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Kcna2
Gene Detail
 Symbol
Name
ID
Kcna2
potassium voltage-gated channel, shaker-related subfamily, member 2
MGI:96659
Synonyms Akr6a4, Kca1-2, Kv1.2, Mk-2
Feature Type protein coding gene
Genetic Map
Chromosome 3
46.61 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr3:107101567-107106879 bp, + strand
From Ensembl annotation of GRCm38

  5313 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:21034  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: potassium voltage-gated channel, alpha subunit, subfamilies A/C/D/F/G/S
Gene Tree: Kcna2

Human
homologs
Human Homolog KCNA2, potassium voltage-gated channel, shaker-related subfamily, member 2
NCBI Gene ID 3737
neXtProt AC  NX_P16389
Human Synonyms  HBK5, HK4, HUKIV, KV1.2, MK2, NGK1, RBK2
Human Chr (Location)  1p13; chr1:110593580-110631474 (-)  GRCh38
Alleles
and
phenotypes
All alleles(5) : Targeted(4) Chemically induced(1)
 
Mice homozygous for a null allele exhibit postnatal lethality, increased susceptibility to spontaneous and chemically-induced seizures and altered neuron electrophysiology. Mice homozygous for an ENU-induced allele exhibit abnormal gait, impaired coordination, and premature lethality.
 
Phenotype Images(1)
Gene Ontology
(GO)
classifications
All GO classifications: (26 annotations)
Process ion transport, optic nerve structural organization, ...
Component integral component of membrane, juxtaparanode region of axon, ...
Function delayed rectifier potassium channel activity, ion channel activity, ...
External Resources: FuncBase
Expression
Literature Summary: (7 records)
Data Summary: Results (38)    Tissues (37)    Images (5)
Theiler Stages: 13, 19, 20, 22, 24, 25, 28
Assay TypeResults
RNA in situ 35
RT-PCR 3
cDNA source data(41)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(50) Genomic(6) cDNA(42) Primer pair(1) Other(1)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000040724 (Evidence)
Entrez Gene16490 (Evidence)
UniGene39285
DFCITC1588112
DoTSDT.101357616, DT.55249363
NIA Mouse Gene IndexU003711, U042469, U350592
Consensus CDS ProjectCCDS17733.1
International Mouse Knockout Project StatusKcna2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000040724 Ensembl Gene Model | MGI Sequence Detail 5313 C57BL/6J ±  kb
transcript ENSMUST00000038695 Ensembl | MGI Sequence Detail 3456 Not Applicable 
polypeptide ENSMUSP00000041702 Ensembl | MGI Sequence Detail 499 Not Applicable 

For the selected sequences
All sequences(39) RefSeq(18) UniProt(3)
Polymorphisms RFLP(2) : SNPs within 2kb(46 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR011333 BTB/POZ fold
InterPro IPR000210 BTB/POZ-like
InterPro IPR005821 Ion transport domain
InterPro IPR003131 Potassium channel tetramerisation-type BTB domain
InterPro IPR003968 Potassium channel, voltage dependent, Kv
InterPro IPR003972 Potassium channel, voltage dependent, Kv1
InterPro IPR004049 Potassium channel, voltage dependent, Kv1.2
InterPro IPR003091 Voltage-dependent potassium channel
InterPro IPR027359 Voltage-dependent potassium channel, four helix bundle domain
Protein Ontology PR:000000810 voltage-gated potassium channel subunit KCNA2
References (Earliest) J:40342 Yokoyama S, et al., Potassium channels from NG108-15 neuroblastoma-glioma hybrid cells. Primary structure and functional expression from cDNAs. FEBS Lett. 1989 Dec 18;259(1):37-42
(Latest) J:197477 Kourrich S, et al., Dynamic interaction between sigma-1 receptor and Kv1.2 shapes neuronal and behavioral responses to cocaine. Cell. 2013 Jan 17;152(1-2):236-47
All references(57)
Other
accession IDs
MGD-MRK-11555, MGD-MRK-11563, MGD-MRK-12249

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/08/2014
MGI 5.17
The Jackson Laboratory