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Jun
Gene Detail
Symbol

Name
ID
Jun
jun proto-oncogene
MGI:96646
Synonyms
c-jun, Junc
Feature Type
protein coding gene
Genetic Map
Chromosome 4
43.34 cM, cytoband C5-C7
Detailed Genetic Map ± 1 cM


Mapping data(34)
Sequence Map
Chr4:95049034-95052222 bp, - strand
From VEGA annotation of GRCm38

  3189 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1679  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: JUN
Protein SuperFamily: transcription factor AP-1
Gene Tree: Jun

Human
homologs
JUN, jun proto-oncogene
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 3725
neXtProt AC: NX_P05412

Human Synonyms: AP1, AP-1, c-Jun

Human Chr (Location): 1p32-p31; chr1:58780791-58784113 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(14) : Targeted(14)
 
Null homozygotes die at midgestation with impaired hepatogenesis, altered fetal liver erythropoiesis and edema. A mutant replacing two serines by alanines is viable, fertile, small-sized and resistant to kainate-induced seizures and neuronal apoptosis.
 
Human Diseases Modeled in Mice Using Jun (2)    Mutations Annotated to Human Diseases (1)    Phenotype Images(4)
Interactions
Jun interacts with 256 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (102 annotations)
Process angiogenesis, axon regeneration, ...
Component cytosol, nuclear chromatin, ...
Function cAMP response element binding, chromatin binding, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (105 records)
Data Summary: Results (392)    Tissues (229)    Images (69)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 2
RNA in situ 233
Northern blot 4
RT-PCR 153
cDNA source data(141)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: GEISHA JUN ; Xenbase jun ; ZFIN jun    NEW 
Molecular
reagents
All nucleic(157) Genomic(4) cDNA(146) Primer pair(5) Other(2)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000008035 (Evidence)
Ensembl Gene Model ENSMUSG00000052684 (Evidence)
Entrez Gene 16476 (Evidence)
UniGene 275071
DFCI TC1572847, TC1596413
DoTS DT.110833148, DT.533179, DT.94265227, DT.94279851
NIA Mouse Gene Index U025271
Consensus CDS Project CCDS18364.1
International Mouse Phenotyping Consortium Status Jun
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000008035 VEGA Gene Model | MGI Sequence Detail 3189 C57BL/6J ±  kb
transcript OTTMUST00000018173 VEGA | MGI Sequence Detail 3189 Not Applicable 
polypeptide OTTMUSP00000008346 VEGA | MGI Sequence Detail 334 Not Applicable 

For the selected sequences
All sequences(38) RefSeq(2) UniProt(5)
Polymorphisms
All PCR and RFLP(9) : PCR(1) RFLP(8) SNPs within 2kb(29 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR004827 Basic-leucine zipper domain
InterPro IPR015558 c-Jun Transcription Factor
InterPro IPR008917 Eukaryotic transcription factor, Skn-1-like, DNA-binding
InterPro IPR005643 Jun-like transcription factor
InterPro IPR002112 Transcription factor Jun
Protein Ontology PR:000009232 transcription factor AP-1
References
(Earliest) J:9056 Ryder K, et al., A gene activated by growth factors is related to the oncogene v-jun. Proc Natl Acad Sci U S A. 1988 Mar;85(5):1487-91
(Latest) J:218165 Bankhead EJ, et al., Multiple requirements of the focal dermal hypoplasia gene porcupine during ocular morphogenesis. Am J Pathol. 2015 Jan;185(1):197-213
All references(328)
Disease annotation references (1)
Other
accession IDs
MGD-MRK-11538, MGD-MRK-11540

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory