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Kcnc1
Gene Detail
 Symbol
Name
ID
Kcnc1
potassium voltage gated channel, Shaw-related subfamily, member 1
MGI:96667
Synonyms C230009H10Rik, Kcr2-1, KShIIIB, Kv3.1, KV4, NGK2, Shaw
Feature Type protein coding gene
Genetic Map
Chromosome 7
30.10 cM
Detailed Genetic Map ± 1 cM


Mapping data(9)
Sequence Map
Chr7:46396497-46438375 bp, + strand
From VEGA annotation of GRCm38

  41879 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:68134  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: potassium voltage-gated channel, alpha subunit, subfamilies A/C/D/F/G/S
Gene Tree: Kcnc1

Human
homologs
Human Homolog KCNC1, potassium voltage-gated channel, Shaw-related subfamily, member 1
NCBI Gene ID 3746
neXtProt AC  NX_P48547
Human Synonyms  KV3.1, KV4, NGK2
Human Chr (Location)  11p15; chr11:17735948-17783055 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Targeted(3)
Incidental mutations (data from APF )
Interactions
Kcnc1 interacts with 436 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (23 annotations)
Process ion transport, potassium ion transmembrane transport, ...
Component axolemma, dendrite membrane, ...
Function delayed rectifier potassium channel activity, ion channel activity, ...
External Resources: FuncBase
Expression
Literature Summary: (9 records)
Data Summary: Results (11)    Tissues (9)   
Theiler Stages: 25, 28
Assay TypeResults
RT-PCR 11
cDNA source data(48)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(52) cDNA(49) Primer pair(3)
Microarray probesets(8)
Other database
links
VEGA Gene ModelOTTMUSG00000034762 (Evidence)
Ensembl Gene ModelENSMUSG00000058975 (Evidence)
Entrez Gene16502 (Evidence)
UniGene249386
DFCITC1583264, TC1584536, TC1642025, TC1647751, TC1661289, TC1672275
DoTSDT.487916, DT.55283062, DT.91327098, DT.94245452
NIA Mouse Gene IndexU008103
Consensus CDS ProjectCCDS21278.1, CCDS52252.1
International Mouse Knockout Project StatusKcnc1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000034762 VEGA Gene Model | MGI Sequence Detail 41879 C57BL/6J ±  kb
transcript OTTMUST00000088338 VEGA | MGI Sequence Detail 2827 Not Applicable 
polypeptide OTTMUSP00000048127 VEGA | MGI Sequence Detail 585 Not Applicable 

For the selected sequences
All sequences(60) RefSeq(11) UniProt(5)
Polymorphisms RFLP(3) : SNPs within 2kb(407 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR011333 BTB/POZ fold
InterPro IPR000210 BTB/POZ-like
InterPro IPR005821 Ion transport domain
InterPro IPR003131 Potassium channel tetramerisation-type BTB domain
InterPro IPR003968 Potassium channel, voltage dependent, Kv
InterPro IPR003974 Potassium channel, voltage dependent, Kv3
InterPro IPR005403 Potassium channel, voltage dependent, Kv3.1
InterPro IPR003091 Voltage-dependent potassium channel
InterPro IPR027359 Voltage-dependent potassium channel, four helix bundle domain
Protein Ontology PR:000000781 voltage-gated potassium channel KCNC1
References (Earliest) J:40342 Yokoyama S, et al., Potassium channels from NG108-15 neuroblastoma-glioma hybrid cells. Primary structure and functional expression from cDNAs. FEBS Lett. 1989 Dec 18;259(1):37-42
(Latest) J:205051 Miller JA, et al., Conserved molecular signatures of neurogenesis in the hippocampal subgranular zone of rodents and primates. Development. 2013 Nov;140(22):4633-44
All references(72)
Other
accession IDs
MGD-MRK-11571, MGD-MRK-11580, MGD-MRK-14399, MGI:2443956

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
07/23/2014
MGI 5.19
The Jackson Laboratory