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Il9
Gene Detail
Symbol

Name
ID
Il9
interleukin 9
MGI:96563
STS
Synonyms
Il-9, P40
Feature Type
protein coding gene
Genetic Map
Chromosome 13
30.06 cM
Detailed Genetic Map ± 1 cM


Mapping data(48)
Sequence Map
Chr13:56479277-56482246 bp, - strand
From NCBI annotation of GRCm38

  2970 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:492  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

HCOP human homology predictions: IL9
Protein SuperFamily: interleukin-9
Gene Tree: Il9

Human
homologs
IL9, interleukin 9
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 3578
neXtProt AC: NX_P15248

Human Synonyms: HP40, IL-9, P40

Human Chr (Location): 5q31.1; chr5:135892246-135895827 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mice are viable and show no overt phenotype, however when challenged, aspects of the inflammatory response are shown to be impaired.
 
Interactions
Il9 interacts with 14 markers (Mir132, Mir184, Mir194-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (11 annotations)
Process immune response, positive regulation of cell growth, ...
Component extracellular region, extracellular space
Function cytokine activity, cytokine receptor binding, ...
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (27)    Tissues (21)    Tissue x Stage Matrix (view)
Assay TypeResults
RT-PCR 27
cDNA source data(1)
Other mouse links: GEO   Expression Atlas
Molecular
reagents
All nucleic(5) Genomic(1) cDNA(1) Primer pair(1) Other(2)
Microarray probesets(3)
Other database
links
Ensembl Gene Model ENSMUSG00000021538 (Evidence)
Entrez Gene 16198 (Evidence)
UniGene 3006
DFCI TC1595383
DoTS DT.91443870
NIA Mouse Gene Index U034833
Consensus CDS Project CCDS26562.1
International Mouse Phenotyping Consortium Status Il9
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 16198 NCBI Gene Model | MGI Sequence Detail 2970 C57BL/6J ±  kb
transcript NM_008373 RefSeq | MGI Sequence Detail 536 C57BL/6 
polypeptide P15247 UniProt | EBI | MGI Sequence Detail 144 Not Applicable 

For the selected sequences
All sequences(14) RefSeq(2) UniProt(1)
Polymorphisms
RFLP(4) : SNPs within 2kb(66 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR018049 Interleukin-7/Interleukin-9, conserved site
InterPro IPR000226 Interleukin-7/interleukin-9 family
InterPro IPR020447 Interleukin-9
Protein Ontology PR:000001396 interleukin-9
Graphical View of Protein Domain Structure
References
(Earliest) J:14595 Uyttenhove C, et al., Functional and structural characterization of P40, a mouse glycoprotein with T-cell growth factor activity. Proc Natl Acad Sci U S A. 1988 Sep;85(18):6934-8
(Latest) J:217175 Hoelzinger DB, et al., Inhibition of adaptive immunity by IL9 can be disrupted to achieve rapid T-cell sensitization and rejection of progressive tumor challenges. Cancer Res. 2014 Dec 1;74(23):6845-55
All references(99)
Other
accession IDs
MGD-MRK-11359, MGD-MRK-11397

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory