Homozygotes show reduced growth, sensitivity to LPS-induced hepatitis, and male infertility due to hormonal imbalance and impaired spermatogenesis. Targeted cells and mice are sensitive to p53-dependent stress and TNF-induced apoptosis, and show aberrant T cell proliferation and Th2 differentiation.
|Process||cellular response to calcium ion, cellular response to hormone stimulus, ...|
|Component||nuclear chromatin, nucleoplasm, ...|
|Function||DNA binding, double-stranded DNA binding, ...|
|InterPro||IPR004827||Basic-leucine zipper domain|
|InterPro||IPR005643||Jun-like transcription factor|
|InterPro||IPR002112||Transcription factor Jun|
|InterPro||IPR029823||Transcription factor JunD|
|InterPro||IPR008917||Transcription factor, Skn-1-like, DNA-binding domain|
|Protein Ontology||PR:000009234||transcription factor jun-D|
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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