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Il12a
Gene Detail
Symbol

Name
ID
Il12a
interleukin 12a
MGI:96539
Synonyms
IL-12p35, p35
Feature Type
protein coding gene
Genetic Map
Chromosome 3
31.92 cM
Detailed Genetic Map ± 1 cM


Mapping data(7)
Sequence Map
Chr3:68691424-68698547 bp, + strand
From VEGA annotation of GRCm38

  7124 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:681  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

HCOP human homology predictions: IL12A
Protein SuperFamily: interleukin-12, subunit alpha
Gene Tree: Il12a

Human
homologs
IL12A, interleukin 12A
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 3592
neXtProt AC: NX_P29459

Human Synonyms: CLMF, IL-12A, NFSK, NKSF1, P35

Human Chr (Location): 3q25.33; chr3:159988836-159996019 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
Null homozygotes have decreased NK cell responses, altered effector T cell differentiation, and increased susceptibility to parasitic infections.
 
Interactions
Il12a interacts with 79 markers (Mir10a, Mir10b, Mir27b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (43 annotations)
Process cell cycle arrest, cell migration, ...
Component cytoplasm, extracellular region, ...
Function cytokine activity, growth factor activity, ...
External Resources: FuncBase
Expression
Literature Summary: (1 records)
cDNA source data(8)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: ZFIN il12a    NEW 
Molecular
reagents
All nucleic(14) Genomic(3) cDNA(9) Other(2)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000051459 (Evidence)
Ensembl Gene Model ENSMUSG00000027776 (Evidence)
Entrez Gene 16159 (Evidence)
UniGene 103783
DFCI TC1589351
DoTS DT.101360402, DT.111049619, DT.40185648, DT.91326166
NIA Mouse Gene Index U003316
Consensus CDS Project CCDS17400.1, CCDS50930.1
International Mouse Phenotyping Consortium Status Il12a
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000051459 VEGA Gene Model | MGI Sequence Detail 7124 C57BL/6J ±  kb
transcript OTTMUST00000130032 VEGA | MGI Sequence Detail 1268 Not Applicable 
polypeptide OTTMUSP00000069767 VEGA | MGI Sequence Detail 215 Not Applicable 

For the selected sequences
All sequences(45) RefSeq(6) UniProt(4)
Polymorphisms
RFLP(2) : SNPs within 2kb(86 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR012351 Four-helical cytokine, core
InterPro IPR009079 Four-helical cytokine-like, core
InterPro IPR004281 Interleukin-12 alpha subunit
Protein Ontology PR:000001368 interleukin-12 subunit alpha
References
(Earliest) J:1053 Schoenhaut DS, et al., Cloning and expression of murine IL-12. J Immunol. 1992 Jun 1;148(11):3433-40
(Latest) J:216089 Ives A, et al., MyD88 and TLR9 dependent immune responses mediate resistance to Leishmania guyanensis infections, irrespective of Leishmania RNA virus burden. PLoS One. 2014;9(5):e96766
All references(320)
Other
accession IDs
MGD-MRK-11348, MGD-MRK-11363

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/18/2015
MGI 6.0
The Jackson Laboratory