Il2rb^M3Btlr
Chemically induced Allele Detail

Summary

• Symbol: Il2rb^M3Btlr
• Name: interleukin 2 receptor, beta chain; mutation 3, Bruce Beutler
• MGI ID: MGI:6285961
• Synonyms: Moonpie
• Gene: Il2rb Location: Chr15:78363456-78379471 bp, - strand Genetic Position: Chr15, 37.52 cM, cytoband E
• Alliance: Il2rb^M3Btlr page

Mutation origin

• Strain of Origin: C57BL/6J
• Project Collection: Beutler Mutagenetix

Mutation description

• Allele Type: Chemically induced (ENU) (Not Specified)
• Mutation: Single point mutation
• Mutation details: ENU-induced TGACTA to TGACTGACTA frameshift at base pair 78,481,834 (v38) on chromosome 15, or base pair 29,783 in the GenBank genomic region NC_000081 encoding Il2rb. The mutation corresponds to residue 1,406 in the mRNA sequence NM_008368 within exon 10 of 10 total exons. The effect of the mutation at the cDNA and protein levels has not been examined, but the mutation is predicted to result in coding of a premature stop codon after amino acid 420 (the protein is normally 539 amino acids in length) in the CD122 protein. (J:272833)
• Inheritance: Semidominant

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Il2rb Mutation: 45 strains or lines available

Notes

https://mutagenetix.utsouthwestern.edu/phenotypic/phenotypic_rec.cfm?pk=4105

References

• Original: J:272833 Zhong X, et al., Mutagenetix entry for Moonpie. MGI Direct Data Submission. 2019
• All: 1 reference(s)