Kcna2
Gene Detail

Symbol Name ID

Kcna2 potassium voltage-gated channel, shaker-related subfamily, member 2 MGI:96659

Synonyms

Akr6a4, Kca1-2, Kv1.2, Mk-2

Feature Type

protein coding gene

Genetic Map

Chromosome 3

46.61 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)

Sequence Map

Chr3:107101567-107106879 bp, + strand From Ensembl annotation of GRCm38   5313 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:21034  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: potassium voltage-gated channel, alpha subunit, subfamilies A/C/D/F/G/S
Gene Tree: Kcna2

Human homologs

Human Homolog		KCNA2, potassium voltage-gated channel, shaker-related subfamily, member 2
NCBI Gene ID		3737
neXtProt AC		NX_P16389
Human Synonyms		HBK5, HK4, HUKIV, KV1.2, MK2, NGK1, RBK2
Human Chr (Location)		1p13; chr1:111136202-111174096 (-)  GRCh37.p10

Alleles and phenotypes

All alleles(5) : Targeted(4) Chemically induced(1)
 

Mice homozygous for a null allele exhibit postnatal lethality, increased susceptibility to spontaneous and chemically-induced seizures and altered neuron electrophysiology. Mice homozygous for an ENU-induced allele exhibit abnormal gait, impaired coordination, and premature lethality.

 

Gene Ontology (GO) classifications

All GO classifications: (28 annotations)

Process	ion transmembrane transport, ion transport, ...
Component	integral to membrane, juxtaparanode region of axon, ...
Function	delayed rectifier potassium channel activity, ion channel activity, ...

External Resources: FuncBase

Expression

Literature Summary: (7 records)
Data Summary: Results (38)    Tissues (37)    Images (5)
Theiler Stages: 13, 19, 20, 22, 24, 25, 28

Assay Type	Results
RNA in situ	35
RT-PCR	3

cDNA source data(10)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(19) Genomic(6) cDNA(11) Primer pair(1) Other(1)
Microarray probesets(3)

Other database links

Ensembl Gene Model	ENSMUSG00000040724 (Evidence)
Entrez Gene	16490 (Evidence)
DFCI	TC1588112
DoTS	DT.101357616, DT.55249363
NIA Mouse Gene Index	U003711, U042469, U350592
Consensus CDS Project	CCDS17733.1
International Mouse Knockout Project Status	Kcna2

Sequences

Length	Strain/Species
genomic	ENSMUSG00000040724	Ensembl Gene Model | MGI Sequence Detail	5313	C57BL/6J
transcript	ENSMUST00000038695	Ensembl | MGI Sequence Detail	3456	Not Applicable
polypeptide	ENSMUSP00000041702	Ensembl | MGI Sequence Detail	499	Not Applicable

All sequences(23) RefSeq(2) UniProt(3)

Polymorphisms

RFLP(2) : SNPs(7 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR011333	BTB/POZ fold
InterPro	IPR000210	BTB/POZ-like
InterPro	IPR005821	Ion transport domain
InterPro	IPR003131	Potassium channel tetramerisation-type BTB domain
InterPro	IPR003968	Potassium channel, voltage dependent, Kv
InterPro	IPR003972	Potassium channel, voltage dependent, Kv1
InterPro	IPR004049	Potassium channel, voltage dependent, Kv1.2
InterPro	IPR003091	Voltage-dependent potassium channel
Protein Ontology	PR:000000810	voltage-gated potassium channel subunit KCNA2

References

(Earliest) J:40342 Yokoyama S, et al., Potassium channels from NG108-15 neuroblastoma-glioma hybrid cells. Primary structure and functional expression from cDNAs. FEBS Lett. 1989 Dec 18;259(1):37-42
(Latest) J:184972 Zenker J, et al., Altered distribution of juxtaparanodal kv1.2 subunits mediates peripheral nerve hyperexcitability in type 2 diabetes mellitus. J Neurosci. 2012 May 30;32(22):7493-8
All references(55)

Other accession IDs

MGD-MRK-11555, MGD-MRK-11563, MGD-MRK-12249