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Kdr
Gene Detail
Symbol

Name
ID
Kdr
kinase insert domain protein receptor
MGI:96683
Synonyms
Flk1, Flk-1, vascular endothelial growth factor receptor- 2, VEGFR2, VEGFR-2, VEGF receptor-2
Feature Type
protein coding gene
Genetic Map
Chromosome 5
40.23 cM
Detailed Genetic Map ± 1 cM


Mapping data(8)
Sequence Map
Chr5:75932827-75978458 bp, - strand
From VEGA annotation of GRCm38

  45632 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:55639  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: KDR
Protein SuperFamily: vascular endothelial growth factor receptor
Gene Tree: Kdr

Human
homologs
KDR, kinase insert domain receptor
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 3791
neXtProt AC: NX_P35968

Human Synonyms: CD309, FLK1, VEGFR, VEGFR2

Human Chr (Location): 4q11-q12; chr4:55078259-55125595 (-)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human KDR

Mutations,
alleles, and
phenotypes
All mutations/alleles(18) : Targeted(17) Transgenic(1)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Homozygous mice die at early embryonic stages due to failure of blood vessel formation.
 
Phenotype Images(3)
Interactions
Kdr interacts with 315 markers (Mir1b, Mir7-1, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (129 annotations)
Process angiogenesis, blood vessel endothelial cell differentiation, ...
Component cell junction, cell periphery, ...
Function ATP binding, growth factor binding, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (432 records)
Data Summary: Results (764)    Tissues (366)    Images (260)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 79
RNA in situ 291
In situ reporter (knock in) 114
Northern blot 45
Western blot 3
RT-PCR 231
RNase protection 1
cDNA source data(105)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: GEISHA KDR ; Xenbase kdr ; ZFIN kdr    NEW 
Molecular
reagents
All nucleic(141) Genomic(8) cDNA(114) Primer pair(18) Other(1)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000021297 (Evidence)
Ensembl Gene Model ENSMUSG00000062960 (Evidence)
Entrez Gene 16542 (Evidence)
UniGene 285
DFCI TC1578991, TC1623597
DoTS DT.101353935, DT.487855
NIA Mouse Gene Index U026313
EC 2.7.10.1
Consensus CDS Project CCDS39114.1
International Mouse Phenotyping Consortium Status Kdr
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000021297 VEGA Gene Model | MGI Sequence Detail 45632 C57BL/6J ±  kb
transcript OTTMUST00000050493 VEGA | MGI Sequence Detail 5924 Not Applicable 
polypeptide OTTMUSP00000023578 VEGA | MGI Sequence Detail 1345 Not Applicable 

For the selected sequences
All sequences(33) RefSeq(4) UniProt(4)
Polymorphisms
RFLP(1) : SNPs within 2kb(223 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR013098 Immunoglobulin I-set
InterPro IPR007110 Immunoglobulin-like domain
InterPro IPR013783 Immunoglobulin-like fold
InterPro IPR003599 Immunoglobulin subtype
InterPro IPR003598 Immunoglobulin subtype 2
InterPro IPR013106 Immunoglobulin V-set domain
InterPro IPR017441 Protein kinase, ATP binding site
InterPro IPR000719 Protein kinase domain
InterPro IPR011009 Protein kinase-like domain
InterPro IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
InterPro IPR008266 Tyrosine-protein kinase, active site
InterPro IPR020635 Tyrosine-protein kinase, catalytic domain
InterPro IPR016243 Tyrosine-protein kinase, CSF-1/PDGF receptor family
InterPro IPR001824 Tyrosine-protein kinase, receptor class III, conserved site
InterPro IPR009136 Vascular endothelial growth factor receptor 2 (VEGFR2)
Protein Ontology PR:000002112 vascular endothelial growth factor receptor 2
References
(Earliest) J:1615 Matthews W, et al., A receptor tyrosine kinase cDNA isolated from a population of enriched primitive hematopoietic cells and exhibiting close genetic linkage to c-kit. Proc Natl Acad Sci U S A. 1991 Oct 15;88(20):9026-30
(Latest) J:222928 Cariboni A, et al., Dysfunctional SEMA3E signaling underlies gonadotropin-releasing hormone neuron deficiency in Kallmann syndrome. J Clin Invest. 2015 Jun;125(6):2413-28
All references(610)
Other
accession IDs
MGD-MRK-11605, MGD-MRK-11606, MGD-MRK-9826, MGD-MRK-9828, MGI:95555

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory