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Il2rb
Gene Detail
Symbol

Name
ID
Il2rb
interleukin 2 receptor, beta chain
MGI:96550
Synonyms
CD122, IL15Rbeta, IL-15Rbeta, IL-15 receptor beta chain, IL-2/15Rbeta, Il-2Rbeta
Feature Type
protein coding gene
Genetic Map
Chromosome 15
37.52 cM, cytoband E
Detailed Genetic Map ± 1 cM


Mapping data(15)
Sequence Map
Chr15:78480553-78495066 bp, - strand
From Ensembl annotation of GRCm38

  14514 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:47955  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

HCOP human homology predictions: IL2RB
Gene Tree: Il2rb

Human
homologs
IL2RB, interleukin 2 receptor, beta
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 3560
neXtProt AC: NX_P14784

Human Synonyms: CD122, IL15RB, P70-75

Human Chr (Location): 22q13.1; chr22:37125838-37149922 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(7) : Radiation induced(1) Targeted(6)
Genomic Mutations involving Il2rb (1)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for a targeted null mutation exhibit spontaneous activation of T cells and differentiation of B cells, elevated immunoglobulins including autoantibodies causing hemolytic anemia, granulocytopoiesis, and death after 3 months of age.
 
Phenotype Images(2)
Interactions
Il2rb interacts with 102 markers (Mir18, Mir22, Mir27a, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (5 records)
Data Summary: Results (34)    Tissues (16)    Images (5)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 5
RT-PCR 29
cDNA source data(17)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: ZFIN il2rb    NEW 
Molecular
reagents
All nucleic(20) cDNA(17) Primer pair(2) Other(1)
Microarray probesets(5)
Other database
links
Ensembl Gene Model ENSMUSG00000068227 (Evidence)
Entrez Gene 16185 (Evidence)
NIA Mouse Gene Index U036383, U221614
Consensus CDS Project CCDS27616.1
International Mouse Phenotyping Consortium Status Il2rb
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000068227 Ensembl Gene Model | MGI Sequence Detail 14514 C57BL/6J ±  kb
transcript ENSMUST00000089398 Ensembl | MGI Sequence Detail 2692 Not Applicable 
polypeptide ENSMUSP00000086820 Ensembl | MGI Sequence Detail 539 Not Applicable 

For the selected sequences
All sequences(35) RefSeq(12) UniProt(5)
Polymorphisms
RFLP(3) : SNPs within 2kb(88 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR003961 Fibronectin, type III
InterPro IPR013783 Immunoglobulin-like fold
InterPro IPR003531 Short hematopoietin receptor, family 1, conserved site
Protein Ontology PR:000001381 interleukin-2 receptor subunit beta
References
(Earliest) J:7697 Fuse A, et al., Organization and structure of the mouse interleukin-2 gene. Nucleic Acids Res. 1984 Dec 21;12(24):9323-31
(Latest) J:195515 Lin GH, et al., GITR-Dependent Regulation of 4-1BB Expression: Implications for T Cell Memory and Anti-4-1BB-Induced Pathology. J Immunol. 2013 May 1;190(9):4627-39
All references(117)
Other
accession IDs
MGD-MRK-11377

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
05/20/2015
MGI 5.22
The Jackson Laboratory