Il12b
Gene Detail

Symbol Name ID

Il12b interleukin 12b MGI:96540

Synonyms

Il-12b, Il-12p40, IL-12 p40, IL-23 subunit p40

Feature Type

protein coding gene

Genetic Map

Chromosome 11

25.94 cM, cytoband A5-B2
Detailed Genetic Map ± 1 cM


Mapping data(7)

Sequence Map

Chr11:44400063-44414033 bp, + strand From VEGA annotation of GRCm38   13971 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:1648  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 2 zebrafish

Protein SuperFamily: interleukin-12, beta subunit
Gene Tree: Il12b

Human homologs

Human Homolog		IL12B, interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40)
NCBI Gene ID		3593
neXtProt AC		NX_P29460
Human Synonyms		CLMF, CLMF2, IL-12B, NKSF, NKSF2
Human Chr (Location)		5q31.1-q33.1; chr5:158741791-158757481 (-)  GRCh37.p10
Disease Associations		(2) Diseases Associated with Human IL12B

Alleles and phenotypes

All alleles(6) : Targeted(6)
 

Mice homozygous for a null allele display impaired Th1 responses, defects in IFN gamma secretion and NK cell activity, increased susceptibility to bacterial and parasitic infection, alveolar bone loss, and resistance to chemically induced tumors and to delayed type hypersensitivity.

 

Gene Ontology (GO) classifications

All GO classifications: (72 annotations)

Process	cell cycle arrest, cell migration, ...
Component	cytoplasm, extracellular region, ...
Function	cytokine activity, cytokine receptor activity, ...

External Resources: FuncBase

Expression

Literature Summary: (2 records)
Data Summary: Results (4)    Tissues (1)    Images (1)
Theiler Stages: 28

Assay Type	Results
RT-PCR	4

cDNA source data(12)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(22) Genomic(9) cDNA(12) Primer pair(1)
Microarray probesets(4)

Other database links

VEGA Gene Model	OTTMUSG00000005468 (Evidence)
Ensembl Gene Model	ENSMUSG00000004296 (Evidence)
Entrez Gene	16160 (Evidence)
UniGene	239707
DFCI	TC1587196
DoTS	DT.101369034, DT.485933, DT.99853854
NIA Mouse Gene Index	U012490
Consensus CDS Project	CCDS24563.1
International Mouse Knockout Project Status	Il12b

Sequences

Length	Strain/Species
genomic	OTTMUSG00000005468	VEGA Gene Model | MGI Sequence Detail	13971	C57BL/6J
transcript	OTTMUST00000012171	VEGA | MGI Sequence Detail	1861	Not Applicable
polypeptide	OTTMUSP00000005619	VEGA | MGI Sequence Detail	335	Not Applicable

All sequences(28) RefSeq(2) UniProt(2)

Polymorphisms

RFLP(3) : SNPs(121 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR003961	Fibronectin, type III
InterPro	IPR007110	Immunoglobulin-like domain
InterPro	IPR013783	Immunoglobulin-like fold
InterPro	IPR003598	Immunoglobulin subtype 2
InterPro	IPR015528	Interleukin-12 beta chain
InterPro	IPR019482	Interleukin-12, beta subunit, central domain
InterPro	IPR003530	Long hematopoietin receptor, soluble alpha chain, conserved site
Protein Ontology	PR:000001369	interleukin-12 subunit beta

References

(Earliest) J:127699 Raich N, et al., Autonomous developmental control of human embryonic globin gene switching in transgenic mice. Science. 1990 Nov 23;250(4984):1147-9
(Latest) J:195506 Duhen R, et al., Cutting Edge: The Pathogenicity of IFN-gamma-Producing Th17 Cells Is Independent of T-bet. J Immunol. 2013 May 1;190(9):4478-82
All references(435)

Other accession IDs

MGD-MRK-11349, MGD-MRK-11364