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Inha
Gene Detail
Symbol

Name
ID
Inha
inhibin alpha
MGI:96569
Feature Type
protein coding gene
Genetic Map
Chromosome 1
39.16 cM, cytoband C5
Detailed Genetic Map ± 1 cM


Mapping data(23)
Sequence Map
Chr1:75507077-75510366 bp, + strand
From VEGA annotation of GRCm38

  3290 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1652  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: Inhibin alpha subunit
Gene Tree: Inha

Human
homologs
Human Homolog INHA, inhibin, alpha
NCBI Gene ID 3623
neXtProt AC  NX_P05111
Human Chr (Location)  2q35; chr2:219572232-219575713 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(8) : Gene trapped(6) Spontaneous(1) Targeted(1)
Genomic Mutations involving Inha (1)
Incidental mutations (data from APF )
 
Mutant mice develop gonadal sex cord-stromal tumors with nearly 100% penetrance and develop cachexia-like symptoms. The wasting syndrome is not observed in gonadectomized mutant mice, which develop adrenal tumors.
 
Alleles Annotated to Human Diseases(1)    Phenotype Images(2)
Interactions
Inha interacts with 25 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (30 annotations)
Process cell development, hemoglobin biosynthetic process, ...
Component cytoplasm, extracellular region, ...
Function cytokine activity, growth factor activity, ...
External Resources: FuncBase
Expression
Literature Summary: (22 records)
Data Summary: Results (66)    Tissues (58)    Images (11)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 44
Northern blot 2
RT-PCR 12
RNase protection 8
cDNA source data(31)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(46) Genomic(3) cDNA(37) Primer pair(3) Other(3)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000019422 (Evidence)
Ensembl Gene ModelENSMUSG00000032968 (Evidence)
Entrez Gene16322 (Evidence)
UniGene1100
DFCITC1582855
DoTSDT.486110
NIA Mouse Gene IndexU000476
Consensus CDS ProjectCCDS15078.1
International Mouse Knockout Project StatusInha
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000019422 VEGA Gene Model | MGI Sequence Detail 3290 C57BL/6J ±  kb
transcript OTTMUST00000046355 VEGA | MGI Sequence Detail 1475 Not Applicable 
polypeptide OTTMUSP00000020926 VEGA | MGI Sequence Detail 366 Not Applicable 

For the selected sequences
All sequences(22) RefSeq(2) UniProt(1)
Polymorphisms
All PCR and RFLP(7) : PCR(1) RFLP(6) SNPs within 2kb(20 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002405 Inhibin, alpha subunit
InterPro IPR017175 Inhibin, alpha subunit subgroup
InterPro IPR017948 Transforming growth factor beta, conserved site
InterPro IPR001839 Transforming growth factor-beta, C-terminal
InterPro IPR015615 Transforming growth factor-beta-related
Protein Ontology PR:000001730 inhibin alpha chain
References
(Earliest) J:8262 Mason AJ, et al., Structure of two human ovarian inhibins. Biochem Biophys Res Commun. 1986 Mar 28;135(3):957-64
(Latest) J:208341 Seth A, et al., Prox1 ablation in hepatic progenitors causes defective hepatocyte specification and increases biliary cell commitment. Development. 2014 Feb;141(3):538-47
All references(126)
Other
accession IDs
MGD-MRK-11406, MGI:2138616

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/18/2014
MGI 5.20
The Jackson Laboratory