Itk
Gene Detail

Symbol Name ID

Itk IL2 inducible T cell kinase MGI:96621

Synonyms

Emt, Tcsk, Tsk

Feature Type

protein coding gene

Genetic Map

Chromosome 11

27.75 cM
Detailed Genetic Map ± 1 cM


Mapping data(6)

Sequence Map

Chr11:46325150-46389515 bp, - strand From VEGA annotation of GRCm38   64366 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Mammalian homology

human; rat; cattle; chimpanzee; dog, domestic    (Mammalian Orthology)
Comparative Map (Mouse/Human Itk ± 2 cM)

Protein SuperFamily: tyrosine-protein kinase, TEC type
Gene Tree: Itk

Human ortholog

ITK IL2-inducible T-cell kinase NCBI Gene ID 3702
Human Synonyms: EMT, LYK, PSCTK2
Human Chr5:156607907-156682109 bp, + strand Reference GRCh37.p2 Primary Assembly
Human Diseases Associated with Human ITK (1)

Alleles and phenotypes

All alleles(5) : Targeted(5)
 

Mice homozygous for disruptions in this gene display decreased percentages of CD4 and CD8 cells, increased percentage of B cells, impaired T cell receptor signaling, and increased susceptibility to Toxoplasma gondii infection.

 

Gene Ontology (GO) classifications

All GO classifications: (27 annotations)

Process	activation of phospholipase C activity, adaptive immune response, ...
Component	cytoplasm
Function	ATP binding, kinase activity, ...

External Resources: FuncBase

Expression

cDNA source data(16)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(23) Genomic(2) cDNA(20) Primer pair(1)
Microarray probesets(5)

Other database links

VEGA Gene Model	OTTMUSG00000005493 (Evidence)
Ensembl Gene Model	ENSMUSG00000020395 (Evidence)
Entrez Gene	16428 (Evidence)
NIA Mouse Gene Index	U032699
EC	2.7.10.2
PDB	1AWJ, 1LUI, 1LUK, 1LUM, 1LUN, 2ETZ, 2EU0, 2K79, 2K7A, 2RN8, 2RNA, 3S9K
Consensus CDS Project	CCDS24575.2
International Mouse Knockout Project Status	Itk

Sequences

Length	Strain/Species
genomic	OTTMUSG00000005493	VEGA Gene Model | MGI Sequence Detail	64366	C57BL/6J
transcript	OTTMUST00000061071	VEGA | MGI Sequence Detail	4268	Not Applicable
polypeptide	OTTMUSP00000029887	VEGA | MGI Sequence Detail	625	Not Applicable

All sequences(41) RefSeq(2) UniProt(6)

Polymorphisms

RFLP(2) : SNPs(268 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR001849	Pleckstrin homology domain
InterPro	IPR011993	Pleckstrin homology-like domain
InterPro	IPR017441	Protein kinase, ATP binding site
InterPro	IPR000719	Protein kinase, catalytic domain
InterPro	IPR011009	Protein kinase-like domain
InterPro	IPR001245	Serine-threonine/tyrosine-protein kinase catalytic domain
InterPro	IPR000980	SH2 domain
InterPro	IPR001452	Src homology-3 domain
InterPro	IPR008266	Tyrosine-protein kinase, active site
InterPro	IPR020635	Tyrosine-protein kinase, catalytic domain
InterPro	IPR001562	Zinc finger, Btk motif
Protein Ontology	PR:000002111	tyrosine-protein kinase ITK/TSK

References

(Earliest) J:33070 Bernards A, et al., The ltk receptor tyrosine kinase is expressed in pre-B lymphocytes and cerebral neurons and uses a non-AUG translational initiator. EMBO J. 1990 Jul;9(7):2279-87
(Latest) J:193616 Yin CC, et al., The Tec Kinase ITK Regulates Thymic Expansion, Emigration, and Maturation of gammadelta NKT Cells. J Immunol. 2013 Mar 15;190(6):2659-69
All references(93)

Other accession IDs

MGD-MRK-11504, MGD-MRK-14937