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Itga2b
Gene Detail
Symbol

Name
ID
Itga2b
integrin alpha 2b
MGI:96601
Synonyms
alphaIIb, CD41, GpIIb, GP IIb, platelet glycoprotein IIb
Feature Type
protein coding gene
Genetic Map
Chromosome 11
66.29 cM
Detailed Genetic Map ± 1 cM


Mapping data(6)
Sequence Map
Chr11:102453297-102470122 bp, - strand
From VEGA annotation of GRCm38

  16826 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:37304  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 2 western clawed frog; 1 zebrafish

Protein SuperFamily: integrin alpha, VLA protein type
Gene Tree: Itga2b

Human
homologs
Human Homolog ITGA2B, integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41)
NCBI Gene ID 3674
neXtProt AC  NX_P08514
Human Synonyms  BDPLT16, BDPLT2, CD41, CD41B, GP2B, GPIIb, GT, GTA, HPA3, PPP1R93
Human Chr (Location)  17q21.32; chr17:44372182-44389505 (-)  GRCh38
Disease Associations  (2) Diseases Associated with Human ITGA2B
Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for targeted null mutations exhibit a bleeding disorder, lack platelet binding to fibrinogen, absence of fibrinogen in platelet alpha granules, and increased numbers of hematopoietic progenitors in yolk sac, fetal liver, and bone marrow.
 
Human Diseases Modeled Using Mouse Itga2b (1)    Alleles Annotated to Human Diseases(1)   
Interactions
Itga2b interacts with 31 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (19 annotations)
Process cell adhesion, cell-matrix adhesion, ...
Component blood microparticle, cell surface, ...
Function extracellular matrix binding, fibrinogen binding, ...
External Resources: FuncBase
Expression
Literature Summary: (43 records)
Data Summary: Results (64)    Tissues (24)    Images (48)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 21
RNA in situ 22
RT-PCR 21
cDNA source data(14)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(22) Genomic(2) cDNA(16) Primer pair(3) Other(1)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000002857 (Evidence)
Ensembl Gene ModelENSMUSG00000034664 (Evidence)
Entrez Gene16399 (Evidence)
DFCITC1575158, TC1633545, TC1673892
DoTSDT.101200079, DT.101228065, DT.101382994, DT.91481720, DT.99863948
Consensus CDS ProjectCCDS25500.1
International Mouse Knockout Project StatusItga2b
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000002857 VEGA Gene Model | MGI Sequence Detail 16826 C57BL/6J ±  kb
transcript OTTMUST00000005811 VEGA | MGI Sequence Detail 3437 Not Applicable 
polypeptide OTTMUSP00000002751 VEGA | MGI Sequence Detail 1033 Not Applicable 

For the selected sequences
All sequences(58) RefSeq(4) UniProt(3)
Polymorphisms
RFLP(1) : SNPs within 2kb(226 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR013517 FG-GAP repeat
InterPro IPR013649 Integrin alpha-2
InterPro IPR013519 Integrin alpha beta-propellor
InterPro IPR000413 Integrin alpha chain
InterPro IPR018184 Integrin alpha chain, C-terminal cytoplasmic region, conserved site
Protein Ontology PR:000009127 integrin alpha-IIb
References
(Earliest) J:35481 Phillips DR, et al., GPIIb-IIIa: the responsive integrin. Cell. 1991 May 3;65(3):359-62
(Latest) J:204818 Wong CH, et al., Nucleation of platelets with blood-borne pathogens on Kupffer cells precedes other innate immunity and contributes to bacterial clearance. Nat Immunol. 2013 Aug;14(8):785-92
All references(111)
Disease annotation references (1)
Other
accession IDs
MGD-MRK-11480, MGI:2144076

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/18/2014
MGI 5.20
The Jackson Laboratory