Ihh
Gene Detail

Symbol Name ID

Ihh Indian hedgehog MGI:96533

Feature Type

protein coding gene

Genetic Map

Chromosome 1

38.55 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr1:74945319-74951651 bp, - strand From Ensembl annotation of GRCm38   6333 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Mammalian homology

human; rat; cattle; chimpanzee; dog, domestic    (Mammalian Orthology)
Comparative Map (Mouse/Human Ihh ± 2 cM)

Protein SuperFamily: hedgehog protein
Gene Tree: Ihh

Human ortholog

IHH Indian hedgehog NCBI Gene ID 3549
Human Synonyms: BDA1, HHG2
Human Chr2:219919142-219925238 bp, - strand Reference GRCh37.p2 Primary Assembly
Human Diseases Associated with Human IHH (2)

Alleles and phenotypes

All alleles(7) : Targeted(7)
 

Homozygotes die before or immediately after birth due to respiratory failure, exhibiting limb dwarfism associated with reduced chondrocyte proliferation, ectopic maturation of chondrocytes, and a failure of osteoblast development in endochondral bones.

 
Human Diseases Modeled Using Mouse Ihh (2)    Alleles Annotated to Human Diseases(2)   

Gene Ontology (GO) classifications

All GO classifications: (72 annotations)

Process	bone resorption, camera-type eye development, ...
Component	extracellular matrix, extracellular region, ...
Function	hydrolase activity, patched binding, ...

External Resources: FuncBase

Expression

Literature Summary: (305 records)
Data Summary: Results (467)    Tissues (203)    Images (198)
Theiler Stages: 2, 3, 9, 12, 13, 15, 17, 19, 20, 21, 22, 23, 24, 25, 26, 28

Assay Type	Results
Immunohistochemistry	3
RNA in situ	344
Northern blot	15
Western blot	2
RT-PCR	103

cDNA source data(24)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(53) cDNA(29) Primer pair(9) Other(15)
Microarray probesets(3)

Other database links

Ensembl Gene Model	ENSMUSG00000006538 (Evidence)
Entrez Gene	16147 (Evidence)
UniGene	439736
DFCI	TC1584652, TC1664307
DoTS	DT.101162915, DT.101362480
NIA Mouse Gene Index	U021486
Consensus CDS Project	CCDS15061.1
International Mouse Knockout Project Status	Ihh

Sequences

Length	Strain/Species
genomic	ENSMUSG00000006538	Ensembl Gene Model | MGI Sequence Detail	6333	C57BL/6J
transcript	ENSMUST00000164097	Ensembl | MGI Sequence Detail	2443	Not Applicable
polypeptide	ENSMUSP00000128056	Ensembl | MGI Sequence Detail	449	Not Applicable

All sequences(19) RefSeq(2) UniProt(2)

Polymorphisms

RFLP(2) : SNPs(51 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR000320	Hedgehog, N-terminal signaling domain
InterPro	IPR001657	Hedgehog protein
InterPro	IPR009045	Hedgehog signalling/DD-peptidase zinc-binding domain
InterPro	IPR001767	Hint domain
InterPro	IPR003586	Hint domain C-terminal
InterPro	IPR003587	Hint domain N-terminal
InterPro	IPR006141	Intein splice site
Protein Ontology	PR:000008974	indian hedgehog protein

References

(Earliest) J:16386 Echelard Y, et al., Sonic hedgehog, a member of a family of putative signaling molecules, is implicated in the regulation of CNS polarity. Cell. 1993 Dec 31;75(7):1417-30
(Latest) J:192870 Biau S, et al., Gastrointestinal defects of the Gas1 mutant involve dysregulated Hedgehog and Ret signaling. Biol Open. 2013;2:144-155
All references(364)

Other accession IDs

MGD-MRK-11343