Kcnc1
Gene Detail

Symbol Name ID

Kcnc1 potassium voltage gated channel, Shaw-related subfamily, member 1 MGI:96667

Synonyms

C230009H10Rik, Kcr2-1, KShIIIB, Kv3.1, KV4, NGK2, Shaw

Feature Type

protein coding gene

Genetic Map

Chromosome 7

30.10 cM
Detailed Genetic Map ± 1 cM


Mapping data(9)

Sequence Map

Chr7:46396497-46438375 bp, + strand From VEGA annotation of GRCm38   41879 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:68134  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: potassium voltage-gated channel, alpha subunit, subfamilies A/C/D/F/G/S
Gene Tree: Kcnc1

Human homologs

Human Homolog		KCNC1, potassium voltage-gated channel, Shaw-related subfamily, member 1
NCBI Gene ID		3746
neXtProt AC		NX_P48547
Human Synonyms		KV3.1, KV4, NGK2
Human Chr (Location)		11p15; chr11:17735948-17783055 (+)  GRCh38

Mutations, alleles, and phenotypes

All mutations/alleles(3) : Targeted(3)
Incidental mutations (data from APF )

Interactions

Kcnc1 interacts with 436 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)

View All

Gene Ontology (GO) classifications

All GO classifications: (23 annotations)

Process	ion transport, potassium ion transmembrane transport, ...
Component	axolemma, dendrite membrane, ...
Function	delayed rectifier potassium channel activity, ion channel activity, ...

External Resources: FuncBase

Expression

Literature Summary: (9 records)

Data Summary: Results (11)    Tissues (9)   
Theiler Stages: 25, 28

Assay Type	Results
RT-PCR	11

cDNA source data(48)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas

Molecular reagents

All nucleic(52) cDNA(49) Primer pair(3)
Microarray probesets(8)

Other database links

VEGA Gene Model	OTTMUSG00000034762 (Evidence)
Ensembl Gene Model	ENSMUSG00000058975 (Evidence)
Entrez Gene	16502 (Evidence)
UniGene	249386
DFCI	TC1583264, TC1584536, TC1642025, TC1647751, TC1661289, TC1672275
DoTS	DT.487916, DT.55283062, DT.91327098, DT.94245452
NIA Mouse Gene Index	U008103
Consensus CDS Project	CCDS21278.1, CCDS52252.1
International Mouse Knockout Project Status	Kcnc1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000034762	VEGA Gene Model | MGI Sequence Detail	41879	C57BL/6J
transcript	OTTMUST00000088338	VEGA | MGI Sequence Detail	2827	Not Applicable
polypeptide	OTTMUSP00000048127	VEGA | MGI Sequence Detail	585	Not Applicable

All sequences(60) RefSeq(11) UniProt(5)

Polymorphisms

RFLP(3) : SNPs within 2kb(407 from dbSNP Build 137)

Protein-related information

Resource	ID	Description
InterPro	IPR011333	BTB/POZ fold
InterPro	IPR000210	BTB/POZ-like
InterPro	IPR005821	Ion transport domain
InterPro	IPR003131	Potassium channel tetramerisation-type BTB domain
InterPro	IPR003968	Potassium channel, voltage dependent, Kv
InterPro	IPR003974	Potassium channel, voltage dependent, Kv3
InterPro	IPR005403	Potassium channel, voltage dependent, Kv3.1
InterPro	IPR003091	Voltage-dependent potassium channel
InterPro	IPR027359	Voltage-dependent potassium channel, four helix bundle domain
Protein Ontology	PR:000000781	voltage-gated potassium channel KCNC1

References

(Earliest) J:40342 Yokoyama S, et al., Potassium channels from NG108-15 neuroblastoma-glioma hybrid cells. Primary structure and functional expression from cDNAs. FEBS Lett. 1989 Dec 18;259(1):37-42
(Latest) J:205051 Miller JA, et al., Conserved molecular signatures of neurogenesis in the hippocampal subgranular zone of rodents and primates. Development. 2013 Nov;140(22):4633-44
All references(72)

Other accession IDs

MGD-MRK-11571, MGD-MRK-11580, MGD-MRK-14399, MGI:2443956