Itga2b
Gene Detail

Symbol Name ID

Itga2b integrin alpha 2b MGI:96601

Synonyms

alphaIIb, CD41, GpIIb, GP IIb, platelet glycoprotein IIb

Feature Type

protein coding gene

Genetic Map

Chromosome 11

66.29 cM
Detailed Genetic Map ± 1 cM


Mapping data(6)

Sequence Map

Chr11:102453297-102470122 bp, - strand From VEGA annotation of GRCm38   16826 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:37304  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 zebrafish

Protein SuperFamily: integrin alpha, VLA protein type
Gene Tree: Itga2b

Human homologs

Human Homolog		ITGA2B, integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41)
NCBI Gene ID		3674
neXtProt AC		NX_P08514
Human Synonyms		BDPLT2, CD41, CD41B, GP2B, GPIIb, GT, GTA, HPA3
Human Chr (Location)		17q21.32; chr17:42449550-42466873 (-)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human ITGA2B

Alleles and phenotypes

All alleles(3) : Targeted(3)
 

Homozygotes for targeted null mutations exhibit a bleeding disorder, lack platelet binding to fibrinogen, absence of fibrinogen in platelet alpha granules, and increased numbers of hematopoietic progenitors in yolk sac, fetal liver, and bone marrow.

 
Human Diseases Modeled Using Mouse Itga2b (1)    Alleles Annotated to Human Diseases(1)   

Gene Ontology (GO) classifications

All GO classifications: (16 annotations)

Process	cell adhesion, cell-matrix adhesion, ...
Component	cell surface, external side of plasma membrane, ...
Function	extracellular matrix binding, fibrinogen binding, ...

External Resources: FuncBase

Expression

Literature Summary: (39 records)
Data Summary: Results (59)    Tissues (19)    Images (39)
Theiler Stages: 1, 3, 4, 10, 11, 12, 13, 15, 17, 19, 23, 28

Assay Type	Results
Immunohistochemistry	10
RNA in situ	22
RT-PCR	27

cDNA source data(14)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(22) Genomic(2) cDNA(16) Primer pair(3) Other(1)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000002857 (Evidence)
Ensembl Gene Model	ENSMUSG00000034664 (Evidence)
Entrez Gene	16399 (Evidence)
DFCI	TC1575158, TC1633545, TC1673892
DoTS	DT.101200079, DT.101228065, DT.101382994, DT.91481720, DT.99863948
Consensus CDS Project	CCDS25500.1
International Mouse Knockout Project Status	Itga2b

Sequences

Length	Strain/Species
genomic	OTTMUSG00000002857	VEGA Gene Model | MGI Sequence Detail	16826	C57BL/6J
transcript	OTTMUST00000005811	VEGA | MGI Sequence Detail	3437	Not Applicable
polypeptide	OTTMUSP00000002751	VEGA | MGI Sequence Detail	1033	Not Applicable

All sequences(55) RefSeq(2) UniProt(2)

Polymorphisms

RFLP(1) : SNPs(206 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR013517	FG-GAP repeat
InterPro	IPR013649	Integrin alpha-2
InterPro	IPR013519	Integrin alpha beta-propellor
InterPro	IPR000413	Integrin alpha chain
InterPro	IPR018184	Integrin alpha chain, C-terminal cytoplasmic region, conserved site
Protein Ontology	PR:000009127	integrin alpha-IIb

References

(Earliest) J:35481 Phillips DR, et al., GPIIb-IIIa: the responsive integrin. Cell. 1991 May 3;65(3):359-62
(Latest) J:193165 Choi E, et al., Dual lineage-specific expression of Sox17 during mouse embryogenesis. Stem Cells. 2012 Oct;30(10):2297-308
All references(102)

Other accession IDs

MGD-MRK-11480, MGI:2144076