Itga2
Gene Detail

Symbol Name ID

Itga2 integrin alpha 2 MGI:96600

Synonyms

CD49B, DX5, VLA-2 receptor, alpha 2 subunit

Feature Type

protein coding gene

Genetic Map

Chromosome 13

64.61 cM
Detailed Genetic Map ± 1 cM


Mapping data(7)

Sequence Map

Chr13:114835916-114932041 bp, - strand From Ensembl annotation of GRCm38   96126 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:1662  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 2 zebrafish

Protein SuperFamily: integrin alpha with I domain
Gene Tree: Itga2

Human homologs

Human Homolog		ITGA2, integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)
NCBI Gene ID		3673
neXtProt AC		NX_P17301
Human Synonyms		BR, CD49B, GPIa, HPA-5, VLA-2, VLAA2
Human Chr (Location)		5q11.2; chr5:52285156-52390609 (+)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human ITGA2

Alleles and phenotypes

All alleles(6) : Targeted(6)
 

Homozygotes for targeted null mutations were viable, fertile, showed no overt anatomical defects, and exhibited no bleeding anomalies. Platelet, primary fibroblast and keratinocytes from homozygous mutant mice show less efficient adhesion to collagens in vitro.

 

Gene Ontology (GO) classifications

All GO classifications: (44 annotations)

Process	cell adhesion, detection of mechanical stimulus involved in sensory perception of pain, ...
Component	axon, axon terminus, ...
Function	integrin binding, laminin binding, ...

External Resources: FuncBase

Expression

Literature Summary: (21 records)
Data Summary: Results (57)    Tissues (50)    Images (11)
Theiler Stages: 11, 22, 23, 25, 28

Assay Type	Results
Immunohistochemistry	4
RNA in situ	6
RT-PCR	47

cDNA source data(7)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(13) cDNA(8) Primer pair(3) Other(2)
Microarray probesets(3)

Other database links

Ensembl Gene Model	ENSMUSG00000015533 (Evidence)
Entrez Gene	16398 (Evidence)
UniGene	5007
DFCI	TC1587356
DoTS	DT.87048053
NIA Mouse Gene Index	U035202
Consensus CDS Project	CCDS26787.1
International Mouse Knockout Project Status	Itga2

Sequences

Length	Strain/Species
genomic	ENSMUSG00000015533	Ensembl Gene Model | MGI Sequence Detail	96126	C57BL/6J
transcript	ENSMUST00000056117	Ensembl | MGI Sequence Detail	4214	Not Applicable
polypeptide	ENSMUSP00000053891	Ensembl | MGI Sequence Detail	1178	Not Applicable

All sequences(17) RefSeq(2) UniProt(2)

Polymorphisms

RFLP(3) : SNPs within 2kb(1407 from dbSNP Build 137)

Protein-related information

Resource	ID	Description
InterPro	IPR013517	FG-GAP repeat
InterPro	IPR013649	Integrin alpha-2
InterPro	IPR013519	Integrin alpha beta-propellor
InterPro	IPR000413	Integrin alpha chain
InterPro	IPR018184	Integrin alpha chain, C-terminal cytoplasmic region, conserved site
InterPro	IPR002035	von Willebrand factor, type A
Protein Ontology	PR:000001008	integrin alpha-2

References

(Earliest) J:34565 Takada Y, et al., The primary structure of the VLA-2/collagen receptor alpha 2 subunit (platelet GPIa): homology to other integrins and the presence of a possible collagen-binding domain. J Cell Biol. 1989 Jul;109(1):397-407
(Latest) J:192816 El Bannoudi H, et al., DX5(+) CD4(+) T cells modulate CD4(+) T-cell response via inhibition of IL-12 production by DCs. Eur J Immunol. 2013 Feb;43(2):439-46
All references(87)

Other accession IDs

MGD-MRK-11479