Automated description from the Alliance of Genome Resources (Release 7.0.0)
Enables integrin binding activity involved in cell-matrix adhesion. Contributes to laminin binding activity. Involved in several processes, including basement membrane organization; cellular response to low-density lipoprotein particle stimulus; and regulation of synapse pruning. Acts upstream of or within with a negative effect on reactive gliosis and regulation of spontaneous synaptic transmission. Acts upstream of or within several processes, including G1/S transition of mitotic cell cycle; circulatory system development; and neuron projection morphogenesis. Located in several cellular components, including intercalated disc; myelin sheath abaxonal region; and sarcolemma. Part of integrin alpha7-beta1 complex and integrin alpha9-beta1 complex. Is active in Schaffer collateral - CA1 synapse and cerebellar climbing fiber to Purkinje cell synapse. Colocalizes with cytoplasmic vesicle; perinuclear region of cytoplasm; and plasma membrane. Is expressed in several structures, including alimentary system; eye; genitourinary system; heart; and nervous system. Used to study Hirschsprung's disease. Orthologous to human ITGB1 (integrin subunit beta 1).
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