Automated description from the Alliance of Genome Resources (Release 7.0.0)
Enables patched binding activity. Involved in several processes, including heart looping; positive regulation of smoothened signaling pathway; and regulation of T cell differentiation. Acts upstream of or within several processes, including camera-type eye development; skeletal system development; and tube morphogenesis. Located in extracellular matrix. Is expressed in several structures, including alimentary system; genitourinary system; limb; retina; and skeleton. Used to study Hirschsprung's disease; annular pancreas; and brachydactyly type A1. Human ortholog(s) of this gene implicated in acrocapitofemoral dysplasia; brachydactyly type A1; retinopathy of prematurity; and syndactyly type 1. Orthologous to human IHH (Indian hedgehog signaling molecule).