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Itpa
Gene Detail
 Symbol
Name
ID
Itpa
inosine triphosphatase (nucleoside triphosphate pyrophosphatase)
MGI:96622
Synonyms 2010016I08Rik, Itp
Feature Type protein coding gene
Genetic Map
Chromosome 2
63.24 cM, cytoband F3
Detailed Genetic Map ± 1 cM


Mapping data(21)
Sequence Map
Chr2:130667610-130681614 bp, + strand
From VEGA annotation of GRCm38

  14005 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:6289  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 2 zebrafish

Gene Tree: Itpa

Human
homologs
Human Homolog ITPA, inosine triphosphatase (nucleoside triphosphate pyrophosphatase)
NCBI Gene ID 3704
neXtProt AC  NX_Q9BY32
Human Synonyms  C20orf37, dJ794I6.3, HLC14-06-P
Human Chr (Location)  20p; chr20:3208719-3223870 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human ITPA
Mutations,
alleles, and
phenotypes
All mutations/alleles(30) : Gene trapped(27) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele exhibit partial perinatal lethality and complete postnatal lethality with postnatal growth retardation, abnormal heart morphology and function, ataxia, and immature hair follicles.
 
Interactions
Itpa interacts with 79 markers (Mir17, Mir19b-1, Mir19b-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (14 annotations)
Process chromosome organization, ITP catabolic process, ...
Component cytoplasm
Function dITP diphosphatase activity, hydrolase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (1 records)
Data Summary: Results (94)    Tissues (94)    Images (15)
Theiler Stages: 22
Assay TypeResults
RNA in situ 94
cDNA source data(15)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(15) cDNA(15)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000015497 (Evidence)
Ensembl Gene ModelENSMUSG00000074797 (Evidence)
Entrez Gene16434 (Evidence)
DFCITC1574171, TC1639594
DoTSDT.101343219, DT.526016, DT.91316618, DT.94195477, DT.99859649, DT.99859652
NIA Mouse Gene IndexU002482, U114237
EC3.6.1.19
Consensus CDS ProjectCCDS16748.1
International Mouse Knockout Project StatusItpa
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000015497 VEGA Gene Model | MGI Sequence Detail 14005 C57BL/6J ±  kb
transcript OTTMUST00000036804 VEGA | MGI Sequence Detail 1390 Not Applicable 
polypeptide OTTMUSP00000016511 VEGA | MGI Sequence Detail 198 Not Applicable 

For the selected sequences
All sequences(46) RefSeq(2) UniProt(3)
Polymorphisms SNPs within 2kb(92 from dbSNP Build 137)    SNPs within 2kb including multiple locations(94)
Protein-related
information
ResourceIDDescription
InterPro IPR002637 Ham1-like protein
InterPro IPR027502 Inosine triphosphate pyrophosphatase
Protein Ontology PR:000009153 inosine triphosphate pyrophosphatase
References (Earliest) J:6674 Stallings RL, et al., Confirmational, provisional, and/or regional assignment of 15 enzyme loci onto Chinese hamster autosomes 1, 2, and 7. Somatic Cell Genet. 1981 Nov;7(6):683-98
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(63)
Other
accession IDs
MGD-MRK-11505, MGI:1914279, MGI:2139184

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/23/2014
MGI 5.19
The Jackson Laboratory