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Il12a
Gene Detail
 Symbol
Name
ID
Il12a
interleukin 12a
MGI:96539
Synonyms IL-12p35, p35
Feature Type protein coding gene
Genetic Map
Chromosome 3
31.92 cM
Detailed Genetic Map ± 1 cM


Mapping data(7)
Sequence Map
Chr3:68690644-68698547 bp, + strand
From NCBI annotation of GRCm38

  7904 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:681  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog

Protein SuperFamily: interleukin-12, subunit alpha
Gene Tree: Il12a

Human
homologs
Human Homolog IL12A, interleukin 12A
NCBI Gene ID 3592
neXtProt AC  NX_P29459
Human Synonyms  CLMF, IL-12A, NFSK, NKSF1, P35
Human Chr (Location)  3q25.33; chr3:159988836-159996019 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
Null homozygotes have decreased NK cell responses, altered effector T cell differentiation, and increased susceptibility to parasitic infections.
 
Interactions
Il12a interacts with 79 markers (Mir10a, Mir10b, Mir27b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (42 annotations)
Process cell cycle arrest, cell migration, ...
Component cytoplasm, extracellular region, ...
Function cytokine activity, growth factor activity, ...
External Resources: FuncBase
Expression
Literature Summary: (1 records)
cDNA source data(8)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(14) Genomic(3) cDNA(9) Other(2)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000027776 (Evidence)
Entrez Gene16159 (Evidence)
UniGene103783
DFCITC1589351
DoTSDT.101360402, DT.111049619, DT.40185648, DT.91326166
NIA Mouse Gene IndexU003316
Consensus CDS ProjectCCDS17400.1, CCDS50930.1
International Mouse Knockout Project StatusIl12a
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 16159 NCBI Gene Model | MGI Sequence Detail 7904 C57BL/6J ±  kb
transcript NM_001159424 RefSeq | MGI Sequence Detail 1303 C57BL/6 
polypeptide P43431 UniProt | EBI | MGI Sequence Detail 215 Not Applicable 

For the selected sequences
All sequences(34) RefSeq(6) UniProt(4)
Polymorphisms RFLP(2) : SNPs within 2kb(86 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR012351 Four-helical cytokine, core
InterPro IPR009079 Four-helical cytokine-like, core
InterPro IPR004281 Interleukin-12 alpha subunit
Protein Ontology PR:000001368 interleukin-12 subunit alpha
Graphical View of Protein Domain Structure
References (Earliest) J:1053 Schoenhaut DS, et al., Cloning and expression of murine IL-12. J Immunol. 1992 Jun 1;148(11):3433-40
(Latest) J:209994 Vitry MA, et al., Humoral immunity and CD4+ Th1 cells are both necessary for a fully protective immune response upon secondary infection with Brucella melitensis. J Immunol. 2014 Apr 15;192(8):3740-52
All references(317)
Other
accession IDs
MGD-MRK-11348, MGD-MRK-11363

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/23/2014
MGI 5.19
The Jackson Laboratory