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Itgb1 Gene Detail
Summary
  • Symbol
    Itgb1
  • Name
    integrin beta 1 (fibronectin receptor beta)
  • Synonyms
    4633401G24Rik, beta1 integrin, CD29, Fnrb, Gm9863
  • Feature Type
    protein coding gene
  • IDs
    MGI:96610
    NCBI Gene: 16412
  • Gene Overview
    MyGene.info: ITGB1
  • Alliance
  • Transcription Start Sites
    12 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:128685654-128733200 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 8, 76.09 cM, cytoband E2
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    184 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_96610
protein coding gene Chr8:128685654-128733579 (.)
129S1/SvImJ MGP_129S1SvImJ_G0034301
protein coding gene Chr8:132647912-132701704 (+)
A/J MGP_AJ_G0034280
protein coding gene Chr8:127155051-127203735 (+)
AKR/J MGP_AKRJ_G0034207
protein coding gene Chr8:130817454-130866553 (+)
BALB/cJ MGP_BALBcJ_G0034273
protein coding gene Chr8:127311820-127359167 (+)
C3H/HeJ MGP_C3HHeJ_G0033984
protein coding gene Chr8:131437715-131490690 (+)
C57BL/6NJ MGP_C57BL6NJ_G0034793
protein coding gene Chr8:136931962-136983308 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0031735
protein coding gene Chr8:119781933-119829542 (+)
CAST/EiJ MGP_CASTEiJ_G0033311
protein coding gene Chr8:131648161-131698693 (+)
CBA/J MGP_CBAJ_G0033958
protein coding gene Chr8:142072060-142121410 (+)
DBA/2J MGP_DBA2J_G0034113
protein coding gene Chr8:126221487-126269363 (+)
FVB/NJ MGP_FVBNJ_G0034058
protein coding gene Chr8:125465478-125512832 (+)
LP/J MGP_LPJ_G0034202
protein coding gene Chr8:132824090-132872550 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0034104
protein coding gene Chr8:143918015-143969030 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0034812
protein coding gene Chr8:131035910-131085990 (+)
PWK/PhJ MGP_PWKPhJ_G0033014
protein coding gene Chr8:126069658-126118360 (+)
SPRET/EiJ MGP_SPRETEiJ_G0032852
protein coding gene Chr8:129703373-129757939 (+)
WSB/EiJ MGP_WSBEiJ_G0033429
protein coding gene Chr8:131792266-131851490 (+)



Homology
more
  • Human Ortholog
    ITGB1, integrin subunit beta 1
  • Vertebrate Orthologs
    11
  • Human Ortholog
    ITGB1, integrin subunit beta 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CD29, FNRB, GPIIA, MDF2, MSK12, VLAB, VLA-BETA
  • Links
    NCBI Gene ID: 3688
    neXtProt AC: NX_P05556
    UniProt: P05556

  • Chr Location
    10p11.22; chr10:32900318-32958365 (-)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with Itgb1 mouse models

Human Disease Mouse Models
      
IDs
View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    5 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    267 phenotypes from 25 alleles in 20 genetic backgrounds
    36 phenotypes from multigenic genotypes
    13 images
    164 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous targeted null mutants die at or soon after implantation. Tissue-specific knockouts exhibit skin blisters, hair-loss, brain and heart defects, and impaired immune responses, wound healing, and hematopoietic stem cell migration, respectively.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000025809 Ensembl Gene Model | MGI Sequence Detail 47547 C57BL/6J ±  kb
    transcript ENSMUST00000090006 Ensembl | MGI Sequence Detail 3815 Not Applicable  
    polypeptide ENSMUSP00000087457 Ensembl | MGI Sequence Detail 798 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 46
      Genomic 5
      cDNA 33
      Primer pair 7
      Other 1

      Microarray probesets 10
    Other
    Accession IDs
    less
    MGD-MRK-11489, MGD-MRK-9852, MGI:1918062, MGI:2142419, MGI:2142452, MGI:3708799
    References
    more
    • Summaries
      All 633
      Developmental Gene Expression 184
      Diseases 2
      Gene Ontology 51
      Phenotypes 164
    • Earliest
      J:9382 Tominaga S, Murine mRNA for the beta-subunit of integrin is increased in BALB/c-3T3 cells entering the G1 phase from the G0 state. FEBS Lett. 1988 Oct 10;238(2):315-9
    • Latest
      J:264500 Tsuchiya Y, et al., Ripply3 is required for the maintenance of epithelial sheets in the morphogenesis of pharyngeal pouches. Dev Growth Differ. 2018 Feb;60(2):87-96

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory