Kcna2 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Kcna2
potassium voltage-gated channel, shaker-related subfamily, member 2
MGI:96659

31 phenotypes from 4 alleles in 6 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Kcna2^em1(IMPC)H/Kcna2⁺ C57BL/6NTac-Kcna2^em1(IMPC)H/H	increased neutrophil cell number	J:211773
Kcna2^em1(IMPC)H/Kcna2^em1(IMPC)H C57BL/6NTac-Kcna2^em1(IMPC)H/H	preweaning lethality, complete penetrance	J:211773
Kcna2^m1Btlr/Kcna2^m1Btlr C57BL/6J-Kcna2^m1Btlr	premature death	J:274750
Kcna2^Pgu/Kcna2⁺ involves: C3H/HeJ * C57BL/6J	abnormal gait	J:166795
	abnormal inhibitory postsynaptic currents	J:166795
	abnormal miniature inhibitory postsynaptic currents	J:166795
	abnormal posture	J:166795
	abnormal single cell response	J:166795
	ataxia	J:166795
	decreased body size	J:166795
	decreased body weight	J:166795
	decreased grip strength	J:166795
	impaired ability to fire action potentials	J:166795
	impaired coordination	J:166795
	limb grasping	J:166795
	long stride length	J:166795
	tremors	J:166795
Kcna2^Pgu/Kcna2^Pgu involves: C3H/HeJ * C57BL/6J	abnormal gait	J:166795
	abnormal inhibitory postsynaptic currents	J:166795
	abnormal miniature inhibitory postsynaptic currents	J:166795
	abnormal posture	J:166795
	abnormal single cell response	J:166795
	ataxia	J:166795
	decreased body size	J:166795
	decreased body weight	J:166795
	decreased grip strength	J:166795
	impaired ability to fire action potentials	J:166795
	impaired coordination	J:166795
	normal nervous system phenotype	J:166795
	postnatal growth retardation	J:166795
	postnatal lethality	J:166795
	premature death	J:166795
	tremors	J:166795
Kcna2^tm1Tem/Kcna2⁺ C3Fe.129S7-Kcna2^tm1Tem	impaired ability to fire action potentials	J:131735
Kcna2^tm1Tem/Kcna2⁺ C3Fe.129S7-Kcna2^tm1Tem	increased susceptibility to pharmacologically induced seizures	J:131735
Kcna2^tm1Tem/Kcna2^tm1Tem C3Fe.129S7-Kcna2^tm1Tem	abnormal action potential	J:131735
	abnormal channel response	J:131735
	abnormal nervous system electrophysiology	J:131735
	apnea	J:131735
	decreased body weight	J:131735
	impaired ability to fire action potentials	J:131735
	increased susceptibility to pharmacologically induced seizures	J:131735
	postnatal lethality, complete penetrance	J:131735
	tonic seizures	J:131735
Kcna2^tm1Tem/Kcna2^tm1Tem involves: 129S7/SvEvBrd	abnormal brain wave pattern	J:130097
	abnormal sleep pattern	J:130097
	decreased body size	J:130097
	postnatal lethality, complete penetrance	J:130097
	seizures	J:130097
Kcna2^tm1Tem/Kcna2^tm1Tem involves: 129S7/SvEvBrd * C57BL/6	normal behavior/neurological phenotype	J:131735
	postnatal lethality, complete penetrance	J:131735
	tonic seizures	J:131735

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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