About   Help   FAQ
Inha Gene Detail
Summary
  • Symbol
    Inha
  • Name
    inhibin alpha
  • Feature Type
    protein coding gene
  • IDs
    MGI:96569
    NCBI Gene: 16322
  • Alliance
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:75483721-75487010 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 1, 39.16 cM, cytoband C5
  • Mapping Data
    23 experiments
Strain
Comparison
more
  • SNPs within 2kb
    20 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_96569
protein coding gene Chr1:75483721-75487010 (+)
129S1/SvImJ MGP_129S1SvImJ_G0016192
protein coding gene Chr1:76086481-76089769 (+)
A/J MGP_AJ_G0016175
protein coding gene Chr1:73432401-73435690 (+)
AKR/J MGP_AKRJ_G0016132
protein coding gene Chr1:75469092-75472379 (+)
BALB/cJ MGP_BALBcJ_G0016130
protein coding gene Chr1:73494299-73497588 (+)
C3H/HeJ MGP_C3HHeJ_G0015961
protein coding gene Chr1:75798166-75801455 (+)
C57BL/6NJ MGP_C57BL6NJ_G0016583
protein coding gene Chr1:79040653-79043942 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0014304
protein coding gene Chr1:68990250-68993789 (+)
CAST/EiJ MGP_CASTEiJ_G0015545
protein coding gene Chr1:75144986-75148283 (+)
CBA/J MGP_CBAJ_G0015934
protein coding gene Chr1:81623578-81626867 (+)
DBA/2J MGP_DBA2J_G0016035
protein coding gene Chr1:72750448-72753736 (+)
FVB/NJ MGP_FVBNJ_G0016038
protein coding gene Chr1:71958189-71961475 (+)
LP/J MGP_LPJ_G0016107
protein coding gene Chr1:77214221-77217509 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0016058
protein coding gene Chr1:84955737-84959023 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0016630
protein coding gene Chr1:75535534-75538822 (+)
PWK/PhJ MGP_PWKPhJ_G0015332
protein coding gene Chr1:72226938-72230227 (+)
SPRET/EiJ MGP_SPRETEiJ_G0015110
protein coding gene Chr1:74891155-74894463 (+)
WSB/EiJ MGP_WSBEiJ_G0015607
protein coding gene Chr1:75346020-75349308 (+)



Homology
more
  • Human Ortholog
    INHA, inhibin subunit alpha
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    INHA, inhibin subunit alpha
  • Links
    NCBI Gene ID: 3623
    neXtProt AC: NX_P05111
    UniProt: P05111

  • Chr Location
    2q35; chr2:219569162-219575711 (+)  GRCh38

Human Diseases
more
  • Diseases
    1 with human INHA associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    40 phenotypes from 2 alleles in 4 genetic backgrounds
    31 phenotypes from multigenic genotypes
    2 images
    70 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mutant mice develop gonadal sex cord-stromal tumors with nearly 100% penetrance and develop cachexia-like symptoms. The wasting syndrome is not observed in gonadectomized mutant mice, which develop adrenal tumors. Homozygous inhibition of inhibin activity leads to increased ovulation but reduced embryo/fetal/newborn survival of offspring of affected mothers, while heterozygote mothers show increased fecundity.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 16322 NCBI Gene Model | MGI Sequence Detail 3290 C57BL/6J ±  kb
    transcript NM_001329843 RefSeq | MGI Sequence Detail 2275 ZRU/MplStud  
    polypeptide Q04997 UniProt | EBI | MGI Sequence Detail 366 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 50
      Genomic 3
      cDNA 38
      Primer pair 5
      Other 4

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-11406, MGI:2138616
    References
    more
    • Summaries
      All 166
      Developmental Gene Expression 32
      Diseases 1
      Gene Ontology 5
      Phenotypes 70
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:342617 Dali O, et al., Transgenerational epigenetic effects imposed by neonicotinoid thiacloprid exposure. Life Sci Alliance. 2024 Feb;7(2)

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.
    last database update
    03/12/2024
    MGI 6.23
    The Jackson Laboratory