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Jup Gene Detail
Summary
  • Symbol
    Jup
  • Name
    junction plakoglobin
  • Synonyms
    Ctnng, D930025P04Rik, gamma-catenin, PG, plakoglobin
  • Feature Type
    protein coding gene
  • IDs
    MGI:96650
    NCBI Gene: 16480
  • Gene Overview
    MyGene.info: JUP
  • Alliance
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:100368958-100397763 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 63.47 cM
  • Mapping Data
    10 experiments
Strain
Comparison
more
  • SNPs within 2kb
    103 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_96650
protein coding gene Chr11:100368856-100397805 (-)
129S1/SvImJ MGP_129S1SvImJ_G0019152
protein coding gene Chr11:103127571-103156093 (-)
A/J MGP_AJ_G0019120
protein coding gene Chr11:98815804-98845629 (-)
AKR/J MGP_AKRJ_G0019089
protein coding gene Chr11:101859473-101888337 (-)
BALB/cJ MGP_BALBcJ_G0019094
protein coding gene Chr11:99297411-99326017 (-)
C3H/HeJ MGP_C3HHeJ_G0018903
protein coding gene Chr11:102059919-102089967 (-)
C57BL/6NJ MGP_C57BL6NJ_G0019543
protein coding gene Chr11:106324875-106359856 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0017169
protein coding gene Chr11:96232630-96262320 (-)
CAST/EiJ MGP_CASTEiJ_G0018457
protein coding gene Chr11:103023920-103058986 (-)
CBA/J MGP_CBAJ_G0018872
protein coding gene Chr11:110753465-110784810 (-)
DBA/2J MGP_DBA2J_G0018984
protein coding gene Chr11:98355656-98384236 (-)
FVB/NJ MGP_FVBNJ_G0018974
protein coding gene Chr11:97886216-97914971 (-)
LP/J MGP_LPJ_G0019053
protein coding gene Chr11:103669682-103699071 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0019005
protein coding gene Chr11:110370954-110400490 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0019581
protein coding gene Chr11:102205625-102235307 (-)
PWK/PhJ MGP_PWKPhJ_G0018220
protein coding gene Chr11:99391281-99420822 (-)
SPRET/EiJ MGP_SPRETEiJ_G0018012
protein coding gene Chr11:101923728-101952885 (-)
WSB/EiJ MGP_WSBEiJ_G0018506
protein coding gene Chr11:102190471-102221540 (-)



Homology
more
  • Human Ortholog
    JUP, junction plakoglobin
  • Vertebrate Orthologs
    11
  • Human Ortholog
    JUP, junction plakoglobin
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CTNNG, DP3, DPIII, PDGB, PKGB
  • Links
    NCBI Gene ID: 3728
    neXtProt AC: NX_P14923
    UniProt: P14923

  • Chr Location
    17q21.2; chr17:41754607-41786853 (-)  GRCh38.p7

Human Diseases
more
  • Diseases
    2 with Jup mouse models; 1 with human JUP associations

Human Disease Mouse Models
      
IDs
View 4 models
      
IDs
View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    5 with disease annotations
  • References
    4 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    92 phenotypes from 10 alleles in 11 genetic backgrounds
    14 phenotypes from multigenic genotypes
    4 images
    37 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous null mutants die with severe heart defects at embryonic day 10.5-16, depending on genetic background. Mutants that survive to birth exhibit skin blistering and subcorneal acantholysis associated with reduced number of desmosomes.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000001552 Ensembl Gene Model | MGI Sequence Detail 28806 C57BL/6J ±  kb
    transcript ENSMUST00000001592 Ensembl | MGI Sequence Detail 3205 Not Applicable  
    polypeptide ENSMUSP00000001592 Ensembl | MGI Sequence Detail 745 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 17
      cDNA 16
      Primer pair 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-11544, MGI:2144342, MGI:2144558
    References
    more
    • Summaries
      All 137
      Developmental Gene Expression 47
      Diseases 4
      Gene Ontology 22
      Phenotypes 37
    • Earliest
      J:37381 Cowin P, et al., Plakoglobin: a protein common to different kinds of intercellular adhering junctions. Cell. 1986 Sep 26;46(7):1063-73
    • Latest
      J:262027 Schinner C, et al., Adrenergic Signaling Strengthens Cardiac Myocyte Cohesion. Circ Res. 2017 Apr 14;120(8):1305-1317

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory