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Ihh
Gene Detail
Symbol

Name
ID
Ihh
Indian hedgehog
MGI:96533
Feature Type
protein coding gene
Genetic Map
Chromosome 1
38.55 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr1:74945315-74951672 bp, - strand
From VEGA annotation of GRCm38

  6358 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:22586  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 2 zebrafish

HCOP human homology predictions: IHH
Protein SuperFamily: hedgehog protein
Gene Tree: Ihh

Human
homologs
IHH, indian hedgehog
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 3549
neXtProt AC: NX_Q14623

Human Synonyms: BDA1, HHG2

Human Chr (Location): 2q33-q35; chr2:219054420-219060516 (-)  GRCh38.p2

Disease Associations: (2) Diseases Associated with Human IHH

Mutations,
alleles, and
phenotypes
All mutations/alleles(8) : Radiation induced(1) Targeted(7)
Genomic Mutations involving Ihh (1)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes die before or immediately after birth due to respiratory failure, exhibiting limb dwarfism associated with reduced chondrocyte proliferation, ectopic maturation of chondrocytes, and a failure of osteoblast development in endochondral bones.
 
Human Diseases Modeled in Mice Using Ihh (2)    Mutations Annotated to Human Diseases (2)   
Interactions
Ihh interacts with 119 markers (Mir1a-1, Mir1a-2, Mir15a, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (81 annotations)
Process bone resorption, camera-type eye development, ...
Component extracellular region, membrane, ...
Function calcium ion binding, hydrolase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (345 records)
Data Summary: Results (526)    Tissues (221)    Images (239)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 3
RNA in situ 395
Northern blot 15
Western blot 2
RT-PCR 111
cDNA source data(25)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: GEISHA IHH ; Xenbase ihh ; ZFIN ihha, ihhb    NEW 
Molecular
reagents
All nucleic(63) cDNA(31) Primer pair(11) Other(21)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000048255 (Evidence)
Ensembl Gene Model ENSMUSG00000006538 (Evidence)
Entrez Gene 16147 (Evidence)
UniGene 439736
DFCI TC1584652, TC1664307
DoTS DT.101162915, DT.101362480
NIA Mouse Gene Index U021486
Consensus CDS Project CCDS15061.1
International Mouse Phenotyping Consortium Status Ihh
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000048255 VEGA Gene Model | MGI Sequence Detail 6358 C57BL/6J ±  kb
transcript OTTMUST00000123861 VEGA | MGI Sequence Detail 2468 Not Applicable 
polypeptide OTTMUSP00000067528 VEGA | MGI Sequence Detail 449 Not Applicable 

For the selected sequences
All sequences(24) RefSeq(2) UniProt(2)
Polymorphisms
RFLP(2) : SNPs within 2kb(64 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR028992 Hedgehog/Intein (Hint) domain
InterPro IPR000320 Hedgehog, N-terminal signalling domain
InterPro IPR001657 Hedgehog protein
InterPro IPR001767 Hedgehog protein, Hint domain
InterPro IPR009045 Hedgehog signalling/DD-peptidase zinc-binding domain
InterPro IPR003586 Hint domain C-terminal
InterPro IPR003587 Hint domain N-terminal
InterPro IPR006141 Intein N-terminal splicing region
Protein Ontology PR:000008974 indian hedgehog protein
References
(Earliest) J:16386 Echelard Y, et al., Sonic hedgehog, a member of a family of putative signaling molecules, is implicated in the regulation of CNS polarity. Cell. 1993 Dec 31;75(7):1417-30
(Latest) J:222787 Liu C, et al., Lineage specification of ovarian theca cells requires multicellular interactions via oocyte and granulosa cells. Nat Commun. 2015;6:6934
All references(406)
Disease annotation references (2)
Other
accession IDs
MGD-MRK-11343

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory