Krt10
Gene Detail

Symbol Name ID

Krt10 keratin 10 MGI:96685

Synonyms

cytokeratin 10, D130054E02Rik, K10, K1C1, keratin 10, Krt-1.10, Krt1-10, suprabasal cytokeratin 10

Feature Type

protein coding gene

Genetic Map

Chromosome 11

62.92 cM
Detailed Genetic Map ± 1 cM


Mapping data(12)

Sequence Map

Chr11:99385254-99389364 bp, - strand From VEGA annotation of GRCm38   4111 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:20125  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog

Gene Tree: Krt10

Human homologs

Human Homolog		KRT10, keratin 10
NCBI Gene ID		3858
neXtProt AC		NX_P13645
Human Synonyms		BCIE, BIE, CK10, EHK, K10, KPP
Human Chr (Location)		17q21; chr17:38974369-38978863 (-)  GRCh37.p10
Disease Associations		(3) Diseases Associated with Human KRT10

Alleles and phenotypes

All alleles(20) : Targeted(5) Gene trapped(14) Chemically induced(1)
 

Mutations may result in hyperkeratosis and blistering of the skin.

 
Human Diseases Modeled Using Mouse Krt10 (1)    Alleles Annotated to Human Diseases(1)    Phenotype Images(4)

Gene Ontology (GO) classifications

All GO classifications: (8 annotations)

Process	cellular response to calcium ion, epithelial cell differentiation
Component	cytoplasm, intermediate filament, ...
Function	protein binding, structural molecule activity

External Resources: FuncBase

Expression

Literature Summary: (103 records)
Data Summary: Results (179)    Tissues (41)    Images (44)
Theiler Stages: 21, 22, 23, 24, 25, 26, 28

Assay Type	Results
Immunohistochemistry	14
RNA in situ	157
RT-PCR	8

cDNA source data(131)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(141) Genomic(5) cDNA(134) Primer pair(2)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000004962 (Evidence)
Ensembl Gene Model	ENSMUSG00000019761 (Evidence)
Entrez Gene	16661 (Evidence)
UniGene	22662
DFCI	TC1572984, TC1596480, TC1672183
DoTS	DT.40149249, DT.91312376
NIA Mouse Gene Index	U033390
Consensus CDS Project	CCDS25380.1
International Mouse Knockout Project Status	Krt10

Sequences

Length	Strain/Species
genomic	OTTMUSG00000004962	VEGA Gene Model | MGI Sequence Detail	4111	C57BL/6J
transcript	OTTMUST00000011028	VEGA | MGI Sequence Detail	2094	Not Applicable
polypeptide	OTTMUSP00000005149	VEGA | MGI Sequence Detail	561	Not Applicable

All sequences(29) RefSeq(2) UniProt(2)

Polymorphisms

SNPs(5 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR016044	Filament
InterPro	IPR001664	Intermediate filament protein
InterPro	IPR018039	Intermediate filament protein, conserved site
InterPro	IPR002957	Keratin, type I
Protein Ontology	PR:000009451	keratin, type I cytoskeletal 10

References

(Earliest) J:16017 Steinert PM, et al., Complete amino acid sequence of a mouse epidermal keratin subunit and implications for the structure of intermediate filaments. Nature. 1983 Apr 28;302(5911):794-800
(Latest) J:195087 Francis JC, et al., beta-catenin is required for prostate development and cooperates with Pten loss to drive invasive carcinoma. PLoS Genet. 2013 Jan;9(1):e1003180
All references(173)

Other accession IDs

MGD-MRK-11630, MGD-MRK-11640, MGI:2441944