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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID
Il2rb
interleukin 2 receptor, beta chain
MGI:96550
53 phenotypes from 5 alleles in 8 genetic backgrounds
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Allelic Composition
Genetic Background
Annotated Term Reference
Il2rbm1Btlr/Il2rbm1Btlr
C57BL/6J-Il2rbm1Btlr
decreased B cell number J:267694
decreased CD4-positive, alpha-beta T cell number J:267694
decreased CD8-positive, naive alpha-beta T cell number J:267694
increased effector memory CD4-positive, alpha-beta T cell number J:267694
increased effector memory CD8-positive, alpha-beta T cell number J:267694
Il2rbm2Btlr/Il2rbm2Btlr
C57BL/6J-Il2rbm2Btlr
increased IgE level J:272832
Il2rbM3Btlr/Il2rbM3Btlr
C57BL/6J-Il2rbM3Btlr
abnormal CD8-positive, alpha-beta T cell differentiation J:272833
abnormal T cell morphology J:272833
decreased CD8-positive, alpha-beta T cell number J:272833
decreased central memory CD8 positive, alpha-beta T cell number J:272833
decreased NK cell number J:272833
decreased NK T cell number J:272833
increased CD4-positive, alpha-beta T cell number J:272833
increased IgM level J:272833
Il2rbtm1b(EUCOMM)Hmgu/Il2rbtm1b(EUCOMM)Hmgu
C57BL/6N-Il2rbtm1b(EUCOMM)Hmgu/Orl
abnormal autopod morphology J:211773
abnormal coat appearance J:211773
abnormal coat/ hair morphology J:211773
abnormal ear morphology J:211773
female infertility J:211773
male infertility J:211773
Il2rbtm1Mak/Il2rbtm1Mak
B6.129-Il2rbtm1Mak
abnormal lymphocyte morphology J:113547
abnormal response to transplant J:113547
abnormal spleen periarteriolar lymphoid sheath morphology J:113547
abnormal T cell activation J:113547
decreased regulatory T cell number J:113547
decreased T cell proliferation J:113547
enlarged lymph nodes J:113547
enlarged spleen J:113547
increased anti-double stranded DNA antibody level J:113547
increased susceptibility to autoimmune hemolytic anemia J:113547
Il2rbtm1Mak/Il2rbtm1Mak
C.129-Il2rbtm1Mak
abnormal immune system organ morphology J:113547
abnormal lymphocyte morphology J:113547
abnormal marginal zone B cell morphology J:113547
abnormal spleen periarteriolar lymphoid sheath morphology J:113547
abnormal T cell activation J:113547
abnormal T cell clonal deletion J:113547
decreased CD8-positive, alpha-beta T cell number J:113547
decreased T cell proliferation J:113547
enlarged lymph nodes J:113547
enlarged spleen J:113547
increased anti-double stranded DNA antibody level J:113547
increased susceptibility to autoimmune hemolytic anemia J:113547
liver inflammation J:113547
premature death J:113547
Il2rbtm1Mak/Il2rbtm1Mak
D2.129-Il2rbtm1Mak
abnormal T cell clonal deletion J:113547
Il2rbtm1Mak/Il2rbtm1Mak
either: (involves: 129P2/OlaHsd) or (involves: 129S2/SvPas)
abnormal B cell activation J:25940
abnormal common myeloid progenitor cell morphology J:25940
abnormal hair texture J:25940
abnormal locomotor behavior J:25940
abnormal mononuclear cell morphology J:25940
abnormal sex gland morphology J:25940
abnormal T cell activation J:25940
decreased B cell number J:25940
decreased double-positive T cell number J:25940
decreased memory T cell number J:25940
enlarged lymph nodes J:25940
enlarged spleen J:25940
increased activated T cell number J:25940
increased anti-nuclear antigen antibody level J:25940
increased CD4-positive, alpha-beta T cell number J:25940
increased CD8-positive, alpha-beta T cell number J:25940
increased erythroid progenitor cell number J:25940
increased granulocyte number J:25940
increased IgE level J:25940
increased IgG1 level J:25940
increased neutrophil cell number J:25940
increased plasma cell number J:25940
increased susceptibility to autoimmune hemolytic anemia J:25940
premature death J:25940
thymus hypoplasia J:25940
weight loss J:25940

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
04/16/2024
MGI 6.23
The Jackson Laboratory