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Il12a Gene Detail
Summary
  • Symbol
    Il12a
  • Name
    interleukin 12a
  • Synonyms
    IL-12p35, p35
  • Feature Type
    protein coding gene
  • IDs
    MGI:96539
    NCBI Gene: 16159
  • Gene Overview
    MyGene.info: IL12A
  • Alliance
  • Transcription Start Sites
    13 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:68690644-68698547 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 3, 31.92 cM
  • Mapping Data
    8 experiments
Strain
Comparison
more
  • SNPs within 2kb
    82 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_96539
protein coding gene Chr3:68690644-68698550 (.)
129S1/SvImJ MGP_129S1SvImJ_G0027287
protein coding gene Chr3:67913814-67921717 (+)
A/J MGP_AJ_G0027249
protein coding gene Chr3:65899113-65907016 (+)
AKR/J MGP_AKRJ_G0027217
protein coding gene Chr3:67302094-67309997 (+)
BALB/cJ MGP_BALBcJ_G0027260
protein coding gene Chr3:65775849-65783752 (+)
C3H/HeJ MGP_C3HHeJ_G0027004
protein coding gene Chr3:67568478-67576381 (+)
C57BL/6NJ MGP_C57BL6NJ_G0027706
protein coding gene Chr3:70440507-70448410 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0025059
protein coding gene Chr3:62178165-62186100 (+)
CAST/EiJ MGP_CASTEiJ_G0026451
protein coding gene Chr3:67503424-67511295 (+)
CBA/J MGP_CBAJ_G0026979
protein coding gene Chr3:72637426-72645329 (+)
DBA/2J MGP_DBA2J_G0027115
protein coding gene Chr3:65401216-65409119 (+)
FVB/NJ MGP_FVBNJ_G0027083
protein coding gene Chr3:64018571-64026474 (+)
LP/J MGP_LPJ_G0027223
protein coding gene Chr3:68845093-68852996 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0027102
protein coding gene Chr3:77253121-77261024 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0027764
protein coding gene Chr3:67179822-67187725 (+)
PWK/PhJ MGP_PWKPhJ_G0026185
protein coding gene Chr3:65133509-65141440 (+)
SPRET/EiJ MGP_SPRETEiJ_G0026001
protein coding gene Chr3:66305649-66313579 (+)
WSB/EiJ MGP_WSBEiJ_G0026529
protein coding gene Chr3:67316361-67324264 (+)



Homology
more
  • Human Ortholog
    IL12A, interleukin 12A
  • Vertebrate Orthologs
    7
  • Human Ortholog
    IL12A, interleukin 12A
    Orthology source: HGNC, HomoloGene
  • Synonyms
    CLMF, IL-12A, NFSK, NKSF1, P35
  • Links
    NCBI Gene ID: 3592
    neXtProt AC: NX_P29459
    UniProt: P29459

  • Chr Location
    3q25.33; chr3:159988836-159996019 (+)  GRCh38.p7

Human Diseases
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  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    11 phenotypes from 3 alleles in 8 genetic backgrounds
    5 phenotypes from multigenic genotypes
    196 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Null homozygotes have decreased NK cell responses, altered effector T cell differentiation, and increased susceptibility to parasitic infections.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000027776 Ensembl Gene Model | MGI Sequence Detail 7904 C57BL/6J ±  kb
transcript ENSMUST00000029345 Ensembl | MGI Sequence Detail 1303 Not Applicable  
polypeptide ENSMUSP00000029345 Ensembl | MGI Sequence Detail 236 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    4 Sequences
  • InterPro Domains
    IPR009079 Four-helical cytokine-like, core
    IPR004281 Interleukin-12 alpha
Molecular
Reagents
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  • All nucleic 13
    Genomic 3
    cDNA 10

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-11348, MGD-MRK-11363
References
more
  • Summaries
    All 391
    Developmental Gene Expression 1
    Diseases 1
    Gene Ontology 17
    Phenotypes 196
  • Earliest
    J:1053 Schoenhaut DS, et al., Cloning and expression of murine IL-12. J Immunol. 1992 Jun 1;148(11):3433-40
  • Latest
    J:246093 Pedrotti LP, et al., Intestinal mononuclear cells primed by systemic interleukin-12 display long-term ability to aggravate colitis in mice. Immunology. 2017 Mar;150(3):290-300

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
12/04/2018
MGI 6.13
The Jackson Laboratory