About   Help   FAQ
Inha
Gene Detail
Symbol

Name
ID
Inha
inhibin alpha
MGI:96569
Feature Type
protein coding gene
Genetic Map
Chromosome 1
39.16 cM, cytoband C5
Detailed Genetic Map ± 1 cM


Mapping data(23)
Sequence Map
Chr1:75507077-75510366 bp, + strand
From VEGA annotation of GRCm38

  3290 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1652  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: INHA
Protein SuperFamily: Inhibin alpha subunit
Gene Tree: Inha

Human
homologs
INHA, inhibin, alpha
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 3623
neXtProt AC: NX_P05111

Human Chr (Location): 2q35; chr2:219572232-219575713 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(9) : Gene trapped(6) Radiation induced(1) Spontaneous(1) Targeted(1)
Genomic Mutations involving Inha (2)
Incidental mutations (data from APF )
 
Mutant mice develop gonadal sex cord-stromal tumors with nearly 100% penetrance and develop cachexia-like symptoms. The wasting syndrome is not observed in gonadectomized mutant mice, which develop adrenal tumors.
 
Mutations Annotated to Human Diseases (1)    Phenotype Images(2)
Interactions
Inha interacts with 25 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (31 annotations)
Process cell development, hemoglobin biosynthetic process, ...
Component cytoplasm, extracellular region, ...
Function cytokine activity, growth factor activity, ...
External Resources: FuncBase
Expression
Literature Summary: (23 records)
Data Summary: Results (66)    Tissues (58)    Images (11)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 44
Northern blot 2
RT-PCR 12
RNase protection 8
cDNA source data(31)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase inha ; ZFIN inha    NEW 
Molecular
reagents
All nucleic(46) Genomic(3) cDNA(37) Primer pair(3) Other(3)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000019422 (Evidence)
Ensembl Gene Model ENSMUSG00000032968 (Evidence)
Entrez Gene 16322 (Evidence)
UniGene 1100
DFCI TC1582855
DoTS DT.486110
NIA Mouse Gene Index U000476
Consensus CDS Project CCDS15078.1
International Mouse Phenotyping Consortium Status Inha
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000019422 VEGA Gene Model | MGI Sequence Detail 3290 C57BL/6J ±  kb
transcript OTTMUST00000046355 VEGA | MGI Sequence Detail 1475 Not Applicable 
polypeptide OTTMUSP00000020926 VEGA | MGI Sequence Detail 366 Not Applicable 

For the selected sequences
All sequences(24) RefSeq(4) UniProt(1)
Polymorphisms
All PCR and RFLP(7) : PCR(1) RFLP(6) SNPs within 2kb(20 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002405 Inhibin, alpha subunit
InterPro IPR017175 Inhibin, alpha subunit subgroup
InterPro IPR017948 Transforming growth factor beta, conserved site
InterPro IPR001839 Transforming growth factor-beta, C-terminal
InterPro IPR015615 Transforming growth factor-beta-related
Protein Ontology PR:000001730 inhibin alpha chain
References
(Earliest) J:8262 Mason AJ, et al., Structure of two human ovarian inhibins. Biochem Biophys Res Commun. 1986 Mar 28;135(3):957-64
(Latest) J:222284 Itman C, et al., Murine Inhibin alpha-Subunit Haploinsufficiency Causes Transient Abnormalities in Prepubertal Testis Development Followed by Adult Testicular Decline. Endocrinology. 2015 Jun;156(6):2254-68
All references(120)
Other
accession IDs
MGD-MRK-11406, MGI:2138616

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
08/18/2015
MGI 6.0
The Jackson Laboratory