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Kdr Gene Detail
Summary
  • Symbol
    Kdr
  • Name
    kinase insert domain protein receptor
  • Synonyms
    Flk1, Flk-1, orv, vascular endothelial growth factor receptor- 2, VEGFR2, VEGFR-2, VEGF receptor-2
  • Feature Type
    protein coding gene
  • IDs
    MGI:96683
    NCBI Gene: 16542
  • Gene Overview
    MyGene.info: KDR
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:75932827-75978458 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 5, 40.23 cM
  • Mapping Data
    8 experiments
Strain
Comparison
more
  • SNPs within 2kb
    223 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_96683
protein coding gene Chr5:75932827-75979074 (-)
129S1/SvImJ MGP_129S1SvImJ_G0029639
protein coding gene Chr5:76105867-76152652 (-)
A/J MGP_AJ_G0029607
protein coding gene Chr5:73195890-73241935 (-)
AKR/J MGP_AKRJ_G0029555
protein coding gene Chr5:75578596-75623933 (-)
BALB/cJ MGP_BALBcJ_G0029616
protein coding gene Chr5:73918076-73964082 (-)
C3H/HeJ MGP_C3HHeJ_G0029339
protein coding gene Chr5:75965056-76011465 (-)
C57BL/6NJ MGP_C57BL6NJ_G0030070
protein coding gene Chr5:79160881-79210489 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0027311
protein coding gene Chr5:68864705-68909947 (-)
CAST/EiJ MGP_CASTEiJ_G0028747
protein coding gene Chr5:75124990-75172990 (-)
CBA/J MGP_CBAJ_G0029308
protein coding gene Chr5:81727995-81776818 (-)
DBA/2J MGP_DBA2J_G0029453
protein coding gene Chr5:73273735-73319659 (-)
FVB/NJ MGP_FVBNJ_G0029414
protein coding gene Chr5:72435976-72481493 (-)
LP/J MGP_LPJ_G0029540
protein coding gene Chr5:76525274-76573961 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0029442
protein coding gene Chr5:84933924-84980837 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0030103
protein coding gene Chr5:75136696-75184118 (-)
PWK/PhJ MGP_PWKPhJ_G0028470
protein coding gene Chr5:72275191-72321669 (-)
SPRET/EiJ MGP_SPRETEiJ_G0028305
protein coding gene Chr5:74461866-74528676 (-)
WSB/EiJ MGP_WSBEiJ_G0028827
protein coding gene Chr5:75429423-75475718 (-)



Homology
more
  • Human Ortholog
    KDR, kinase insert domain receptor
  • Vertebrate Orthologs
    10
  • Human Ortholog
    KDR, kinase insert domain receptor
    Orthology source: HGNC, HomoloGene
  • Synonyms
    CD309, FLK1, VEGFR, VEGFR2
  • Links
    NCBI Gene ID: 3791
    neXtProt AC: NX_P35968
    UniProt: P35968

  • Chr Location
    4q12; chr4:55078259-55125595 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    59 phenotypes from 15 alleles in 17 genetic backgrounds
    46 phenotypes from multigenic genotypes
    8 images
    157 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous mice die at early embryonic stages due to failure of blood vessel formation.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
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    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000062960 Ensembl Gene Model | MGI Sequence Detail 45632 C57BL/6J ±  kb
    transcript ENSMUST00000113516 Ensembl | MGI Sequence Detail 5924 Not Applicable  
    polypeptide ENSMUSP00000109144 Ensembl | MGI Sequence Detail 1345 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 148
      Genomic 8
      cDNA 117
      Primer pair 22
      Other 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-11605, MGD-MRK-11606, MGD-MRK-9826, MGD-MRK-9828, MGI:5004964, MGI:95555
    References
    more
    • Summaries
      All 805
      Developmental Gene Expression 513
      Gene Ontology 38
      Phenotypes 157
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:266598 Ustiyan V, et al., FOXF1 transcription factor promotes lung morphogenesis by inducing cellular proliferation in fetal lung mesenchyme. Dev Biol. 2018 Nov 1;443(1):50-63

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    12/04/2018
    MGI 6.13
    The Jackson Laboratory