About   Help   FAQ
Jun
Gene Detail
Symbol

Name
ID
Jun
jun proto-oncogene
MGI:96646
Synonyms
c-jun, Junc
Feature Type
protein coding gene
Genetic Map
Chromosome 4
43.34 cM, cytoband C5-C7
Detailed Genetic Map ± 1 cM


Mapping data(34)
Sequence Map
Chr4:95049034-95052222 bp, - strand
From VEGA annotation of GRCm38

  3189 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1679  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: transcription factor AP-1
Gene Tree: Jun

Human
homologs
Human Homolog JUN, jun proto-oncogene
NCBI Gene ID 3725
neXtProt AC  NX_P05412
Human Synonyms  AP1, AP-1, c-Jun
Human Chr (Location)  1p32-p31; chr1:58780791-58784113 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(12) : Targeted(12)
 
Null homozygotes die at midgestation with impaired hepatogenesis, altered fetal liver erythropoiesis and edema. A mutant replacing two serines by alanines is viable, fertile, small-sized and resistant to kainate-induced seizures and neuronal apoptosis.
 
Human Diseases Modeled Using Mouse Jun (2)    Alleles Annotated to Human Diseases(1)    Phenotype Images(4)
Interactions
Jun interacts with 256 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (88 annotations)
Process angiogenesis, axon regeneration, ...
Component cytosol, nuclear chromatin, ...
Function cAMP response element binding, chromatin binding, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (101 records)
Data Summary: Results (392)    Tissues (229)    Images (69)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 2
RNA in situ 233
Northern blot 4
RT-PCR 153
cDNA source data(141)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(157) Genomic(4) cDNA(146) Primer pair(5) Other(2)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000008035 (Evidence)
Ensembl Gene ModelENSMUSG00000052684 (Evidence)
Entrez Gene16476 (Evidence)
UniGene275071
DFCITC1572847, TC1596413
DoTSDT.110833148, DT.533179, DT.94265227, DT.94279851
NIA Mouse Gene IndexU025271
Consensus CDS ProjectCCDS18364.1
International Mouse Knockout Project StatusJun
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000008035 VEGA Gene Model | MGI Sequence Detail 3189 C57BL/6J ±  kb
transcript OTTMUST00000018173 VEGA | MGI Sequence Detail 3189 Not Applicable 
polypeptide OTTMUSP00000008346 VEGA | MGI Sequence Detail 334 Not Applicable 

For the selected sequences
All sequences(44) RefSeq(2) UniProt(9)
Polymorphisms
All PCR and RFLP(9) : PCR(1) RFLP(8) SNPs within 2kb(29 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR004827 Basic-leucine zipper domain
InterPro IPR015558 c-Jun Transcription Factor
InterPro IPR008917 Eukaryotic transcription factor, Skn-1-like, DNA-binding
InterPro IPR005643 Jun-like transcription factor
InterPro IPR002112 Transcription factor Jun
Protein Ontology PR:000009232 transcription factor AP-1
References
(Earliest) J:9056 Ryder K, et al., A gene activated by growth factors is related to the oncogene v-jun. Proc Natl Acad Sci U S A. 1988 Mar;85(5):1487-91
(Latest) J:214780 Forkel S, et al., Inositoylated platelet-activating factor (Ino-C2-PAF) modulates dynamic lymphocyte-endothelial cell interactions and alleviates psoriasis-like skin inflammation in two complementary mouse models. J Invest Dermatol. 2014 Oct;134(10):2510-20
All references(324)
Disease annotation references (1)
Other
accession IDs
MGD-MRK-11538, MGD-MRK-11540

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
12/09/2014
MGI 5.20
The Jackson Laboratory