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Il12b
Gene Detail
Symbol

Name
ID
Il12b
interleukin 12b
MGI:96540
Synonyms
Il-12b, Il-12p40, IL-12 p40, IL-23 subunit p40
Feature Type
protein coding gene
Genetic Map
Chromosome 11
25.94 cM, cytoband A5-B2
Detailed Genetic Map ± 1 cM


Mapping data(7)
Sequence Map
Chr11:44400063-44414033 bp, + strand
From VEGA annotation of GRCm38

  13971 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1648  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 2 zebrafish

HCOP human homology predictions: IL12B
Protein SuperFamily: interleukin-12, beta subunit
Gene Tree: Il12b

Human
homologs
IL12B, interleukin 12B
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 3593
neXtProt AC: NX_P29460

Human Synonyms: CLMF, CLMF2, IL-12B, IMD28, IMD29, NKSF, NKSF2

Human Chr (Location): 5q33.3; chr5:159314783-159330473 (-)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human IL12B

Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Targeted(6)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a null allele display impaired Th1 responses, defects in IFN gamma secretion and NK cell activity, increased susceptibility to bacterial and parasitic infection, alveolar bone loss, and resistance to chemically induced tumors and to delayed type hypersensitivity.
 
Interactions
Il12b interacts with 137 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (81 annotations)
Process cell cycle arrest, cell migration, ...
Component cytoplasm, extracellular region, ...
Function cytokine activity, cytokine receptor activity, ...
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (4)    Tissues (1)    Images (1)    Tissue x Stage Matrix (view)
Assay TypeResults
RT-PCR 4
cDNA source data(12)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: ZFIN il12ba, il12bb    NEW 
Molecular
reagents
All nucleic(22) Genomic(9) cDNA(12) Primer pair(1)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000005468 (Evidence)
Ensembl Gene Model ENSMUSG00000004296 (Evidence)
Entrez Gene 16160 (Evidence)
UniGene 239707
DFCI TC1587196
DoTS DT.101369034, DT.485933, DT.99853854
NIA Mouse Gene Index U012490
Consensus CDS Project CCDS24563.1
International Mouse Phenotyping Consortium Status Il12b
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000005468 VEGA Gene Model | MGI Sequence Detail 13971 C57BL/6J ±  kb
transcript OTTMUST00000012171 VEGA | MGI Sequence Detail 1861 Not Applicable 
polypeptide OTTMUSP00000005619 VEGA | MGI Sequence Detail 335 Not Applicable 

For the selected sequences
All sequences(30) RefSeq(3) UniProt(2)
Polymorphisms
RFLP(3) : SNPs within 2kb(225 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR003961 Fibronectin, type III
InterPro IPR007110 Immunoglobulin-like domain
InterPro IPR013783 Immunoglobulin-like fold
InterPro IPR003598 Immunoglobulin subtype 2
InterPro IPR015528 Interleukin-12 beta chain
InterPro IPR019482 Interleukin-12, beta subunit, central domain
InterPro IPR003530 Long hematopoietin receptor, soluble alpha chain, conserved site
Protein Ontology PR:000001369 interleukin-12 subunit beta
References
(Earliest) J:127699 Raich N, et al., Autonomous developmental control of human embryonic globin gene switching in transgenic mice. Science. 1990 Nov 23;250(4984):1147-9
(Latest) J:221887 Aychek T, et al., IL-23-mediated mononuclear phagocyte crosstalk protects mice from Citrobacter rodentium-induced colon immunopathology. Nat Commun. 2015;6:6525
All references(456)
Other
accession IDs
MGD-MRK-11349, MGD-MRK-11364

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory