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Il2rb
Gene Detail
 Symbol
Name
ID
Il2rb
interleukin 2 receptor, beta chain
MGI:96550
Synonyms CD122, IL15Rbeta, IL-15Rbeta, IL-15 receptor beta chain, IL-2/15Rbeta, Il-2Rbeta
Feature Type protein coding gene
Genetic Map
Chromosome 15
37.52 cM, cytoband E
Detailed Genetic Map ± 1 cM


Mapping data(15)
Sequence Map
Chr15:78480553-78495066 bp, - strand
From Ensembl annotation of GRCm38

  14514 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:47955  Vertebrate Homology Class
1 human; 1 mouse; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 zebrafish

Gene Tree: Il2rb

Human
homologs
Human Homolog IL2RB, interleukin 2 receptor, beta
NCBI Gene ID 3560
neXtProt AC  NX_P14784
Human Synonyms  CD122, IL15RB, P70-75
Human Chr (Location)  22q13.1; chr22:37125838-37149922 (-)  GRCh38
Alleles
and
phenotypes
All alleles(6) : Targeted(6)
 
Homozygotes for a targeted null mutation exhibit spontaneous activation of T cells and differentiation of B cells, elevated immunoglobulins including autoantibodies causing hemolytic anemia, granulocytopoiesis, and death after 3 months of age.
 
Gene Ontology
(GO)
classifications
All GO classifications: (10 annotations)
Process cytokine-mediated signaling pathway, interleukin-2-mediated signaling pathway, ...
Component external side of plasma membrane, integral component of membrane, ...
Function cytokine receptor activity, interleukin-2 binding, ...
External Resources: FuncBase
Expression
Literature Summary: (5 records)
Data Summary: Results (35)    Tissues (17)    Images (5)
Theiler Stages: 4, 22, 23, 24, 25, 26
Assay TypeResults
RNA in situ 5
RT-PCR 30
cDNA source data(17)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(20) cDNA(17) Primer pair(2) Other(1)
Microarray probesets(5)
Other database
links
Ensembl Gene ModelENSMUSG00000068227 (Evidence)
Entrez Gene16185 (Evidence)
NIA Mouse Gene IndexU036383, U221614
Consensus CDS ProjectCCDS27616.1
International Mouse Knockout Project StatusIl2rb
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000068227 Ensembl Gene Model | MGI Sequence Detail 14514 C57BL/6J ±  kb
transcript ENSMUST00000089398 Ensembl | MGI Sequence Detail 2692 Not Applicable 
polypeptide ENSMUSP00000086820 Ensembl | MGI Sequence Detail 539 Not Applicable 

For the selected sequences
All sequences(35) RefSeq(12) UniProt(5)
Polymorphisms RFLP(3) : SNPs within 2kb(88 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR003961 Fibronectin, type III
InterPro IPR013783 Immunoglobulin-like fold
InterPro IPR003531 Short hematopoietin receptor, family 1, conserved site
Protein Ontology PR:000001381 interleukin-2 receptor subunit beta
References (Earliest) J:7697 Fuse A, et al., Organization and structure of the mouse interleukin-2 gene. Nucleic Acids Res. 1984 Dec 21;12(24):9323-31
(Latest) J:195515 Lin GH, et al., GITR-Dependent Regulation of 4-1BB Expression: Implications for T Cell Memory and Anti-4-1BB-Induced Pathology. J Immunol. 2013 May 1;190(9):4627-39
All references(118)
Other
accession IDs
MGD-MRK-11377

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
04/08/2014
MGI 5.17
The Jackson Laboratory