jackson Laboratory