Itga6
Gene Detail

Symbol Name ID

Itga6 integrin alpha 6 MGI:96605

Synonyms

5033401O05Rik, Cd49f

Feature Type

protein coding gene

Genetic Map

Chromosome 2

42.79 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)

Sequence Map

Chr2:71745616-71858416 bp, + strand From VEGA annotation of GRCm38   112801 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:20091  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: integrin alpha, VLA protein type
Gene Tree: Itga6

Human homologs

Human Homolog		ITGA6, integrin, alpha 6
NCBI Gene ID		3655
neXtProt AC		NX_P23229
Human Synonyms		CD49f, ITGA6B, VLA-6
Human Chr (Location)		2q31.1; chr2:173291954-173371181 (+)  GRCh37.p13
Disease Associations		(1) Diseases Associated with Human ITGA6

Alleles and phenotypes

All alleles(121) : Targeted(3) Gene trapped(118)
 

Homozygotes for a targeted null mutation exhibit severe blistering of the skin and other epithelia, absence of hemidesmosomes, altered laminin deposition in brain, and ectopic neuroblastic outgrowths on the brain and in the eye. Mutants die at birth.

 
Human Diseases Modeled Using Mouse Itga6 (1)    Alleles Annotated to Human Diseases(1)   

Gene Ontology (GO) classifications

All GO classifications: (37 annotations)

Process	brown fat cell differentiation, cell adhesion, ...
Component	alpha6-beta4 integrin complex, basal part of cell, ...
Function	integrin binding, laminin binding, ...

External Resources: FuncBase

Expression

Literature Summary: (99 records)

Data Summary: Results (636)    Tissues (339)    Images (125)
Theiler Stages: 4, 11, 13, 14, 15, 17, 19, 20, 21, 22, 23, 25, 26, 28

Assay Type	Results
Immunohistochemistry	126
RNA in situ	347
RT-PCR	163

cDNA source data(252)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(262) Genomic(1) cDNA(257) Primer pair(4)
Microarray probesets(4)

Other database links

VEGA Gene Model	OTTMUSG00000013266 (Evidence)
Ensembl Gene Model	ENSMUSG00000027111 (Evidence)
Entrez Gene	16403 (Evidence)
UniGene	225096
DFCI	TC1573023, TC1597642, TC1598657, TC1598836
DoTS	DT.101399010, DT.101718571, DT.101720597, DT.495132, DT.94195227, DT.94195255, DT.99843588
NIA Mouse Gene Index	U001906
Consensus CDS Project	CCDS16118.1
International Mouse Knockout Project Status	Itga6

Sequences

Length	Strain/Species
genomic	OTTMUSG00000013266	VEGA Gene Model | MGI Sequence Detail	112801	C57BL/6J
transcript	OTTMUST00000032064	VEGA | MGI Sequence Detail	4156	Not Applicable
polypeptide	OTTMUSP00000014264	VEGA | MGI Sequence Detail	1091	Not Applicable

All sequences(70) RefSeq(8) UniProt(7)

Polymorphisms

SNPs within 2kb(1098 from dbSNP Build 137)

Protein-related information

Resource	ID	Description
InterPro	IPR013517	FG-GAP repeat
InterPro	IPR013649	Integrin alpha-2
InterPro	IPR013519	Integrin alpha beta-propellor
InterPro	IPR000413	Integrin alpha chain
InterPro	IPR018184	Integrin alpha chain, C-terminal cytoplasmic region, conserved site
Protein Ontology	PR:000009131	integrin alpha-6

References

(Earliest) J:35482 Sonnenberg A, et al., Laminin receptor on platelets is the integrin VLA-6. Nature. 1988 Dec 1;336(6198):487-9
(Latest) J:202224 Crish J, et al., Keratin 5-Cre-driven excision of nonmuscle myosin IIA in early embryo trophectoderm leads to placenta defects and embryonic lethality. Dev Biol. 2013 Oct 1;382(1):136-48
All references(196)

Other accession IDs

MGD-MRK-11484, MGI:1923212, MGI:2138837