About   Help   FAQ
Itk
Gene Detail
Symbol

Name
ID
Itk
IL2 inducible T cell kinase
MGI:96621
Synonyms
Emt, Tcsk, Tsk
Feature Type
protein coding gene
Genetic Map
Chromosome 11
27.75 cM
Detailed Genetic Map ± 1 cM


Mapping data(6)
Sequence Map
Chr11:46325150-46389515 bp, - strand
From VEGA annotation of GRCm38

  64366 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:4051  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: tyrosine-protein kinase, TEC type
Gene Tree: Itk

Human
homologs
Human Homolog ITK, IL2-inducible T-cell kinase
NCBI Gene ID 3702
neXtProt AC  NX_Q08881
Human Synonyms  EMT, LPFS1, LYK, PSCTK2
Human Chr (Location)  5q31-q32; chr5:157180896-157255099 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human ITK
Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for disruptions in this gene display decreased percentages of CD4 and CD8 cells, increased percentage of B cells, impaired T cell receptor signaling, and increased susceptibility to Toxoplasma gondii infection.
 
Interactions
Itk interacts with 277 markers (Mir16-1, Mir17, Mir20b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (29 annotations)
Process activation of phospholipase C activity, adaptive immune response, ...
Component cell-cell junction, cytoplasm
Function ATP binding, kinase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (1 records)
cDNA source data(16)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(23) Genomic(2) cDNA(20) Primer pair(1)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000005493 (Evidence)
Ensembl Gene ModelENSMUSG00000020395 (Evidence)
Entrez Gene16428 (Evidence)
NIA Mouse Gene IndexU032699
EC2.7.10.2
PDB1AWJ, 1LUI, 1LUK, 1LUM, 1LUN, 2ETZ, 2K7A, 2RNA, 3S9K, 2EU0, 2K79, 2RN8
Consensus CDS ProjectCCDS24575.2, CCDS70168.1, CCDS70169.1
International Mouse Knockout Project StatusItk
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000005493 VEGA Gene Model | MGI Sequence Detail 64366 C57BL/6J ±  kb
transcript OTTMUST00000061071 VEGA | MGI Sequence Detail 4268 Not Applicable 
polypeptide OTTMUSP00000029887 VEGA | MGI Sequence Detail 625 Not Applicable 

For the selected sequences
All sequences(50) RefSeq(10) UniProt(6)
Polymorphisms
RFLP(2) : SNPs within 2kb(506 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001849 Pleckstrin homology domain
InterPro IPR011993 Pleckstrin homology-like domain
InterPro IPR017441 Protein kinase, ATP binding site
InterPro IPR000719 Protein kinase, catalytic domain
InterPro IPR011009 Protein kinase-like domain
InterPro IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
InterPro IPR000980 SH2 domain
InterPro IPR001452 Src homology-3 domain
InterPro IPR008266 Tyrosine-protein kinase, active site
InterPro IPR020635 Tyrosine-protein kinase, catalytic domain
InterPro IPR001562 Zinc finger, Btk motif
Protein Ontology PR:000002111 tyrosine-protein kinase ITK/TSK
References
(Earliest) J:33070 Bernards A, et al., The ltk receptor tyrosine kinase is expressed in pre-B lymphocytes and cerebral neurons and uses a non-AUG translational initiator. EMBO J. 1990 Jul;9(7):2279-87
(Latest) J:212002 Huang W, et al., ITK tunes IL-4-induced development of innate memory CD8+ T cells in a gammadelta T and invariant NKT cell-independent manner. J Leukoc Biol. 2014 Jul;96(1):55-63
All references(101)
Other
accession IDs
MGD-MRK-11504, MGD-MRK-14937

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
10/08/2014
MGI 5.20
The Jackson Laboratory