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Jup
Gene Detail
Symbol

Name
ID
Jup
junction plakoglobin
MGI:96650
Synonyms
Ctnng, D930025P04Rik, gamma-catenin, PG, plakoglobin
Feature Type
protein coding gene
Genetic Map
Chromosome 11
63.47 cM
Detailed Genetic Map ± 1 cM


Mapping data(10)
Sequence Map
Chr11:100368958-100397763 bp, - strand
From VEGA annotation of GRCm38

  28806 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1680  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 2 zebrafish

Protein SuperFamily: beta-catenin/plakoglobin
Gene Tree: Jup

Human
homologs
Human Homolog JUP, junction plakoglobin
NCBI Gene ID 3728
neXtProt AC  NX_P14923
Human Synonyms  ARVD12, CTNNG, DP3, DPIII, PDGB, PKGB
Human Chr (Location)  17q21; chr17:41754607-41786712 (-)  GRCh38
Disease Associations  (2) Diseases Associated with Human JUP
Mutations,
alleles, and
phenotypes
All mutations/alleles(227) : Gene trapped(217) Targeted(10)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mutants die with severe heart defects at embryonic day 10.5-16, depending on genetic background. Mutants that survive to birth exhibit skin blistering and subcorneal acantholysis associated with reduced number of desmosomes.
 
Human Diseases Modeled Using Mouse Jup (3)    Alleles Annotated to Human Diseases(4)    Phenotype Images(3)
Interactions
Jup interacts with 187 markers (Mir7-1, Mir9-1, Mir9-2, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (41 records)
Data Summary: Results (300)    Tissues (106)    Images (27)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 38
RNA in situ 211
Western blot 5
RT-PCR 46
cDNA source data(12)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(16) cDNA(15) Primer pair(1)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000006276 (Evidence)
Ensembl Gene ModelENSMUSG00000001552 (Evidence)
Entrez Gene16480 (Evidence)
DFCITC1572492, TC1613857
DoTSDT.55212740, DT.91593022, DT.94126436, DT.94246154, DT.94336103
NIA Mouse Gene IndexU033422
Consensus CDS ProjectCCDS25420.1
International Mouse Knockout Project StatusJup
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000006276 VEGA Gene Model | MGI Sequence Detail 28806 C57BL/6J ±  kb
transcript OTTMUST00000014199 VEGA | MGI Sequence Detail 3205 Not Applicable 
polypeptide OTTMUSP00000006595 VEGA | MGI Sequence Detail 745 Not Applicable 

For the selected sequences
All sequences(54) RefSeq(8) UniProt(1)
Polymorphisms
RFLP(2) : SNPs within 2kb(103 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000225 Armadillo
InterPro IPR011989 Armadillo-like helical
InterPro IPR016024 Armadillo-type fold
InterPro IPR013284 Beta-catenin
Protein Ontology PR:000009235 junction plakoglobin
References
(Earliest) J:37381 Cowin P, et al., Plakoglobin: a protein common to different kinds of intercellular adhering junctions. Cell. 1986 Sep 26;46(7):1063-73
(Latest) J:202157 Mahendram S, et al., Ectopic gamma-catenin expression partially mimics the effects of stabilized beta-catenin on embryonic stem cell differentiation. PLoS One. 2013;8(5):e65320
All references(112)
Disease annotation references (5)
Other
accession IDs
MGD-MRK-11544, MGI:2144342, MGI:2144558

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/16/2014
MGI 5.20
The Jackson Laboratory