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Ihh Gene Detail
Summary
  • Symbol
    Ihh
  • Name
    Indian hedgehog
  • Feature Type
    protein coding gene
  • IDs
    MGI:96533
    NCBI Gene: 16147
  • Gene Overview
    MyGene.info: IHH
Location & Maps
more
  • Sequence Map
    Chr1:74945315-74951672 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      6358 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 1, 38.55 cM
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    IHH, indian hedgehog
  • Vertebrate Orthologs
    11
  • Human Ortholog
    IHH, indian hedgehog
    Orthology source: HomoloGene, HGNC
  • Synonyms
    BDA1, HHG2
  • Links
    NCBI Gene ID: 3549
    neXtProt AC: NX_Q14623

  • Chr Location
    2q35; chr2:219054420-219060516 (-)  GRCh38.p2

Human Diseases
more
  • Diseases
    2 with Ihh mouse models; 2 with human IHH associations

Human Disease Mouse Models
       Brachydactyly, Type A1; BDA1   OMIM: 112500 View 1 model
       Pancreas, Annular   OMIM: 167750 View 1 model
       Acrocapitofemoral Dysplasia; ACFD   OMIM: 607778
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    65 phenotypes from 3 alleles in 5 genetic backgrounds
    25 phenotypes from multigenic genotypes
    62 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    11
  • Chemically induced (other)
    1
  • Radiation induced
    2
  • Targeted
    7
  • Transgenic
    1
  • Genomic Mutations
    3 involving Ihh
  • Incidental Mutations
Homozygotes die before or immediately after birth due to respiratory failure, exhibiting limb dwarfism associated with reduced chondrocyte proliferation, ectopic maturation of chondrocytes, and a failure of osteoblast development in endochondral bones.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000048255 VEGA Gene Model | MGI Sequence Detail 6358 C57BL/6J ±  kb
transcript OTTMUST00000123861 VEGA | MGI Sequence Detail 2468 Not Applicable  
polypeptide OTTMUSP00000067528 VEGA | MGI Sequence Detail 449 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    64 from dbSNP Build 142
  • RFLP
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 65
    cDNA 31
    Primer pair 12
    Other 22

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-11343
References
more
  • Summaries
    All 425
    Developmental Gene Expression 362
    Diseases 2
    Gene Ontology 28
    Phenotypes 62
  • Earliest
    J:16386 Echelard Y, et al., Sonic hedgehog, a member of a family of putative signaling molecules, is implicated in the regulation of CNS polarity. Cell. 1993 Dec 31;75(7):1417-30
  • Latest
    J:236232 Wang W, et al., Smad2 and Smad3 Regulate Chondrocyte Proliferation and Differentiation in the Growth Plate. PLoS Genet. 2016 Oct;12(10):e1006352

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/29/2016
MGI 6.06
The Jackson Laboratory