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Itk Gene Detail
Summary
  • Symbol
    Itk
  • Name
    IL2 inducible T cell kinase
  • Synonyms
    Emt, Tcsk, Tsk
  • Feature Type
    protein coding gene
  • IDs
    MGI:96621
    NCBI Gene: 16428
  • Gene Overview
    MyGene.info: ITK
Location & Maps
more
  • Sequence Map
    Chr11:46325150-46389515 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      64366 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 27.75 cM
  • Mapping Data
    6 experiments
Homology
more
  • Human Ortholog
    ITK, IL2 inducible T-cell kinase
  • Vertebrate Orthologs
    9
  • Human Ortholog
    ITK, IL2 inducible T-cell kinase
    Orthology source: HomoloGene, HGNC
  • Synonyms
    EMT, LPFS1, LYK, PSCTK2
  • Links
    NCBI Gene ID: 3702
    neXtProt AC: NX_Q08881

  • Chr Location
    5q31-q32; chr5:157180896-157255099 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with human ITK associations

Human Disease Mouse Models
       Lymphoproliferative Syndrome 1; LPFS1   OMIM: 613011
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    29 phenotypes from 3 alleles in 8 genetic backgrounds
    67 phenotypes from multigenic genotypes
    3 images
    65 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    9
  • Chemically induced (other)
    1
  • Targeted
    8
  • Genomic Mutations
    1 involving Itk
  • Incidental Mutations
Mice homozygous for disruptions in this gene display decreased percentages of CD4 and CD8 cells, increased percentage of B cells, impaired T cell receptor signaling, and increased susceptibility to Toxoplasma gondii infection.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000005493 VEGA Gene Model | MGI Sequence Detail 64366 C57BL/6J ±  kb
transcript OTTMUST00000061071 VEGA | MGI Sequence Detail 4268 Not Applicable  
polypeptide OTTMUSP00000029887 VEGA | MGI Sequence Detail 625 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    492 from dbSNP Build 142
  • RFLP
Protein
Information
less
Molecular
Reagents
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  • All nucleic 23
    Genomic 2
    cDNA 20
    Primer pair 1

    Microarray probesets 5
Other
Accession IDs
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MGD-MRK-11504, MGD-MRK-14937
References
more
  • Summaries
    All 104
    Developmental Gene Expression 1
    Gene Ontology 8
    Phenotypes 65
  • Earliest
    J:33070 Bernards A, et al., The ltk receptor tyrosine kinase is expressed in pre-B lymphocytes and cerebral neurons and uses a non-AUG translational initiator. EMBO J. 1990 Jul;9(7):2279-87
  • Latest
    J:229743 Kannan A, et al., Allele-sensitive mutant, Itkas, reveals that Itk kinase activity is required for Th1, Th2, Th17, and iNKT-cell cytokine production. Eur J Immunol. 2015 Aug;45(8):2276-85

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/20/2016
MGI 6.05
The Jackson Laboratory