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Ihh
Gene Detail
Symbol

Name
ID
Ihh
Indian hedgehog
MGI:96533
Feature Type
protein coding gene
Genetic Map
Chromosome 1
38.55 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr1:74945315-74951672 bp, - strand
From VEGA annotation of GRCm38

  6358 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:22586  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 2 zebrafish

Protein SuperFamily: hedgehog protein
Gene Tree: Ihh

Human
homologs
Human Homolog IHH, Indian hedgehog
NCBI Gene ID 3549
neXtProt AC  NX_Q14623
Human Synonyms  BDA1, HHG2
Human Chr (Location)  2q33-q35; chr2:219054420-219060516 (-)  GRCh38
Disease Associations  (2) Diseases Associated with Human IHH
Mutations,
alleles, and
phenotypes
All mutations/alleles(7) : Targeted(7)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes die before or immediately after birth due to respiratory failure, exhibiting limb dwarfism associated with reduced chondrocyte proliferation, ectopic maturation of chondrocytes, and a failure of osteoblast development in endochondral bones.
 
Human Diseases Modeled Using Mouse Ihh (2)    Alleles Annotated to Human Diseases(2)   
Interactions
Ihh interacts with 119 markers (Mir1a-1, Mir1a-2, Mir15a, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (77 annotations)
Process bone resorption, camera-type eye development, ...
Component extracellular matrix, extracellular region, ...
Function calcium ion binding, hydrolase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (330 records)
Data Summary: Results (513)    Tissues (215)    Images (232)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 3
RNA in situ 388
Northern blot 15
Western blot 2
RT-PCR 105
cDNA source data(25)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(61) cDNA(31) Primer pair(10) Other(20)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000048255 (Evidence)
Ensembl Gene ModelENSMUSG00000006538 (Evidence)
Entrez Gene16147 (Evidence)
UniGene439736
DFCITC1584652, TC1664307
DoTSDT.101162915, DT.101362480
NIA Mouse Gene IndexU021486
Consensus CDS ProjectCCDS15061.1
International Mouse Knockout Project StatusIhh
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000048255 VEGA Gene Model | MGI Sequence Detail 6358 C57BL/6J ±  kb
transcript OTTMUST00000123861 VEGA | MGI Sequence Detail 2468 Not Applicable 
polypeptide OTTMUSP00000067528 VEGA | MGI Sequence Detail 449 Not Applicable 

For the selected sequences
All sequences(24) RefSeq(2) UniProt(3)
Polymorphisms
RFLP(2) : SNPs within 2kb(64 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000320 Hedgehog, N-terminal signaling domain
InterPro IPR001657 Hedgehog protein
InterPro IPR009045 Hedgehog signalling/DD-peptidase zinc-binding domain
InterPro IPR001767 Hint domain
InterPro IPR003586 Hint domain C-terminal
InterPro IPR003587 Hint domain N-terminal
InterPro IPR006141 Intein splice site
Protein Ontology PR:000008974 indian hedgehog protein
References
(Earliest) J:16386 Echelard Y, et al., Sonic hedgehog, a member of a family of putative signaling molecules, is implicated in the regulation of CNS polarity. Cell. 1993 Dec 31;75(7):1417-30
(Latest) J:211696 Goggolidou P, et al., Atmin mediates kidney morphogenesis by modulating Wnt signaling. Hum Mol Genet. 2014 May 22;
All references(393)
Disease annotation references (2)
Other
accession IDs
MGD-MRK-11343

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/11/2014
MGI 5.20
The Jackson Laboratory