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Itgb1
Gene Detail
 Symbol
Name
ID
Itgb1
integrin beta 1 (fibronectin receptor beta)
MGI:96610
Synonyms 4633401G24Rik, beta1 integrin, CD29, Fnrb, Gm9863
Feature Type protein coding gene
Genetic Map
Chromosome 8
76.09 cM, cytoband E2
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr8:128685654-128733200 bp, + strand
From VEGA annotation of GRCm38

  47547 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:22999  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 2 zebrafish

Protein SuperFamily: integrin, beta subunit
Gene Tree: Itgb1

Human
homologs
Human Homolog ITGB1, integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)
NCBI Gene ID 3688
neXtProt AC  NX_P05556
Human Synonyms  CD29, FNRB, GPIIA, MDF2, MSK12, VLAB, VLA-BETA
Human Chr (Location)  10p11.2; chr10:32900318-32958365 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(56) : Gene trapped(28) Targeted(28)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous targeted null mutants die at or soon after implantation. Tissue-specific knockouts exhibit skin blisters, hair-loss, brain and heart defects, and impaired immune responses, wound healing, and hematopoietic stem cell migration, respectively.
 
Phenotype Images(13)
Interactions
Itgb1 interacts with 388 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (112 annotations)
Process axon extension, calcium-independent cell-matrix adhesion, ...
Component acrosomal vesicle, adherens junction, ...
Function actin binding, alpha-actinin binding, ...
External Resources: FuncBase
Expression
Literature Summary: (142 records)
Data Summary: Results (259)    Tissues (127)    Images (48)
Theiler Stages: 1, 2, 3, 4, 11, 15, 17, 19, 20, 21, 22, 23, 25, 28
Assay TypeResults
Immunohistochemistry 27
RNA in situ 169
Northern blot 8
Western blot 3
RT-PCR 52
cDNA source data(27)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(40) Genomic(5) cDNA(29) Primer pair(5) Other(1)
Microarray probesets(10)
Other database
links
VEGA Gene ModelOTTMUSG00000034034 (Evidence)
Ensembl Gene ModelENSMUSG00000025809 (Evidence)
Entrez Gene16412 (Evidence)
DFCITC1573144, TC1599010, TC1644698, TC1700562, TC1765398
DoTSDT.101148623, DT.495375, DT.55244968, DT.94370001, DT.97415022
NIA Mouse Gene IndexU009995, U200362
Consensus CDS ProjectCCDS22791.1
International Mouse Knockout Project StatusItgb1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000034034 VEGA Gene Model | MGI Sequence Detail 47547 C57BL/6J ±  kb
transcript OTTMUST00000085926 VEGA | MGI Sequence Detail 3815 Not Applicable 
polypeptide OTTMUSP00000046463 VEGA | MGI Sequence Detail 798 Not Applicable 

For the selected sequences
All sequences(60) RefSeq(2) UniProt(4)
Polymorphisms SNPs within 2kb(184 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR013111 EGF, extracellular
InterPro IPR027071 Integrin beta-1 subunit
InterPro IPR015812 Integrin beta subunit
InterPro IPR014836 Integrin beta subunit, cytoplasmic domain
InterPro IPR002369 Integrin beta subunit, N-terminal
InterPro IPR012896 Integrin beta subunit, tail
InterPro IPR016201 Plexin-like fold
InterPro IPR002035 von Willebrand factor, type A
Protein Ontology PR:000002040 integrin beta-1
References (Earliest) J:9382 Tominaga S, Murine mRNA for the beta-subunit of integrin is increased in BALB/c-3T3 cells entering the G1 phase from the G0 state. FEBS Lett. 1988 Oct 10;238(2):315-9
(Latest) J:208648 Montani L, et al., Profilin 1 is required for peripheral nervous system myelination. Development. 2014 Apr;141(7):1553-61
All references(423)
Other
accession IDs
MGD-MRK-11489, MGD-MRK-9852, MGI:1918062, MGI:2142419, MGI:2142452, MGI:3708799

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/23/2014
MGI 5.19
The Jackson Laboratory