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Itgal Gene Detail
Summary
  • Symbol
    Itgal
  • Name
    integrin alpha L
  • Synonyms
    Cd11a, LFA-1, Ly-15, Ly-21
  • Feature Type
    protein coding gene
  • IDs
    MGI:96606
    NCBI Gene: 16408
  • Gene Overview
    MyGene.info: ITGAL
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr7:127296260-127335138 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      38879 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 69.44 cM
  • Mapping Data
    17 experiments
Homology
more
  • Human Ortholog
    ITGAL, integrin subunit alpha L
  • Vertebrate Orthologs
    7
  • Human Ortholog
    ITGAL, integrin subunit alpha L
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CD11A, LFA-1, LFA1A
  • Links
    NCBI Gene ID: 3683
    neXtProt AC: NX_P20701
    UniProt: P20701

  • Chr Location
    16p11.2; chr16:30472662-30523185 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    38 phenotypes from 6 alleles in 8 genetic backgrounds
    3 phenotypes from multigenic genotypes
    79 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Nullizygous mutations of this gene lead to increased leukocyte cell number, alter T cell activation, leukocyte migration and adhesion, spleen and lymph node morphology, and may affect humoral immune responses, metastatic potential, and susceptibility to endotoxin shock.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000031314 VEGA Gene Model | MGI Sequence Detail 38879 C57BL/6J ±  kb
    transcript OTTMUST00000077570 VEGA | MGI Sequence Detail 4533 Not Applicable  
    polypeptide OTTMUSP00000041058 VEGA | MGI Sequence Detail 1201 Not Applicable  
    For the selected sequence
    Polymorphisms
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    • SNPs within 2kb
      355 from dbSNP Build 142
    • PCR
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 42
      cDNA 40
      Primer pair 2

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-11485, MGD-MRK-11953, MGD-MRK-11960, MGD-MRK-1830
    References
    more
    • Summaries
      All 164
      Developmental Gene Expression 4
      Gene Ontology 12
      Phenotypes 79
    • Earliest
      J:6511 Potter TA, et al., Ly-15: a new murine lymphocyte alloantigenic locus. Transplantation. 1981 May;31(5):339-42
    • Latest
      J:256313 Saitoh SI, et al., TLR7 mediated viral recognition results in focal type I interferon secretion by dendritic cells. Nat Commun. 2017 Nov 17;8(1):1592

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    06/12/2018
    MGI 6.12
    The Jackson Laboratory