Itgal MGI Mouse Gene Detail - MGI:96606

Symbol

Itgal
Name

integrin alpha L
Synonyms

Cd11a, LFA-1, Ly-15, Ly-21

Feature Type

protein coding gene
IDs

MGI:96606
NCBI Gene: 16408
Alliance

gene page
Transcription Start Sites

18 TSS

Sequence Map

Chr7:126895432-126934310 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 7, 69.44 cM
Mapping Data

19 experiments

SNPs within 2kb

355 from dbSNP Build 142
Strain Annotations

18
PCR

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_96606	protein coding gene	Chr7:126895404-126934310 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0033031	protein coding gene	Chr7:131638327-131682541 (+)
A/J	MGP_AJ_G0033014	protein coding gene	Chr7:128130752-128169886 (+)
AKR/J	MGP_AKRJ_G0032946	protein coding gene	Chr7:131395358-131449668 (+)
BALB/cJ	MGP_BALBcJ_G0033019	protein coding gene	Chr7:127810278-127850370 (+)
C3H/HeJ	MGP_C3HHeJ_G0032729	protein coding gene	Chr7:131323487-131363772 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0033525	protein coding gene	Chr7:136750350-136798478 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0030497	protein coding gene	Chr7:129340031-129379450 (+)
CAST/EiJ	MGP_CASTEiJ_G0032058	protein coding gene	Chr7:123126225-123168947 (+)
CBA/J	MGP_CBAJ_G0032702	protein coding gene	Chr7:141371889-141413017 (+)
DBA/2J	MGP_DBA2J_G0032854	protein coding gene	Chr7:126105539-126144528 (+)
FVB/NJ	MGP_FVBNJ_G0032807	protein coding gene	Chr7:125958069-125996730 (+)
LP/J	MGP_LPJ_G0032948	protein coding gene	Chr7:133099922-133139788 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0032839	protein coding gene	Chr7:142493612-142538738 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0033544	protein coding gene	Chr7:130407383-130447399 (+)
PWK/PhJ	MGP_PWKPhJ_G0031766	protein coding gene	Chr7:119114925-119157144 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0031611	protein coding gene	Chr7:117244694-117283326 (+)
WSB/EiJ	MGP_WSBEiJ_G0032170	protein coding gene	Chr7:131372531-131430694 (+)

Human Ortholog

ITGAL, integrin subunit alpha L

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

ITGAL, integrin subunit alpha L
Synonyms

CD11A, LFA-1, LFA1A
Links

HGNC:6148

NCBI Gene ID: 3683

neXtProt AC: NX_P20701

UniProt: P20701
Chr Location

16p11.2; chr16:30472658-30523567 (+) GRCh38

MGI Vertebrate Homology

Itgal stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: ITGAL
Gene Tree

Itgal

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Phenotype Summary

42 phenotypes from 7 alleles in 9 genetic backgrounds
3 phenotypes from multigenic genotypes
112 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

12
Endonuclease-mediated

4
Gene trapped

1
Spontaneous

1
Targeted

6
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

74 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Nullizygous mutations of this gene lead to increased leukocyte cell number, alter T cell activation, leukocyte migration and adhesion, spleen and lymph node morphology, and may affect humoral immune responses, metastatic potential, and susceptibility to endotoxin shock.

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All GO Annotations

35
GO References

13

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

720
Tissues

11
cDNA Data

41
Literature Summary

5

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase itgal

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All Sequences

70
RefSeq

10
UniProt

13
CCDS

CCDS57588.1, CCDS57589.1

Ensembl

ENSMUSG00000030830 (Evidence)
NCBI Gene

16408

			Length	Strain/Species	Flank
genomic	ENSMUSG00000030830	Ensembl Gene Model \| MGI Sequence Detail	38879	C57BL/6J	± kb
transcript	ENSMUST00000120857	Ensembl \| MGI Sequence Detail	4533	Not Applicable
polypeptide	ENSMUSP00000113396	Ensembl \| MGI Sequence Detail	1201	Not Applicable

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UniProt

13 Sequences
Protein Ontology

PR:000001011 integrin alpha-L

(term hierarchy)
InterPro Domains

IPR013517 FG-GAP repeat

IPR013519 Integrin alpha beta-propellor

IPR000413 Integrin alpha chain

IPR018184 Integrin alpha chain, C-terminal cytoplasmic region, conserved site

IPR013649 Integrin alpha, first immunoglubulin-like domain

IPR028994 Integrin alpha, N-terminal

IPR048285 Integrin alpha, second immunoglobulin-like domain

IPR032695 Integrin domain superfamily

IPR036465 von Willebrand factor A-like domain superfamily

IPR002035 von Willebrand factor, type A

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All nucleic 44

cDNA 41

Primer pair 3

Microarray probesets 4

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MGD-MRK-11485, MGD-MRK-11953, MGD-MRK-11960, MGD-MRK-1830

Summaries

All 203

Developmental Gene Expression 5

Gene Ontology 13

Phenotypes 112
Earliest

J:6511 Potter TA, et al., Ly-15: a new murine lymphocyte alloantigenic locus. Transplantation. 1981 May;31(5):339-42
Latest

J:340745 Niu T, et al., LFA-1 knockout inhibited the tumor growth and is correlated with treg cells. Cell Commun Signal. 2023 Sep 18;21(1):233

TSS for Itgal:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr69188	Chr7:126895401-126895404 (+)	-29 bp
Tssr69189	Chr7:126895408-126895419 (+)	-18 bp
Tssr69190	Chr7:126895423-126895447 (+)	3 bp
Tssr69191	Chr7:126895463-126895492 (+)	46 bp
Tssr69192	Chr7:126895510-126895524 (+)	85 bp
Tssr69193	Chr7:126895541-126895561 (+)	119 bp
Tssr69194	Chr7:126896500-126896549 (+)	1,093 bp
Tssr69195	Chr7:126896559-126896571 (+)	1,133 bp
Tssr69196	Chr7:126896586-126896606 (+)	1,164 bp
Tssr69197	Chr7:126896780-126896791 (+)	1,354 bp
Tssr69198	Chr7:126924392-126924415 (+)	28,972 bp
Tssr69199	Chr7:126925483-126925517 (+)	30,068 bp
Tssr69200	Chr7:126931526-126931534 (+)	36,098 bp
Tssr69201	Chr7:126932742-126932753 (+)	37,316 bp
Tssr69202	Chr7:126932774-126932797 (+)	37,354 bp
Tssr69203	Chr7:126932822-126932839 (+)	37,399 bp
Tssr69204	Chr7:126932953-126933007 (+)	37,548 bp
Tssr69205	Chr7:126933885-126933920 (+)	38,471 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/16/2024 MGI 6.23