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Jund
Gene Detail
Symbol

Name
ID
Jund
jun D proto-oncogene
MGI:96648
Feature Type
protein coding gene
Genetic Map
Chromosome 8
34.15 cM, cytoband C2
Detailed Genetic Map ± 1 cM


Mapping data(23)
Sequence Map
Chr8:70697739-70700616 bp, + strand
From NCBI annotation of GRCm38

  2878 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3910  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 cattle; 1 dog; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: JUND
Protein SuperFamily: transcription factor AP-1
Gene Tree: Jund

Human
homologs
JUND, jun D proto-oncogene
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 3727
neXtProt AC: NX_P17535

Human Synonyms: AP-1

Human Chr (Location): 19p13.2; chr19:18279694-18281656 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Gene trapped(4) Targeted(2)
Incidental mutations (data from APF , CvDC )
 
Homozygotes show reduced growth, sensitivity to LPS-induced hepatitis, and male infertility due to hormonal imbalance and impaired spermatogenesis. Targeted cells and mice are sensitive to p53-dependent stress and TNF-induced apoptosis, and show aberrant T cell proliferation and Th2 differentiation.
 
Interactions
Jund interacts with 60 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (42 annotations)
Process cellular response to calcium ion, cellular response to hormone stimulus, ...
Component nuclear chromatin, nucleoplasm, ...
Function DNA binding, double-stranded DNA binding, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (8 records)
Data Summary: Results (170)    Tissues (169)    Images (13)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 124
RT-PCR 46
cDNA source data(17)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase jund, LOC100485288    NEW 
Molecular
reagents
All nucleic(22) Genomic(1) cDNA(18) Primer pair(2) Other(1)
Microarray probesets(3)
Other database
links
Ensembl Gene Model ENSMUSG00000071076 (Evidence)
Entrez Gene 16478 (Evidence)
DFCI TC1575686, TC1596368, TC1672579, TC1676440, TC1676925
NIA Mouse Gene Index U009438
Consensus CDS Project CCDS40375.1
International Mouse Phenotyping Consortium Status Jund
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 16478 NCBI Gene Model | MGI Sequence Detail 2878 C57BL/6J ±  kb
transcript NM_010592 RefSeq | MGI Sequence Detail 2894 C57BL/6 
polypeptide P15066 UniProt | EBI | MGI Sequence Detail 341 Not Applicable 

For the selected sequences
All sequences(33) RefSeq(4) UniProt(2)
Polymorphisms
RFLP(4) : SNPs within 2kb(31 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR004827 Basic-leucine zipper domain
InterPro IPR005643 Jun-like transcription factor
InterPro IPR002112 Transcription factor Jun
InterPro IPR029823 Transcription factor JunD
InterPro IPR008917 Transcription factor, Skn-1-like, DNA-binding domain
Protein Ontology PR:000009234 transcription factor jun-D
Graphical View of Protein Domain Structure
References
(Earliest) J:9466 Nakabeppu Y, et al., DNA binding activities of three murine Jun proteins: stimulation by Fos. Cell. 1988 Dec 2;55(5):907-15
(Latest) J:210545 Hasenfuss SC, et al., Regulation of steatohepatitis and PPARgamma signaling by distinct AP-1 dimers. Cell Metab. 2014 Jan 7;19(1):84-95
All references(89)
Other
accession IDs
MGD-MRK-11541, MGD-MRK-11542

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory