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Irf2
Gene Detail
 Symbol
Name
ID
Irf2
interferon regulatory factor 2
MGI:96591
Synonyms 9830146E22Rik, Irf-2
Feature Type protein coding gene
Genetic Map
Chromosome 8
26.42 cM, cytoband B2
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr8:46739745-46847458 bp, + strand
From NCBI annotation of GRCm38

  107714 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1659  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: interferon regulatory factor, types 1/2
Gene Tree: Irf2

Human
homologs
Human Homolog IRF2, interferon regulatory factor 2
NCBI Gene ID 3660
neXtProt AC  NX_P14316
Human Synonyms  IRF-2
Human Chr (Location)  4q34.1-q35.1; chr4:184387713-184474580 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(2) : Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele exhibit abnormalities in B lymphopoiesis and hematopoiesis, often die prematurely, show increased mortality following lymphocytic choriomeningitis virus infection, and develop an inflammatory skin disease involving CD8+ Tcells.
 
Interactions
Irf2 interacts with 259 markers (Mir7-1, Mir15a, Mir15b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (6 annotations)
Process regulation of transcription, DNA-templated, transcription, DNA-templated
Component nucleus
Function DNA binding, regulatory region DNA binding, ...
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (34)    Tissues (22)    Images (6)
Theiler Stages: 17, 19, 23, 25, 28
Assay TypeResults
Immunohistochemistry 4
RNA in situ 28
Western blot 1
RT-PCR 1
cDNA source data(39)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(41) cDNA(40) Primer pair(1)
Microarray probesets(2)
Other database
links
Ensembl Gene ModelENSMUSG00000031627 (Evidence)
Entrez Gene16363 (Evidence)
UniGene1149
DFCITC1579245
DoTSDT.101155946, DT.101199183, DT.87068463
NIA Mouse Gene IndexU009319
PDB1IRF, 1IRG, 2IRF
Consensus CDS ProjectCCDS22295.1
International Mouse Knockout Project StatusIrf2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 16363 NCBI Gene Model | MGI Sequence Detail 107714 C57BL/6J ±  kb
transcript NM_008391 RefSeq | MGI Sequence Detail 2484 C57BL/6 
polypeptide P23906 UniProt | EBI | MGI Sequence Detail 349 Not Applicable 

For the selected sequences
All sequences(37) RefSeq(14) UniProt(5)
Polymorphisms SNPs within 2kb(883 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017431 Interferon regulatory factor-1/2
InterPro IPR019817 Interferon regulatory factor, conserved site
InterPro IPR001346 Interferon regulatory factor DNA-binding domain
InterPro IPR011991 Winged helix-turn-helix DNA-binding domain
Protein Ontology PR:000002044 interferon regulatory factor 2
Graphical View of Protein Domain Structure
References (Earliest) J:17557 Harada H, et al., Structurally similar but functionally distinct factors, IRF-1 and IRF-2, bind to the same regulatory elements of IFN and IFN-inducible genes. Cell. 1989 Aug 25;58(4):729-39
(Latest) J:196707 Sato T, et al., Novel interferon-based pre-transplantation conditioning in the treatment of a congenital metabolic disorder. Blood. 2013 Apr 18;121(16):3267-73
All references(69)
Other
accession IDs
MGD-MRK-11466, MGI:2142602, MGI:2443654

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/19/2014
MGI 5.19
The Jackson Laboratory