Kdr
Gene Detail

Symbol Name ID

Kdr kinase insert domain protein receptor MGI:96683

Synonyms

Flk1, Flk-1, vascular endothelial growth factor receptor- 2, VEGFR2, VEGFR-2, VEGF receptor-2

Feature Type

protein coding gene

Genetic Map

Chromosome 5

40.23 cM
Detailed Genetic Map ± 1 cM


Mapping data(8)

Sequence Map

Chr5:75932827-75978458 bp, - strand From VEGA annotation of GRCm38   45632 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:55639  Vertebrate Homology Class
1 human; 1 mouse; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: vascular endothelial growth factor receptor
Gene Tree: Kdr

Human homologs

Human Homolog		KDR, kinase insert domain receptor (a type III receptor tyrosine kinase)
NCBI Gene ID		3791
neXtProt AC		NX_P35968
Human Synonyms		CD309, FLK1, VEGFR, VEGFR2
Human Chr (Location)		4q11-q12; chr4:55944426-55991762 (-)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human KDR

Alleles and phenotypes

All alleles(16) : Targeted(16)
 

Homozygous mice die at early embryonic stages due to failure of blood vessel formation.

 
Phenotype Images(2)

Gene Ontology (GO) classifications

All GO classifications: (91 annotations)

Process	angiogenesis, blood vessel endothelial cell differentiation, ...
Component	cell periphery, cell surface, ...
Function	ATP binding, growth factor binding, ...

This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase

Expression

Literature Summary: (378 records)
Data Summary: Results (631)    Tissues (284)    Images (200)
Theiler Stages: 2, 3, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 28

Assay Type	Results
Immunohistochemistry	60
RNA in situ	214
In situ reporter (knock in)	77
Northern blot	45
Western blot	3
RT-PCR	231
RNase protection	1

cDNA source data(102)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(138) Genomic(8) cDNA(111) Primer pair(18) Other(1)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000021297 (Evidence)
Ensembl Gene Model	ENSMUSG00000062960 (Evidence)
Entrez Gene	16542 (Evidence)
UniGene	285
DFCI	TC1578991, TC1623597
DoTS	DT.101353935, DT.487855
NIA Mouse Gene Index	U026313
EC	2.7.10.1
Consensus CDS Project	CCDS39114.1
International Mouse Knockout Project Status	Kdr

Sequences

Length	Strain/Species
genomic	OTTMUSG00000021297	VEGA Gene Model | MGI Sequence Detail	45632	C57BL/6J
transcript	OTTMUST00000050493	VEGA | MGI Sequence Detail	5924	Not Applicable
polypeptide	OTTMUSP00000023578	VEGA | MGI Sequence Detail	1345	Not Applicable

All sequences(30) RefSeq(2) UniProt(4)

Polymorphisms

RFLP(1) : SNPs(174 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR013098	Immunoglobulin I-set
InterPro	IPR007110	Immunoglobulin-like
InterPro	IPR013783	Immunoglobulin-like fold
InterPro	IPR003599	Immunoglobulin subtype
InterPro	IPR003598	Immunoglobulin subtype 2
InterPro	IPR013106	Immunoglobulin V-set
InterPro	IPR017441	Protein kinase, ATP binding site
InterPro	IPR000719	Protein kinase, catalytic domain
InterPro	IPR011009	Protein kinase-like domain
InterPro	IPR001245	Serine-threonine/tyrosine-protein kinase catalytic domain
InterPro	IPR008266	Tyrosine-protein kinase, active site
InterPro	IPR020635	Tyrosine-protein kinase, catalytic domain
InterPro	IPR001824	Tyrosine-protein kinase, receptor class III, conserved site
InterPro	IPR009136	Tyrosine-protein kinase, vascular endothelial growth factor receptor 2 (VEGFR2)
InterPro	IPR009134	Tyrosine-protein kinase, vascular endothelial growth factor receptor (VEGFR), N-terminal
Protein Ontology	PR:000002112	vascular endothelial growth factor receptor 2

References

(Earliest) J:1615 Matthews W, et al., A receptor tyrosine kinase cDNA isolated from a population of enriched primitive hematopoietic cells and exhibiting close genetic linkage to c-kit. Proc Natl Acad Sci U S A. 1991 Oct 15;88(20):9026-30
(Latest) J:193389 Ding G, et al., PDGF Receptor Alpha+ Mesoderm Contributes to Endothelial and Hematopoietic Cells in Mice. Dev Dyn. 2013 Mar;242(3):254-68
All references(529)

Other accession IDs

MGD-MRK-11605, MGD-MRK-11606, MGD-MRK-9826, MGD-MRK-9828, MGI:95555