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Irf2 Gene Detail
Summary
  • Symbol
    Irf2
  • Name
    interferon regulatory factor 2
  • Synonyms
    9830146E22Rik, Irf-2
  • Feature Type
    protein coding gene
  • IDs
    MGI:96591
    NCBI Gene: 16363
  • Gene Overview
    MyGene.info: IRF2
Location & Maps
more
  • Sequence Map
    Chr8:46739732-46847458 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      107727 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 8, 26.42 cM, cytoband B2
  • Mapping Data
    4 experiments
Homology
more
  • Human Ortholog
    IRF2, interferon regulatory factor 2
  • Vertebrate Orthologs
    10
  • Human Ortholog
    IRF2, interferon regulatory factor 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    IRF-2
  • Links
    NCBI Gene ID: 3660
    neXtProt AC: NX_P14316

  • Chr Location
    4q35.1; chr4:184387713-184474580 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    18 phenotypes from 1 allele in 2 genetic backgrounds
    2 phenotypes from multigenic genotypes
    27 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    3
  • Chemically induced (other)
    1
  • Targeted
    2
  • Genomic Mutations
    1 involving Irf2
  • Incidental Mutations
Mice homozygous for a knock-out allele exhibit abnormalities in B lymphopoiesis and hematopoiesis, often die prematurely, show increased mortality following lymphocytic choriomeningitis virus infection, and develop an inflammatory skin disease involving CD8+ Tcells.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000059880 VEGA Gene Model | MGI Sequence Detail 107727 C57BL/6J ±  kb
transcript OTTMUST00000146711 VEGA | MGI Sequence Detail 2497 Not Applicable  
polypeptide OTTMUSP00000076338 VEGA | MGI Sequence Detail 349 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    883 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 41
    cDNA 40
    Primer pair 1

    Microarray probesets 2
Other
Accession IDs
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MGD-MRK-11466, MGI:2142602, MGI:2443654
References
more
  • Summaries
    All 65
    Developmental Gene Expression 4
    Gene Ontology 3
    Phenotypes 27
  • Earliest
    J:17557 Harada H, et al., Structurally similar but functionally distinct factors, IRF-1 and IRF-2, bind to the same regulatory elements of IFN and IFN-inducible genes. Cell. 1989 Aug 25;58(4):729-39
  • Latest
    J:196707 Sato T, et al., Novel interferon-based pre-transplantation conditioning in the treatment of a congenital metabolic disorder. Blood. 2013 Apr 18;121(16):3267-73

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
11/29/2016
MGI 6.06
The Jackson Laboratory