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Il2rg
Gene Detail
Symbol

Name
ID
Il2rg
interleukin 2 receptor, gamma chain
MGI:96551
Synonyms
CD132, common cytokine receptor gamma chain, common gamma chain, gamma(c), gamma C receptor, gc, [g]c
Feature Type
protein coding gene
Genetic Map
Chromosome X
43.90 cM
Detailed Genetic Map ± 1 cM


Mapping data(7)
Sequence Map
ChrX:101264378-101268255 bp, - strand
From VEGA annotation of GRCm38

  3878 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:172  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 2 zebrafish

Protein SuperFamily: interleukin-2 receptor gamma chain
Gene Tree: Il2rg

Human
homologs
Human Homolog IL2RG, interleukin 2 receptor, gamma
NCBI Gene ID 3561
neXtProt AC  NX_P31785
Human Synonyms  CD132, CIDX, IL-2RG, IMD4, P64, SCIDX, SCIDX1
Human Chr (Location)  Xq13.1; chrX:71107404-71111631 (-)  GRCh38
Disease Associations  (2) Diseases Associated with Human IL2RG
Mutations,
alleles, and
phenotypes
All mutations/alleles(9) : Targeted(9)
Incidental mutations (data from APF )
 
Males hemizygous for targeted null mutations exhibit markedly reduced numbers of T and B cells, lack NK cells and Peyer's patches, and have severely reduced numbers of gut-associated intraepithelial lymphocytes.
 
Interactions
Il2rg interacts with 81 markers (Mir1a-1, Mir1a-2, Mir15b, ...)
Expression
Literature Summary: (9 records)
Data Summary: Results (109)    Tissues (58)    Images (3)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 2
RT-PCR 107
cDNA source data(76)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(85) Genomic(5) cDNA(76) Primer pair(4)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000018211 (Evidence)
Ensembl Gene ModelENSMUSG00000031304 (Evidence)
Entrez Gene16186 (Evidence)
UniGene2923
DFCITC1574674
DoTSDT.533324
NIA Mouse Gene IndexU039577
Consensus CDS ProjectCCDS30312.1
International Mouse Knockout Project StatusIl2rg
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000018211 VEGA Gene Model | MGI Sequence Detail 3878 C57BL/6J ±  kb
transcript OTTMUST00000043978 VEGA | MGI Sequence Detail 1670 Not Applicable 
polypeptide OTTMUSP00000019747 VEGA | MGI Sequence Detail 369 Not Applicable 

For the selected sequences
All sequences(47) RefSeq(4) UniProt(7)
Polymorphisms
RFLP(2) : SNPs within 2kb(7 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR003961 Fibronectin, type III
InterPro IPR013783 Immunoglobulin-like fold
InterPro IPR015321 Interleukin-6 receptor alpha chain, binding
InterPro IPR003531 Short hematopoietin receptor, family 1, conserved site
Protein Ontology PR:000001340 cytokine receptor common subunit gamma
References
(Earliest) J:12198 Kumaki S, et al., Cloning of the mouse interleukin 2 receptor gamma chain: demonstration of functional differences between the mouse and human receptors. Biochem Biophys Res Commun. 1993 May 28;193(1):356-63
(Latest) J:214815 Haddad G, et al., Phosphoinositide 3-kinase beta mediates microvascular endothelial repair of thrombotic microangiopathy. Blood. 2014 Sep 25;124(13):2142-9
All references(440)
Other
accession IDs
MGD-MRK-11378

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/09/2014
MGI 5.20
The Jackson Laboratory