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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Kcnc1
potassium voltage gated channel, Shaw-related subfamily, member 1
MGI:96667
26 phenotypes from 2 alleles in 2 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Kcnc1em1Emgol/Kcnc1+
C57BL/6J-Kcnc1em1Emgol 		abnormal action potential J:378003
abnormal afterhyperpolarization J:378003
ataxia J:378003
audiogenic seizures J:378003
normal behavior/neurological phenotype J:378003
decreased single cell response intensity J:378003
normal growth/size/body region phenotype J:378003
impaired synaptic plasticity J:378003
increased susceptibility to pharmacologically induced seizures J:378003
increased synaptic depression J:378003
limb grasping J:378003
seizures J:378003
sporadic seizures J:378003
Kcnc1em1Emgol/Kcnc1em1Emgol
C57BL/6J-Kcnc1em1Emgol 		postnatal lethality, complete penetrance J:378003
Kcnc1tm1Emgol/Kcnc1+
Tg(Pvalb-tdTomato)15Gfng/0
Tmem163Tg(ACTB-cre)2Mrt/Tmem163+
involves: C57BL/6J * C57BL/6N * C57BL/6NTac * FVB/N 		abnormal GABAergic neuron physiology J:386140
normal behavior/neurological phenotype J:386140
convulsive seizures J:386140
decreased body weight J:386140
decreased brain weight J:386140
decreased paired-pulse facilitation J:386140
facial muscle spasm J:386140
normal growth/size/body region phenotype J:386140
impaired spatial learning J:386140
impaired spatial working memory J:386140
increased inhibitory postsynaptic current amplitude J:386140
lethality, complete penetrance J:386140
myoclonus J:386140
normal nervous system phenotype J:386140
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
05/19/2026
MGI 6.24 		The Jackson Laboratory