Itgb1
Gene Detail

Symbol Name ID

Itgb1 integrin beta 1 (fibronectin receptor beta) MGI:96610

Synonyms

4633401G24Rik, beta1 integrin, CD29, Fnrb, Gm9863

Feature Type

protein coding gene

Genetic Map

Chromosome 8

76.09 cM, cytoband E2
Detailed Genetic Map ± 1 cM


Mapping data(4)

Sequence Map

Chr8:128685654-128733200 bp, + strand From VEGA annotation of GRCm38   47547 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:22999  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 2 zebrafish

Protein SuperFamily: integrin, beta subunit
Gene Tree: Itgb1

Human homologs

Human Homolog		ITGB1, integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)
NCBI Gene ID		3688
neXtProt AC		NX_P05556
Human Synonyms		CD29, FNRB, GPIIA, MDF2, MSK12, VLAB, VLA-BETA
Human Chr (Location)		10p11.2; chr10:32900318-32958365 (-)  GRCh38

Mutations, alleles, and phenotypes

All mutations/alleles(56) : Gene trapped(28) Targeted(28)
Incidental mutations (data from Mutagenetix , APF )
 

Homozygous targeted null mutants die at or soon after implantation. Tissue-specific knockouts exhibit skin blisters, hair-loss, brain and heart defects, and impaired immune responses, wound healing, and hematopoietic stem cell migration, respectively.

 
Phenotype Images(13)

Interactions

Itgb1 interacts with 388 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)

View All

Gene Ontology (GO) classifications

All GO classifications: (112 annotations)

Process	axon extension, calcium-independent cell-matrix adhesion, ...
Component	acrosomal vesicle, adherens junction, ...
Function	actin binding, alpha-actinin binding, ...

External Resources: FuncBase

Expression

Literature Summary: (142 records)

Data Summary: Results (259)    Tissues (127)    Images (48)
Theiler Stages: 1, 2, 3, 4, 11, 15, 17, 19, 20, 21, 22, 23, 25, 28

Assay Type	Results
Immunohistochemistry	27
RNA in situ	169
Northern blot	8
Western blot	3
RT-PCR	52

cDNA source data(27)
External Resources: Allen Institute   GEO   Expression Atlas

Molecular reagents

All nucleic(40) Genomic(5) cDNA(29) Primer pair(5) Other(1)
Microarray probesets(10)

Other database links

VEGA Gene Model	OTTMUSG00000034034 (Evidence)
Ensembl Gene Model	ENSMUSG00000025809 (Evidence)
Entrez Gene	16412 (Evidence)
DFCI	TC1573144, TC1599010, TC1644698, TC1700562, TC1765398
DoTS	DT.101148623, DT.495375, DT.55244968, DT.94370001, DT.97415022
NIA Mouse Gene Index	U009995, U200362
Consensus CDS Project	CCDS22791.1
International Mouse Knockout Project Status	Itgb1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000034034	VEGA Gene Model | MGI Sequence Detail	47547	C57BL/6J
transcript	OTTMUST00000085926	VEGA | MGI Sequence Detail	3815	Not Applicable
polypeptide	OTTMUSP00000046463	VEGA | MGI Sequence Detail	798	Not Applicable

All sequences(60) RefSeq(2) UniProt(4)

Polymorphisms

SNPs within 2kb(184 from dbSNP Build 137)

Protein-related information

Resource	ID	Description
InterPro	IPR013111	EGF, extracellular
InterPro	IPR027071	Integrin beta-1 subunit
InterPro	IPR015812	Integrin beta subunit
InterPro	IPR014836	Integrin beta subunit, cytoplasmic domain
InterPro	IPR002369	Integrin beta subunit, N-terminal
InterPro	IPR012896	Integrin beta subunit, tail
InterPro	IPR016201	Plexin-like fold
InterPro	IPR002035	von Willebrand factor, type A
Protein Ontology	PR:000002040	integrin beta-1

References

(Earliest) J:9382 Tominaga S, Murine mRNA for the beta-subunit of integrin is increased in BALB/c-3T3 cells entering the G1 phase from the G0 state. FEBS Lett. 1988 Oct 10;238(2):315-9
(Latest) J:208648 Montani L, et al., Profilin 1 is required for peripheral nervous system myelination. Development. 2014 Apr;141(7):1553-61
All references(423)

Other accession IDs

MGD-MRK-11489, MGD-MRK-9852, MGI:1918062, MGI:2142419, MGI:2142452, MGI:3708799