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Itga2b Gene Detail
Summary
  • Symbol
    Itga2b
  • Name
    integrin alpha 2b
  • Synonyms
    alphaIIb, CD41, GpIIb, GP IIb, platelet glycoprotein IIb
  • Feature Type
    protein coding gene
  • IDs
    MGI:96601
    NCBI Gene: 16399
  • Gene Overview
    MyGene.info: ITGA2B
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr11:102453297-102470122 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      16826 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 66.29 cM
  • Mapping Data
    6 experiments
Homology
more
  • Human Ortholog
    ITGA2B, integrin subunit alpha 2b
  • Vertebrate Orthologs
    10
  • Human Ortholog
    ITGA2B, integrin subunit alpha 2b
    Orthology source: HomoloGene, HGNC
  • Synonyms
    BDPLT16, BDPLT2, CD41, CD41B, GP2B, GPIIb, GT, GTA, HPA3, PPP1R93
  • Links
    NCBI Gene ID: 3674
    neXtProt AC: NX_P08514
    UniProt: P08514

  • Chr Location
    17q21.31; chr17:44372181-44389601 (-)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with Itga2b mouse models; 2 with human ITGA2B associations

Human Disease Mouse Models
      
IDs
View 1 model
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    20 phenotypes from 3 alleles in 3 genetic backgrounds
    4 phenotypes from multigenic genotypes
    31 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for targeted null mutations exhibit a bleeding disorder, lack platelet binding to fibrinogen, absence of fibrinogen in platelet alpha granules, and increased numbers of hematopoietic progenitors in yolk sac, fetal liver, and bone marrow.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000002857 VEGA Gene Model | MGI Sequence Detail 16826 C57BL/6J ±  kb
    transcript OTTMUST00000005811 VEGA | MGI Sequence Detail 3437 Not Applicable  
    polypeptide OTTMUSP00000002751 VEGA | MGI Sequence Detail 1033 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      210 from dbSNP Build 142
    • RFLP
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 22
      Genomic 2
      cDNA 16
      Primer pair 3
      Other 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-11480, MGI:2144076
    References
    more
    • Summaries
      All 158
      Developmental Gene Expression 56
      Diseases 1
      Gene Ontology 10
      Phenotypes 31
    • Earliest
      J:35481 Phillips DR, et al., GPIIb-IIIa: the responsive integrin. Cell. 1991 May 3;65(3):359-62
    • Latest
      J:250001 Gaertner F, et al., Migrating Platelets Are Mechano-scavengers that Collect and Bundle Bacteria. Cell. 2017 Nov 30;171(6):1368-1382.e23

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    05/15/2018
    MGI 6.12
    The Jackson Laboratory