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Itgb1 Gene Detail
Summary
  • Symbol
    Itgb1
  • Name
    integrin beta 1 (fibronectin receptor beta)
  • Synonyms
    4633401G24Rik, beta1 integrin, CD29, Fnrb, Gm9863
  • Feature Type
    protein coding gene
  • IDs
    MGI:96610
    NCBI Gene: 16412
  • Gene Overview
    MyGene.info: ITGB1
  • Alliance
    gene page
Location & Maps
more
  • Sequence Map
    Chr8:128685654-128733200 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser
  • Download
    Sequence
      47547 bp   ±  kb flank

  • Genome Browsers
    VEGA | Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 76.09 cM, cytoband E2
  • Mapping Data
    4 experiments
Homology
more
  • Human Ortholog
    ITGB1, integrin subunit beta 1
  • Vertebrate Orthologs
    11
  • Human Ortholog
    ITGB1, integrin subunit beta 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CD29, FNRB, GPIIA, MDF2, MSK12, VLAB, VLA-BETA
  • Links
    NCBI Gene ID: 3688
    neXtProt AC: NX_P05556
    UniProt: P05556

  • Chr Location
    10p11.22; chr10:32900318-32958365 (-)  GRCh38.p7
Human Diseases
more
  • Diseases
    1 with Itgb1 mouse models

Human Disease Mouse Models
      
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    5 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    267 phenotypes from 25 alleles in 20 genetic backgrounds
    36 phenotypes from multigenic genotypes
    13 images
    157 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous targeted null mutants die at or soon after implantation. Tissue-specific knockouts exhibit skin blisters, hair-loss, brain and heart defects, and impaired immune responses, wound healing, and hematopoietic stem cell migration, respectively.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    153
  • GO References
    47
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    317
  • Tissues
    179
  • cDNA Data
    30
  • Literature Summary
    179
  • Comparison Matrix
    Gene Expression + Phenotype
    • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000034034 VEGA Gene Model | MGI Sequence Detail 47547 C57BL/6J ±  kb
    transcript OTTMUST00000085926 VEGA | MGI Sequence Detail 3815 Not Applicable  
    polypeptide OTTMUSP00000046463 VEGA | MGI Sequence Detail 798 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      184 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 44
      Genomic 5
      cDNA 31
      Primer pair 7
      Other 1

      Microarray probesets 10
    Other
    Accession IDs
    less
    MGD-MRK-11489, MGD-MRK-9852, MGI:1918062, MGI:2142419, MGI:2142452, MGI:3708799
    References
    more
    • Summaries
      All 622
      Developmental Gene Expression 179
      Diseases 2
      Gene Ontology 47
      Phenotypes 157
    • Earliest
      J:9382 Tominaga S, Murine mRNA for the beta-subunit of integrin is increased in BALB/c-3T3 cells entering the G1 phase from the G0 state. FEBS Lett. 1988 Oct 10;238(2):315-9
    • Latest
      J:258463 Wang Y, et al., beta1-Integrin Deletion From the Lens Activates Cellular Stress Responses Leading to Apoptosis and Fibrosis. Invest Ophthalmol Vis Sci. 2017 Aug 1;58(10):3896-3922
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    05/15/2018
    MGI 6.12     		The Jackson Laboratory