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Kcna2 Gene Detail
Summary
  • Symbol
    Kcna2
  • Name
    potassium voltage-gated channel, shaker-related subfamily, member 2
  • Synonyms
    Akr6a4, Kca1-2, Kv1.2, Mk-2
  • Feature Type
    protein coding gene
  • IDs
    MGI:96659
    NCBI Gene: 16490
  • Gene Overview
    MyGene.info: KCNA2
  • Alliance
  • Transcription Start Sites
    10 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:107101146-107115005 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 3, 46.61 cM
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    77 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_96659
protein coding gene Chr3:107090852-107115005 (.)
129S1/SvImJ MGP_129S1SvImJ_G0027740
protein coding gene Chr3:108571249-108586068 (+)
A/J MGP_AJ_G0027700
protein coding gene Chr3:105131386-105145339 (+)
AKR/J MGP_AKRJ_G0027665
protein coding gene Chr3:107701773-107717477 (+)
BALB/cJ MGP_BALBcJ_G0027712
protein coding gene Chr3:104828382-104838186 (+)
C3H/HeJ MGP_C3HHeJ_G0027442
protein coding gene Chr3:108044548-108058329 (+)
C57BL/6NJ MGP_C57BL6NJ_G0028156
protein coding gene Chr3:112650611-112666701 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0025494
protein coding gene Chr3:101286510-101300280 (+)
CAST/EiJ MGP_CASTEiJ_G0026898
protein coding gene Chr3:107404251-107418177 (+)
CBA/J MGP_CBAJ_G0027417
protein coding gene Chr3:116437842-116457234 (+)
DBA/2J MGP_DBA2J_G0027559
protein coding gene Chr3:104334708-104348467 (+)
FVB/NJ MGP_FVBNJ_G0027527
protein coding gene Chr3:102214637-102224385 (+)
LP/J MGP_LPJ_G0027666
protein coding gene Chr3:109990563-110005224 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0027557
protein coding gene Chr3:122571508-122586476 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0028211
protein coding gene Chr3:107283511-107293287 (+)
PWK/PhJ MGP_PWKPhJ_G0026624
protein coding gene Chr3:104054931-104064669 (+)
SPRET/EiJ MGP_SPRETEiJ_G0026444
protein coding gene Chr3:105425989-105434168 (+)
WSB/EiJ MGP_WSBEiJ_G0026978
protein coding gene Chr3:107818878-107832796 (+)



Homology
more
  • Human Ortholog
    KCNA2, potassium voltage-gated channel subfamily A member 2
  • Vertebrate Orthologs
    10
  • Human Ortholog
    KCNA2, potassium voltage-gated channel subfamily A member 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    EIEE32, HBK5, HK4, HUKIV, KV1.2, MK2, NGK1, RBK2
  • Links
    NCBI Gene ID: 3737
    neXtProt AC: NX_P16389
    UniProt: P16389

  • Chr Location
    1p13.3; chr1:110593580-110631536 (-)  GRCh38.p7

Human Diseases
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  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    29 phenotypes from 2 alleles in 4 genetic backgrounds
    1 images
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit postnatal lethality, increased susceptibility to spontaneous and chemically-induced seizures and altered neuron electrophysiology. Mice homozygous for an ENU-induced allele exhibit abnormal gait, impaired coordination, and premature lethality.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000040724 Ensembl Gene Model | MGI Sequence Detail 13860 C57BL/6J ±  kb
    transcript ENSMUST00000197470 Ensembl | MGI Sequence Detail 4370 Not Applicable  
    polypeptide ENSMUSP00000143798 Ensembl | MGI Sequence Detail 499 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 52
      Genomic 6
      cDNA 44
      Primer pair 1
      Other 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-11555, MGD-MRK-11563, MGD-MRK-12249
    References
    more
    • Summaries
      All 70
      Developmental Gene Expression 11
      Diseases 1
      Gene Ontology 18
      Phenotypes 12
    • Earliest
      J:40342 Yokoyama S, et al., Potassium channels from NG108-15 neuroblastoma-glioma hybrid cells. Primary structure and functional expression from cDNAs. FEBS Lett. 1989 Dec 18;259(1):37-42
    • Latest
      J:256225 Sergaki MC, et al., Compromised Survival of Cerebellar Molecular Layer Interneurons Lacking GDNF Receptors GFRalpha1 or RET Impairs Normal Cerebellar Motor Learning. Cell Rep. 2017 Jun 6;19(10):1977-1986

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory