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Jun Gene Detail
Summary
  • Symbol
    Jun
  • Name
    jun proto-oncogene
  • Synonyms
    c-jun, Junc
  • Feature Type
    protein coding gene
  • IDs
    MGI:96646
    NCBI Gene: 16476
  • Gene Overview
    MyGene.info: JUN
Location & Maps
more
  • Sequence Map
    Chr4:95049034-95052222 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      3189 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 4, 43.34 cM, cytoband C5-C7
  • Mapping Data
    34 experiments
Homology
more
  • Human Ortholog
    JUN, Jun proto-oncogene, AP-1 transcription factor subunit
  • Vertebrate Orthologs
    10
  • Human Ortholog
    JUN, Jun proto-oncogene, AP-1 transcription factor subunit
    Orthology source: HomoloGene, HGNC
  • Synonyms
    AP1, AP-1, c-Jun
  • Links
    NCBI Gene ID: 3725
    neXtProt AC: NX_P05412

  • Chr Location
    1p32.1; chr1:58780791-58784113 (-)  GRCh38.p2

Human Diseases
more
  • Diseases
    2 with Jun mouse models

Human Disease Mouse Models
       Emphysema, Hereditary Pulmonary   OMIM: 130700 View 1 model
Pulmonary Disease, Chronic Obstructive; COPD   OMIM: 606963 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    67 phenotypes from 9 alleles in 14 genetic backgrounds
    30 phenotypes from multigenic genotypes
    4 images
    80 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    18
  • Chemically induced (other)
    2
  • Radiation induced
    1
  • Targeted
    14
  • Transgenic
    1
  • Genomic Mutations
    3 involving Jun
Null homozygotes die at midgestation with impaired hepatogenesis, altered fetal liver erythropoiesis and edema. A mutant replacing two serines by alanines is viable, fertile, small-sized and resistant to kainate-induced seizures and neuronal apoptosis.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000008035 VEGA Gene Model | MGI Sequence Detail 3189 C57BL/6J ±  kb
transcript OTTMUST00000018173 VEGA | MGI Sequence Detail 3189 Not Applicable  
polypeptide OTTMUSP00000008346 VEGA | MGI Sequence Detail 334 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    29 from dbSNP Build 142
  • PCR
  • RFLP
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 158
    Genomic 4
    cDNA 146
    Primer pair 6
    Other 2

    Microarray probesets 4
Other
Accession IDs
less
MGD-MRK-11538, MGD-MRK-11540
References
more
  • Summaries
    All 344
    Developmental Gene Expression 114
    Diseases 1
    Gene Ontology 29
    Phenotypes 80
  • Earliest
    J:9056 Ryder K, et al., A gene activated by growth factors is related to the oncogene v-jun. Proc Natl Acad Sci U S A. 1988 Mar;85(5):1487-91
  • Latest
    J:231932 Fernandes KA, et al., Novel axon projection after stress and degeneration in the Dscam mutant retina. Mol Cell Neurosci. 2016 Mar;71:1-12

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/29/2016
MGI 6.06
The Jackson Laboratory