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Inha Gene Detail
Summary
  • Symbol
    Inha
  • Name
    inhibin alpha
  • Feature Type
    protein coding gene
  • IDs
    MGI:96569
    NCBI Gene: 16322
  • Gene Overview
    MyGene.info: INHA
  • Alliance
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:75507077-75510366 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 1, 39.16 cM, cytoband C5
  • Mapping Data
    23 experiments
Strain
Comparison
more
  • SNPs within 2kb
    20 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_96569
protein coding gene Chr1:75507077-75510366 (+)
129S1/SvImJ MGP_129S1SvImJ_G0016192
protein coding gene Chr1:76086481-76089769 (+)
A/J MGP_AJ_G0016175
protein coding gene Chr1:73432401-73435690 (+)
AKR/J MGP_AKRJ_G0016132
protein coding gene Chr1:75469092-75472379 (+)
BALB/cJ MGP_BALBcJ_G0016130
protein coding gene Chr1:73494299-73497588 (+)
C3H/HeJ MGP_C3HHeJ_G0015961
protein coding gene Chr1:75798166-75801455 (+)
C57BL/6NJ MGP_C57BL6NJ_G0016583
protein coding gene Chr1:79040653-79043942 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0014304
protein coding gene Chr1:68990250-68993789 (+)
CAST/EiJ MGP_CASTEiJ_G0015545
protein coding gene Chr1:75144986-75148283 (+)
CBA/J MGP_CBAJ_G0015934
protein coding gene Chr1:81623578-81626867 (+)
DBA/2J MGP_DBA2J_G0016035
protein coding gene Chr1:72750448-72753736 (+)
FVB/NJ MGP_FVBNJ_G0016038
protein coding gene Chr1:71958189-71961475 (+)
LP/J MGP_LPJ_G0016107
protein coding gene Chr1:77214221-77217509 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0016058
protein coding gene Chr1:84955737-84959023 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0016630
protein coding gene Chr1:75535534-75538822 (+)
PWK/PhJ MGP_PWKPhJ_G0015332
protein coding gene Chr1:72226938-72230227 (+)
SPRET/EiJ MGP_SPRETEiJ_G0015110
protein coding gene Chr1:74891155-74894463 (+)
WSB/EiJ MGP_WSBEiJ_G0015607
protein coding gene Chr1:75346020-75349308 (+)



Homology
more
  • Human Ortholog
    INHA, inhibin subunit alpha
  • Vertebrate Orthologs
    10
  • Human Ortholog
    INHA, inhibin subunit alpha
    Orthology source: HomoloGene, HGNC
  • Links
    NCBI Gene ID: 3623
    neXtProt AC: NX_P05111
    UniProt: P05111

  • Chr Location
    2q35; chr2:219572232-219575713 (+)  GRCh38.p7

Human Diseases
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  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    27 phenotypes from 1 allele in 2 genetic backgrounds
    31 phenotypes from multigenic genotypes
    2 images
    59 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mutant mice develop gonadal sex cord-stromal tumors with nearly 100% penetrance and develop cachexia-like symptoms. The wasting syndrome is not observed in gonadectomized mutant mice, which develop adrenal tumors.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
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    Representative SequencesLengthStrain/SpeciesFlank
    genomic 16322 NCBI Gene Model | MGI Sequence Detail 3290 C57BL/6J ±  kb
    transcript NM_001329843 RefSeq | MGI Sequence Detail 1910 C57BL/6  
    polypeptide Q04997 UniProt | EBI | MGI Sequence Detail 366 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 49
      Genomic 3
      cDNA 38
      Primer pair 4
      Other 4

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-11406, MGI:2138616
    References
    more
    • Summaries
      All 151
      Developmental Gene Expression 29
      Diseases 1
      Gene Ontology 5
      Phenotypes 59
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:263346 Wijayarathna R, et al., Activin over-expression in the testis of mice lacking the inhibin alpha-subunit gene is associated with androgen deficiency and regression of the male reproductive tract. Mol Cell Endocrinol. 2018 Jul 15;470:188-198

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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    last database update
    11/26/2019
    MGI 6.14
    The Jackson Laboratory