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Itk Gene Detail
Summary
  • Symbol
    Itk
  • Name
    IL2 inducible T cell kinase
  • Synonyms
    Emt, Tcsk, Tsk
  • Feature Type
    protein coding gene
  • IDs
    MGI:96621
    NCBI Gene: 16428
  • Gene Overview
    MyGene.info: ITK
  • Alliance
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:46325150-46389515 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 27.75 cM
  • Mapping Data
    6 experiments
Strain
Comparison
more
  • SNPs within 2kb
    492 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_96621
protein coding gene Chr11:46325148-46389515 (-)
129S1/SvImJ MGP_129S1SvImJ_G0018192
protein coding gene Chr11:45238981-45306515 (-)
A/J MGP_AJ_G0018164
protein coding gene Chr11:43503601-43568648 (-)
AKR/J MGP_AKRJ_G0018129
protein coding gene Chr11:44750447-44818999 (-)
BALB/cJ MGP_BALBcJ_G0018133
protein coding gene Chr11:43661257-43726199 (-)
C3H/HeJ MGP_C3HHeJ_G0017947
protein coding gene Chr11:44796375-44860990 (-)
C57BL/6NJ MGP_C57BL6NJ_G0018587
protein coding gene Chr11:46583740-46652304 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0016242
protein coding gene Chr11:41480708-41547004 (-)
CAST/EiJ MGP_CASTEiJ_G0017510
protein coding gene Chr11:44920027-44987068 (-)
CBA/J MGP_CBAJ_G0017919
protein coding gene Chr11:48763944-48831765 (-)
DBA/2J MGP_DBA2J_G0018029
protein coding gene Chr11:43247829-43313367 (-)
FVB/NJ MGP_FVBNJ_G0018023
protein coding gene Chr11:42924194-42989103 (-)
LP/J MGP_LPJ_G0018101
protein coding gene Chr11:45487679-45554259 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0018047
protein coding gene Chr11:50289729-50358429 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0018626
protein coding gene Chr11:44913474-44981074 (-)
PWK/PhJ MGP_PWKPhJ_G0017290
protein coding gene Chr11:43334605-43400113 (-)
SPRET/EiJ MGP_SPRETEiJ_G0017083
protein coding gene Chr11:44730649-44797223 (-)
WSB/EiJ MGP_WSBEiJ_G0017560
protein coding gene Chr11:44613051-44681282 (-)



Homology
more
  • Human Ortholog
    ITK, IL2 inducible T cell kinase
  • Vertebrate Orthologs
    9
  • Human Ortholog
    ITK, IL2 inducible T cell kinase
    Orthology source: HGNC, HomoloGene
  • Synonyms
    EMT, LPFS1, LYK, PSCTK2
  • Links
    NCBI Gene ID: 3702
    neXtProt AC: NX_Q08881
    UniProt: Q08881

  • Chr Location
    5q33.3; chr5:157180896-157255185 (+)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with human ITK associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    38 phenotypes from 5 alleles in 10 genetic backgrounds
    67 phenotypes from multigenic genotypes
    3 images
    74 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions in this gene display decreased percentages of CD4 and CD8 cells, increased percentage of B cells, impaired T cell receptor signaling, and increased susceptibility to Toxoplasma gondii infection.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000020395 Ensembl Gene Model | MGI Sequence Detail 64366 C57BL/6J ±  kb
transcript ENSMUST00000109237 Ensembl | MGI Sequence Detail 4268 Not Applicable  
polypeptide ENSMUSP00000104860 Ensembl | MGI Sequence Detail 625 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 24
    Genomic 2
    cDNA 21
    Primer pair 1

    Microarray probesets 5
Other
Accession IDs
less
MGD-MRK-11504, MGD-MRK-14937
References
more
  • Summaries
    All 127
    Developmental Gene Expression 1
    Gene Ontology 11
    Phenotypes 74
  • Earliest
    J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
  • Latest
    J:254179 Wartewig T, et al., PD-1 is a haploinsufficient suppressor of T cell lymphomagenesis. Nature. 2017 Dec 7;552(7683):121-125

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
12/04/2018
MGI 6.13
The Jackson Laboratory