About   Help   FAQ
Il2rg Gene Detail
Summary
  • Symbol
    Il2rg
  • Name
    interleukin 2 receptor, gamma chain
  • Synonyms
    CD132, common cytokine receptor gamma chain, common gamma chain, gamma(c), gamma C receptor, gc, [g]c
  • Feature Type
    protein coding gene
  • IDs
    MGI:96551
    NCBI Gene: 16186
  • Gene Overview
    MyGene.info: IL2RG
Location & Maps
more
  • Sequence Map
    ChrX:101264378-101268255 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      3878 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome X, 43.90 cM
  • Mapping Data
    7 experiments
Homology
more
  • Human Ortholog
    IL2RG, interleukin 2 receptor subunit gamma
  • Vertebrate Orthologs
    11
  • Human Ortholog
    IL2RG, interleukin 2 receptor subunit gamma
    Orthology source: HGNC, HomoloGene
  • Synonyms
    CD132, CIDX, IL-2RG, IMD4, P64, SCIDX, SCIDX1
  • Links
    NCBI Gene ID: 3561
    neXtProt AC: NX_P31785

  • Chr Location
    Xq13.1; chrX:71107404-71111631 (-)  GRCh38.p2

Human Diseases
more
  • Diseases
    2 with Il2rg mouse models; 2 with human IL2RG associations

Human Disease Mouse Models
       Combined Immunodeficiency, X-Linked; CIDX   OMIM: 312863 View 3 "NOT" models
Severe Combined Immunodeficiency, X-Linked; SCIDX1   OMIM: 300400 View 3 "NOT" models
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    82 phenotypes from 7 alleles in 9 genetic backgrounds
    55 phenotypes from multigenic genotypes
    427 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    14
  • Targeted
    9
  • Transgenic
    5
  • Incidental Mutations
    APF
Males hemizygous for targeted null mutations exhibit markedly reduced numbers of T and B cells, lack NK cells and Peyer's patches, and have severely reduced numbers of gut-associated intraepithelial lymphocytes.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000018211 VEGA Gene Model | MGI Sequence Detail 3878 C57BL/6J ±  kb
transcript OTTMUST00000043978 VEGA | MGI Sequence Detail 1670 Not Applicable  
polypeptide OTTMUSP00000019747 VEGA | MGI Sequence Detail 369 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    7 from dbSNP Build 142
  • RFLP
Protein
Information
less
  • UniProt
    4 Sequences
  • Protein Ontology
    PR:000001340 cytokine receptor common subunit gamma
  • InterPro Domains
    IPR003961 Fibronectin type III
    IPR013783 Immunoglobulin-like fold
    IPR003531 Short hematopoietin receptor, family 1, conserved site
    IPR015321 Type I cytokine receptor, cytokine-binding domain
Molecular
Reagents
less
  • All nucleic 85
    Genomic 5
    cDNA 76
    Primer pair 4

    Microarray probesets 4
Other
Accession IDs
less
MGD-MRK-11378
References
more
  • Summaries
    All 493
    Developmental Gene Expression 9
    Diseases 2
    Gene Ontology 9
    Phenotypes 427
  • Earliest
    J:12198 Kumaki S, et al., Cloning of the mouse interleukin 2 receptor gamma chain: demonstration of functional differences between the mouse and human receptors. Biochem Biophys Res Commun. 1993 May 28;193(1):356-63
  • Latest
    J:231799 Bryce PJ, et al., Humanized mouse model of mast cell-mediated passive cutaneous anaphylaxis and passive systemic anaphylaxis. J Allergy Clin Immunol. 2016 Apr 6;

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
06/22/2016
MGI 6.04
The Jackson Laboratory