Jun
Gene Detail

Symbol Name ID

Jun Jun oncogene MGI:96646

Synonyms

c-jun, Junc

Feature Type

protein coding gene

Genetic Map

Chromosome 4

43.34 cM, cytoband C5-C7
Detailed Genetic Map ± 1 cM


Mapping data(34)

Sequence Map

Chr4:95049034-95052222 bp, - strand From VEGA annotation of GRCm38   3189 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:1679  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: transcription factor AP-1
Gene Tree: Jun

Human homologs

Human Homolog		JUN, jun proto-oncogene
NCBI Gene ID		3725
neXtProt AC		NX_P05412
Human Synonyms		AP1, AP-1, c-Jun
Human Chr (Location)		1p32-p31; chr1:59246463-59249785 (-)  GRCh37.p10

Alleles and phenotypes

All alleles(12) : Targeted(12)
 

Null homozygotes die at midgestation with impaired hepatogenesis, altered fetal liver erythropoiesis and edema. A mutant replacing two serines by alanines is viable, fertile, small-sized and resistant to kainate-induced seizures and neuronal apoptosis.

 
Human Diseases Modeled Using Mouse Jun (2)    Alleles Annotated to Human Diseases(1)    Phenotype Images(4)

Gene Ontology (GO) classifications

All GO classifications: (79 annotations)

Process	angiogenesis, axon regeneration, ...
Component	cytosol, nuclear chromatin, ...
Function	cAMP response element binding, DNA binding, ...

This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase

Expression

Literature Summary: (89 records)
Data Summary: Results (397)    Tissues (233)    Images (67)
Theiler Stages: 2, 3, 4, 5, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 28

Assay Type	Results
RNA in situ	233
Northern blot	4
RT-PCR	160

cDNA source data(130)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(146) Genomic(4) cDNA(135) Primer pair(5) Other(2)
Microarray probesets(4)

Other database links

VEGA Gene Model	OTTMUSG00000008035 (Evidence)
Ensembl Gene Model	ENSMUSG00000052684 (Evidence)
Entrez Gene	16476 (Evidence)
UniGene	275071
DFCI	TC1572847, TC1596413
DoTS	DT.110833148, DT.533179, DT.94265227, DT.94279851
NIA Mouse Gene Index	U025271
Consensus CDS Project	CCDS18364.1
International Mouse Knockout Project Status	Jun

Sequences

Length	Strain/Species
genomic	OTTMUSG00000008035	VEGA Gene Model | MGI Sequence Detail	3189	C57BL/6J
transcript	OTTMUST00000018173	VEGA | MGI Sequence Detail	3189	Not Applicable
polypeptide	OTTMUSP00000008346	VEGA | MGI Sequence Detail	334	Not Applicable

All sequences(40) RefSeq(2) UniProt(5)

Polymorphisms

All PCR and RFLP(9) : PCR(1) RFLP(8) SNPs(18 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR004827	Basic-leucine zipper domain
InterPro	IPR015558	c-Jun Transcription Factor
InterPro	IPR008917	Eukaryotic transcription factor, Skn-1-like, DNA-binding
InterPro	IPR005643	Jun-like transcription factor
InterPro	IPR002112	Transcription factor Jun
Protein Ontology	PR:000009232	transcription factor AP-1

References

(Earliest) J:9056 Ryder K, et al., A gene activated by growth factors is related to the oncogene v-jun. Proc Natl Acad Sci U S A. 1988 Mar;85(5):1487-91
(Latest) J:194035 Kan A, et al., c-Jun is required for the specification of joint cell fates. Genes Dev. 2013 Mar 1;27(5):514-24
All references(294)

Other accession IDs

MGD-MRK-11538, MGD-MRK-11540