About   Help   FAQ
Targeted Allele Detail
Symbol: Itga2btm1Tlr
Name: integrin alpha 2b; targeted mutation 1, Diana Tronik-Le Roux
MGI ID: MGI:2385793
Synonyms: alphaIIb-
Gene: Itga2b  Location: Chr11:102344123-102360709 bp, - strand  Genetic Position: Chr11, 66.29 cM
Alliance: Itga2btm1Tlr page
Germline Transmission:  Earliest citation of germline transmission: J:63961
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsThe gene was disrupted by insertion of a TK-PGK-neo cassette into exon 1 via homologous recombination. Northern blot analysis showed the absence of Itga2b expression and presence of TK transcripts in the bone marrow of homozygous mutant animals. Immunoblot analysis using an antibody directed against human Itga2b confirmed absence of protein product in platelet extracts from homozygous mutant mice. (J:63961)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
In Structures Affected by this Mutation: 3 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Itga2b Mutation:  29 strains or lines available
Original:  J:63961 Tronik-Le Roux D, et al., Thrombasthenic mice generated by replacement of the integrin alpha(IIb) gene: demonstration that transcriptional activation of this megakaryocytic locus precedes lineage commitment. Blood. 2000 Aug 15;96(4):1399-408
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Copyright, and Privacy Statement
Send questions and comments to User Support.
last database update
MGI 6.22
The Jackson Laboratory