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Gene Detail
integrin alpha 6
Synonyms 5033401O05Rik, Cd49f
Feature Type protein coding gene
Genetic Map
Chromosome 2
42.79 cM
Detailed Genetic Map ± 1 cM

Mapping data(4)
Sequence Map
Chr2:71745616-71858416 bp, + strand
From VEGA annotation of GRCm38

  112801 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser
HomoloGene:20091  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: integrin alpha, VLA protein type
Gene Tree: Itga6

Human Homolog ITGA6, integrin, alpha 6
NCBI Gene ID 3655
neXtProt AC  NX_P23229
Human Synonyms  CD49f, ITGA6B, VLA-6
Human Chr (Location)  2q31.1; chr2:172427586-172506453 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human ITGA6
alleles, and
All mutations/alleles(126) : Gene trapped(118) Targeted(8)
Genomic Mutations involving Itga6 (4)
Incidental mutations (data from Mutagenetix , APF )
Homozygotes for a targeted null mutation exhibit severe blistering of the skin and other epithelia, absence of hemidesmosomes, altered laminin deposition in brain, and ectopic neuroblastic outgrowths on the brain and in the eye. Mutants die at birth.
Human Diseases Modeled Using Mouse Itga6 (1)    Alleles Annotated to Human Diseases(1)   
Itga6 interacts with 223 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
All GO classifications: (45 annotations)
Process amelogenesis, brown fat cell differentiation, ...
Component basal part of cell, basal plasma membrane, ...
Function integrin binding, laminin binding, ...
External Resources: FuncBase
Literature Summary: (102 records)
Data Summary: Results (633)    Tissues (339)    Images (125)
Theiler Stages: 4, 5, 11, 13, 14, 15, 17, 19, 20, 21, 22, 23, 25, 26, 27, 28
Assay TypeResults
Immunohistochemistry 126
RNA in situ 347
RT-PCR 160
cDNA source data(252)
External Resources: Allen Institute   GEO   Expression Atlas
All nucleic(262) Genomic(1) cDNA(257) Primer pair(4)
Microarray probesets(4)
Other database
VEGA Gene ModelOTTMUSG00000013266 (Evidence)
Ensembl Gene ModelENSMUSG00000027111 (Evidence)
Entrez Gene16403 (Evidence)
DFCITC1573023, TC1597642, TC1598657, TC1598836
DoTSDT.101399010, DT.101718571, DT.101720597, DT.495132, DT.94195227, DT.94195255, DT.99843588
NIA Mouse Gene IndexU001906
Consensus CDS ProjectCCDS16118.1, CCDS71074.1
International Mouse Knockout Project StatusItga6
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000013266 VEGA Gene Model | MGI Sequence Detail 112801 C57BL/6J ±  kb
transcript OTTMUST00000032064 VEGA | MGI Sequence Detail 4156 Not Applicable 
polypeptide OTTMUSP00000014264 VEGA | MGI Sequence Detail 1091 Not Applicable 

For the selected sequences
All sequences(70) RefSeq(8) UniProt(7)
Polymorphisms SNPs within 2kb(1098 from dbSNP Build 137)
InterPro IPR013517 FG-GAP repeat
InterPro IPR013649 Integrin alpha-2
InterPro IPR013519 Integrin alpha beta-propellor
InterPro IPR000413 Integrin alpha chain
InterPro IPR018184 Integrin alpha chain, C-terminal cytoplasmic region, conserved site
Protein Ontology PR:000009131 integrin alpha-6
References (Earliest) J:35482 Sonnenberg A, et al., Laminin receptor on platelets is the integrin VLA-6. Nature. 1988 Dec 1;336(6198):487-9
(Latest) J:209511 Basu S, et al., alpha6 integrin transactivates insulin-like growth factor receptor-1 (IGF-1R) to regulate caspase-3-mediated lens epithelial cell differentiation initiation. J Biol Chem. 2014 Feb 14;289(7):3842-55
All references(203)
Disease annotation references (1)
accession IDs
MGD-MRK-11484, MGI:1923212, MGI:2138837

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
MGI 5.19
The Jackson Laboratory