Il2rg
Gene Detail

Symbol Name ID

Il2rg interleukin 2 receptor, gamma chain MGI:96551

Synonyms

CD132, common cytokine receptor gamma chain, common gamma chain, gamma(c), gamma C receptor, gc, [g]c

Feature Type

protein coding gene

Genetic Map

Chromosome X

43.90 cM
Detailed Genetic Map ± 1 cM


Mapping data(7)

Sequence Map

ChrX:101264378-101268255 bp, - strand From VEGA annotation of GRCm38   3878 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:172  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 dog; 1 chicken; 2 zebrafish

Protein SuperFamily: interleukin-2 receptor gamma chain
Gene Tree: Il2rg

Human homologs

Human Homolog		IL2RG, interleukin 2 receptor, gamma
NCBI Gene ID		3561
neXtProt AC		NX_P31785
Human Synonyms		CD132, CIDX, IL-2RG, IMD4, P64, SCIDX, SCIDX1
Human Chr (Location)		Xq13.1; chrX:70327254-70331481 (-)  GRCh37.p10
Disease Associations		(2) Diseases Associated with Human IL2RG

Alleles and phenotypes

All alleles(7) : Targeted(7)
 

Males hemizygous for targeted null mutations exhibit markedly reduced numbers of T and B cells, lack NK cells and Peyer's patches, and have severely reduced numbers of gut-associated intraepithelial lymphocytes.

 

Gene Ontology (GO) classifications

All GO classifications: (15 annotations)

Process	positive regulation of B cell differentiation, positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation, ...
Component	cell surface, external side of plasma membrane, ...
Function	cytokine receptor activity, interleukin-2 binding, ...

External Resources: FuncBase

Expression

Literature Summary: (9 records)
Data Summary: Results (109)    Tissues (58)    Images (3)
Theiler Stages: 13, 14, 17, 20, 21, 22, 23, 24, 25, 28

Assay Type	Results
RNA in situ	2
RT-PCR	107

cDNA source data(75)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(84) Genomic(5) cDNA(75) Primer pair(4)
Microarray probesets(4)

Other database links

VEGA Gene Model	OTTMUSG00000018211 (Evidence)
Ensembl Gene Model	ENSMUSG00000031304 (Evidence)
Entrez Gene	16186 (Evidence)
UniGene	2923
DFCI	TC1574674
DoTS	DT.533324
NIA Mouse Gene Index	U039577
Consensus CDS Project	CCDS30312.1
International Mouse Knockout Project Status	Il2rg

Sequences

Length	Strain/Species
genomic	OTTMUSG00000018211	VEGA Gene Model | MGI Sequence Detail	3878	C57BL/6J
transcript	OTTMUST00000043978	VEGA | MGI Sequence Detail	1670	Not Applicable
polypeptide	OTTMUSP00000019747	VEGA | MGI Sequence Detail	369	Not Applicable

All sequences(40) RefSeq(2) UniProt(3)

Polymorphisms

RFLP(2) : SNPs(7 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR003961	Fibronectin, type III
InterPro	IPR013783	Immunoglobulin-like fold
InterPro	IPR015321	Interleukin-6 receptor alpha chain, binding
InterPro	IPR003531	Short hematopoietin receptor, family 1, conserved site
Protein Ontology	PR:000001340	cytokine receptor common gamma chain

References

(Earliest) J:12198 Kumaki S, et al., Cloning of the mouse interleukin 2 receptor gamma chain: demonstration of functional differences between the mouse and human receptors. Biochem Biophys Res Commun. 1993 May 28;193(1):356-63
(Latest) J:194772 Garcia-Ojeda ME, et al., GATA-3 promotes T-cell specification by repressing B-cell potential in pro-T cells in mice. Blood. 2013 Mar 7;121(10):1749-59
All references(364)

Other accession IDs

MGD-MRK-11378