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Kcnc1 Gene Detail
Summary
  • Symbol
    Kcnc1
  • Name
    potassium voltage gated channel, Shaw-related subfamily, member 1
  • Synonyms
    C230009H10Rik, Kcr2-1, KShIIIB, Kv3.1, KV4, NGK2, Shaw
  • Feature Type
    protein coding gene
  • IDs
    MGI:96667
    NCBI Gene: 16502
  • Gene Overview
    MyGene.info: KCNC1
  • Alliance
    gene page
  • Transcription Start Sites
    15 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:46396497-46438704 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 30.10 cM
  • Mapping Data
    9 experiments
Strain
Comparison
more
  • SNPs within 2kb
    405 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    3
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_96667
 protein coding gene Chr7:46396219-46438706 (+)
129S1/SvImJ MGP_129S1SvImJ_G0032264
 protein coding gene Chr7:46768646-46810585 (+)
A/J MGP_AJ_G0032243
 protein coding gene Chr7:45803029-45844757 (+)
AKR/J MGP_AKRJ_G0032179
 protein coding gene Chr7:47097520-47142183 (+)
BALB/cJ MGP_BALBcJ_G0032255
 protein coding gene Chr7:45809502-45852469 (+)
C3H/HeJ MGP_C3HHeJ_G0031970
 protein coding gene Chr7:47595592-47637421 (+)
C57BL/6NJ MGP_C57BL6NJ_G0032747
 protein coding gene Chr7:49042103-49084029 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0029761
 protein coding gene Chr7:48355344-48397002 (+)
CAST/EiJ MGP_CASTEiJ_G0031298
 protein coding gene Chr7:39027852-39072679 (+)
CBA/J MGP_CBAJ_G0031935
 protein coding gene Chr7:50679607-50721293 (+)
DBA/2J MGP_DBA2J_G0032092
 protein coding gene Chr7:45499197-45541047 (+)
FVB/NJ MGP_FVBNJ_G0032044
 protein coding gene Chr7:45284658-45327706 (+)
LP/J MGP_LPJ_G0032171
 protein coding gene Chr7:47463545-47505343 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0032081
 protein coding gene Chr7:49312415-49356345 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0032762
 protein coding gene Chr7:46312790-46354660 (+)
PWK/PhJ MGP_PWKPhJ_G0031021
 protein coding gene Chr7:38866095-38908908 (+)
SPRET/EiJ MGP_SPRETEiJ_G0030859
 protein coding gene Chr7:34330192-34371812 (+)
WSB/EiJ MGP_WSBEiJ_G0031416
 protein coding gene Chr7:46811956-46857083 (+)



Homology
more
  • Human Ortholog
    KCNC1, potassium voltage-gated channel subfamily C member 1
  • Vertebrate Orthologs
    9
  • Human Ortholog
    KCNC1, potassium voltage-gated channel subfamily C member 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    EPM7, KV3.1, KV4, NGK2
  • Links
    NCBI Gene ID: 3746
    neXtProt AC: NX_P48547
    UniProt: P48547

  • Chr Location
    11p15.1; chr11:17734810-17783055 (+)  GRCh38.p7
Human Diseases
more
  • Diseases
    1 with human KCNC1 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    17 phenotypes from multigenic genotypes
    21 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    49
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    662
  • Tissues
    19
  • cDNA Data
    52
  • Literature Summary
    13
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000058975 Ensembl Gene Model | MGI Sequence Detail 42208 C57BL/6J ±  kb
transcript ENSMUST00000160433 Ensembl | MGI Sequence Detail 3156 Not Applicable  
polypeptide ENSMUSP00000124938 Ensembl | MGI Sequence Detail 585 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 56
    cDNA 53
    Primer pair 3

    Microarray probesets 8
Other
Accession IDs
less
MGD-MRK-11571, MGD-MRK-11580, MGD-MRK-14399, MGI:2443956
References
more
  • Summaries
    All 80
    Developmental Gene Expression 13
    Gene Ontology 9
    Phenotypes 21
  • Earliest
    J:40342 Yokoyama S, et al., Potassium channels from NG108-15 neuroblastoma-glioma hybrid cells. Primary structure and functional expression from cDNAs. FEBS Lett. 1989 Dec 18;259(1):37-42
  • Latest
    J:269845 Rowan MJM, et al., Rapid State-Dependent Alteration in Kv3 Channel Availability Drives Flexible Synaptic Signaling Dependent on Somatic Subthreshold Depolarization. Cell Rep. 2017 Feb 21;18(8):2018-2029
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
05/19/2020
MGI 6.15 		The Jackson Laboratory