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Itga6 Gene Detail
Summary
  • Symbol
    Itga6
  • Name
    integrin alpha 6
  • Synonyms
    5033401O05Rik, Cd49f
  • Feature Type
    protein coding gene
  • IDs
    MGI:96605
    NCBI Gene: 16403
  • Gene Overview
    MyGene.info: ITGA6
Location & Maps
more
  • Sequence Map
    Chr2:71745616-71858416 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser
  • Download
    Sequence
      112801 bp   ±  kb flank

  • Genome Browsers
    VEGA | Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 42.79 cM
  • Mapping Data
    4 experiments
Homology
more
  • Human Ortholog
    ITGA6, integrin subunit alpha 6
  • Vertebrate Orthologs
    10
  • Human Ortholog
    ITGA6, integrin subunit alpha 6
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CD49f, ITGA6B, VLA-6
  • Links
    NCBI Gene ID: 3655
    neXtProt AC: NX_P23229

  • Chr Location
    2q31.1; chr2:172427586-172506453 (+)  GRCh38.p2
Human Diseases
more
  • Diseases
    1 with Itga6 mouse models; 1 with human ITGA6 associations

Human Disease Mouse Models
       Epidermolysis Bullosa, Junctional, Herlitz Type   OMIM: 226700 View 1 model
       Epidermolysis Bullosa Junctionalis with Pyloric Atresia   OMIM: 226730
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    27 phenotypes from 5 alleles in 7 genetic backgrounds
    34 phenotypes from multigenic genotypes
    40 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    129
  • Chemically induced (other)
    1
  • Gene trapped
    118
  • Targeted
    10
  • Genomic Mutations
    7 involving Itga6
  • Incidental Mutations
    Mutagenetix , APF , CvDC
Homozygotes for a targeted null mutation exhibit severe blistering of the skin and other epithelia, absence of hemidesmosomes, altered laminin deposition in brain, and ectopic neuroblastic outgrowths on the brain and in the eye. Mutants die at birth.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    53
  • GO References
    30
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    656
  • Tissues
    356
  • cDNA Data
    253
  • Literature Summary
    111
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000013266 VEGA Gene Model | MGI Sequence Detail 112801 C57BL/6J ±  kb
transcript OTTMUST00000032064 VEGA | MGI Sequence Detail 4156 Not Applicable  
polypeptide OTTMUSP00000014264 VEGA | MGI Sequence Detail 1091 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    1092 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 264
    Genomic 1
    cDNA 257
    Primer pair 5
    Other 1

    Microarray probesets 4
Other
Accession IDs
less
MGD-MRK-11484, MGI:1923212, MGI:2138837
References
more
  • Summaries
    All 211
    Developmental Gene Expression 111
    Diseases 1
    Gene Ontology 30
    Phenotypes 40
  • Earliest
    J:35482 Sonnenberg A, et al., Laminin receptor on platelets is the integrin VLA-6. Nature. 1988 Dec 1;336(6198):487-9
  • Latest
    J:227059 Li J, et al., Integrin beta4 regulation of PTHrP underlies its contribution to mammary gland development. Dev Biol. 2015 Nov 15;407(2):313-20
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/27/2016
MGI 6.05 		The Jackson Laboratory