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Itga2
Gene Detail
 Symbol
Name
ID
Itga2
integrin alpha 2
MGI:96600
Synonyms CD49B, DX5, VLA-2 receptor, alpha 2 subunit
Feature Type protein coding gene
Genetic Map
Chromosome 13
64.61 cM
Detailed Genetic Map ± 1 cM


Mapping data(7)
Sequence Map
Chr13:114835916-114932041 bp, - strand
From Ensembl annotation of GRCm38

  96126 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1662  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 2 zebrafish

Protein SuperFamily: integrin alpha with I domain
Gene Tree: Itga2

Human
homologs
Human Homolog ITGA2, integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)
NCBI Gene ID 3673
neXtProt AC  NX_P17301
Human Synonyms  BR, CD49B, GPIa, HPA-5, VLA-2, VLAA2
Human Chr (Location)  5q11.2; chr5:52989326-53094779 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human ITGA2
Alleles
and
phenotypes
All alleles(7) : Targeted(7)
 
Homozygotes for targeted null mutations were viable, fertile, showed no overt anatomical defects, and exhibited no bleeding anomalies. Platelet, primary fibroblast and keratinocytes from homozygous mutant mice show less efficient adhesion to collagens in vitro.
 
Gene Ontology
(GO)
classifications
All GO classifications: (43 annotations)
Process cell adhesion, detection of mechanical stimulus involved in sensory perception of pain, ...
Component axon, axon terminus, ...
Function integrin binding, laminin binding, ...
External Resources: FuncBase
Expression
Literature Summary: (21 records)
Data Summary: Results (61)    Tissues (52)    Images (15)
Theiler Stages: 11, 22, 23, 25, 28
Assay TypeResults
Immunohistochemistry 8
RNA in situ 6
RT-PCR 47
cDNA source data(7)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(13) cDNA(8) Primer pair(3) Other(2)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000015533 (Evidence)
Entrez Gene16398 (Evidence)
UniGene5007
DFCITC1587356
DoTSDT.87048053
NIA Mouse Gene IndexU035202
Consensus CDS ProjectCCDS26787.1
International Mouse Knockout Project StatusItga2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000015533 Ensembl Gene Model | MGI Sequence Detail 96126 C57BL/6J ±  kb
transcript ENSMUST00000056117 Ensembl | MGI Sequence Detail 4214 Not Applicable 
polypeptide ENSMUSP00000053891 Ensembl | MGI Sequence Detail 1178 Not Applicable 

For the selected sequences
All sequences(17) RefSeq(2) UniProt(2)
Polymorphisms RFLP(3) : SNPs within 2kb(1407 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR013517 FG-GAP repeat
InterPro IPR013649 Integrin alpha-2
InterPro IPR013519 Integrin alpha beta-propellor
InterPro IPR000413 Integrin alpha chain
InterPro IPR018184 Integrin alpha chain, C-terminal cytoplasmic region, conserved site
InterPro IPR002035 von Willebrand factor, type A
Protein Ontology PR:000001008 integrin alpha-2
References (Earliest) J:34565 Takada Y, et al., The primary structure of the VLA-2/collagen receptor alpha 2 subunit (platelet GPIa): homology to other integrins and the presence of a possible collagen-binding domain. J Cell Biol. 1989 Jul;109(1):397-407
(Latest) J:203557 Stange R, et al., Age-related bone deterioration is diminished by disrupted collagen sensing in integrin alpha2beta1 deficient mice. Bone. 2013 Sep;56(1):48-54
All references(93)
Other
accession IDs
MGD-MRK-11479

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
04/08/2014
MGI 5.17
The Jackson Laboratory