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Kdr Gene Detail
Summary
  • Symbol
    Kdr
  • Name
    kinase insert domain protein receptor
  • Synonyms
    Flk1, Flk-1, vascular endothelial growth factor receptor- 2, VEGFR2, VEGFR-2, VEGF receptor-2
  • Feature Type
    protein coding gene
  • IDs
    MGI:96683
    NCBI Gene: 16542
  • Gene Overview
    MyGene.info: KDR
Location & Maps
more
  • Sequence Map
    Chr5:75932827-75978458 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      45632 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 5, 40.23 cM
  • Mapping Data
    8 experiments
Homology
more
  • Human Ortholog
    KDR, kinase insert domain receptor
  • Vertebrate Orthologs
    10
  • Human Ortholog
    KDR, kinase insert domain receptor
    Orthology source: HGNC, HomoloGene
  • Synonyms
    CD309, FLK1, VEGFR, VEGFR2
  • Links
    NCBI Gene ID: 3791
    neXtProt AC: NX_P35968

  • Chr Location
    4q11-q12; chr4:55078259-55125595 (-)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with human KDR associations

Human Disease Mouse Models
       Hemangioma, Capillary Infantile   OMIM: 602089
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    49 phenotypes from 14 alleles in 16 genetic backgrounds
    46 phenotypes from multigenic genotypes
    3 images
    124 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    23
  • Chemically induced (other)
    2
  • Radiation induced
    1
  • Spontaneous
    1
  • Targeted
    18
  • Transgenic
    1
  • Genomic Mutations
    4 involving Kdr
  • Incidental Mutations
Homozygous mice die at early embryonic stages due to failure of blood vessel formation.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000021297 VEGA Gene Model | MGI Sequence Detail 45632 C57BL/6J ±  kb
transcript OTTMUST00000050493 VEGA | MGI Sequence Detail 5924 Not Applicable  
polypeptide OTTMUSP00000023578 VEGA | MGI Sequence Detail 1345 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    223 from dbSNP Build 142
  • RFLP
Protein
Information
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  • UniProt
    4 Sequences
  • Protein Ontology
    PR:000002112 vascular endothelial growth factor receptor 2
  • EC
  • InterPro Domains
    IPR013098 Immunoglobulin I-set
    IPR007110 Immunoglobulin-like domain
    IPR013783 Immunoglobulin-like fold
    IPR003599 Immunoglobulin subtype
    IPR003598 Immunoglobulin subtype 2
    IPR017441 Protein kinase, ATP binding site
    IPR000719 Protein kinase domain
    IPR011009 Protein kinase-like domain
    IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
    IPR008266 Tyrosine-protein kinase, active site
    IPR020635 Tyrosine-protein kinase, catalytic domain
    IPR016243 Tyrosine-protein kinase, CSF-1/PDGF receptor family
    IPR001824 Tyrosine-protein kinase, receptor class III, conserved site
    IPR009136 Vascular endothelial growth factor receptor 2 (VEGFR2)
Molecular
Reagents
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  • All nucleic 143
    Genomic 8
    cDNA 115
    Primer pair 19
    Other 1

    Microarray probesets 3
Other
Accession IDs
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MGD-MRK-11605, MGD-MRK-11606, MGD-MRK-9826, MGD-MRK-9828, MGI:95555
References
more
  • Summaries
    All 635
    Developmental Gene Expression 454
    Gene Ontology 34
    Phenotypes 124
  • Earliest
    J:1615 Matthews W, et al., A receptor tyrosine kinase cDNA isolated from a population of enriched primitive hematopoietic cells and exhibiting close genetic linkage to c-kit. Proc Natl Acad Sci U S A. 1991 Oct 15;88(20):9026-30
  • Latest
    J:232444 Li S, et al., Ggnbp2 Is Essential for Pregnancy Success via Regulation of Mouse Trophoblast Stem Cell Proliferation and Differentiation. Biol Reprod. 2016 Feb;94(2):41

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/23/2016
MGI 6.05
The Jackson Laboratory