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Ihh Gene Detail
Summary
  • Symbol
    Ihh
  • Name
    Indian hedgehog
  • Feature Type
    protein coding gene
  • IDs
    MGI:96533
    NCBI Gene: 16147
  • Gene Overview
    MyGene.info: IHH
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr1:74945315-74951672 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      6358 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 1, 38.55 cM
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    IHH, indian hedgehog
  • Vertebrate Orthologs
    11
  • Human Ortholog
    IHH, indian hedgehog
    Orthology source: HGNC, HomoloGene
  • Synonyms
    BDA1, HHG2
  • Links
    NCBI Gene ID: 3549
    neXtProt AC: NX_Q14623
    UniProt: Q14623

  • Chr Location
    2q35; chr2:219054420-219060516 (-)  GRCh38.p7

Human Diseases
more
  • Diseases
    3 with Ihh mouse models; 2 with human IHH associations

Human Disease Mouse Models
      
IDs
View 1 model
      
IDs
View 1 model
IDs
View 1 model
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    66 phenotypes from 3 alleles in 5 genetic backgrounds
    29 phenotypes from multigenic genotypes
    69 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygotes die before or immediately after birth due to respiratory failure, exhibiting limb dwarfism associated with reduced chondrocyte proliferation, ectopic maturation of chondrocytes, and a failure of osteoblast development in endochondral bones.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
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    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000048255 VEGA Gene Model | MGI Sequence Detail 6358 C57BL/6J ±  kb
    transcript OTTMUST00000123861 VEGA | MGI Sequence Detail 2468 Not Applicable  
    polypeptide OTTMUSP00000067528 VEGA | MGI Sequence Detail 449 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      64 from dbSNP Build 142
    • RFLP
    Protein
    Information
    less
    • UniProt
      3 Sequences
    • InterPro Domains
      IPR000320 Hedgehog, N-terminal signalling domain
      IPR001657 Hedgehog protein
      IPR001767 Hedgehog protein, Hint domain
      IPR009045 Hedgehog signalling/DD-peptidase zinc-binding domain superfamily
      IPR003586 Hint domain C-terminal
      IPR003587 Hint domain N-terminal
      IPR036844 Hint domain superfamily
      IPR006141 Intein N-terminal splicing region
    Molecular
    Reagents
    less
    • All nucleic 70
      cDNA 32
      Primer pair 15
      Other 23

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-11343
    References
    more
    • Summaries
      All 488
      Developmental Gene Expression 391
      Diseases 2
      Gene Ontology 28
      Phenotypes 69
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:263887 Yan J, et al., Smad4 deficiency impairs chondrocyte hypertrophy via the Runx2 transcription factor in mouse skeletal development. J Biol Chem. 2018 Jun 15;293(24):9162-9175

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    09/18/2018
    MGI 6.12
    The Jackson Laboratory