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Il2rg Gene Detail
Summary
  • Symbol
    Il2rg
  • Name
    interleukin 2 receptor, gamma chain
  • Synonyms
    CD132, common cytokine receptor gamma chain, common gamma chain, gamma(c), gammaC, gamma C receptor, gc, [g]c
  • Feature Type
    protein coding gene
  • IDs
    MGI:96551
    NCBI Gene: 16186
  • Alliance
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    ChrX:100307991-100311861 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome X, 43.90 cM
  • Mapping Data
    7 experiments
Strain
Comparison
more
  • SNPs within 2kb
    7 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_96551
protein coding gene ChrX:100307984-100311861 (-)
129S1/SvImJ MGP_129S1SvImJ_G0035956
protein coding gene ChrX:97763679-97767542 (-)
A/J MGP_AJ_G0035941
protein coding gene ChrX:97769543-97773584 (-)
AKR/J MGP_AKRJ_G0035857
protein coding gene ChrX:100568551-100572467 (-)
BALB/cJ MGP_BALBcJ_G0035924
protein coding gene ChrX:96508935-96512751 (-)
C3H/HeJ MGP_C3HHeJ_G0035633
protein coding gene ChrX:98170416-98174936 (-)
C57BL/6NJ MGP_C57BL6NJ_G0036453
protein coding gene ChrX:100670938-100675268 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0033283
protein coding gene ChrX:95523734-95527687 (-)
CAST/EiJ MGP_CASTEiJ_G0034920
protein coding gene ChrX:82474481-82479324 (-)
CBA/J MGP_CBAJ_G0035608
protein coding gene ChrX:103786295-103790098 (-)
DBA/2J MGP_DBA2J_G0035762
protein coding gene ChrX:96983390-96987658 (-)
FVB/NJ MGP_FVBNJ_G0035700
protein coding gene ChrX:96367960-96371970 (-)
LP/J MGP_LPJ_G0035852
protein coding gene ChrX:98726438-98730303 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0035735
protein coding gene ChrX:108336436-108340286 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0036480
protein coding gene ChrX:97456274-97460139 (-)
PWK/PhJ MGP_PWKPhJ_G0034619
protein coding gene ChrX:80081812-80085638 (-)
SPRET/EiJ MGP_SPRETEiJ_G0034447
protein coding gene ChrX:83380340-83384174 (-)
WSB/EiJ MGP_WSBEiJ_G0035059
protein coding gene ChrX:96161755-96165603 (-)



Homology
more
  • Human Ortholog
    IL2RG, interleukin 2 receptor subunit gamma
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    IL2RG, interleukin 2 receptor subunit gamma
  • Synonyms
    CD132, CIDX, IL-2RG, IMD4, P64, SCIDX, SCIDX1
  • Links
    NCBI Gene ID: 3561
    neXtProt AC: NX_P31785
    UniProt: P31785

  • Chr Location
    Xq13.1; chrX:71107404-71112108 (-)  GRCh38

Human Diseases
more
  • Diseases
    3 with human IL2RG associations

Human Disease Mouse Models
      
IDs
View 3 "NOT" models
IDs
IDs
View 3 "NOT" models
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    82 phenotypes from 7 alleles in 9 genetic backgrounds
    54 phenotypes from multigenic genotypes
    744 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Males hemizygous for targeted null mutations exhibit markedly reduced numbers of T and B cells, lack NK cells and Peyer's patches, and have severely reduced numbers of gut-associated intraepithelial lymphocytes.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 16186 NCBI Gene Model | MGI Sequence Detail 3871 C57BL/6J ±  kb
    transcript NM_013563 RefSeq | MGI Sequence Detail 1663 ZRU/MplStud  
    polypeptide P34902 UniProt | EBI | MGI Sequence Detail 369 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 86
      Genomic 5
      cDNA 77
      Primer pair 4

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-11378
    References
    more
    • Summaries
      All 829
      Developmental Gene Expression 10
      Diseases 2
      Gene Ontology 10
      Phenotypes 744
    • Earliest
      J:12198 Kumaki S, et al., Cloning of the mouse interleukin 2 receptor gamma chain: demonstration of functional differences between the mouse and human receptors. Biochem Biophys Res Commun. 1993 May 28;193(1):356-63
    • Latest
      J:344578 Kessler K, et al., Behavioral and cognitive performance of humanized APOEepsilon3/epsilon3 liver mice in relation to plasma apolipoprotein E levels. Sci Rep. 2023 Jan 31;13(1):1728

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    last database update
    03/12/2024
    MGI 6.23
    The Jackson Laboratory