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Il12b
Gene Detail
 Symbol
Name
ID
Il12b
interleukin 12b
MGI:96540
Synonyms Il-12b, Il-12p40, IL-12 p40, IL-23 subunit p40
Feature Type protein coding gene
Genetic Map
Chromosome 11
25.94 cM, cytoband A5-B2
Detailed Genetic Map ± 1 cM


Mapping data(7)
Sequence Map
Chr11:44400063-44414033 bp, + strand
From VEGA annotation of GRCm38

  13971 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1648  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 2 zebrafish

Protein SuperFamily: interleukin-12, beta subunit
Gene Tree: Il12b

Human
homologs
Human Homolog IL12B, interleukin 12B
NCBI Gene ID 3593
neXtProt AC  NX_P29460
Human Synonyms  CLMF, CLMF2, IL-12B, NKSF, NKSF2
Human Chr (Location)  5q31.1-q33.1; chr5:159314783-159330473 (-)  GRCh38
Disease Associations  (2) Diseases Associated with Human IL12B
Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Targeted(6)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a null allele display impaired Th1 responses, defects in IFN gamma secretion and NK cell activity, increased susceptibility to bacterial and parasitic infection, alveolar bone loss, and resistance to chemically induced tumors and to delayed type hypersensitivity.
 
Interactions
Il12b interacts with 138 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (74 annotations)
Process cell cycle arrest, cell migration, ...
Component cytoplasm, extracellular region, ...
Function cytokine activity, cytokine receptor activity, ...
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (4)    Tissues (1)    Images (1)
Theiler Stages: 28
Assay TypeResults
RT-PCR 4
cDNA source data(12)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(22) Genomic(9) cDNA(12) Primer pair(1)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000005468 (Evidence)
Ensembl Gene ModelENSMUSG00000004296 (Evidence)
Entrez Gene16160 (Evidence)
UniGene239707
DFCITC1587196
DoTSDT.101369034, DT.485933, DT.99853854
NIA Mouse Gene IndexU012490
Consensus CDS ProjectCCDS24563.1
International Mouse Knockout Project StatusIl12b
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000005468 VEGA Gene Model | MGI Sequence Detail 13971 C57BL/6J ±  kb
transcript OTTMUST00000012171 VEGA | MGI Sequence Detail 1861 Not Applicable 
polypeptide OTTMUSP00000005619 VEGA | MGI Sequence Detail 335 Not Applicable 

For the selected sequences
All sequences(30) RefSeq(4) UniProt(2)
Polymorphisms RFLP(3) : SNPs within 2kb(225 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR003961 Fibronectin, type III
InterPro IPR007110 Immunoglobulin-like domain
InterPro IPR013783 Immunoglobulin-like fold
InterPro IPR003598 Immunoglobulin subtype 2
InterPro IPR015528 Interleukin-12 beta chain
InterPro IPR019482 Interleukin-12, beta subunit, central domain
InterPro IPR003530 Long hematopoietin receptor, soluble alpha chain, conserved site
Protein Ontology PR:000001369 interleukin-12 subunit beta
References (Earliest) J:127699 Raich N, et al., Autonomous developmental control of human embryonic globin gene switching in transgenic mice. Science. 1990 Nov 23;250(4984):1147-9
(Latest) J:211092 Wang Y, et al., STAT4 knockout mice are more susceptible to concanavalin A-induced T-cell hepatitis. Am J Pathol. 2014 Jun;184(6):1785-94
All references(451)
Other
accession IDs
MGD-MRK-11349, MGD-MRK-11364

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/02/2014
MGI 5.19
The Jackson Laboratory