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Krt10 Gene Detail
Summary
  • Symbol
    Krt10
  • Name
    keratin 10
  • Synonyms
    cytokeratin 10, D130054E02Rik, K10, K1C1, keratin 10, Krt-1.10, Krt1-10, suprabasal cytokeratin 10
  • Feature Type
    protein coding gene
  • IDs
    MGI:96685
    NCBI Gene: 16661
  • Gene Overview
    MyGene.info: KRT10
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:99385254-99389364 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 62.92 cM
  • Mapping Data
    12 experiments
Strain
Comparison
more
  • SNPs within 2kb
    57 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_96685
protein coding gene Chr11:99385254-99389699 (-)
129S1/SvImJ MGP_129S1SvImJ_G0019091
protein coding gene Chr11:102049455-102053577 (-)
A/J MGP_AJ_G0019059
protein coding gene Chr11:97753129-97757241 (-)
AKR/J MGP_AKRJ_G0019029
protein coding gene Chr11:100787836-100792005 (-)
BALB/cJ MGP_BALBcJ_G0019033
protein coding gene Chr11:98259020-98263127 (-)
C3H/HeJ MGP_C3HHeJ_G0018846
protein coding gene Chr11:100937692-100941814 (-)
C57BL/6NJ MGP_C57BL6NJ_G0019484
protein coding gene Chr11:105187820-105191930 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0017116
protein coding gene Chr11:95315029-95319130 (-)
CAST/EiJ MGP_CASTEiJ_G0018401
protein coding gene Chr11:101932934-101937077 (-)
CBA/J MGP_CBAJ_G0018817
protein coding gene Chr11:109568855-109572963 (-)
DBA/2J MGP_DBA2J_G0018925
protein coding gene Chr11:97319629-97323750 (-)
FVB/NJ MGP_FVBNJ_G0018914
protein coding gene Chr11:96829819-96833941 (-)
LP/J MGP_LPJ_G0018995
protein coding gene Chr11:102516579-102520701 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0018941
protein coding gene Chr11:109234360-109238481 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0019524
protein coding gene Chr11:101145311-101149415 (-)
PWK/PhJ MGP_PWKPhJ_G0018172
protein coding gene Chr11:98392438-98396558 (-)
SPRET/EiJ MGP_SPRETEiJ_G0017960
protein coding gene Chr11:100902200-100906309 (-)
WSB/EiJ MGP_WSBEiJ_G0018449
protein coding gene Chr11:101121626-101125735 (-)



Homology
more
  • Human Ortholog
    KRT10, keratin 10
  • Vertebrate Orthologs
    2
  • Human Ortholog
    KRT10, keratin 10
    Orthology source: HGNC
  • Synonyms
    BCIE, BIE, CK10, EHK, K10, KPP
  • Links
    NCBI Gene ID: 3858
    neXtProt AC: NX_P13645
    UniProt: P13645

  • Chr Location
    17q21.2; chr17:40818117-40822621 (-)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with Krt10 mouse models; 1 with human KRT10 associations

Human Disease Mouse Models
      
IDs
View 2 models
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    37 phenotypes from 4 alleles in 5 genetic backgrounds
    9 phenotypes from multigenic genotypes
    4 images
    27 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mutations may result in hyperkeratosis and blistering of the skin.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000019761 Ensembl Gene Model | MGI Sequence Detail 4111 C57BL/6J ±  kb
    transcript ENSMUST00000103131 Ensembl | MGI Sequence Detail 2094 Not Applicable  
    polypeptide ENSMUSP00000099420 Ensembl | MGI Sequence Detail 561 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      3 Sequences
    • InterPro Domains
      IPR001664 Intermediate filament protein
      IPR018039 Intermediate filament protein, conserved site
      IPR039008 Intermediate filament, rod domain
      IPR002957 Keratin, type I
    Molecular
    Reagents
    less
    • All nucleic 143
      Genomic 5
      cDNA 136
      Primer pair 2

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-11630, MGD-MRK-11640, MGI:2441944
    References
    more
    • Summaries
      All 231
      Developmental Gene Expression 156
      Diseases 1
      Gene Ontology 8
      Phenotypes 27
    • Earliest
      J:16017 Steinert PM, et al., Complete amino acid sequence of a mouse epidermal keratin subunit and implications for the structure of intermediate filaments. Nature. 1983 Apr 28;302(5911):794-800
    • Latest
      J:263836 Srivillibhuthur M, et al., TFAM is required for maturation of the fetal and adult intestinal epithelium. Dev Biol. 2018 Jul 15;439(2):92-101

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    12/04/2018
    MGI 6.13
    The Jackson Laboratory