Jund
Gene Detail

Symbol Name ID

Jund Jun proto-oncogene related gene d MGI:96648

Feature Type

protein coding gene

Genetic Map

Chromosome 8

34.15 cM, cytoband C2
Detailed Genetic Map ± 1 cM


Mapping data(23)

Sequence Map

Chr8:70697739-70700616 bp, + strand From NCBI annotation of GRCm38   2878 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:3910  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 cattle; 1 dog; 1 zebrafish

Protein SuperFamily: transcription factor AP-1
Gene Tree: Jund

Human homologs

Human Homolog		JUND, jun D proto-oncogene
NCBI Gene ID		3727
neXtProt AC		NX_P17535
Human Synonyms		AP-1
Human Chr (Location)		19p13.2; chr19:18390563-18392432 (-)  GRCh37.p10

Alleles and phenotypes

All alleles(5) : Targeted(1) Gene trapped(4)
 

Homozygotes show reduced growth, sensitivity to LPS-induced hepatitis, and male infertility due to hormonal imbalance and impaired spermatogenesis. Targeted cells and mice are sensitive to p53-dependent stress and TNF-induced apoptosis, and show aberrant T cell proliferation and Th2 differentiation.

 

Gene Ontology (GO) classifications

All GO classifications: (15 annotations)

Process	cellular response to calcium ion, osteoblast development, ...
Component	nucleus, protein complex
Function	DNA binding, double-stranded DNA binding, ...

This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase

Expression

Literature Summary: (8 records)
Data Summary: Results (169)    Tissues (168)    Images (13)
Theiler Stages: 17, 18, 21, 22, 23, 28

Assay Type	Results
RNA in situ	123
RT-PCR	46

cDNA source data(14)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(19) Genomic(1) cDNA(15) Primer pair(2) Other(1)
Microarray probesets(3)

Other database links

Ensembl Gene Model	ENSMUSG00000071076 (Evidence)
Entrez Gene	16478 (Evidence)
DFCI	TC1575686, TC1596368
NIA Mouse Gene Index	U009438
Consensus CDS Project	CCDS40375.1
International Mouse Knockout Project Status	Jund

Sequences

Length	Strain/Species
genomic	16478	NCBI Gene Model | MGI Sequence Detail	2878	C57BL/6J
transcript	NM_010592	RefSeq | MGI Sequence Detail	2878	Not Specified
polypeptide	P15066	UniProt | EBI | MGI Sequence Detail	341	Not Applicable

All sequences(19) RefSeq(2) UniProt(2)

Polymorphisms

RFLP(4) : SNPs(13 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR004827	Basic-leucine zipper domain
InterPro	IPR008917	Eukaryotic transcription factor, Skn-1-like, DNA-binding
InterPro	IPR005643	Jun-like transcription factor
InterPro	IPR002112	Transcription factor Jun
Protein Ontology	PR:000009234	transcription factor jun-D

Graphical View of Protein Domain Structure

References

(Earliest) J:9466 Nakabeppu Y, et al., DNA binding activities of three murine Jun proteins: stimulation by Fos. Cell. 1988 Dec 2;55(5):907-15
(Latest) J:194035 Kan A, et al., c-Jun is required for the specification of joint cell fates. Genes Dev. 2013 Mar 1;27(5):514-24
All references(85)

Other accession IDs

MGD-MRK-11541, MGD-MRK-11542