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Kcnc1 Gene Detail
Summary
  • Symbol
    Kcnc1
  • Name
    potassium voltage gated channel, Shaw-related subfamily, member 1
  • Synonyms
    C230009H10Rik, Kcr2-1, KShIIIB, Kv3.1, KV4, NGK2, Shaw
  • Feature Type
    protein coding gene
  • IDs
    MGI:96667
    NCBI Gene: 16502
  • Gene Overview
    MyGene.info: KCNC1
Location & Maps
more
  • Sequence Map
    Chr7:46396497-46438375 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      41879 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 30.10 cM
  • Detailed Genetic Map ± 1 cM
  • Mapping Data
    9 experiments
Homology
more
  • Human Ortholog
    KCNC1, potassium voltage-gated channel subfamily C member 1
  • Vertebrate Orthologs
    9
  • Human Ortholog
    KCNC1, potassium voltage-gated channel subfamily C member 1
    Orthology source: HGNC, HomoloGene
  • Synonyms
    EPM7, KV3.1, KV4, NGK2
  • Links
    NCBI Gene ID: 3746
    neXtProt AC: NX_P48547

  • Chr Location
    11p15; chr11:17735910-17864288 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with human KCNC1 associations

Human Disease Mouse Models
       Epilepsy, Progressive Myoclonic 7; EPM7   OMIM: 616187
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    17 phenotypes from multigenic genotypes
    19 phenotype references
  • All Mutations and Alleles
    3
  • Targeted
    3
  • Incidental Mutations
    APF , CvDC
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000034762 VEGA Gene Model | MGI Sequence Detail 41879 C57BL/6J ±  kb
transcript OTTMUST00000088338 VEGA | MGI Sequence Detail 2827 Not Applicable  
polypeptide OTTMUSP00000048127 VEGA | MGI Sequence Detail 585 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    405 from dbSNP Build 142
  • RFLP
Protein
Information
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  • UniProt
    5 Sequences
  • Protein Ontology
    PR:000000781 voltage-gated potassium channel KCNC1
  • InterPro Domains
    IPR000210 BTB/POZ domain
    IPR005821 Ion transport domain
    IPR003131 Potassium channel tetramerisation-type BTB domain
    IPR003968 Potassium channel, voltage dependent, Kv
    IPR003974 Potassium channel, voltage dependent, Kv3
    IPR005403 Potassium channel, voltage dependent, Kv3.1
    IPR011333 SKP1/BTB/POZ domain
    IPR027359 Voltage-dependent channel, four helix bundle domain
    IPR028325 Voltage-gated potassium channel
Molecular
Reagents
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  • All nucleic 52
    cDNA 49
    Primer pair 3

    Microarray probesets 8
Other
Accession IDs
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MGD-MRK-11571, MGD-MRK-11580, MGD-MRK-14399, MGI:2443956
References
more
  • Summaries
    All 70
    Developmental Gene Expression 10
    Gene Ontology 9
    Phenotypes 19
  • Earliest
    J:40342 Yokoyama S, et al., Potassium channels from NG108-15 neuroblastoma-glioma hybrid cells. Primary structure and functional expression from cDNAs. FEBS Lett. 1989 Dec 18;259(1):37-42
  • Latest
    J:218988 Smith KM, et al., Fgfr1 inactivation in the mouse telencephalon results in impaired maturation of interneurons expressing parvalbumin. PLoS One. 2014;9(8):e103696

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
05/24/2016
MGI 6.04
The Jackson Laboratory