Itgb1 MGI Mouse Gene Detail - MGI:96610 - integrin beta 1 (fibronectin receptor beta)

Itgb1 Gene Detail

Symbol

Itgb1
Name

integrin beta 1 (fibronectin receptor beta)
Synonyms

4633401G24Rik, beta1 integrin, CD29, Fnrb, Gm9863

Feature Type

protein coding gene
IDs

MGI:96610
NCBI Gene: 16412
Gene Overview

MyGene.info: ITGB1

Sequence Map

Chr8:128685654-128733200 bp, + strand
From VEGA annotation of GRCm38

Mouse Genome Browser
Download
Sequence

47547 bp ± kb flank
Genome Browsers

VEGA | Ensembl | UCSC | NCBI

Genetic Map

Chromosome 8, 76.09 cM, cytoband E2
Mapping Data

4 experiments

Human Ortholog

ITGB1, integrin subunit beta 1

Vertebrate Orthologs

11

Human Ortholog

ITGB1, integrin subunit beta 1
Orthology source: HomoloGene, HGNC
Synonyms

CD29, FNRB, GPIIA, MDF2, MSK12, VLAB, VLA-BETA
Links

HGNC:6153

NCBI Gene ID: 3688

neXtProt AC: NX_P05556
Chr Location

10p11.2; chr10:32900318-32958365 (-) GRCh38.p2

HomoloGene

Vertebrate Homology Class 22999
1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;2 zebrafish;1 frog, western clawed
HCOP

human homology predictions: ITGB1
Protein SuperFamily

integrin, beta subunit
Gene Tree

Itgb1

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Phenotype Summary

264 phenotypes from 25 alleles in 20 genetic backgrounds
36 phenotypes from multigenic genotypes
13 images
144 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

59
Gene trapped

28
Targeted

28
Transgenic

3
Incidental Mutations

Mutagenetix , APF , CvDC

Homozygous targeted null mutants die at or soon after implantation. Tissue-specific knockouts exhibit skin blisters, hair-loss, brain and heart defects, and impaired immune responses, wound healing, and hematopoietic stem cell migration, respectively.

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All GO Annotations

150
GO References

46

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	receptor	receptor binding	RNA binding	transcription	transferase	transporter

Biological Process

nucleic acid-templated transcription	carbohydrate derivative metabolism	cell death	cell differentiation	cell proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

306
Tissues

168
cDNA Data

30
Literature Summary

160

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO
Other Vertebrate Links

GEISHA ITGB1

Xenbase itgb1

ZFIN itgb1a

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Itgb1 interacts with 387 markers (Mir1a-1, Mir1a-2, Mir7-1, ...) View All

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All Sequences

49
RefSeq

2
UniProt

5
CCDS

CCDS22791.1

			Length	Strain/Species	Flank
genomic	OTTMUSG00000034034	VEGA Gene Model \| MGI Sequence Detail	47547	C57BL/6J	± kb
transcript	OTTMUST00000085926	VEGA \| MGI Sequence Detail	3815	Not Applicable
polypeptide	OTTMUSP00000046463	VEGA \| MGI Sequence Detail	798	Not Applicable

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SNPs within 2kb

184 from dbSNP Build 142

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UniProt

5 Sequences
Protein Ontology

PR:000002040 integrin beta-1
InterPro Domains

IPR013111 EGF-like domain, extracellular

IPR027071 Integrin beta-1 subunit

IPR015812 Integrin beta subunit

IPR014836 Integrin beta subunit, cytoplasmic domain

IPR002369 Integrin beta subunit, N-terminal

IPR012896 Integrin beta subunit, tail

IPR032695 Integrin domain

IPR016201 Plexin-like fold

IPR002035 von Willebrand factor, type A

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All nucleic 44

Genomic 5

cDNA 31

Primer pair 7

Other 1

Microarray probesets 10

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MGD-MRK-11489, MGD-MRK-9852, MGI:1918062, MGI:2142419, MGI:2142452, MGI:3708799

Summaries

All 463

Developmental Gene Expression 160

Gene Ontology 46

Phenotypes 144
Earliest

J:9382 Tominaga S, Murine mRNA for the beta-subunit of integrin is increased in BALB/c-3T3 cells entering the G1 phase from the G0 state. FEBS Lett. 1988 Oct 10;238(2):315-9
Latest

J:233754 Broders-Bondon F, et al., Control of the collective migration of enteric neural crest cells by the Complement anaphylatoxin C3a and N-cadherin. Dev Biol. 2016 Jun 1;414(1):85-99

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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